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Mycobacterial antigens accumulation in foamy macrophages in murine pulmonary tuberculosis lesions: Association with necrosis and making of cavities.

Riaz SM, Bjune GA, Wiker HG, Sviland L, Mustafa T.

Scand J Immunol. 2020 Jan 21:e12866. doi: 10.1111/sji.12866. [Epub ahead of print]


Sputum microbiota and inflammation at stable state and during exacerbations in a cohort of chronic obstructive pulmonary disease (COPD) patients.

Tangedal S, Nielsen R, Aanerud M, Persson LJ, Wiker HG, Bakke PS, Hiemstra PS, Eagan TM.

PLoS One. 2019 Sep 17;14(9):e0222449. doi: 10.1371/journal.pone.0222449. eCollection 2019.


Laboratory contamination in airway microbiome studies.

Drengenes C, Wiker HG, Kalananthan T, Nordeide E, Eagan TML, Nielsen R.

BMC Microbiol. 2019 Aug 14;19(1):187. doi: 10.1186/s12866-019-1560-1.


On the Impact of the Pangenome and Annotation Discrepancies While Building Protein Sequence Databases for Bacteria Proteogenomics.

Machado KCT, Fortuin S, Tomazella GG, Fonseca AF, Warren RM, Wiker HG, de Souza SJ, de Souza GA.

Front Microbiol. 2019 Jun 20;10:1410. doi: 10.3389/fmicb.2019.01410. eCollection 2019.


Comparative Proteomics of Enterotoxigenic Escherichia coli Reveals Differences in Surface Protein Production and Similarities in Metabolism.

Pettersen VK, Steinsland H, Wiker HG.

J Proteome Res. 2018 Jan 5;17(1):325-336. doi: 10.1021/acs.jproteome.7b00593. Epub 2017 Dec 12.


Protected sampling is preferable in bronchoscopic studies of the airway microbiome.

Grønseth R, Drengenes C, Wiker HG, Tangedal S, Xue Y, Husebø GR, Svanes Ø, Lehmann S, Aardal M, Hoang T, Kalananthan T, Hjellestad Martinsen EM, Orvedal Leiten E, Aanerud M, Nordeide E, Haaland I, Jonassen I, Bakke P, Eagan T.

ERJ Open Res. 2017 Aug 30;3(3). pii: 00019-2017. doi: 10.1183/23120541.00019-2017. eCollection 2017 Jul.


Comparing microbiota profiles in induced and spontaneous sputum samples in COPD patients.

Tangedal S, Aanerud M, Grønseth R, Drengenes C, Wiker HG, Bakke PS, Eagan TM.

Respir Res. 2017 Aug 29;18(1):164. doi: 10.1186/s12931-017-0645-3.


Quantitative proteomic analysis of extracellular matrix extracted from mono- and dual-species biofilms of Fusobacterium nucleatum and Porphyromonas gingivalis.

Mohammed MMA, Pettersen VK, Nerland AH, Wiker HG, Bakken V.

Anaerobe. 2017 Apr;44:133-142. doi: 10.1016/j.anaerobe.2017.03.002. Epub 2017 Mar 9.


Zoonotic necrotizing myositis caused by Streptococcus equi subsp. zooepidemicus in a farmer.

Kittang BR, Pettersen VK, Oppegaard O, Skutlaberg DH, Dale H, Wiker HG, Skrede S.

BMC Infect Dis. 2017 Feb 15;17(1):147. doi: 10.1186/s12879-017-2262-7.


Coordination of Metabolism and Virulence Factors Expression of Extraintestinal Pathogenic Escherichia coli Purified from Blood Cultures of Patients with Sepsis.

Pettersen VK, Mosevoll KA, Lindemann PC, Wiker HG.

Mol Cell Proteomics. 2016 Sep;15(9):2890-907. doi: 10.1074/mcp.M116.060582. Epub 2016 Jun 30.


Improving genome annotation of enterotoxigenic Escherichia coli TW10598 by a label-free quantitative MS/MS approach.

Pettersen VK, Steinsland H, Wiker HG.

Proteomics. 2015 Nov;15(22):3826-34. doi: 10.1002/pmic.201500278. Epub 2015 Oct 7.


Multiplex Analysis of Pro- or Anti-Inflammatory Serum Cytokines and Chemokines in relation to Gender and Age among Tanzanian Tuberculous Lymphadenitis Patients.

Mustafa T, Brokstad KA, Mfinanga SG, Wiker HG.

Tuberc Res Treat. 2015;2015:561490. doi: 10.1155/2015/561490. Epub 2015 Apr 28.


Diffusion blotting: a rapid and simple method for production of multiple blots from a single gel.

Olsen I, Wiker HG.

Methods Mol Biol. 2015;1312:73-6. doi: 10.1007/978-1-4939-2694-7_10.


Phosphoproteomics analysis of a clinical Mycobacterium tuberculosis Beijing isolate: expanding the mycobacterial phosphoproteome catalog.

Fortuin S, Tomazella GG, Nagaraj N, Sampson SL, Gey van Pittius NC, Soares NC, Wiker HG, de Souza GA, Warren RM.

Front Microbiol. 2015 Feb 10;6:6. doi: 10.3389/fmicb.2015.00006. eCollection 2015.


Effect of non-tuberculous Mycobacteria on host biomarkers potentially relevant for tuberculosis management.

Dhanasekaran S, Jenum S, Stavrum R, Wiker HG, Kenneth J, Vaz M, Doherty TM, Grewal HM; TB Trials Study Group.

PLoS Negl Trop Dis. 2014 Oct 16;8(10):e3243. doi: 10.1371/journal.pntd.0003243. eCollection 2014 Oct.


Differential in vivo expression of mycobacterial antigens in Mycobacterium tuberculosis infected lungs and lymph node tissues.

Mustafa T, Leversen NA, Sviland L, Wiker HG.

BMC Infect Dis. 2014 Oct 3;14:535. doi: 10.1186/1471-2334-14-535.


Proteogenomics in microbiology: taking the right turn at the junction of genomics and proteomics.

Kucharova V, Wiker HG.

Proteomics. 2014 Dec;14(23-24):2360-675. doi: 10.1002/pmic.201400168. Epub 2014 Nov 19.


The Bergen COPD microbiome study (MicroCOPD): rationale, design, and initial experiences.

Grønseth R, Haaland I, Wiker HG, Martinsen EM, Leiten EO, Husebø G, Svanes Ø, Bakke PS, Eagan TM.

Eur Clin Respir J. 2014 Dec 29;1. doi: 10.3402/ecrj.v1.26196. eCollection 2014.


Aminoglycoside resistance in clinical Escherichia coli and Klebsiella pneumoniae isolates from Western Norway.

Lindemann PC, Risberg K, Wiker HG, Mylvaganam H.

APMIS. 2012 Jun;120(6):495-502. doi: 10.1111/j.1600-0463.2011.02856.x. Epub 2011 Dec 19.


Improved signal peptide predictions in mycobacteria?

Leversen NA, Wiker HG.

Tuberculosis (Edinb). 2012 Jul;92(4):291-2. doi: 10.1016/ Epub 2012 Apr 7. No abstract available.


Dual priming oligonucleotides for broad-range amplification of the bacterial 16S rRNA gene directly from human clinical specimens.

Kommedal Ø, Simmon K, Karaca D, Langeland N, Wiker HG.

J Clin Microbiol. 2012 Apr;50(4):1289-94. doi: 10.1128/JCM.06269-11. Epub 2012 Jan 25.


Long-term persistence of BCG Pasteur in lungs of C57BL/6 mice following intranasal infection.

Leversen NA, Sviland L, Wiker HG, Mustafa T.

Scand J Immunol. 2012 May;75(5):489-99. doi: 10.1111/j.1365-3083.2012.02683.x.


Proteomic analysis of a multi-resistant clinical Escherichia coli isolate of unknown genomic background.

Tomazella GG, Risberg K, Mylvaganam H, Lindemann PC, Thiede B, Souza GA, Wiker HG.

J Proteomics. 2012 Mar 16;75(6):1830-7. doi: 10.1016/j.jprot.2011.12.024. Epub 2011 Dec 30.


Bacterial proteins with cleaved or uncleaved signal peptides of the general secretory pathway.

de Souza GA, Leversen NA, Målen H, Wiker HG.

J Proteomics. 2011 Dec 21;75(2):502-10. doi: 10.1016/j.jprot.2011.08.016. Epub 2011 Sep 5.


A proteomic view of mycobacteria.

de Souza GA, Wiker HG.

Proteomics. 2011 Aug;11(15):3118-27. doi: 10.1002/pmic.201100043. Epub 2011 Jul 4. Review.


Characterization of polybacterial clinical samples using a set of group-specific broad-range primers targeting the 16S rRNA gene followed by DNA sequencing and RipSeq analysis.

Kommedal O, Lekang K, Langeland N, Wiker HG.

J Med Microbiol. 2011 Jul;60(Pt 7):927-36. doi: 10.1099/jmm.0.028373-0. Epub 2011 Mar 24.


Rapid diagnosis of tuberculosis in aspirate, effusions, and cerebrospinal fluid by immunocytochemical detection of Mycobacterium tuberculosis complex specific antigen MPT64.

Purohit MR, Mustafa T, Wiker HG, Sviland L.

Diagn Cytopathol. 2012 Sep;40(9):782-91. doi: 10.1002/dc.21637. Epub 2011 Mar 17.


A quantitative view on Mycobacterium leprae antigens by proteomics.

Wiker HG, Tomazella GG, de Souza GA.

J Proteomics. 2011 Aug 24;74(9):1711-9. doi: 10.1016/j.jprot.2011.01.004. Epub 2011 Jan 26.


Comparison of membrane proteins of Mycobacterium tuberculosis H37Rv and H37Ra strains.

Målen H, De Souza GA, Pathak S, Søfteland T, Wiker HG.

BMC Microbiol. 2011 Jan 24;11:18. doi: 10.1186/1471-2180-11-18.


Proteogenomic analysis of polymorphisms and gene annotation divergences in prokaryotes using a clustered mass spectrometry-friendly database.

de Souza GA, Arntzen MØ, Fortuin S, Schürch AC, Målen H, McEvoy CR, van Soolingen D, Thiede B, Warren RM, Wiker HG.

Mol Cell Proteomics. 2011 Jan;10(1):M110.002527. doi: 10.1074/mcp.M110.002527. Epub 2010 Oct 28.


Definition of novel cell envelope associated proteins in Triton X-114 extracts of Mycobacterium tuberculosis H37Rv.

Målen H, Pathak S, Søfteland T, de Souza GA, Wiker HG.

BMC Microbiol. 2010 Apr 29;10:132. doi: 10.1186/1471-2180-10-132.


Serodiagnosis of tuberculous lymphadenitis using a combination of antigens.

Beyene D, Lumc Franken K, Yamuah L, Aseffa A, Wiker HG, Kolk A, Engers H, Klatser P, Sviland L.

J Infect Dev Ctries. 2010 Mar 8;4(2):96-102.


Using a label-free proteomics method to identify differentially abundant proteins in closely related hypo- and hypervirulent clinical Mycobacterium tuberculosis Beijing isolates.

de Souza GA, Fortuin S, Aguilar D, Pando RH, McEvoy CR, van Helden PD, Koehler CJ, Thiede B, Warren RM, Wiker HG.

Mol Cell Proteomics. 2010 Nov;9(11):2414-23. doi: 10.1074/mcp.M900422-MCP200. Epub 2010 Feb 26.


Evidence for waning of latency in a cohort study of tuberculosis.

Wiker HG, Mustafa T, Bjune GA, Harboe M.

BMC Infect Dis. 2010 Feb 23;10:37. doi: 10.1186/1471-2334-10-37.


Analysis of detergent-insoluble and whole cell lysate fractions of resting neutrophils using high-resolution mass spectrometry.

Tomazella GG, daSilva I, Thomé CH, Greene LJ, Koehler CJ, Thiede B, Wiker HG, de Souza GA.

J Proteome Res. 2010 Apr 5;9(4):2030-6. doi: 10.1021/pr1000253. Erratum in: J Proteome Res. 2010 Jul 2;9(7):3764.


MSMSpdbb: providing protein databases of closely related organisms to improve proteomic characterization of prokaryotic microbes.

de Souza GA, Arntzen MØ, Wiker HG.

Bioinformatics. 2010 Mar 1;26(5):698-9. doi: 10.1093/bioinformatics/btq004. Epub 2010 Jan 14.


Identification and genotyping of the etiological agent of tuberculous lymphadenitis in Ethiopia.

Beyene D, Bergval I, Hailu E, Ashenafi S, Yamuah L, Aseffa A, Wiker HG, Engers H, Klatser P, Sviland L.

J Infect Dev Ctries. 2009 Jul 1;3(6):412-9.


Direct 16S rRNA gene sequencing from clinical specimens, with special focus on polybacterial samples and interpretation of mixed DNA chromatograms.

Kommedal O, Kvello K, Skjåstad R, Langeland N, Wiker HG.

J Clin Microbiol. 2009 Nov;47(11):3562-8. doi: 10.1128/JCM.00973-09. Epub 2009 Sep 9.


Proteomic analysis of total cellular proteins of human neutrophils.

Tomazella GG, da Silva I, Laure HJ, Rosa JC, Chammas R, Wiker HG, de Souza GA, Greene LJ.

Proteome Sci. 2009 Aug 31;7:32. doi: 10.1186/1477-5956-7-32.


HIV induces both a down-regulation of IRAK-4 that impairs TLR signalling and an up-regulation of the antibiotic peptide dermcidin in monocytic cells.

Pathak S, De Souza GA, Salte T, Wiker HG, Asjö B.

Scand J Immunol. 2009 Sep;70(3):264-76. doi: 10.1111/j.1365-3083.2009.02299.x.


Validating divergent ORF annotation of the Mycobacterium leprae genome through a full translation data set and peptide identification by tandem mass spectrometry.

de Souza GA, Søfteland T, Koehler CJ, Thiede B, Wiker HG.

Proteomics. 2009 Jun;9(12):3233-43. doi: 10.1002/pmic.200800955.


Allergic sensitisation in tuberculosis patients at the time of diagnosis and following chemotherapy.

Ellertsen LK, Storla DG, Diep LM, Brokstad KA, Wiker HG, Hetland G.

BMC Infect Dis. 2009 Jun 26;9:100. doi: 10.1186/1471-2334-9-100.


MPB70 and MPB83--major antigens of Mycobacterium bovis.

Wiker HG.

Scand J Immunol. 2009 Jun;69(6):492-9. doi: 10.1111/j.1365-3083.2009.02256.x. Review.


Evaluation of signal peptide prediction algorithms for identification of mycobacterial signal peptides using sequence data from proteomic methods.

Leversen NA, de Souza GA, Målen H, Prasad S, Jonassen I, Wiker HG.

Microbiology. 2009 Jul;155(Pt 7):2375-2383. doi: 10.1099/mic.0.025270-0. Epub 2009 Apr 23.


Rapid and specific diagnosis of tuberculous pleuritis with immunohistochemistry by detecting Mycobacterium tuberculosis complex specific antigen MPT64 in patients from a HIV endemic area.

Baba K, Dyrhol-Riise AM, Sviland L, Langeland N, Hoosen AA, Wiker HG, Mustafa T.

Appl Immunohistochem Mol Morphol. 2008 Dec;16(6):554-61. doi: 10.1097/PAI.0b013e31816c3f79.


High accuracy mass spectrometry analysis as a tool to verify and improve gene annotation using Mycobacterium tuberculosis as an example.

de Souza GA, Målen H, Søfteland T, Saelensminde G, Prasad S, Jonassen I, Wiker HG.

BMC Genomics. 2008 Jul 2;9:316. doi: 10.1186/1471-2164-9-316.


Membrane and membrane-associated proteins in Triton X-114 extracts of Mycobacterium bovis BCG identified using a combination of gel-based and gel-free fractionation strategies.

Målen H, Berven FS, Søfteland T, Arntzen MØ, D'Santos CS, De Souza GA, Wiker HG.

Proteomics. 2008 May;8(9):1859-70. doi: 10.1002/pmic.200700528.


Antigen analysis of Mycobacterium tuberculosis H37Rv culture filtrate proteins.

Målen H, Søfteland T, Wiker HG.

Scand J Immunol. 2008 Mar;67(3):245-52. doi: 10.1111/j.1365-3083.2007.02064.x. Epub 2008 Jan 16. Erratum in: Scand J Immunol. 2009 Jan;71(1):61.

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