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A novel NADPH oxidase inhibitor targeting Nox4 in TGFβ-induced lens epithelial to mesenchymal transition.

Das S, Wikström P, Walum E, Lovicu FJ.

Exp Eye Res. 2019 Aug;185:107692. doi: 10.1016/j.exer.2019.107692. Epub 2019 Jun 9.


Gene expression profiles define molecular subtypes of prostate cancer bone metastases with different outcomes and morphology traceable back to the primary tumor.

Thysell E, Vidman L, Ylitalo EB, Jernberg E, Crnalic S, Iglesias-Gato D, Flores-Morales A, Stattin P, Egevad L, Widmark A, Rydén P, Bergh A, Wikström P.

Mol Oncol. 2019 Aug;13(8):1763-1777. doi: 10.1002/1878-0261.12526. Epub 2019 Jun 27.


Immunoreactivity for prostate specific antigen and Ki67 differentiates subgroups of prostate cancer related to outcome.

Hammarsten P, Josefsson A, Thysell E, Lundholm M, Hägglöf C, Iglesias-Gato D, Flores-Morales A, Stattin P, Egevad L, Granfors T, Wikström P, Bergh A.

Mod Pathol. 2019 Sep;32(9):1310-1319. doi: 10.1038/s41379-019-0260-6. Epub 2019 Apr 12.


Vitamin A decreases the anabolic bone response to mechanical loading by suppressing bone formation.

Lionikaite V, Henning P, Drevinge C, Shah FA, Palmquist A, Wikström P, Windahl SH, Lerner UH.

FASEB J. 2019 Apr;33(4):5237-5247. doi: 10.1096/fj.201802040R. Epub 2019 Jan 22.


The novel NADPH oxidase 4 selective inhibitor GLX7013114 counteracts human islet cell death in vitro.

Wang X, Elksnis A, Wikström P, Walum E, Welsh N, Carlsson PO.

PLoS One. 2018 Sep 28;13(9):e0204271. doi: 10.1371/journal.pone.0204271. eCollection 2018.


The Proteome of Prostate Cancer Bone Metastasis Reveals Heterogeneity with Prognostic Implications.

Iglesias-Gato D, Thysell E, Tyanova S, Crnalic S, Santos A, Lima TS, Geiger T, Cox J, Widmark A, Bergh A, Mann M, Flores-Morales A, Wikström P.

Clin Cancer Res. 2018 Nov 1;24(21):5433-5444. doi: 10.1158/1078-0432.CCR-18-1229. Epub 2018 Jul 24.


Bone Cell Activity in Clinical Prostate Cancer Bone Metastasis and Its Inverse Relation to Tumor Cell Androgen Receptor Activity.

Nordstrand A, Bovinder Ylitalo E, Thysell E, Jernberg E, Crnalic S, Widmark A, Bergh A, Lerner UH, Wikström P.

Int J Mol Sci. 2018 Apr 18;19(4). pii: E1223. doi: 10.3390/ijms19041223.


Young people's differential vulnerability to criminogenic exposure: Bridging the gap between people- and place-oriented approaches in the study of crime causation.

Wikström PH, Mann RP, Hardie B.

Eur J Criminol. 2018 Jan;15(1):10-31. doi: 10.1177/1477370817732477. Epub 2018 Jan 14.


High inducible nitric oxide synthase in prostate tumor epithelium is associated with lethal prostate cancer.

Erlandsson A, Carlsson J, Andersson SO, Vyas C, Wikström P, Andrén O, Davidsson S, Rider JR.

Scand J Urol. 2018 Apr;52(2):129-133. doi: 10.1080/21681805.2017.1421261. Epub 2018 Jan 8.


A Systems Approach to Prostate Cancer Classification-Letter.

Thysell E, Ylitalo EB, Jernberg E, Bergh A, Wikström P.

Cancer Res. 2017 Dec 15;77(24):7131-7132. doi: 10.1158/0008-5472.CAN-16-3231. Epub 2017 Dec 6. No abstract available.


Platelets harbor prostate cancer biomarkers and the ability to predict therapeutic response to abiraterone in castration resistant patients.

Tjon-Kon-Fat LA, Lundholm M, Schröder M, Wurdinger T, Thellenberg-Karlsson C, Widmark A, Wikström P, Nilsson RJA.

Prostate. 2018 Jan;78(1):48-53. doi: 10.1002/pros.23443. Epub 2017 Nov 2.


Clinical relevance of androgen receptor alterations in prostate cancer.

Jernberg E, Bergh A, Wikström P.

Endocr Connect. 2017 Nov;6(8):R146-R161. doi: 10.1530/EC-17-0118. Review.


Inhibition of the insulin-like growth factor-1 receptor potentiates acute effects of castration in a rat model for prostate cancer growth in bone.

Nordstrand A, Bergström SH, Thysell E, Bovinder-Ylitalo E, Lerner UH, Widmark A, Bergh A, Wikström P.

Clin Exp Metastasis. 2017 Apr;34(3-4):261-271. doi: 10.1007/s10585-017-9848-8. Epub 2017 Apr 26.


Long leukocyte telomere length in prostate cancer patients at diagnosis is associated with poor metastasis-free and cancer-specific survival.

Svenson U, Roos G, Wikström P.

Tumour Biol. 2017 Feb;39(2):1010428317692236. doi: 10.1177/1010428317692236.


High levels of the AR-V7 Splice Variant and Co-Amplification of the Golgi Protein Coding YIPF6 in AR Amplified Prostate Cancer Bone Metastases.

Djusberg E, Jernberg E, Thysell E, Golovleva I, Lundberg P, Crnalic S, Widmark A, Bergh A, Brattsand M, Wikström P.

Prostate. 2017 May;77(6):625-638. doi: 10.1002/pros.23307. Epub 2017 Feb 1.


High Caveolin-1 Expression in Tumor Stroma Is Associated with a Favourable Outcome in Prostate Cancer Patients Managed by Watchful Waiting.

Hammarsten P, Dahl Scherdin T, Hägglöf C, Andersson P, Wikström P, Stattin P, Egevad L, Granfors T, Bergh A.

PLoS One. 2016 Oct 20;11(10):e0164016. doi: 10.1371/journal.pone.0164016. eCollection 2016.


Extracellular Vesicles from Metastatic Rat Prostate Tumors Prime the Normal Prostate Tissue to Facilitate Tumor Growth.

Halin Bergström S, Hägglöf C, Thysell E, Bergh A, Wikström P, Lundholm M.

Sci Rep. 2016 Aug 23;6:31805. doi: 10.1038/srep31805.


Social Disadvantage and Crime: A Criminological Puzzle.

Wikström PH, Treiber K.

Am Behav Sci. 2016 Sep;60(10):1232-1259. Epub 2016 Apr 27.


Subgroups of Castration-resistant Prostate Cancer Bone Metastases Defined Through an Inverse Relationship Between Androgen Receptor Activity and Immune Response.

Ylitalo EB, Thysell E, Jernberg E, Lundholm M, Crnalic S, Egevad L, Stattin P, Widmark A, Bergh A, Wikström P.

Eur Urol. 2017 May;71(5):776-787. doi: 10.1016/j.eururo.2016.07.033. Epub 2016 Aug 3.


Extratumoral Heme Oxygenase-1 (HO-1) Expressing Macrophages Likely Promote Primary and Metastatic Prostate Tumor Growth.

Halin Bergström S, Nilsson M, Adamo H, Thysell E, Jernberg E, Stattin P, Widmark A, Wikström P, Bergh A.

PLoS One. 2016 Jun 9;11(6):e0157280. doi: 10.1371/journal.pone.0157280. eCollection 2016.


The Proteome of Primary Prostate Cancer.

Iglesias-Gato D, Wikström P, Tyanova S, Lavallee C, Thysell E, Carlsson J, Hägglöf C, Cox J, Andrén O, Stattin P, Egevad L, Widmark A, Bjartell A, Collins CC, Bergh A, Geiger T, Mann M, Flores-Morales A.

Eur Urol. 2016 May;69(5):942-52. doi: 10.1016/j.eururo.2015.10.053. Epub 2015 Dec 2.


Secreted Factors from Colorectal and Prostate Cancer Cells Skew the Immune Response in Opposite Directions.

Lundholm M, Hägglöf C, Wikberg ML, Stattin P, Egevad L, Bergh A, Wikström P, Palmqvist R, Edin S.

Sci Rep. 2015 Oct 27;5:15651. doi: 10.1038/srep15651.


High Lysyl Oxidase (LOX) in the Non-Malignant Prostate Epithelium Predicts a Poor Outcome in Prostate Cancer Patient Managed by Watchful Waiting.

Nilsson M, Hägglöf C, Hammarsten P, Thysell E, Stattin P, Egevad L, Granfors T, Jernberg E, Wikstrom P, Halin Bergström S, Bergh A.

PLoS One. 2015 Oct 26;10(10):e0140985. doi: 10.1371/journal.pone.0140985. eCollection 2015.


Constrained randomization and multivariate effect projections improve information extraction and biomarker pattern discovery in metabolomics studies involving dependent samples.

Jonsson P, Wuolikainen A, Thysell E, Chorell E, Stattin P, Wikström P, Antti H.

Metabolomics. 2015;11(6):1667-1678. doi: 10.1007/s11306-015-0818-3. Epub 2015 Jun 2.


The novel NADPH oxidase 4 inhibitor GLX351322 counteracts glucose intolerance in high-fat diet-treated C57BL/6 mice.

Anvari E, Wikström P, Walum E, Welsh N.

Free Radic Res. 2015;49(11):1308-18. doi: 10.3109/10715762.2015.1067697. Epub 2015 Jul 30.


Mutations of ribosomal protein S5 suppress a defect in late-30S ribosomal subunit biogenesis caused by lack of the RbfA biogenesis factor.

Nord S, Bhatt MJ, Tükenmez H, Farabaugh PJ, Wikström PM.

RNA. 2015 Aug;21(8):1454-68. doi: 10.1261/rna.051383.115. Epub 2015 Jun 18.


Erratum: OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo.

Iglesias-Gato D, Chuan YC, Jiang N, Svensson C, Bao J, Shang Z, Paul I, Egevad L, Kessler BM, Wikström P, Niu Y, Flores-Morales A.

Mol Cancer. 2015 Apr 18;14:88. doi: 10.1186/s12943-015-0341-1. No abstract available.


Intensive land use in the Swedish mountains between AD 800 and 1200 led to deforestation and ecosystem transformation with long-lasting effects.

Östlund L, Hörnberg G, DeLuca TH, Liedgren L, Wikström P, Zackrisson O, Josefsson T.

Ambio. 2015 Oct;44(6):508-20. doi: 10.1007/s13280-015-0634-z. Epub 2015 Feb 13.


OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo.

Iglesias-Gato D, Chuan YC, Jiang N, Svensson C, Bao J, Paul I, Egevad L, Kessler BM, Wikström P, Niu Y, Flores-Morales A.

Mol Cancer. 2015 Jan 27;14:8. doi: 10.1186/s12943-014-0280-2. Erratum in: Mol Cancer. 2015;14:88.


Prostate tumor-derived exosomes down-regulate NKG2D expression on natural killer cells and CD8+ T cells: mechanism of immune evasion.

Lundholm M, Schröder M, Nagaeva O, Baranov V, Widmark A, Mincheva-Nilsson L, Wikström P.

PLoS One. 2014 Sep 30;9(9):e108925. doi: 10.1371/journal.pone.0108925. eCollection 2014.


High density of S100A9 positive inflammatory cells in prostate cancer stroma is associated with poor outcome.

Tidehag V, Hammarsten P, Egevad L, Granfors T, Stattin P, Leanderson T, Wikström P, Josefsson A, Hägglöf C, Bergh A.

Eur J Cancer. 2014 Jul;50(10):1829-1835. doi: 10.1016/j.ejca.2014.03.278. Epub 2014 Apr 10.


Characterization of prostate cancer bone metastases according to expression levels of steroidogenic enzymes and androgen receptor splice variants.

Jernberg E, Thysell E, Bovinder Ylitalo E, Rudolfsson S, Crnalic S, Widmark A, Bergh A, Wikström P.

PLoS One. 2013 Nov 7;8(11):e77407. doi: 10.1371/journal.pone.0077407. eCollection 2013.


SOCS2 mediates the cross talk between androgen and growth hormone signaling in prostate cancer.

Iglesias-Gato D, Chuan YC, Wikström P, Augsten S, Jiang N, Niu Y, Seipel A, Danneman D, Vermeij M, Fernandez-Perez L, Jenster G, Egevad L, Norstedt G, Flores-Morales A.

Carcinogenesis. 2014 Jan;35(1):24-33. doi: 10.1093/carcin/bgt304. Epub 2013 Sep 12.


Inhibition of the insulin-like growth factor-1 receptor enhances effects of simvastatin on prostate cancer cells in co-culture with bone.

Nordstrand A, Lundholm M, Larsson A, Lerner UH, Widmark A, Wikström P.

Cancer Microenviron. 2013 Dec;6(3):231-40. doi: 10.1007/s12307-013-0129-z. Epub 2013 Jan 22.


The mitochondrial and autosomal mutation landscapes of prostate cancer.

Lindberg J, Mills IG, Klevebring D, Liu W, Neiman M, Xu J, Wikström P, Wiklund P, Wiklund F, Egevad L, Grönberg H.

Eur Urol. 2013 Apr;63(4):702-8. doi: 10.1016/j.eururo.2012.11.053. Epub 2012 Dec 5.


Tumour epithelial expression levels of endocannabinoid markers modulate the value of endoglin-positive vascular density as a prognostic marker in prostate cancer.

Fowler CJ, Josefsson A, Thors L, Chung SC, Hammarsten P, Wikström P, Bergh A.

Biochim Biophys Acta. 2013 Oct;1831(10):1579-87. doi: 10.1016/j.bbalip.2012.12.005. Epub 2012 Dec 20.


S100A9 interaction with TLR4 promotes tumor growth.

Källberg E, Vogl T, Liberg D, Olsson A, Björk P, Wikström P, Bergh A, Roth J, Ivars F, Leanderson T.

PLoS One. 2012;7(3):e34207. doi: 10.1371/journal.pone.0034207. Epub 2012 Mar 28.


Low endoglin vascular density and Ki67 index in Gleason score 6 tumours may identify prostate cancer patients suitable for surveillance.

Josefsson A, Wikström P, Egevad L, Granfors T, Karlberg L, Stattin P, Bergh A.

Scand J Urol Nephrol. 2012 Aug;46(4):247-57. doi: 10.3109/00365599.2012.669791. Epub 2012 Mar 27.


Rapid identification of bio-molecules applied for detection of biosecurity agents using rolling circle amplification.

Göransson J, Ke R, Nong RY, Howell WM, Karman A, Grawé J, Stenberg J, Granberg M, Elgh M, Herthnek D, Wikström P, Jarvius J, Nilsson M.

PLoS One. 2012;7(2):e31068. doi: 10.1371/journal.pone.0031068. Epub 2012 Feb 22.


LC-MS/MS profiling for detection of endogenous steroids and prostaglandins in tissue samples.

Surowiec I, Koc M, Antti H, Wikström P, Moritz T.

J Sep Sci. 2011 Oct;34(19):2650-8. doi: 10.1002/jssc.201100436. Epub 2011 Sep 6.


Prostate cancer increases hyaluronan in surrounding nonmalignant stroma, and this response is associated with tumor growth and an unfavorable outcome.

Josefsson A, Adamo H, Hammarsten P, Granfors T, Stattin P, Egevad L, Laurent AE, Wikström P, Bergh A.

Am J Pathol. 2011 Oct;179(4):1961-8. doi: 10.1016/j.ajpath.2011.06.005. Epub 2011 Aug 18.


Alterations in the β flap and β' dock domains of the RNA polymerase abolish NusA-mediated feedback regulation of the metY-nusA-infB operon.

Bylund GO, Nord S, Lövgren JM, Wikström PM.

J Bacteriol. 2011 Aug;193(16):4113-22. doi: 10.1128/JB.00196-11. Epub 2011 Jun 17.


Outcome after surgery for metastatic spinal cord compression in 54 patients with prostate cancer.

Crnalic S, Hildingsson C, Wikström P, Bergh A, Löfvenberg R, Widmark A.

Acta Orthop. 2012 Feb;83(1):80-6. doi: 10.3109/17453674.2011.590761. Epub 2011 Jun 10.


Expression of androgen receptor splice variants in prostate cancer bone metastases is associated with castration-resistance and short survival.

Hörnberg E, Ylitalo EB, Crnalic S, Antti H, Stattin P, Widmark A, Bergh A, Wikström P.

PLoS One. 2011 Apr 28;6(4):e19059. doi: 10.1371/journal.pone.0019059.


Tumor indicating normal tissue could be a new source of diagnostic and prognostic markers for prostate cancer.

Halin S, Hammarsten P, Adamo H, Wikström P, Bergh A.

Expert Opin Med Diagn. 2011 Jan;5(1):37-47. doi: 10.1517/17530059.2011.540009. Epub 2010 Dec 8.


Metabolomic characterization of human prostate cancer bone metastases reveals increased levels of cholesterol.

Thysell E, Surowiec I, Hörnberg E, Crnalic S, Widmark A, Johansson AI, Stattin P, Bergh A, Moritz T, Antti H, Wikström P.

PLoS One. 2010 Dec 3;5(12):e14175. doi: 10.1371/journal.pone.0014175.


Molecular Detection of Persistent Francisella tularensis Subspecies holarctica in Natural Waters.

Broman T, Thelaus J, Andersson AC, Bäckman S, Wikström P, Larsson E, Granberg M, Karlsson L, Bäck E, Eliasson H, Mattsson R, Sjöstedt A, Forsman M.

Int J Microbiol. 2011;2011. pii: 851946. doi: 10.1155/2011/851946. Epub 2010 Sep 8.


Nuclear androgen receptor staining in bone metastases is related to a poor outcome in prostate cancer patients.

Crnalic S, Hörnberg E, Wikström P, Lerner UH, Tieva A, Svensson O, Widmark A, Bergh A.

Endocr Relat Cancer. 2010 Oct 5;17(4):885-95. doi: 10.1677/ERC-10-0059. Print 2010 Dec.


Indoleamine 2,3-dioxygenase (IDO) activity influence tumor growth in the TRAMP prostate cancer model.

Källberg E, Wikström P, Bergh A, Ivars F, Leanderson T.

Prostate. 2010 Sep 15;70(13):1461-70. doi: 10.1002/pros.21181.


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