Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 75


TDP-43 and FUS-structural insights into RNA recognition and self-association.

Loughlin FE, Wilce JA.

Curr Opin Struct Biol. 2019 Aug 30;59:134-142. doi: 10.1016/ [Epub ahead of print] Review.


The TRIM-NHL protein NHL-2 is a co-factor in the nuclear and somatic RNAi pathways in C. elegans.

Davis GM, Tu S, Anderson JW, Colson RN, Gunzburg MJ, Francisco MA, Ray D, Shrubsole SP, Sobotka JA, Seroussi U, Lao RX, Maity T, Wu MZ, McJunkin K, Morris QD, Hughes TR, Wilce JA, Claycomb JM, Weng Z, Boag PR.

Elife. 2018 Dec 21;7. pii: e35478. doi: 10.7554/eLife.35478.


Combined roles of ATP and small hairpin RNA in the activation of RIG-I revealed by solution-based analysis.

Shah N, Beckham SA, Wilce JA, Wilce MCJ.

Nucleic Acids Res. 2018 Apr 6;46(6):3169-3186. doi: 10.1093/nar/gkx1307.


Shortened Penetratin Cell-Penetrating Peptide Is Insufficient for Cytosolic Delivery of a Grb7 Targeting Peptide.

Watson GM, Kulkarni K, Brandt R, Del Borgo MP, Aguilar MI, Wilce JA.

ACS Omega. 2017 Feb 28;2(2):670-677. doi: 10.1021/acsomega.6b00561. Epub 2017 Feb 23.


Discovery, Development, and Cellular Delivery of Potent and Selective Bicyclic Peptide Inhibitors of Grb7 Cancer Target.

Watson GM, Kulkarni K, Sang J, Ma X, Gunzburg MJ, Perlmutter P, Wilce MCJ, Wilce JA.

J Med Chem. 2017 Nov 22;60(22):9349-9359. doi: 10.1021/acs.jmedchem.7b01320. Epub 2017 Nov 10.


Insight into the Selectivity of the G7-18NATE Inhibitor Peptide for the Grb7-SH2 Domain Target.

Watson GM, Lucas WAH, Gunzburg MJ, Wilce JA.

Front Mol Biosci. 2017 Sep 26;4:64. doi: 10.3389/fmolb.2017.00064. eCollection 2017.


Huntingtin Inclusions Trigger Cellular Quiescence, Deactivate Apoptosis, and Lead to Delayed Necrosis.

Ramdzan YM, Trubetskov MM, Ormsby AR, Newcombe EA, Sui X, Tobin MJ, Bongiovanni MN, Gras SL, Dewson G, Miller JML, Finkbeiner S, Moily NS, Niclis J, Parish CL, Purcell AW, Baker MJ, Wilce JA, Waris S, Stojanovski D, Böcking T, Ang CS, Ascher DB, Reid GE, Hatters DM.

Cell Rep. 2017 May 2;19(5):919-927. doi: 10.1016/j.celrep.2017.04.029.


TIA-1 RRM23 binding and recognition of target oligonucleotides.

Waris S, García-Mauriño SM, Sivakumaran A, Beckham SA, Loughlin FE, Gorospe M, Díaz-Moreno I, Wilce MCJ, Wilce JA.

Nucleic Acids Res. 2017 May 5;45(8):4944-4957. doi: 10.1093/nar/gkx102.


Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7.

Gunzburg MJ, Kulkarni K, Watson GM, Ambaye ND, Del Borgo MP, Brandt R, Pero SC, Perlmutter P, Wilce MC, Wilce JA.

Sci Rep. 2016 Jun 3;6:27060. doi: 10.1038/srep27060.


The impact of cell-penetrating peptides on membrane bilayer structure during binding and insertion.

Hirst DJ, Lee TH, Kulkarni K, Wilce JA, Aguilar MI.

Biochim Biophys Acta. 2016 Aug;1858(8):1841-9. doi: 10.1016/j.bbamem.2016.05.004. Epub 2016 May 7.


Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target.

Watson GM, Gunzburg MJ, Ambaye ND, Lucas WA, Traore DA, Kulkarni K, Cergol KM, Payne RJ, Panjikar S, Pero SC, Perlmutter P, Wilce MC, Wilce JA.

J Med Chem. 2015 Oct 8;58(19):7707-18. doi: 10.1021/acs.jmedchem.5b00609. Epub 2015 Sep 23.


Cooperative interplay of let-7 mimic and HuR with MYC RNA.

Gunzburg MJ, Sivakumaran A, Pendini NR, Yoon JH, Gorospe M, Wilce MC, Wilce JA.

Cell Cycle. 2015;14(17):2729-33. doi: 10.1080/15384101.2015.1069930. Epub 2015 Jul 15.


RNA recognition and stress granule formation by TIA proteins.

Waris S, Wilce MC, Wilce JA.

Int J Mol Sci. 2014 Dec 16;15(12):23377-88. doi: 10.3390/ijms151223377. Review.


The binding of TIA-1 to RNA C-rich sequences is driven by its C-terminal RRM domain.

Cruz-Gallardo I, Aroca Á, Gunzburg MJ, Sivakumaran A, Yoon JH, Angulo J, Persson C, Gorospe M, Karlsson BG, Wilce JA, Díaz-Moreno I.

RNA Biol. 2014;11(6):766-76. Epub 2014 Apr 24.


Preparation of crystals for characterizing the Grb7 SH2 domain before and after complex formation with a bicyclic peptide antagonist.

Ambaye ND, Gunzburg MJ, Traore DA, Del Borgo MP, Perlmutter P, Wilce MC, Wilce JA.

Acta Crystallogr F Struct Biol Commun. 2014 Feb;70(Pt 2):182-6. doi: 10.1107/S2053230X13033414. Epub 2014 Jan 21.


Context-dependent role of Grb7 in HER2+ve and triple-negative breast cancer cell lines.

Lim RC, Price JT, Wilce JA.

Breast Cancer Res Treat. 2014 Feb;143(3):593-603. doi: 10.1007/s10549-014-2838-5. Epub 2014 Jan 25.


Domain-specific phosphomimetic mutation allows dissection of different protein kinase C (PKC) isotype-triggered activities of the RNA binding protein HuR.

Schulz S, Doller A, Pendini NR, Wilce JA, Pfeilschifter J, Eberhardt W.

Cell Signal. 2013 Dec;25(12):2485-95. doi: 10.1016/j.cellsig.2013.08.003. Epub 2013 Aug 23.


RBM5 is a male germ cell splicing factor and is required for spermatid differentiation and male fertility.

O'Bryan MK, Clark BJ, McLaughlin EA, D'Sylva RJ, O'Donnell L, Wilce JA, Sutherland J, O'Connor AE, Whittle B, Goodnow CC, Ormandy CJ, Jamsai D.

PLoS Genet. 2013;9(7):e1003628. doi: 10.1371/journal.pgen.1003628. Epub 2013 Jul 25.


Supramolecular self-assembly of N-acetyl-capped β-peptides leads to nano- to macroscale fiber formation.

Del Borgo MP, Mechler AI, Traore D, Forsyth C, Wilce JA, Wilce MC, Aguilar MI, Perlmutter P.

Angew Chem Int Ed Engl. 2013 Aug 5;52(32):8266-70. doi: 10.1002/anie.201303175. Epub 2013 Jun 19. No abstract available.


Distinct binding properties of TIAR RRMs and linker region.

Kim HS, Headey SJ, Yoga YM, Scanlon MJ, Gorospe M, Wilce MC, Wilce JA.

RNA Biol. 2013 Apr;10(4):579-89. doi: 10.4161/rna.24341. Epub 2013 Apr 1.


A molecular switch governs the interaction between the human complement protease C1s and its substrate, complement C4.

Perry AJ, Wijeyewickrema LC, Wilmann PG, Gunzburg MJ, D'Andrea L, Irving JA, Pang SS, Duncan RC, Wilce JA, Whisstock JC, Pike RN.

J Biol Chem. 2013 May 31;288(22):15821-9. doi: 10.1074/jbc.M113.464545. Epub 2013 Apr 16.


Structural characterization of Staphylococcus aureus biotin protein ligase and interaction partners: an antibiotic target.

Pendini NR, Yap MY, Traore DA, Polyak SW, Cowieson NP, Abell A, Booker GW, Wallace JC, Wilce JA, Wilce MC.

Protein Sci. 2013 Jun;22(6):762-73. doi: 10.1002/pro.2262. Erratum in: Protein Sci. 2014 Jan;23(1):121. Traore, D A K [added].


Design and testing of bicyclic inhibitors of Grb7--are two cycles better than one?

Gunzburg MJ, Ambaye ND, Del Borgo MP, Perlmutter P, Wilce JA.

Biopolymers. 2013 Sep;100(5):543-9. doi: 10.1002/bip.22237.


The discovery of phenylbenzamide derivatives as Grb7-based antitumor agents.

Ambaye ND, Gunzburg MJ, Lim RC, Price JT, Wilce MC, Wilce JA.

ChemMedChem. 2013 Feb;8(2):280-8. doi: 10.1002/cmdc.201200400. Epub 2012 Dec 17.


Conformational rearrangements of RIG-I receptor on formation of a multiprotein:dsRNA assembly.

Beckham SA, Brouwer J, Roth A, Wang D, Sadler AJ, John M, Jahn-Hofmann K, Williams BR, Wilce JA, Wilce MC.

Nucleic Acids Res. 2013 Mar 1;41(5):3436-45. doi: 10.1093/nar/gks1477. Epub 2013 Jan 15.


Sequence requirements for RNA binding by HuR and AUF1.

Barker A, Epis MR, Porter CJ, Hopkins BR, Wilce MC, Wilce JA, Giles KM, Leedman PJ.

J Biochem. 2012 Apr;151(4):423-37. doi: 10.1093/jb/mvs010. Epub 2012 Feb 25.


Contribution of the first K-homology domain of poly(C)-binding protein 1 to its affinity and specificity for C-rich oligonucleotides.

Yoga YM, Traore DA, Sidiqi M, Szeto C, Pendini NR, Barker A, Leedman PJ, Wilce JA, Wilce MC.

Nucleic Acids Res. 2012 Jun;40(11):5101-14. doi: 10.1093/nar/gks058. Epub 2012 Feb 16.


Conformational stability studies of a stapled hexa-β3-peptide library.

Gopalan RD, Del Borgo MP, Bergman YE, Unabia S, Mulder RJ, Wilce MC, Wilce JA, Aguilar MI, Perlmutter P.

Org Biomol Chem. 2012 Mar 7;10(9):1802-6. doi: 10.1039/c2ob06617c. Epub 2012 Jan 18.


Interaction of the non-phosphorylated peptide G7-18NATE with Grb7-SH2 domain requires phosphate for enhanced affinity and specificity.

Gunzburg MJ, Ambaye ND, Del Borgo MP, Pero SC, Krag DN, Wilce MC, Wilce JA.

J Mol Recognit. 2012 Jan;25(1):57-67. doi: 10.1002/jmr.2148.


Mutation and crystallization of the first KH domain of human polycytosine-binding protein 1 (PCBP1) in complex with DNA.

Yoga YM, Traore DA, Wilce JA, Wilce MC.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Oct 1;67(Pt 10):1257-61. doi: 10.1107/S1744309111028004. Epub 2011 Sep 30.


Structural basis of binding by cyclic nonphosphorylated peptide antagonists of Grb7 implicated in breast cancer progression.

Ambaye ND, Pero SC, Gunzburg MJ, Yap M, Clayton DJ, Del Borgo MP, Perlmutter P, Aguilar MI, Shukla GS, Peletskaya E, Cookson MM, Krag DN, Wilce MC, Wilce JA.

J Mol Biol. 2011 Sep 23;412(3):397-411. doi: 10.1016/j.jmb.2011.07.030. Epub 2011 Jul 23.


Different modes of interaction by TIAR and HuR with target RNA and DNA.

Kim HS, Wilce MC, Yoga YM, Pendini NR, Gunzburg MJ, Cowieson NP, Wilson GM, Williams BR, Gorospe M, Wilce JA.

Nucleic Acids Res. 2011 Feb;39(3):1117-30. doi: 10.1093/nar/gkq837. Epub 2011 Jan 13.


Preparation and crystallization of the Grb7 SH2 domain in complex with the G7-18NATE nonphosphorylated cyclic inhibitor peptide.

Yap MY, Wilce MC, Clayton DJ, Perlmutter P, Aguilar MI, Wilce JA.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Dec 1;66(Pt 12):1640-3. doi: 10.1107/S1744309110041850. Epub 2010 Nov 26.


Benzopyrazine derivatives: A novel class of growth factor receptor bound protein 7 antagonists.

Ambaye ND, Gunzburg MJ, Lim RC, Price JT, Wilce MC, Wilce JA.

Bioorg Med Chem. 2011 Jan 1;19(1):693-701. doi: 10.1016/j.bmc.2010.10.030. Epub 2010 Oct 19.


Uptake of a cell permeable G7-18NATE contruct into cells and binding with the Grb-7-SH2 domain.

Ambaye ND, Lim RC, Clayton DJ, Gunzburg MJ, Price JT, Pero SC, Krag DN, Wilce MC, Aguilar MI, Perlmutter P, Wilce JA.

Biopolymers. 2011;96(2):181-8. doi: 10.1002/bip.21403.


Constraints within major histocompatibility complex class I restricted peptides: presentation and consequences for T-cell recognition.

Theodossis A, Guillonneau C, Welland A, Ely LK, Clements CS, Williamson NA, Webb AI, Wilce JA, Mulder RJ, Dunstone MA, Doherty PC, McCluskey J, Purcell AW, Turner SJ, Rossjohn J.

Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5534-9. doi: 10.1073/pnas.1000032107. Epub 2010 Mar 8.


Synthesis of stapled beta3-peptides through ring-closing metathesis.

Bergman YE, Del Borgo MP, Gopalan RD, Jalal S, Unabia SE, Ciampini M, Clayton DJ, Fletcher JM, Mulder RJ, Wilce JA, Aguilar MI, Perlmutter P.

Org Lett. 2009 Oct 1;11(19):4438-40. doi: 10.1021/ol901803d.


Purification, crystallization and preliminary crystallographic analysis of DehI, a group I alpha-haloacid dehalogenase from Pseudomonas putida strain PP3.

Schmidberger JW, Wilce JA, Weightman AJ, Wilce MC.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Jul 1;64(Pt 7):596-8. doi: 10.1107/S1744309108008865. Epub 2008 Jun 7.


The crystal structure of DehI reveals a new alpha-haloacid dehalogenase fold and active-site mechanism.

Schmidberger JW, Wilce JA, Weightman AJ, Whisstock JC, Wilce MC.

J Mol Biol. 2008 Apr 18;378(1):284-94. doi: 10.1016/j.jmb.2008.02.035. Epub 2008 Feb 29.


The intracellular and nuclear-targeted delivery of an antiandrogen drug by carrier peptides.

Hodoniczky J, Sims CG, Best WM, Bentel JM, Wilce JA.

Biopolymers. 2008;90(5):595-603. doi: 10.1002/bip.20986.


Grb7 SH2 domain structure and interactions with a cyclic peptide inhibitor of cancer cell migration and proliferation.

Porter CJ, Matthews JM, Mackay JP, Pursglove SE, Schmidberger JW, Leedman PJ, Pero SC, Krag DN, Wilce MC, Wilce JA.

BMC Struct Biol. 2007 Sep 25;7:58.


Elucidation of a C-rich signature motif in target mRNAs of RNA-binding protein TIAR.

Kim HS, Kuwano Y, Zhan M, Pullmann R Jr, Mazan-Mamczarz K, Li H, Kedersha N, Anderson P, Wilce MC, Gorospe M, Wilce JA.

Mol Cell Biol. 2007 Oct;27(19):6806-17. Epub 2007 Aug 6.


An asymmetric structure of the Bacillus subtilis replication terminator protein in complex with DNA.

Vivian JP, Porter CJ, Wilce JA, Wilce MC.

J Mol Biol. 2007 Jul 13;370(3):481-91. Epub 2007 Mar 2.


Crystallization and preliminary X-ray diffraction analysis of the Bacillus subtilis replication termination protein in complex with the 37-base-pair TerI-binding site.

Vivian JP, Porter C, Wilce JA, Wilce MC.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Nov 1;62(Pt 11):1104-7. Epub 2006 Oct 20.


SLIRP, a small SRA binding protein, is a nuclear receptor corepressor.

Hatchell EC, Colley SM, Beveridge DJ, Epis MR, Stuart LM, Giles KM, Redfern AD, Miles LE, Barker A, MacDonald LM, Arthur PG, Lui JC, Golding JL, McCulloch RK, Metcalf CB, Wilce JA, Wilce MC, Lanz RB, O'Malley BW, Leedman PJ.

Mol Cell. 2006 Jun 9;22(5):657-68.


Toxins not neutralized by brown snake antivenom.

Judge RK, Henry PJ, Mirtschin P, Jelinek G, Wilce JA.

Toxicol Appl Pharmacol. 2006 Jun 1;213(2):117-25. Epub 2005 Oct 26.


Interaction of the replication terminator protein of Bacillus subtilis with DNA probed by NMR spectroscopy.

Hastings AF, Otting G, Folmer RH, Duggin IG, Wake RG, Wilce MC, Wilce JA.

Biochem Biophys Res Commun. 2005 Sep 23;335(2):361-6.


Grb7-SH2 domain dimerisation is affected by a single point mutation.

Porter CJ, Wilce MC, Mackay JP, Leedman P, Wilce JA.

Eur Biophys J. 2005 Jul;34(5):454-60. Epub 2005 Apr 20.


Supplemental Content

Loading ...
Support Center