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Items: 39


Enrichment of the lung microbiome with oral taxa is associated with lung inflammation of a Th17 phenotype.

Segal LN, Clemente JC, Tsay JC, Koralov SB, Keller BC, Wu BG, Li Y, Shen N, Ghedin E, Morris A, Diaz P, Huang L, Wikoff WR, Ubeda C, Artacho A, Rom WN, Sterman DH, Collman RG, Blaser MJ, Weiden MD.

Nat Microbiol. 2016 Apr 4;1:16031. doi: 10.1038/nmicrobiol.2016.31.


Randomised, double-blind, placebo-controlled trial with azithromycin selects for anti-inflammatory microbial metabolites in the emphysematous lung.

Segal LN, Clemente JC, Wu BG, Wikoff WR, Gao Z, Li Y, Ko JP, Rom WN, Blaser MJ, Weiden MD.

Thorax. 2017 Jan;72(1):13-22. doi: 10.1136/thoraxjnl-2016-208599. Epub 2016 Aug 2.


Serum phosphatidylethanolamine levels distinguish benign from malignant solitary pulmonary nodules and represent a potential diagnostic biomarker for lung cancer.

Fahrmann JF, Grapov D, DeFelice BC, Taylor S, Kim K, Kelly K, Wikoff WR, Pass H, Rom WN, Fiehn O, Miyamoto S.

Cancer Biomark. 2016 Mar 11;16(4):609-17. doi: 10.3233/CBM-160602.


Diacetylspermine Is a Novel Prediagnostic Serum Biomarker for Non-Small-Cell Lung Cancer and Has Additive Performance With Pro-Surfactant Protein B.

Wikoff WR, Hanash S, DeFelice B, Miyamoto S, Barnett M, Zhao Y, Goodman G, Feng Z, Gandara D, Fiehn O, Taguchi A.

J Clin Oncol. 2015 Nov 20;33(33):3880-6. doi: 10.1200/JCO.2015.61.7779. Epub 2015 Aug 17.


Systemic Metabolomic Changes in Blood Samples of Lung Cancer Patients Identified by Gas Chromatography Time-of-Flight Mass Spectrometry.

Miyamoto S, Taylor SL, Barupal DK, Taguchi A, Wohlgemuth G, Wikoff WR, Yoneda KY, Gandara DR, Hanash SM, Kim K, Fiehn O.

Metabolites. 2015 Apr 9;5(2):192-210. doi: 10.3390/metabo5020192.


Metabolomic markers of altered nucleotide metabolism in early stage adenocarcinoma.

Wikoff WR, Grapov D, Fahrmann JF, DeFelice B, Rom WN, Pass HI, Kim K, Nguyen U, Taylor SL, Gandara DR, Kelly K, Fiehn O, Miyamoto S.

Cancer Prev Res (Phila). 2015 May;8(5):410-8. doi: 10.1158/1940-6207.CAPR-14-0329. Epub 2015 Feb 5.


Is diabetes mellitus-linked amino acid signature associated with β-blocker-induced impaired fasting glucose?

Cooper-Dehoff RM, Hou W, Weng L, Baillie RA, Beitelshees AL, Gong Y, Shahin MH, Turner ST, Chapman A, Gums JG, Boyle SH, Zhu H, Wikoff WR, Boerwinkle E, Fiehn O, Frye RF, Kaddurah-Daouk R, Johnson JA.

Circ Cardiovasc Genet. 2014 Apr;7(2):199-205. doi: 10.1161/CIRCGENETICS.113.000421. Epub 2014 Mar 13.


Pharmacometabolomic signature of ataxia SCA1 mouse model and lithium effects.

Perroud B, Jafar-Nejad P, Wikoff WR, Gatchel JR, Wang L, Barupal DK, Crespo-Barreto J, Fiehn O, Zoghbi HY, Kaddurah-Daouk R.

PLoS One. 2013 Aug 2;8(8):e70610. doi: 10.1371/journal.pone.0070610. Print 2013.


Pharmacometabolomics reveals racial differences in response to atenolol treatment.

Wikoff WR, Frye RF, Zhu H, Gong Y, Boyle S, Churchill E, Cooper-Dehoff RM, Beitelshees AL, Chapman AB, Fiehn O, Johnson JA, Kaddurah-Daouk R; Pharmacometabolomics Research Network.

PLoS One. 2013;8(3):e57639. doi: 10.1371/journal.pone.0057639. Epub 2013 Mar 11.


Pharmacometabolomic mapping of early biochemical changes induced by sertraline and placebo.

Kaddurah-Daouk R, Bogdanov MB, Wikoff WR, Zhu H, Boyle SH, Churchill E, Wang Z, Rush AJ, Krishnan RR, Pickering E, Delnomdedieu M, Fiehn O.

Transl Psychiatry. 2013 Jan 22;3:e223. doi: 10.1038/tp.2012.142.


Metabolomics reveals amino acids contribute to variation in response to simvastatin treatment.

Trupp M, Zhu H, Wikoff WR, Baillie RA, Zeng ZB, Karp PD, Fiehn O, Krauss RM, Kaddurah-Daouk R.

PLoS One. 2012;7(7):e38386. doi: 10.1371/journal.pone.0038386. Epub 2012 Jul 9.


Identification of naturally occurring fatty acids of the myelin sheath that resolve neuroinflammation.

Ho PP, Kanter JL, Johnson AM, Srinagesh HK, Chang EJ, Purdy TM, van Haren K, Wikoff WR, Kind T, Khademi M, Matloff LY, Narayana S, Hur EM, Lindstrom TM, He Z, Fiehn O, Olsson T, Han X, Han MH, Steinman L, Robinson WH.

Sci Transl Med. 2012 Jun 6;4(137):137ra73. doi: 10.1126/scitranslmed.3003831.


Untargeted metabolomics identifies enterobiome metabolites and putative uremic toxins as substrates of organic anion transporter 1 (Oat1).

Wikoff WR, Nagle MA, Kouznetsova VL, Tsigelny IF, Nigam SK.

J Proteome Res. 2011 Jun 3;10(6):2842-51. doi: 10.1021/pr200093w. Epub 2011 Apr 22.


Variability analysis of human plasma and cerebral spinal fluid reveals statistical significance of changes in mass spectrometry-based metabolomics data.

Crews B, Wikoff WR, Patti GJ, Woo HK, Kalisiak E, Heideker J, Siuzdak G.

Anal Chem. 2009 Oct 15;81(20):8538-44. doi: 10.1021/ac9014947.


Response and recovery in the plasma metabolome tracks the acute LCMV-induced immune response.

Wikoff WR, Kalisak E, Trauger S, Manchester M, Siuzdak G.

J Proteome Res. 2009 Jul;8(7):3578-87. doi: 10.1021/pr900275p.


Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites.

Wikoff WR, Anfora AT, Liu J, Schultz PG, Lesley SA, Peters EC, Siuzdak G.

Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3698-703. doi: 10.1073/pnas.0812874106. Epub 2009 Feb 20.


Novel multiprotein complexes identified in the hyperthermophilic archaeon Pyrococcus furiosus by non-denaturing fractionation of the native proteome.

Menon AL, Poole FL 2nd, Cvetkovic A, Trauger SA, Kalisiak E, Scott JW, Shanmukh S, Praissman J, Jenney FE Jr, Wikoff WR, Apon JV, Siuzdak G, Adams MW.

Mol Cell Proteomics. 2009 Apr;8(4):735-51. doi: 10.1074/mcp.M800246-MCP200. Epub 2008 Nov 28.


Metabolomic analysis of the cerebrospinal fluid reveals changes in phospholipase expression in the CNS of SIV-infected macaques.

Wikoff WR, Pendyala G, Siuzdak G, Fox HS.

J Clin Invest. 2008 Jul;118(7):2661-9. doi: 10.1172/JCI34138.


Organic anion transporter 3 contributes to the regulation of blood pressure.

Vallon V, Eraly SA, Wikoff WR, Rieg T, Kaler G, Truong DM, Ahn SY, Mahapatra NR, Mahata SK, Gangoiti JA, Wu W, Barshop BA, Siuzdak G, Nigam SK.

J Am Soc Nephrol. 2008 Sep;19(9):1732-40. doi: 10.1681/ASN.2008020180. Epub 2008 May 28.


Multiple organic anion transporters contribute to net renal excretion of uric acid.

Eraly SA, Vallon V, Rieg T, Gangoiti JA, Wikoff WR, Siuzdak G, Barshop BA, Nigam SK.

Physiol Genomics. 2008 Apr 22;33(2):180-92. doi: 10.1152/physiolgenomics.00207.2007. Epub 2008 Feb 12.


Metabolomics identifies perturbations in human disorders of propionate metabolism.

Wikoff WR, Gangoiti JA, Barshop BA, Siuzdak G.

Clin Chem. 2007 Dec;53(12):2169-76. Epub 2007 Oct 19.


Mobilization of pro-inflammatory lipids in obese Plscr3-deficient mice.

Mutch DM, O'Maille G, Wikoff WR, Wiedmer T, Sims PJ, Siuzdak G.

Genome Biol. 2007;8(3):R38.


Mass spectrometry reveals specific and global molecular transformations during viral infection.

Go EP, Wikoff WR, Shen Z, O'Maille G, Morita H, Conrads TP, Nordstrom A, Trauger SA, Uritboonthai W, Lucas DA, Chan KC, Veenstra TD, Lewicki H, Oldstone MB, Schneemann A, Siuzdak G.

J Proteome Res. 2006 Sep;5(9):2405-16.


Time-resolved molecular dynamics of bacteriophage HK97 capsid maturation interpreted by electron cryo-microscopy and X-ray crystallography.

Wikoff WR, Conway JF, Tang J, Lee KK, Gan L, Cheng N, Duda RL, Hendrix RW, Steven AC, Johnson JE.

J Struct Biol. 2006 Mar;153(3):300-6. Epub 2005 Dec 22.


Crystallization and preliminary analysis of a dsDNA bacteriophage capsid intermediate: Prohead II of HK97.

Wikoff WR, Che Z, Duda RL, Hendrix RW, Johnson JE.

Acta Crystallogr D Biol Crystallogr. 2003 Dec;59(Pt 12):2060-4. Epub 2003 Nov 27.


The refined structure of a protein catenane: the HK97 bacteriophage capsid at 3.44 A resolution.

Helgstrand C, Wikoff WR, Duda RL, Hendrix RW, Johnson JE, Liljas L.

J Mol Biol. 2003 Dec 12;334(5):885-99.


Virus maturation involving large subunit rotations and local refolding.

Conway JF, Wikoff WR, Cheng N, Duda RL, Hendrix RW, Johnson JE, Steven AC.

Science. 2001 Apr 27;292(5517):744-8.


Topologically linked protein rings in the bacteriophage HK97 capsid.

Wikoff WR, Liljas L, Duda RL, Tsuruta H, Hendrix RW, Johnson JE.

Science. 2000 Sep 22;289(5487):2129-33.


Increased resolution data from a large unit cell crystal collected at a third-generation synchrotron X-ray source.

Wikoff WR, Schildkamp W, Johnson JE.

Acta Crystallogr D Biol Crystallogr. 2000 Jul;56(Pt 7):890-3.


Maturation dynamics of a viral capsid: visualization of transitional intermediate states.

Lata R, Conway JF, Cheng N, Duda RL, Hendrix RW, Wikoff WR, Johnson JE, Tsuruta H, Steven AC.

Cell. 2000 Jan 21;100(2):253-63.


Virus assembly: Imaging a molecular machine.

Wikoff WR, Johnson JE.

Curr Biol. 1999 Apr 22;9(8):R296-300. Review.


Crystallographic analysis of the dsDNA bacteriophage HK97 mature empty capsid.

Wikoff WR, Duda RL, Hendrix RW, Johnson JE.

Acta Crystallogr D Biol Crystallogr. 1999 Apr;55(Pt 4):763-71.


Macromolecular assembly: chainmail stabilization of a viral capsid.

Johnson JE, Wikoff WR.

Curr Biol. 1998 Dec 17-31;8(25):R914-7.


Crystallization and preliminary X-ray analysis of the dsDNA bacteriophage HK97 mature empty capsid.

Wikoff WR, Duda RL, Hendrix RW, Johnson JE.

Virology. 1998 Mar 30;243(1):113-8.


The structure of cucumber mosaic virus: cryoelectron microscopy, X-ray crystallography, and sequence analysis.

Wikoff WR, Tsai CJ, Wang G, Baker TS, Johnson JE.

Virology. 1997 May 26;232(1):91-7.


Structure determination of minute virus of mice.

Llamas-Saiz AL, Agbandje-McKenna M, Wikoff WR, Bratton J, Tattersall P, Rossmann MG.

Acta Crystallogr D Biol Crystallogr. 1997 Jan 1;53(Pt 1):93-102.


The structure of a neutralized virus: canine parvovirus complexed with neutralizing antibody fragment.

Wikoff WR, Wang G, Parrish CR, Cheng RH, Strassheim ML, Baker TS, Rossmann MG.

Structure. 1994 Jul 15;2(7):595-607.

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