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Items: 1 to 50 of 88

1.

CRB2 Loss in Rod Photoreceptors Is Associated with Progressive Loss of Retinal Contrast Sensitivity.

Alves CH, Boon N, Mulder AA, Koster AJ, Jost CR, Wijnholds J.

Int J Mol Sci. 2019 Aug 21;20(17). pii: E4069. doi: 10.3390/ijms20174069.

2.

Human iPSC-Derived Retinas Recapitulate the Fetal CRB1 CRB2 Complex Formation and Demonstrate that Photoreceptors and Müller Glia Are Targets of AAV5.

Quinn PM, Buck TM, Mulder AA, Ohonin C, Alves CH, Vos RM, Bialecka M, van Herwaarden T, van Dijk EHC, Talib M, Freund C, Mikkers HMM, Hoeben RC, Goumans MJ, Boon CJF, Koster AJ, Chuva de Sousa Lopes SM, Jost CR, Wijnholds J.

Stem Cell Reports. 2019 May 14;12(5):906-919. doi: 10.1016/j.stemcr.2019.03.002. Epub 2019 Apr 4.

3.

"Basal Cell Migration" in Regeneration of the Corneal Wound-Bed.

Wijnholds J.

Stem Cell Reports. 2019 Jan 8;12(1):3-5. doi: 10.1016/j.stemcr.2018.12.009.

4.

Loss of CRB2 in Müller glial cells modifies a CRB1-associated retinitis pigmentosa phenotype into a Leber congenital amaurosis phenotype.

Quinn PM, Mulder AA, Henrique Alves C, Desrosiers M, de Vries SI, Klooster J, Dalkara D, Koster AJ, Jost CR, Wijnholds J.

Hum Mol Genet. 2019 Jan 1;28(1):105-123. doi: 10.1093/hmg/ddy337.

PMID:
30239717
5.

The Spectrum of Structural and Functional Abnormalities in Female Carriers of Pathogenic Variants in the RPGR Gene.

Talib M, van Schooneveld MJ, Van Cauwenbergh C, Wijnholds J, Ten Brink JB, Florijn RJ, Schalij-Delfos NE, Dagnelie G, van Genderen MM, De Baere E, Meester-Smoor MA, De Zaeytijd J, Cremers FPM, van den Born LI, Thiadens AA, Hoyng CB, Klaver CC, Leroy BP, Bergen AA, Boon CJF.

Invest Ophthalmol Vis Sci. 2018 Aug 1;59(10):4123-4133. doi: 10.1167/iovs.17-23453.

PMID:
30105367
6.

CRB2 in immature photoreceptors determines the superior-inferior symmetry of the developing retina to maintain retinal structure and function.

Quinn PM, Alves CH, Klooster J, Wijnholds J.

Hum Mol Genet. 2018 Sep 15;27(18):3137-3153. doi: 10.1093/hmg/ddy194.

PMID:
29893966
7.

CLINICAL AND GENETIC CHARACTERISTICS OF MALE PATIENTS WITH RPGR-ASSOCIATED RETINAL DYSTROPHIES: A Long-Term Follow-up Study.

Talib M, van Schooneveld MJ, Thiadens AA, Fiocco M, Wijnholds J, Florijn RJ, Schalij-Delfos NE, van Genderen MM, Putter H, Cremers FPM, Dagnelie G, Ten Brink JB, Klaver CCW, van den Born LI, Hoyng CB, Bergen AA, Boon CJF.

Retina. 2019 Jun;39(6):1186-1199. doi: 10.1097/IAE.0000000000002125.

PMID:
29528978
8.

AAV Serotype Testing on Cultured Human Donor Retinal Explants.

Buck TM, Pellissier LP, Vos RM, van Dijk EHC, Boon CJF, Wijnholds J.

Methods Mol Biol. 2018;1715:275-288. doi: 10.1007/978-1-4939-7522-8_20.

PMID:
29188521
9.

Production of iPS-Derived Human Retinal Organoids for Use in Transgene Expression Assays.

Quinn PM, Buck TM, Ohonin C, Mikkers HMM, Wijnholds J.

Methods Mol Biol. 2018;1715:261-273. doi: 10.1007/978-1-4939-7522-8_19.

PMID:
29188520
10.

AAV Gene Augmentation Therapy for CRB1-Associated Retinitis Pigmentosa.

Alves CH, Wijnholds J.

Methods Mol Biol. 2018;1715:135-151. doi: 10.1007/978-1-4939-7522-8_10.

PMID:
29188511
11.

Genetic and Molecular Approaches to Study Neuronal Migration in the Developing Cerebral Cortex.

Dudok JJ, Leonards PEG, Wijnholds J.

Brain Sci. 2017 May 5;7(5). pii: E53. doi: 10.3390/brainsci7050053. Review.

12.

The CRB1 Complex: Following the Trail of Crumbs to a Feasible Gene Therapy Strategy.

Quinn PM, Pellissier LP, Wijnholds J.

Front Neurosci. 2017 Apr 5;11:175. doi: 10.3389/fnins.2017.00175. eCollection 2017. Review.

13.

Genotypic and Phenotypic Characteristics of CRB1-Associated Retinal Dystrophies: A Long-Term Follow-up Study.

Talib M, van Schooneveld MJ, van Genderen MM, Wijnholds J, Florijn RJ, Ten Brink JB, Schalij-Delfos NE, Dagnelie G, Cremers FPM, Wolterbeek R, Fiocco M, Thiadens AA, Hoyng CB, Klaver CC, Bergen AA, Boon CJF.

Ophthalmology. 2017 Jun;124(6):884-895. doi: 10.1016/j.ophtha.2017.01.047. Epub 2017 Mar 21.

PMID:
28341475
14.

Crumbs2 promotes cell ingression during the epithelial-to-mesenchymal transition at gastrulation.

Ramkumar N, Omelchenko T, Silva-Gagliardi NF, McGlade CJ, Wijnholds J, Anderson KV.

Nat Cell Biol. 2016 Dec;18(12):1281-1291. doi: 10.1038/ncb3442. Epub 2016 Nov 21.

15.

Crumbs 2 prevents cortical abnormalities in mouse dorsal telencephalon.

Dudok JJ, Murtaza M, Henrique Alves C, Rashbass P, Wijnholds J.

Neurosci Res. 2016 Jul;108:12-23. doi: 10.1016/j.neures.2016.01.001. Epub 2016 Jan 21.

16.

Protein O-Glucosyltransferase 1 (POGLUT1) Promotes Mouse Gastrulation through Modification of the Apical Polarity Protein CRUMBS2.

Ramkumar N, Harvey BM, Lee JD, Alcorn HL, Silva-Gagliardi NF, McGlade CJ, Bestor TH, Wijnholds J, Haltiwanger RS, Anderson KV.

PLoS Genet. 2015 Oct 23;11(10):e1005551. doi: 10.1371/journal.pgen.1005551. eCollection 2015 Oct.

17.

A new CRB1 rat mutation links Müller glial cells to retinal telangiectasia.

Zhao M, Andrieu-Soler C, Kowalczuk L, Paz Cortés M, Berdugo M, Dernigoghossian M, Halili F, Jeanny JC, Goldenberg B, Savoldelli M, El Sanharawi M, Naud MC, van Ijcken W, Pescini-Gobert R, Martinet D, Maass A, Wijnholds J, Crisanti P, Rivolta C, Behar-Cohen F.

J Neurosci. 2015 Apr 15;35(15):6093-106. doi: 10.1523/JNEUROSCI.3412-14.2015.

18.

Gene therapy into photoreceptors and Müller glial cells restores retinal structure and function in CRB1 retinitis pigmentosa mouse models.

Pellissier LP, Quinn PM, Alves CH, Vos RM, Klooster J, Flannery JG, Heimel JA, Wijnholds J.

Hum Mol Genet. 2015 Jun 1;24(11):3104-18. doi: 10.1093/hmg/ddv062. Epub 2015 Feb 20.

19.

CRB2 acts as a modifying factor of CRB1-related retinal dystrophies in mice.

Pellissier LP, Lundvig DM, Tanimoto N, Klooster J, Vos RM, Richard F, Sothilingam V, Garcia Garrido M, Le Bivic A, Seeliger MW, Wijnholds J.

Hum Mol Genet. 2014 Jul 15;23(14):3759-71. doi: 10.1093/hmg/ddu089. Epub 2014 Feb 23.

PMID:
24565864
20.

The CRB1 and adherens junction complex proteins in retinal development and maintenance.

Alves CH, Pellissier LP, Wijnholds J.

Prog Retin Eye Res. 2014 May;40:35-52. doi: 10.1016/j.preteyeres.2014.01.001. Epub 2014 Feb 6. Review.

PMID:
24508727
21.

Targeted ablation of Crb2 in photoreceptor cells induces retinitis pigmentosa.

Alves CH, Pellissier LP, Vos RM, Garcia Garrido M, Sothilingam V, Seide C, Beck SC, Klooster J, Furukawa T, Flannery JG, Verhaagen J, Seeliger MW, Wijnholds J.

Hum Mol Genet. 2014 Jul 1;23(13):3384-401. doi: 10.1093/hmg/ddu048. Epub 2014 Feb 2.

22.

Specific tools for targeting and expression in Müller glial cells.

Pellissier LP, Hoek RM, Vos RM, Aartsen WM, Klimczak RR, Hoyng SA, Flannery JG, Wijnholds J.

Mol Ther Methods Clin Dev. 2014 Mar 19;1:14009. doi: 10.1038/mtm.2014.9. eCollection 2014.

23.

Targeted ablation of CRB1 and CRB2 in retinal progenitor cells mimics Leber congenital amaurosis.

Pellissier LP, Alves CH, Quinn PM, Vos RM, Tanimoto N, Lundvig DM, Dudok JJ, Hooibrink B, Richard F, Beck SC, Huber G, Sothilingam V, Garcia Garrido M, Le Bivic A, Seeliger MW, Wijnholds J.

PLoS Genet. 2013;9(12):e1003976. doi: 10.1371/journal.pgen.1003976. Epub 2013 Dec 5.

24.

Microarray and morphological analysis of early postnatal CRB2 mutant retinas on a pure C57BL/6J genetic background.

Alves CH, Bossers K, Vos RM, Essing AH, Swagemakers S, van der Spek PJ, Verhaagen J, Wijnholds J.

PLoS One. 2013 Dec 6;8(12):e82532. doi: 10.1371/journal.pone.0082532. eCollection 2013.

25.

MPP3 regulates levels of PALS1 and adhesion between photoreceptors and Müller cells.

Dudok JJ, Sanz AS, Lundvig DM, Sothilingam V, Garcia Garrido M, Klooster J, Seeliger MW, Wijnholds J.

Glia. 2013 Oct;61(10):1629-44. doi: 10.1002/glia.22545. Epub 2013 Jul 25.

PMID:
23893895
26.

The multi-PDZ domain protein-1 (MUPP-1) expression regulates cellular levels of the PALS-1/PATJ polarity complex.

Assémat E, Crost E, Ponserre M, Wijnholds J, Le Bivic A, Massey-Harroche D.

Exp Cell Res. 2013 Oct 15;319(17):2514-25. doi: 10.1016/j.yexcr.2013.07.011. Epub 2013 Jul 20.

PMID:
23880463
27.

MPP3 is required for maintenance of the apical junctional complex, neuronal migration, and stratification in the developing cortex.

Dudok JJ, Sanz AS, Lundvig DM, Wijnholds J.

J Neurosci. 2013 May 8;33(19):8518-27. doi: 10.1523/JNEUROSCI.5627-12.2013.

28.

Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene.

Alves CH, Sanz AS, Park B, Pellissier LP, Tanimoto N, Beck SC, Huber G, Murtaza M, Richard F, Sridevi Gurubaran I, Garcia Garrido M, Levelt CN, Rashbass P, Le Bivic A, Seeliger MW, Wijnholds J.

Hum Mol Genet. 2013 Jan 1;22(1):35-50. doi: 10.1093/hmg/dds398. Epub 2012 Sep 21.

PMID:
23001562
29.

PALS1 is essential for retinal pigment epithelium structure and neural retina stratification.

Park B, Alves CH, Lundvig DM, Tanimoto N, Beck SC, Huber G, Richard F, Klooster J, Andlauer TF, Swindell EC, Jamrich M, Le Bivic A, Seeliger MW, Wijnholds J.

J Neurosci. 2011 Nov 23;31(47):17230-41. doi: 10.1523/JNEUROSCI.4430-11.2011.

30.

GFAP-driven GFP expression in activated mouse Müller glial cells aligning retinal blood vessels following intravitreal injection of AAV2/6 vectors.

Aartsen WM, van Cleef KW, Pellissier LP, Hoek RM, Vos RM, Blits B, Ehlert EM, Balaggan KS, Ali RR, Verhaagen J, Wijnholds J.

PLoS One. 2010 Aug 24;5(8):e12387. doi: 10.1371/journal.pone.0012387.

31.

The apical complex couples cell fate and cell survival to cerebral cortical development.

Kim S, Lehtinen MK, Sessa A, Zappaterra MW, Cho SH, Gonzalez D, Boggan B, Austin CA, Wijnholds J, Gambello MJ, Malicki J, LaMantia AS, Broccoli V, Walsh CA.

Neuron. 2010 Apr 15;66(1):69-84. doi: 10.1016/j.neuron.2010.03.019.

32.

Bone spicule pigment formation in retinitis pigmentosa: insights from a mouse model.

Jaissle GB, May CA, van de Pavert SA, Wenzel A, Claes-May E, Giessl A, Szurman P, Wolfrum U, Wijnholds J, Fischer MD, Humphries P, Seeliger MW.

Graefes Arch Clin Exp Ophthalmol. 2010 Aug;248(8):1063-70. doi: 10.1007/s00417-009-1253-9. Epub 2009 Dec 12. Erratum in: Graefes Arch Clin Exp Ophthalmol. 2010 Sep;248(9):1365. Fisher, M D [corrected to Fischer, M D].

PMID:
20012642
33.

Noninvasive, in vivo assessment of mouse retinal structure using optical coherence tomography.

Fischer MD, Huber G, Beck SC, Tanimoto N, Muehlfriedel R, Fahl E, Grimm C, Wenzel A, Remé CE, van de Pavert SA, Wijnholds J, Pacal M, Bremner R, Seeliger MW.

PLoS One. 2009 Oct 19;4(10):e7507. doi: 10.1371/journal.pone.0007507.

34.

TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals.

Stöhr H, Heisig JB, Benz PM, Schöberl S, Milenkovic VM, Strauss O, Aartsen WM, Wijnholds J, Weber BH, Schulz HL.

J Neurosci. 2009 May 27;29(21):6809-18. doi: 10.1523/JNEUROSCI.5546-08.2009.

35.

PSD95beta regulates plasma membrane Ca2+ pump localization at the photoreceptor synapse.

Aartsen WM, Arsanto JP, Chauvin JP, Vos RM, Versteeg I, Cardozo BN, Bivic AL, Wijnholds J.

Mol Cell Neurosci. 2009 Jun;41(2):156-65. doi: 10.1016/j.mcn.2009.02.003. Epub 2009 Feb 21.

PMID:
19233278
36.

Contribution of the drug transporter ABCG2 (breast cancer resistance protein) to resistance against anticancer nucleosides.

de Wolf C, Jansen R, Yamaguchi H, de Haas M, van de Wetering K, Wijnholds J, Beijnen J, Borst P.

Mol Cancer Ther. 2008 Sep;7(9):3092-102. doi: 10.1158/1535-7163.MCT-08-0427. Epub 2008 Sep 2.

37.

Crb1 is a determinant of retinal apical Müller glia cell features.

van de Pavert SA, Sanz AS, Aartsen WM, Vos RM, Versteeg I, Beck SC, Klooster J, Seeliger MW, Wijnholds J.

Glia. 2007 Nov 1;55(14):1486-97.

PMID:
17705196
38.

A single amino acid substitution (Cys249Trp) in Crb1 causes retinal degeneration and deregulates expression of pituitary tumor transforming gene Pttg1.

van de Pavert SA, Meuleman J, Malysheva A, Aartsen WM, Versteeg I, Tonagel F, Kamphuis W, McCabe CJ, Seeliger MW, Wijnholds J.

J Neurosci. 2007 Jan 17;27(3):564-73.

39.

cGMP transport by vesicles from human and mouse erythrocytes.

de Wolf CJ, Yamaguchi H, van der Heijden I, Wielinga PR, Hundscheid SL, Ono N, Scheffer GL, de Haas M, Schuetz JD, Wijnholds J, Borst P.

FEBS J. 2007 Jan;274(2):439-50.

40.

Towards understanding CRUMBS function in retinal dystrophies.

Richard M, Roepman R, Aartsen WM, van Rossum AG, den Hollander AI, Knust E, Wijnholds J, Cremers FP.

Hum Mol Genet. 2006 Oct 15;15 Spec No 2:R235-43. Review.

PMID:
16987889
41.

Opposite effects of PSD-95 and MPP3 PDZ proteins on serotonin 5-hydroxytryptamine2C receptor desensitization and membrane stability.

Gavarini S, Bécamel C, Altier C, Lory P, Poncet J, Wijnholds J, Bockaert J, Marin P.

Mol Biol Cell. 2006 Nov;17(11):4619-31. Epub 2006 Aug 16.

42.

Pals1/Mpp5 is required for correct localization of Crb1 at the subapical region in polarized Muller glia cells.

van Rossum AG, Aartsen WM, Meuleman J, Klooster J, Malysheva A, Versteeg I, Arsanto JP, Le Bivic A, Wijnholds J.

Hum Mol Genet. 2006 Sep 15;15(18):2659-72. Epub 2006 Aug 2.

PMID:
16885194
43.

The multidrug resistance protein 1 (Mrp1), but not Mrp5, mediates export of glutathione and glutathione disulfide from brain astrocytes.

Minich T, Riemer J, Schulz JB, Wielinga P, Wijnholds J, Dringen R.

J Neurochem. 2006 Apr;97(2):373-84. Epub 2006 Mar 15.

44.

Mpp4 recruits Psd95 and Veli3 towards the photoreceptor synapse.

Aartsen WM, Kantardzhieva A, Klooster J, van Rossum AG, van de Pavert SA, Versteeg I, Cardozo BN, Tonagel F, Beck SC, Tanimoto N, Seeliger MW, Wijnholds J.

Hum Mol Genet. 2006 Apr 15;15(8):1291-302. Epub 2006 Mar 6.

PMID:
16520334
45.

MPP3 is recruited to the MPP5 protein scaffold at the retinal outer limiting membrane.

Kantardzhieva A, Alexeeva S, Versteeg I, Wijnholds J.

FEBS J. 2006 Mar;273(6):1152-65.

46.

Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides.

Zelcer N, van de Wetering K, de Waart R, Scheffer GL, Marschall HU, Wielinga PR, Kuil A, Kunne C, Smith A, van der Valk M, Wijnholds J, Elferink RO, Borst P.

J Hepatol. 2006 Apr;44(4):768-75. Epub 2005 Aug 9.

PMID:
16225954
47.

In vivo confocal imaging of the retina in animal models using scanning laser ophthalmoscopy.

Seeliger MW, Beck SC, Pereyra-Muñoz N, Dangel S, Tsai JY, Luhmann UF, van de Pavert SA, Wijnholds J, Samardzija M, Wenzel A, Zrenner E, Narfström K, Fahl E, Tanimoto N, Acar N, Tonagel F.

Vision Res. 2005 Dec;45(28):3512-9. Epub 2005 Sep 26.

48.

PATJ connects and stabilizes apical and lateral components of tight junctions in human intestinal cells.

Michel D, Arsanto JP, Massey-Harroche D, Béclin C, Wijnholds J, Le Bivic A.

J Cell Sci. 2005 Sep 1;118(Pt 17):4049-57.

49.

MPP5 recruits MPP4 to the CRB1 complex in photoreceptors.

Kantardzhieva A, Gosens I, Alexeeva S, Punte IM, Versteeg I, Krieger E, Neefjes-Mol CA, den Hollander AI, Letteboer SJ, Klooster J, Cremers FP, Roepman R, Wijnholds J.

Invest Ophthalmol Vis Sci. 2005 Jun;46(6):2192-201.

PMID:
15914641
50.

The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates.

Wielinga P, Hooijberg JH, Gunnarsdottir S, Kathmann I, Reid G, Zelcer N, van der Born K, de Haas M, van der Heijden I, Kaspers G, Wijnholds J, Jansen G, Peters G, Borst P.

Cancer Res. 2005 May 15;65(10):4425-30.

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