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Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics.

Brinson RG, Marino JP, Delaglio F, Arbogast LW, Evans RM, Kearsley A, Gingras G, Ghasriani H, Aubin Y, Pierens GK, Jia X, Mobli M, Grant HG, Keizer DW, Schweimer K, Ståhle J, Widmalm G, Zartler ER, Lawrence CW, Reardon PN, Cort JR, Xu P, Ni F, Yanaka S, Kato K, Parnham SR, Tsao D, Blomgren A, Rundlöf T, Trieloff N, Schmieder P, Ross A, Skidmore K, Chen K, Keire D, Freedberg DI, Suter-Stahel T, Wider G, Ilc G, Plavec J, Bradley SA, Baldisseri DM, Sforça ML, Zeri ACM, Wei JY, Szabo CM, Amezcua CA, Jordan JB, Wikström M.

MAbs. 2019 Jan;11(1):94-105. doi: 10.1080/19420862.2018.1544454. Epub 2018 Dec 22.


Redox-coupled quinone dynamics in the respiratory complex I.

Warnau J, Sharma V, Gamiz-Hernandez AP, Di Luca A, Haapanen O, Vattulainen I, Wikström M, Hummer G, Kaila VRI.

Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):E8413-E8420. doi: 10.1073/pnas.1805468115. Epub 2018 Aug 17.


Streptococcal inhibitor of complement (SIC) modulates fibrinolysis and enhances bacterial survival within fibrin clots.

Frick IM, Shannon O, Neumann A, Karlsson C, Wikström M, Björck L.

J Biol Chem. 2018 Aug 31;293(35):13578-13591. doi: 10.1074/jbc.RA118.001988. Epub 2018 Jul 12.


Proton pumping by cytochrome c oxidase - A 40 year anniversary.

Wikström M, Sharma V.

Biochim Biophys Acta Bioenerg. 2018 Sep;1859(9):692-698. doi: 10.1016/j.bbabio.2018.03.009. Epub 2018 Mar 19. Review.


Bladder irrigation with Chlorhexidine reduces bacteriuria in persons with spinal cord injury.

Wikström M, Levi R, Antepohl W.

J Rehabil Med. 2018 Feb 13;50(2):181-184. doi: 10.2340/16501977-2298.


Oxygen Activation and Energy Conservation by Cytochrome c Oxidase.

Wikström M, Krab K, Sharma V.

Chem Rev. 2018 Mar 14;118(5):2469-2490. doi: 10.1021/acs.chemrev.7b00664. Epub 2018 Jan 19.


Ocular antigen does not cause disease unless presented in the context of inflammation.

Voigt V, Wikstrom ME, Kezic JM, Schuster IS, Fleming P, Makinen K, Daley SR, Andoniou CE, Degli-Esposti MA, Forrester JV.

Sci Rep. 2017 Oct 27;7(1):14226. doi: 10.1038/s41598-017-14618-z.


The structure of the Brassica napus seed microbiome is cultivar-dependent and affects the interactions of symbionts and pathogens.

Rybakova D, Mancinelli R, Wikström M, Birch-Jensen AS, Postma J, Ehlers RU, Goertz S, Berg G.

Microbiome. 2017 Sep 1;5(1):104. doi: 10.1186/s40168-017-0310-6.


Time-resolved generation of membrane potential by ba3 cytochrome c oxidase from Thermus thermophilus coupled to single electron injection into the O and OH states.

Siletsky SA, Belevich I, Belevich NP, Soulimane T, Wikström M.

Biochim Biophys Acta Bioenerg. 2017 Nov;1858(11):915-926. doi: 10.1016/j.bbabio.2017.08.007. Epub 2017 Aug 12.


Understanding the essential proton-pumping kinetic gates and decoupling mutations in cytochrome c oxidase.

Liang R, Swanson JMJ, Wikström M, Voth GA.

Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):5924-5929. doi: 10.1073/pnas.1703654114. Epub 2017 May 23.


Short communication: Variation in the composition and properties of Swedish raw milk for ultra-high-temperature processing.

Karlsson MA, Langton M, Innings F, Wikström M, Lundh ÅS.

J Dairy Sci. 2017 Apr;100(4):2582-2590. doi: 10.3168/jds.2016-12185. Epub 2017 Feb 8.


Effect of 12-month weekly professional oral hygiene care on the composition of the oral flora in dentate, dependent elderly residents: A prospective study.

Wikström M, Kareem KL, Almståhl A, Palmgren E, Lingström P, Wårdh I.

Gerodontology. 2017 Jun;34(2):240-248. doi: 10.1111/ger.12256. Epub 2016 Dec 18.


Oral Care and Mortality in Older Adults with Pneumonia in Hospitals or Nursing Homes: Systematic Review and Meta-Analysis.

Sjögren P, Wårdh I, Zimmerman M, Almståhl A, Wikström M.

J Am Geriatr Soc. 2016 Oct;64(10):2109-2115. doi: 10.1111/jgs.14260. Epub 2016 Sep 2. Review.


Multiscale simulations reveal key features of the proton-pumping mechanism in cytochrome c oxidase.

Liang R, Swanson JM, Peng Y, Wikström M, Voth GA.

Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7420-5. doi: 10.1073/pnas.1601982113. Epub 2016 Jun 23.


Structural Analysis of a Complex between Small Ubiquitin-like Modifier 1 (SUMO1) and the ZZ Domain of CREB-binding Protein (CBP/p300) Reveals a New Interaction Surface on SUMO.

Diehl C, Akke M, Bekker-Jensen S, Mailand N, Streicher W, Wikström M.

J Biol Chem. 2016 Jun 10;291(24):12658-72. doi: 10.1074/jbc.M115.711325. Epub 2016 Apr 25.


Human mesothelioma induces defects in dendritic cell numbers and antigen-processing function which predict survival outcomes.

Cornwall SM, Wikstrom M, Musk AW, Alvarez J, Nowak AK, Nelson DJ.

Oncoimmunology. 2015 Aug 31;5(2):e1082028. eCollection 2016 Feb.


Structure and Interactions of a Dimeric Variant of sHIP, a Novel Virulence Determinant of Streptococcus pyogenes.

Diehl C, Wisniewska M, Frick IM, Streicher W, Björck L, Malmström J, Wikström M.

Front Microbiol. 2016 Feb 5;7:95. doi: 10.3389/fmicb.2016.00095. eCollection 2016.


The role of the K-channel and the active-site tyrosine in the catalytic mechanism of cytochrome c oxidase.

Sharma V, Wikström M.

Biochim Biophys Acta. 2016 Aug;1857(8):1111-1115. doi: 10.1016/j.bbabio.2016.02.008. Epub 2016 Feb 17. Review.


Molecular simulation and modeling of complex I.

Hummer G, Wikström M.

Biochim Biophys Acta. 2016 Jul;1857(7):915-21. doi: 10.1016/j.bbabio.2016.01.005. Epub 2016 Jan 11. Review.


Gene therapy with recombinant adeno-associated vectors for neovascular age-related macular degeneration: 1 year follow-up of a phase 1 randomised clinical trial.

Rakoczy EP, Lai CM, Magno AL, Wikstrom ME, French MA, Pierce CM, Schwartz SD, Blumenkranz MS, Chalberg TW, Degli-Esposti MA, Constable IJ.

Lancet. 2015 Dec 12;386(10011):2395-403. doi: 10.1016/S0140-6736(15)00345-1. Epub 2015 Sep 30.


Redox-induced activation of the proton pump in the respiratory complex I.

Sharma V, Belevich G, Gamiz-Hernandez AP, Róg T, Vattulainen I, Verkhovskaya ML, Wikström M, Hummer G, Kaila VR.

Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):11571-6. doi: 10.1073/pnas.1503761112. Epub 2015 Sep 1.


Kupffer cell-monocyte communication is essential for initiating murine liver progenitor cell-mediated liver regeneration.

Elsegood CL, Chan CW, Degli-Esposti MA, Wikstrom ME, Domenichini A, Lazarus K, van Rooijen N, Ganss R, Olynyk JK, Yeoh GC.

Hepatology. 2015 Oct;62(4):1272-84. doi: 10.1002/hep.27977. Epub 2015 Jul 31.


Acute GVHD results in a severe DC defect that prevents T-cell priming and leads to fulminant cytomegalovirus disease in mice.

Wikstrom ME, Fleming P, Kuns RD, Schuster IS, Voigt V, Miller G, Clouston AD, Tey SK, Andoniou CE, Hill GR, Degli-Esposti MA.

Blood. 2015 Sep 17;126(12):1503-14. doi: 10.1182/blood-2015-01-622837. Epub 2015 Jun 30.


Microflora in oral ecosystems and salivary secretion rates--A 3-year follow-up after radiation therapy to the head and neck region.

Almståhl A, Wikström M, Fagerberg-Mohlin B.

Arch Oral Biol. 2015 Sep;60(9):1187-95. doi: 10.1016/j.archoralbio.2015.04.004. Epub 2015 May 22.


Role of subunit III and its lipids in the molecular mechanism of cytochrome c oxidase.

Sharma V, Ala-Vannesluoma P, Vattulainen I, Wikström M, Róg T.

Biochim Biophys Acta. 2015 Aug;1847(8):690-7. doi: 10.1016/j.bbabio.2015.04.007. Epub 2015 Apr 17.


Nitric oxide is a potent inhibitor of the cbb(3)-type heme-copper oxidases.

Arjona D, Wikström M, Ädelroth P.

FEBS Lett. 2015 May 8;589(11):1214-8. doi: 10.1016/j.febslet.2015.03.033. Epub 2015 Apr 8.


New perspectives on proton pumping in cellular respiration.

Wikström M, Sharma V, Kaila VR, Hosler JP, Hummer G.

Chem Rev. 2015 Mar 11;115(5):2196-221. doi: 10.1021/cr500448t. Epub 2015 Feb 19. Review. No abstract available.


Using heterozygosity-fitness correlations to study inbreeding depression in an isolated population of white-tailed deer founded by few individuals.

Brommer JE, Kekkonen J, Wikström M.

Ecol Evol. 2015 Jan;5(2):357-67. doi: 10.1002/ece3.1362. Epub 2014 Dec 24.


Proton-coupled electron transfer and the role of water molecules in proton pumping by cytochrome c oxidase.

Sharma V, Enkavi G, Vattulainen I, Róg T, Wikström M.

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):2040-5. doi: 10.1073/pnas.1409543112. Epub 2015 Feb 2.


A natural genetic variant of granzyme B confers lethality to a common viral infection.

Andoniou CE, Sutton VR, Wikstrom ME, Fleming P, Thia KY, Matthews AY, Kaiserman D, Schuster IS, Coudert JD, Eldi P, Chaudhri G, Karupiah G, Bird PI, Trapani JA, Degli-Esposti MA.

PLoS Pathog. 2014 Dec 11;10(12):e1004526. doi: 10.1371/journal.ppat.1004526. eCollection 2014 Dec.


Production of functional human insulin-like growth factor binding proteins (IGFBPs) using recombinant expression in HEK293 cells.

Wanscher ASM, Williamson M, Ebersole TW, Streicher W, Wikström M, Cazzamali G.

Protein Expr Purif. 2015 Apr;108:97-105. doi: 10.1016/j.pep.2014.10.017. Epub 2014 Nov 11.


Persistent and compartmentalised disruption of dendritic cell subpopulations in the lung following influenza A virus infection.

Strickland DH, Fear V, Shenton S, Wikstrom ME, Zosky G, Larcombe AN, Holt PG, Berry C, von Garnier C, Stumbles PA.

PLoS One. 2014 Nov 14;9(11):e111520. doi: 10.1371/journal.pone.0111520. eCollection 2014.


TRAIL+ NK cells control CD4+ T cell responses during chronic viral infection to limit autoimmunity.

Schuster IS, Wikstrom ME, Brizard G, Coudert JD, Estcourt MJ, Manzur M, O'Reilly LA, Smyth MJ, Trapani JA, Hill GR, Andoniou CE, Degli-Esposti MA.

Immunity. 2014 Oct 16;41(4):646-56. doi: 10.1016/j.immuni.2014.09.013.


A structural and functional perspective on the evolution of the heme-copper oxidases.

Sharma V, Wikström M.

FEBS Lett. 2014 Nov 3;588(21):3787-92. doi: 10.1016/j.febslet.2014.09.020. Epub 2014 Sep 26.


Functional and structural properties of a novel protein and virulence factor (Protein sHIP) in Streptococcus pyogenes.

Wisniewska M, Happonen L, Kahn F, Varjosalo M, Malmström L, Rosenberger G, Karlsson C, Cazzamali G, Pozdnyakova I, Frick IM, Björck L, Streicher W, Malmström J, Wikström M.

J Biol Chem. 2014 Jun 27;289(26):18175-88. doi: 10.1074/jbc.M114.565978. Epub 2014 May 13.


Electrostatics, hydration, and proton transfer dynamics in the membrane domain of respiratory complex I.

Kaila VR, Wikström M, Hummer G.

Proc Natl Acad Sci U S A. 2014 May 13;111(19):6988-93. doi: 10.1073/pnas.1319156111. Epub 2014 Apr 28.


Long-term effects of using oral care aides at a nursing home for elderly dependent residents--a pilot study.

Wårdh IM, Wikström MB.

Spec Care Dentist. 2014 Mar-Apr;34(2):64-9. doi: 10.1111/scd.12009. Epub 2013 Jan 8.


The causes of reduced proton-pumping efficiency in type B and C respiratory heme-copper oxidases, and in some mutated variants of type A.

Rauhamäki V, Wikström M.

Biochim Biophys Acta. 2014 Jul;1837(7):999-1003. doi: 10.1016/j.bbabio.2014.02.020. Epub 2014 Feb 26.


Assessing the correlation between mutant rhodopsin stability and the severity of retinitis pigmentosa.

McKeone R, Wikstrom M, Kiel C, Rakoczy PE.

Mol Vis. 2014 Feb 7;20:183-99. eCollection 2014.


Oxidoreduction properties of bound ubiquinone in Complex I from Escherichia coli.

Verkhovskaya M, Wikström M.

Biochim Biophys Acta. 2014 Feb;1837(2):246-50. doi: 10.1016/j.bbabio.2013.11.001. Epub 2013 Nov 9.


The early monocytic response to cytomegalovirus infection is MyD88 dependent but occurs independently of common inflammatory cytokine signals.

Wikstrom ME, Khong A, Fleming P, Kuns R, Hertzog PJ, Frazer IH, Andoniou CE, Hill GR, Degli-Esposti MA.

Eur J Immunol. 2014 Feb;44(2):409-19. doi: 10.1002/eji.201243109. Epub 2013 Dec 16.


Computational study of the activated O(H) state in the catalytic mechanism of cytochrome c oxidase.

Sharma V, Karlin KD, Wikström M.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16844-9. doi: 10.1073/pnas.1220379110. Epub 2013 Sep 30.


Functional proteomics defines the molecular switch underlying FGF receptor trafficking and cellular outputs.

Francavilla C, Rigbolt KT, Emdal KB, Carraro G, Vernet E, Bekker-Jensen DB, Streicher W, Wikström M, Sundström M, Bellusci S, Cavallaro U, Blagoev B, Olsen JV.

Mol Cell. 2013 Sep 26;51(6):707-22. doi: 10.1016/j.molcel.2013.08.002. Epub 2013 Sep 5.


A cluster of deaths involving 5-(2-aminopropyl)indole (5-IT).

Kronstrand R, Roman M, Dahlgren M, Thelander G, Wikström M, Druid H.

J Anal Toxicol. 2013 Oct;37(8):542-6. doi: 10.1093/jat/bkt058. Epub 2013 Jul 9.


RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response.

Poulsen SL, Hansen RK, Wagner SA, van Cuijk L, van Belle GJ, Streicher W, Wikström M, Choudhary C, Houtsmuller AB, Marteijn JA, Bekker-Jensen S, Mailand N.

J Cell Biol. 2013 Jun 10;201(6):797-807. doi: 10.1083/jcb.201212075.


CpG pretreatment enhances antiviral T-cell immunity against cytomegalovirus.

Ong ML, Wikstrom ME, Fleming P, Estcourt MJ, Hertzog PJ, Hill GR, Andoniou CE, Degli-Esposti MA.

Blood. 2013 Jul 4;122(1):55-60. doi: 10.1182/blood-2012-12-471227. Epub 2013 May 14.


A chemokine-like viral protein enhances alpha interferon production by plasmacytoid dendritic cells but delays CD8+ T cell activation and impairs viral clearance.

Wikstrom ME, Fleming P, Comerford I, McColl SR, Andoniou CE, Degli-Esposti MA.

J Virol. 2013 Jul;87(14):7911-20. doi: 10.1128/JVI.00187-13. Epub 2013 May 8.


Cell-based therapies for ocular inflammation.

Forrester JV, Steptoe RJ, Klaska IP, Martin-Granados C, Dua HS, Degli-Esposti MA, Wikstrom ME.

Prog Retin Eye Res. 2013 Jul;35:82-101. doi: 10.1016/j.preteyeres.2013.02.002. Epub 2013 Mar 29. Review.


Root Rot of Pea and Faba Bean in Southern Sweden Caused by Phytophthora pisi sp. nov.

Heyman F, Blair JE, Persson L, Wikström M.

Plant Dis. 2013 Apr;97(4):461-471. doi: 10.1094/PDIS-09-12-0823-RE.


[Extensive pneumatization of the posterior skull].

Kreibich M, Dzilic E, Wikström M.

Unfallchirurg. 2013 Nov;116(11):1036-8. doi: 10.1007/s00113-012-2318-5. German.


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