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Items: 48

1.

The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution.

Taylor DM, Aronow BJ, Tan K, Bernt K, Salomonis N, Greene CS, Frolova A, Henrickson SE, Wells A, Pei L, Jaiswal JK, Whitsett J, Hamilton KE, MacParland SA, Kelsen J, Heuckeroth RO, Potter SS, Vella LA, Terry NA, Ghanem LR, Kennedy BC, Helbig I, Sullivan KE, Castelo-Soccio L, Kreigstein A, Herse F, Nawijn MC, Koppelman GH, Haendel M, Harris NL, Rokita JL, Zhang Y, Regev A, Rozenblatt-Rosen O, Rood JE, Tickle TL, Vento-Tormo R, Alimohamed S, Lek M, Mar JC, Loomes KM, Barrett DM, Uapinyoying P, Beggs AH, Agrawal PB, Chen YW, Muir AB, Garmire LX, Snapper SB, Nazarian J, Seeholzer SH, Fazelinia H, Singh LN, Faryabi RB, Raman P, Dawany N, Xie HM, Devkota B, Diskin SJ, Anderson SA, Rappaport EF, Peranteau W, Wikenheiser-Brokamp KA, Teichmann S, Wallace D, Peng T, Ding YY, Kim MS, Xing Y, Kong SW, Bönnemann CG, Mandl KD, White PS.

Dev Cell. 2019 Apr 8;49(1):10-29. doi: 10.1016/j.devcel.2019.03.001. Epub 2019 Mar 28. Review.

2.

Neonatal Lung Disease Associated with TBX4 Mutations.

Suhrie K, Pajor NM, Ahlfeld SK, Dawson DB, Dufendach KR, Kitzmiller JA, Leino D, Lombardo RC, Smolarek TA, Rathbun PA, Whitsett JA, Towe C, Wikenheiser-Brokamp KA.

J Pediatr. 2019 Mar;206:286-292.e1. doi: 10.1016/j.jpeds.2018.10.018. Epub 2018 Nov 7.

PMID:
30413314
3.

Smoking-Related Diffuse Cystic Lung Disease.

Gupta N, Colby TV, Meyer CA, McCormack FX, Wikenheiser-Brokamp KA.

Chest. 2018 Aug;154(2):e31-e35. doi: 10.1016/j.chest.2018.02.027.

PMID:
30080520
4.

Hypereosinophilic syndrome in the differential diagnosis of pulmonary infiltrates with eosinophilia.

Zimmermann N, Wikenheiser-Brokamp KA.

Ann Allergy Asthma Immunol. 2018 Aug;121(2):179-185. doi: 10.1016/j.anai.2018.05.014. Epub 2018 May 24. Review.

PMID:
29803709
5.

The Protein Tyrosine Phosphatase Activity of Eyes Absent Contributes to Tumor Angiogenesis and Tumor Growth.

Wang Y, Pandey RN, Riffle S, Chintala H, Wikenheiser-Brokamp KA, Hegde RS.

Mol Cancer Ther. 2018 Aug;17(8):1659-1669. doi: 10.1158/1535-7163.MCT-18-0057. Epub 2018 May 25.

PMID:
29802120
6.

Dek overexpression in murine epithelia increases overt esophageal squamous cell carcinoma incidence.

Matrka MC, Cimperman KA, Haas SR, Guasch G, Ehrman LA, Waclaw RR, Komurov K, Lane A, Wikenheiser-Brokamp KA, Wells SI.

PLoS Genet. 2018 Mar 14;14(3):e1007227. doi: 10.1371/journal.pgen.1007227. eCollection 2018 Mar.

7.

Lymphangioleiomyomatosis Diagnosis and Management: High-Resolution Chest Computed Tomography, Transbronchial Lung Biopsy, and Pleural Disease Management. An Official American Thoracic Society/Japanese Respiratory Society Clinical Practice Guideline.

Gupta N, Finlay GA, Kotloff RM, Strange C, Wilson KC, Young LR, Taveira-DaSilva AM, Johnson SR, Cottin V, Sahn SA, Ryu JH, Seyama K, Inoue Y, Downey GP, Han MK, Colby TV, Wikenheiser-Brokamp KA, Meyer CA, Smith K, Moss J, McCormack FX; ATS Assembly on Clinical Problems.

Am J Respir Crit Care Med. 2017 Nov 15;196(10):1337-1348. doi: 10.1164/rccm.201709-1965ST.

8.

TRP53 Mutants Drive Neuroendocrine Lung Cancer Through Loss-of-Function Mechanisms with Gain-of-Function Effects on Chemotherapy Response.

Akeno N, Reece AL, Callahan M, Miller AL, Kim RG, He D, Lane A, Moulton JS, Wikenheiser-Brokamp KA.

Mol Cancer Ther. 2017 Dec;16(12):2913-2926. doi: 10.1158/1535-7163.MCT-17-0353. Epub 2017 Aug 28.

9.

Tuberin Regulates Prostaglandin Receptor-Mediated Viability, via Rheb, in mTORC1-Hyperactive Cells.

Li C, Liu X, Liu Y, Zhang E, Medepalli K, Masuda K, Li N, Wikenheiser-Brokamp KA, Osterburg A, Borchers MT, Kopras EJ, Plas DR, Sun J, Franz DN, Capal JK, Mays M, Sun Y, Kwiatkowski DJ, Alayev A, Holz MK, Krueger DA, Siroky BJ, Yu JJ.

Mol Cancer Res. 2017 Oct;15(10):1318-1330. doi: 10.1158/1541-7786.MCR-17-0077. Epub 2017 Jul 14.

10.

p16 controls epithelial cell growth and suppresses carcinogenesis through mechanisms that do not require RB1 function.

Sen M, Akeno N, Reece A, Miller AL, Simpson DS, Wikenheiser-Brokamp KA.

Oncogenesis. 2017 Apr 17;6(4):e320. doi: 10.1038/oncsis.2017.5.

11.

Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells.

Nalapareddy K, Nattamai KJ, Kumar RS, Karns R, Wikenheiser-Brokamp KA, Sampson LL, Mahe MM, Sundaram N, Yacyshyn MB, Yacyshyn B, Helmrath MA, Zheng Y, Geiger H.

Cell Rep. 2017 Mar 14;18(11):2608-2621. doi: 10.1016/j.celrep.2017.02.056.

12.

Single-cell RNA sequencing identifies diverse roles of epithelial cells in idiopathic pulmonary fibrosis.

Xu Y, Mizuno T, Sridharan A, Du Y, Guo M, Tang J, Wikenheiser-Brokamp KA, Perl AT, Funari VA, Gokey JJ, Stripp BR, Whitsett JA.

JCI Insight. 2016 Dec 8;1(20):e90558. doi: 10.1172/jci.insight.90558.

13.

Evaluation of Fellows' CrossTalk Effectiveness in Promoting Transdisciplinary Networking and Research.

Wikenheiser-Brokamp KA, Klein M, Hershey GKK, Devarajan P, DeWitt TG, Loch J, Strauss AW, Muglia LJ, Hostetter MK.

J Pediatr. 2017 Feb;181:5-6.e3. doi: 10.1016/j.jpeds.2016.10.063. Epub 2016 Nov 11. No abstract available.

PMID:
27839701
14.

NK cell activating receptor ligand expression in lymphangioleiomyomatosis is associated with lung function decline.

Osterburg AR, Nelson RL, Yaniv BZ, Foot R, Donica WR, Nashu MA, Liu H, Wikenheiser-Brokamp KA, Moss J, Gupta N, McCormack FX, Borchers MT.

JCI Insight. 2016 Oct 6;1(16):e87270. doi: 10.1172/jci.insight.87270.

15.

Official American Thoracic Society/Japanese Respiratory Society Clinical Practice Guidelines: Lymphangioleiomyomatosis Diagnosis and Management.

McCormack FX, Gupta N, Finlay GR, Young LR, Taveira-DaSilva AM, Glasgow CG, Steagall WK, Johnson SR, Sahn SA, Ryu JH, Strange C, Seyama K, Sullivan EJ, Kotloff RM, Downey GP, Chapman JT, Han MK, D'Armiento JM, Inoue Y, Henske EP, Bissler JJ, Colby TV, Kinder BW, Wikenheiser-Brokamp KA, Brown KK, Cordier JF, Meyer C, Cottin V, Brozek JL, Smith K, Wilson KC, Moss J; ATS/JRS Committee on Lymphangioleiomyomatosis.

Am J Respir Crit Care Med. 2016 Sep 15;194(6):748-61. doi: 10.1164/rccm.201607-1384ST.

16.

Overcoming Pluripotent Stem Cell Dependence on the Repair of Endogenous DNA Damage.

Chlon TM, Ruiz-Torres S, Maag L, Mayhew CN, Wikenheiser-Brokamp KA, Davies SM, Mehta P, Myers KC, Wells JM, Wells SI.

Stem Cell Reports. 2016 Jan 12;6(1):44-54. doi: 10.1016/j.stemcr.2015.12.001.

17.

Diffuse Cystic Lung Disease as the Presenting Manifestation of Sjögren Syndrome.

Gupta N, Wikenheiser-Brokamp KA, Fischer A, McCormack FX.

Ann Am Thorac Soc. 2016 Mar;13(3):371-5. doi: 10.1513/AnnalsATS.201511-759BC.

18.

Modeling pulmonary alveolar microlithiasis by epithelial deletion of the Npt2b sodium phosphate cotransporter reveals putative biomarkers and strategies for treatment.

Saito A, Nikolaidis NM, Amlal H, Uehara Y, Gardner JC, LaSance K, Pitstick LB, Bridges JP, Wikenheiser-Brokamp KA, McGraw DW, Woods JC, Sabbagh Y, Schiavi SC, Altinişik G, Jakopović M, Inoue Y, McCormack FX.

Sci Transl Med. 2015 Nov 11;7(313):313ra181. doi: 10.1126/scitranslmed.aac8577.

19.

Enhancing Pediatric Fellows' Research Training: Development of an Office of Pediatric Clinical Fellowships.

Klein M, Hershey GK, Devarajan P, Muglia LJ, Wikenheiser-Brokamp KA, Loch J, Hostetter MK, Strauss AW, DeWitt TG.

J Pediatr. 2015 Sep;167(3):506-7.e1. doi: 10.1016/j.jpeds.2015.05.053. No abstract available.

20.

Diffuse Cystic Lung Disease. Part II.

Gupta N, Vassallo R, Wikenheiser-Brokamp KA, McCormack FX.

Am J Respir Crit Care Med. 2015 Jul 1;192(1):17-29. doi: 10.1164/rccm.201411-2096CI. Review.

21.

Diffuse Cystic Lung Disease. Part I.

Gupta N, Vassallo R, Wikenheiser-Brokamp KA, McCormack FX.

Am J Respir Crit Care Med. 2015 Jun 15;191(12):1354-66. doi: 10.1164/rccm.201411-2094CI. Review.

22.

Acquisition of Relative Interstrand Crosslinker Resistance and PARP Inhibitor Sensitivity in Fanconi Anemia Head and Neck Cancers.

Lombardi AJ, Hoskins EE, Foglesong GD, Wikenheiser-Brokamp KA, Wiesmüller L, Hanenberg H, Andreassen PR, Jacobs AJ, Olson SB, Keeble WW, Hays LE, Wells SI.

Clin Cancer Res. 2015 Apr 15;21(8):1962-72. doi: 10.1158/1078-0432.CCR-14-2616. Epub 2015 Jan 21.

23.

Cell- and developmental stage-specific Dicer1 ablation in the lung epithelium models cystic pleuropulmonary blastoma.

Wagh PK, Gardner MA, Ma X, Callahan M, Shannon JM, Wert SE, Messinger YH, Dehner LP, Hill DA, Wikenheiser-Brokamp KA.

J Pathol. 2015 May;236(1):41-52. doi: 10.1002/path.4500. Epub 2015 Jan 20.

24.

TGFβ signaling inhibits goblet cell differentiation via SPDEF in conjunctival epithelium.

McCauley HA, Liu CY, Attia AC, Wikenheiser-Brokamp KA, Zhang Y, Whitsett JA, Guasch G.

Development. 2014 Dec;141(23):4628-39. doi: 10.1242/dev.117804. Epub 2014 Nov 5.

25.

High-risk human papillomavirus E6 protein promotes reprogramming of Fanconi anemia patient cells through repression of p53 but does not allow for sustained growth of induced pluripotent stem cells.

Chlon TM, Hoskins EE, Mayhew CN, Wikenheiser-Brokamp KA, Davies SM, Mehta P, Myers KC, Wells JM, Wells SI.

J Virol. 2014 Oct;88(19):11315-26. doi: 10.1128/JVI.01533-14. Epub 2014 Jul 16.

26.

DEK promotes HPV-positive and -negative head and neck cancer cell proliferation.

Adams AK, Hallenbeck GE, Casper KA, Patil YJ, Wilson KM, Kimple RJ, Lambert PF, Witte DP, Xiao W, Gillison ML, Wikenheiser-Brokamp KA, Wise-Draper TM, Wells SI.

Oncogene. 2015 Feb 12;34(7):868-77. doi: 10.1038/onc.2014.15. Epub 2014 Mar 10.

27.

p53 suppresses carcinoma progression by inhibiting mTOR pathway activation.

Akeno N, Miller AL, Ma X, Wikenheiser-Brokamp KA.

Oncogene. 2015 Jan 29;34(5):589-99. doi: 10.1038/onc.2013.589. Epub 2014 Jan 27.

28.

Mucoepidermoid carcinoma of the lung: a case report and literature review.

Alsidawi S, Morris JC, Wikenheiser-Brokamp KA, Starnes SL, Karim NA.

Case Rep Oncol Med. 2013;2013:625243. doi: 10.1155/2013/625243. Epub 2013 Nov 4.

29.

Pulmonary vascular shunts in exercise-intolerant patients with lymphangioleiomyomatosis.

Zafar MA, McCormack FX, Rahman S, Tencza C, Wikenheiser-Brokamp KA, Young LR, Shizukuda Y, Elwing JM.

Am J Respir Crit Care Med. 2013 Nov 1;188(9):1167-70. doi: 10.1164/rccm.201304-0618LE. No abstract available.

PMID:
24180449
30.

Utility of transbronchial biopsy in the diagnosis of lymphangioleiomyomatosis.

Meraj R, Wikenheiser-Brokamp KA, Young LR, Byrnes S, McCormack FX.

Front Med. 2012 Dec;6(4):395-405. doi: 10.1007/s11684-012-0231-5. Epub 2012 Dec 7.

PMID:
23224417
31.

Occam's razor or Hickam's dictum?

Gupta N, Aragaki A, Wikenheiser-Brokamp KA, Benzaquen S, Panos RJ.

J Bronchology Interv Pulmonol. 2012 Jul;19(3):216-9. doi: 10.1097/LBR.0b013e31825c6d0d.

PMID:
23207465
32.

The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer.

Privette Vinnedge LM, Ho SM, Wikenheiser-Brokamp KA, Wells SI.

PLoS One. 2012;7(10):e46985. doi: 10.1371/journal.pone.0046985. Epub 2012 Oct 10.

33.

Lymphangioleiomyomatosis: new concepts in pathogenesis, diagnosis, and treatment.

Meraj R, Wikenheiser-Brokamp KA, Young LR, McCormack FX.

Semin Respir Crit Care Med. 2012 Oct;33(5):486-97. Epub 2012 Sep 21. Review.

PMID:
23001803
34.

Future directions and treatment strategies for head and neck squamous cell carcinomas.

Wise-Draper TM, Draper DJ, Gutkind JS, Molinolo AA, Wikenheiser-Brokamp KA, Wells SI.

Transl Res. 2012 Sep;160(3):167-77. doi: 10.1016/j.trsl.2012.02.002. Epub 2012 Feb 28.

35.

The fanconi anemia pathway limits human papillomavirus replication.

Hoskins EE, Morreale RJ, Werner SP, Higginbotham JM, Laimins LA, Lambert PF, Brown DR, Gillison ML, Nuovo GJ, Witte DP, Kim MO, Davies SM, Mehta PA, Butsch Kovacic M, Wikenheiser-Brokamp KA, Wells SI.

J Virol. 2012 Aug;86(15):8131-8. doi: 10.1128/JVI.00408-12. Epub 2012 May 23.

36.

The human DEK oncogene stimulates β-catenin signaling, invasion and mammosphere formation in breast cancer.

Privette Vinnedge LM, McClaine R, Wagh PK, Wikenheiser-Brokamp KA, Waltz SE, Wells SI.

Oncogene. 2011 Jun 16;30(24):2741-52. doi: 10.1038/onc.2011.2. Epub 2011 Feb 14.

37.

Divergent Protein Kinase A isoforms co-ordinately regulate conidial germination, carbohydrate metabolism and virulence in Aspergillus fumigatus.

Fuller KK, Richie DL, Feng X, Krishnan K, Stephens TJ, Wikenheiser-Brokamp KA, Askew DS, Rhodes JC.

Mol Microbiol. 2011 Feb;79(4):1045-62. doi: 10.1111/j.1365-2958.2010.07509.x. Epub 2011 Jan 6.

38.

Vitamin D deficiency and reduced lung function in connective tissue-associated interstitial lung diseases.

Hagaman JT, Panos RJ, McCormack FX, Thakar CV, Wikenheiser-Brokamp KA, Shipley RT, Kinder BW.

Chest. 2011 Feb;139(2):353-360. doi: 10.1378/chest.10-0968. Epub 2010 Aug 5.

39.

Retinoblastoma family proteins have distinct functions in pulmonary epithelial cells in vivo critical for suppressing cell growth and tumorigenesis.

Simpson DS, Mason-Richie NA, Gettler CA, Wikenheiser-Brokamp KA.

Cancer Res. 2009 Nov 15;69(22):8733-41. doi: 10.1158/0008-5472.CAN-09-1359. Epub 2009 Nov 3.

40.

DICER1 mutations in familial pleuropulmonary blastoma.

Hill DA, Ivanovich J, Priest JR, Gurnett CA, Dehner LP, Desruisseau D, Jarzembowski JA, Wikenheiser-Brokamp KA, Suarez BK, Whelan AJ, Williams G, Bracamontes D, Messinger Y, Goodfellow PJ.

Science. 2009 Aug 21;325(5943):965. doi: 10.1126/science.1174334. Epub 2009 Jun 25.

41.

Utility of [18F]2-fluoro-2-deoxyglucose-PET in sporadic and tuberous sclerosis-associated lymphangioleiomyomatosis.

Young LR, Franz DN, Nagarkatte P, Fletcher CDM, Wikenheiser-Brokamp KA, Galsky MD, Corbridge TC, Lam AP, Gelfand MJ, McCormack FX.

Chest. 2009 Sep;136(3):926-933. doi: 10.1378/chest.09-0336. Epub 2009 Apr 6.

42.

Overexpression of the cellular DEK protein promotes epithelial transformation in vitro and in vivo.

Wise-Draper TM, Mintz-Cole RA, Morris TA, Simpson DS, Wikenheiser-Brokamp KA, Currier MA, Cripe TP, Grosveld GC, Wells SI.

Cancer Res. 2009 Mar 1;69(5):1792-9. doi: 10.1158/0008-5472.CAN-08-2304. Epub 2009 Feb 17.

43.

DEK proto-oncogene expression interferes with the normal epithelial differentiation program.

Wise-Draper TM, Morreale RJ, Morris TA, Mintz-Cole RA, Hoskins EE, Balsitis SJ, Husseinzadeh N, Witte DP, Wikenheiser-Brokamp KA, Lambert PF, Wells SI.

Am J Pathol. 2009 Jan;174(1):71-81. doi: 10.2353/ajpath.2009.080330. Epub 2008 Nov 26.

44.

Fanconi anemia deficiency stimulates HPV-associated hyperplastic growth in organotypic epithelial raft culture.

Hoskins EE, Morris TA, Higginbotham JM, Spardy N, Cha E, Kelly P, Williams DA, Wikenheiser-Brokamp KA, Duensing S, Wells SI.

Oncogene. 2009 Feb 5;28(5):674-85. doi: 10.1038/onc.2008.416. Epub 2008 Nov 17.

45.

Retinoblastoma function is essential for establishing lung epithelial quiescence after injury.

Mason-Richie NA, Mistry MJ, Gettler CA, Elayyadi A, Wikenheiser-Brokamp KA.

Cancer Res. 2008 Jun 1;68(11):4068-76. doi: 10.1158/0008-5472.CAN-07-5667.

46.

Retinoblastoma regulatory pathway in lung cancer.

Wikenheiser-Brokamp KA.

Curr Mol Med. 2006 Nov;6(7):783-93. Review.

PMID:
17100603
47.

Retinoblastoma family proteins: insights gained through genetic manipulation of mice.

Wikenheiser-Brokamp KA.

Cell Mol Life Sci. 2006 Apr;63(7-8):767-80. Review.

PMID:
16465443
48.

Rb family proteins differentially regulate distinct cell lineages during epithelial development.

Wikenheiser-Brokamp KA.

Development. 2004 Sep;131(17):4299-310. Epub 2004 Aug 4.

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