Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 31

1.

Behavioral Abnormalities in Knockout and Humanized Tau Mice.

Gonçalves RA, Wijesekara N, Fraser PE, De Felice FG.

Front Endocrinol (Lausanne). 2020 Mar 12;11:124. doi: 10.3389/fendo.2020.00124. eCollection 2020.

2.

The Link Between Tau and Insulin Signaling: Implications for Alzheimer's Disease and Other Tauopathies.

Gonçalves RA, Wijesekara N, Fraser PE, De Felice FG.

Front Cell Neurosci. 2019 Feb 5;13:17. doi: 10.3389/fncel.2019.00017. eCollection 2019.

3.

Tau ablation in mice leads to pancreatic β cell dysfunction and glucose intolerance.

Wijesekara N, Gonçalves RA, Ahrens R, De Felice FG, Fraser PE.

FASEB J. 2018 Jun;32(6):3166-3173. doi: 10.1096/fj.201701352. Epub 2018 Jan 18.

PMID:
29401605
4.

Impaired peripheral glucose homeostasis and Alzheimer's disease.

Wijesekara N, Gonçalves RA, De Felice FG, Fraser PE.

Neuropharmacology. 2018 Jul 1;136(Pt B):172-181. doi: 10.1016/j.neuropharm.2017.11.027. Epub 2017 Nov 21. Review.

PMID:
29169962
5.

Insulin resistance is associated with reductions in specific cognitive domains and increases in CSF tau in cognitively normal adults.

Laws SM, Gaskin S, Woodfield A, Srikanth V, Bruce D, Fraser PE, Porter T, Newsholme P, Wijesekara N, Burnham S, Doré V, Li QX, Maruff P, Masters CL, Rainey-Smith S, Rowe CC, Salvado O, Villemagne VL, Martins RN, Verdile G.

Sci Rep. 2017 Aug 29;7(1):9766. doi: 10.1038/s41598-017-09577-4.

6.

Amyloid-β and islet amyloid pathologies link Alzheimer's disease and type 2 diabetes in a transgenic model.

Wijesekara N, Ahrens R, Sabale M, Wu L, Ha K, Verdile G, Fraser PE.

FASEB J. 2017 Dec;31(12):5409-5418. doi: 10.1096/fj.201700431R. Epub 2017 Aug 14.

PMID:
28808140
7.

The Link between Type 2 Diabetes and Neurodegeneration: Roles for Amyloid-β, Amylin, and Tau Proteins.

Bharadwaj P, Wijesekara N, Liyanapathirana M, Newsholme P, Ittner L, Fraser P, Verdile G.

J Alzheimers Dis. 2017;59(2):421-432. doi: 10.3233/JAD-161192. Review.

PMID:
28269785
8.

ABCA1 deficiency and cellular cholesterol accumulation increases islet amyloidogenesis in mice.

Wijesekara N, Kaur A, Westwell-Roper C, Nackiewicz D, Soukhatcheva G, Hayden MR, Verchere CB.

Diabetologia. 2016 Jun;59(6):1242-6. doi: 10.1007/s00125-016-3907-6. Epub 2016 Mar 12.

PMID:
26970755
9.

Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer's Disease.

Verdile G, Keane KN, Cruzat VF, Medic S, Sabale M, Rowles J, Wijesekara N, Martins RN, Fraser PE, Newsholme P.

Mediators Inflamm. 2015;2015:105828. doi: 10.1155/2015/105828. Epub 2015 Nov 26. Review.

10.

A shortened verbal autopsy instrument for use in routine mortality surveillance systems.

Serina P, Riley I, Stewart A, Flaxman AD, Lozano R, Mooney MD, Luning R, Hernandez B, Black R, Ahuja R, Alam N, Alam SS, Ali SM, Atkinson C, Baqui AH, Chowdhury HR, Dandona L, Dandona R, Dantzer E, Darmstadt GL, Das V, Dhingra U, Dutta A, Fawzi W, Freeman M, Gamage S, Gomez S, Hensman D, James SL, Joshi R, Kalter HD, Kumar A, Kumar V, Lucero M, Mehta S, Neal B, Ohno SL, Phillips D, Pierce K, Prasad R, Praveen D, Premji Z, Ramirez-Villalobos D, Rampatige R, Remolador H, Romero M, Said M, Sanvictores D, Sazawal S, Streatfield PK, Tallo V, Vadhatpour A, Wijesekara N, Murray CJ, Lopez AD.

BMC Med. 2015 Dec 16;13:302. doi: 10.1186/s12916-015-0528-8.

11.

Islet amyloid inhibitors improve glucose homeostasis in a transgenic mouse model of type 2 diabetes.

Wijesekara N, Ahrens R, Wu L, Ha K, Liu Y, Wheeler MB, Fraser PE.

Diabetes Obes Metab. 2015 Oct;17(10):1003-6. doi: 10.1111/dom.12529. Epub 2015 Aug 19.

PMID:
26095311
12.

Loss of Cyp8b1 improves glucose homeostasis by increasing GLP-1.

Kaur A, Patankar JV, de Haan W, Ruddle P, Wijesekara N, Groen AK, Verchere CB, Singaraja RR, Hayden MR.

Diabetes. 2015 Apr;64(4):1168-79. doi: 10.2337/db14-0716. Epub 2014 Oct 22.

13.

[Acute adrenal insufficiency. Easy to miss Waterhouse-Friderichsen syndrome, as shown in two cases].

Wijesekara N, Falhammar H, Rzewuski M, Volpe C, Calissendorff J, Mannheimer B.

Lakartidningen. 2013 Oct 9-15;110(41):1807-8. Swedish. No abstract available.

PMID:
24187895
14.

Regulation of ABCA1 protein expression and function in hepatic and pancreatic islet cells by miR-145.

Kang MH, Zhang LH, Wijesekara N, de Haan W, Butland S, Bhattacharjee A, Hayden MR.

Arterioscler Thromb Vasc Biol. 2013 Dec;33(12):2724-32. doi: 10.1161/ATVBAHA.113.302004. Epub 2013 Oct 17.

PMID:
24135019
15.

Effects of high-fat diet feeding on Znt8-null mice: differences between β-cell and global knockout of Znt8.

Hardy AB, Wijesekara N, Genkin I, Prentice KJ, Bhattacharjee A, Kong D, Chimienti F, Wheeler MB.

Am J Physiol Endocrinol Metab. 2012 May 15;302(9):E1084-96. doi: 10.1152/ajpendo.00448.2011. Epub 2012 Feb 14.

16.

miR-33a modulates ABCA1 expression, cholesterol accumulation, and insulin secretion in pancreatic islets.

Wijesekara N, Zhang LH, Kang MH, Abraham T, Bhattacharjee A, Warnock GL, Verchere CB, Hayden MR.

Diabetes. 2012 Mar;61(3):653-8. doi: 10.2337/db11-0944. Epub 2012 Feb 7.

17.

Loss of both ABCA1 and ABCG1 results in increased disturbances in islet sterol homeostasis, inflammation, and impaired β-cell function.

Kruit JK, Wijesekara N, Westwell-Roper C, Vanmierlo T, de Haan W, Bhattacharjee A, Tang R, Wellington CL, LütJohann D, Johnson JD, Brunham LR, Verchere CB, Hayden MR.

Diabetes. 2012 Mar;61(3):659-64. doi: 10.2337/db11-1341. Epub 2012 Feb 7.

18.

Islet cholesterol accumulation due to loss of ABCA1 leads to impaired exocytosis of insulin granules.

Kruit JK, Wijesekara N, Fox JE, Dai XQ, Brunham LR, Searle GJ, Morgan GP, Costin AJ, Tang R, Bhattacharjee A, Johnson JD, Light PE, Marsh BJ, Macdonald PE, Verchere CB, Hayden MR.

Diabetes. 2011 Dec;60(12):3186-96. doi: 10.2337/db11-0081. Epub 2011 Oct 12.

19.

Regulation of glucagon secretion by zinc: lessons from the β cell-specific Znt8 knockout mouse model.

Hardy AB, Serino AS, Wijesekara N, Chimienti F, Wheeler MB.

Diabetes Obes Metab. 2011 Oct;13 Suppl 1:112-7. doi: 10.1111/j.1463-1326.2011.01451.x. Review.

PMID:
21824264
20.

Dihydrofolate reductase mutations-associated megaloblastic anemia and cerebral folate deficiency.

Wijesekara N.

Clin Genet. 2011 Jun;79(6):507-8. doi: 10.1111/j.1399-0004.2011.01662.x. Epub 2011 Apr 4. No abstract available.

PMID:
21388369
21.

Adiponectin-induced ERK and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion.

Wijesekara N, Krishnamurthy M, Bhattacharjee A, Suhail A, Sweeney G, Wheeler MB.

J Biol Chem. 2010 Oct 29;285(44):33623-31. doi: 10.1074/jbc.M109.085084. Epub 2010 Aug 13.

22.

Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion.

Wijesekara N, Dai FF, Hardy AB, Giglou PR, Bhattacharjee A, Koshkin V, Chimienti F, Gaisano HY, Rutter GA, Wheeler MB.

Diabetologia. 2010 Aug;53(8):1656-68. doi: 10.1007/s00125-010-1733-9. Epub 2010 Apr 28.

23.

Zinc, a regulator of islet function and glucose homeostasis.

Wijesekara N, Chimienti F, Wheeler MB.

Diabetes Obes Metab. 2009 Nov;11 Suppl 4:202-14. doi: 10.1111/j.1463-1326.2009.01110.x. Review.

PMID:
19817803
24.

Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice.

Fu A, Ng AC, Depatie C, Wijesekara N, He Y, Wang GS, Bardeesy N, Scott FW, Touyz RM, Wheeler MB, Screaton RA.

Cell Metab. 2009 Oct;10(4):285-95. doi: 10.1016/j.cmet.2009.08.008.

25.

Characterization of Erg K+ channels in alpha- and beta-cells of mouse and human islets.

Hardy AB, Fox JE, Giglou PR, Wijesekara N, Bhattacharjee A, Sultan S, Gyulkhandanyan AV, Gaisano HY, MacDonald PE, Wheeler MB.

J Biol Chem. 2009 Oct 30;284(44):30441-52. doi: 10.1074/jbc.M109.040659. Epub 2009 Aug 18.

26.

Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants.

Nicolson TJ, Bellomo EA, Wijesekara N, Loder MK, Baldwin JM, Gyulkhandanyan AV, Koshkin V, Tarasov AI, Carzaniga R, Kronenberger K, Taneja TK, da Silva Xavier G, Libert S, Froguel P, Scharfmann R, Stetsyuk V, Ravassard P, Parker H, Gribble FM, Reimann F, Sladek R, Hughes SJ, Johnson PR, Masseboeuf M, Burcelin R, Baldwin SA, Liu M, Lara-Lemus R, Arvan P, Schuit FC, Wheeler MB, Chimienti F, Rutter GA.

Diabetes. 2009 Sep;58(9):2070-83. doi: 10.2337/db09-0551. Epub 2009 Jun 19.

27.

The identification of potential factors associated with the development of type 2 diabetes: a quantitative proteomics approach.

Lu H, Yang Y, Allister EM, Wijesekara N, Wheeler MB.

Mol Cell Proteomics. 2008 Aug;7(8):1434-51. doi: 10.1074/mcp.M700478-MCP200. Epub 2008 Apr 30.

28.

Investigation of transport mechanisms and regulation of intracellular Zn2+ in pancreatic alpha-cells.

Gyulkhandanyan AV, Lu H, Lee SC, Bhattacharjee A, Wijesekara N, Fox JE, MacDonald PE, Chimienti F, Dai FF, Wheeler MB.

J Biol Chem. 2008 Apr 11;283(15):10184-97. doi: 10.1074/jbc.M707005200. Epub 2008 Feb 4.

29.

Muscle cell depolarization induces a gain in surface GLUT4 via reduced endocytosis independently of AMPK.

Wijesekara N, Tung A, Thong F, Klip A.

Am J Physiol Endocrinol Metab. 2006 Jun;290(6):E1276-86. Epub 2006 Jan 17.

30.

Muscle-specific Pten deletion protects against insulin resistance and diabetes.

Wijesekara N, Konrad D, Eweida M, Jefferies C, Liadis N, Giacca A, Crackower M, Suzuki A, Mak TW, Kahn CR, Klip A, Woo M.

Mol Cell Biol. 2005 Feb;25(3):1135-45.

31.

Indinavir uncovers different contributions of GLUT4 and GLUT1 towards glucose uptake in muscle and fat cells and tissues.

Rudich A, Konrad D, Török D, Ben-Romano R, Huang C, Niu W, Garg RR, Wijesekara N, Germinario RJ, Bilan PJ, Klip A.

Diabetologia. 2003 May;46(5):649-58. Epub 2003 Apr 24.

PMID:
12712244

Supplemental Content

Loading ...
Support Center