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Measurement of Basal Neurotransmitter Levels Using Convolution-Based Nonfaradaic Current Removal.

Johnson JA, Rodeberg NT, Wightman RM.

Anal Chem. 2018 Jun 19;90(12):7181-7189. doi: 10.1021/acs.analchem.7b04682. Epub 2018 Jun 7.


Dopamine's Effects on Corticostriatal Synapses during Reward-Based Behaviors.

Bamford NS, Wightman RM, Sulzer D.

Neuron. 2018 Feb 7;97(3):494-510. doi: 10.1016/j.neuron.2018.01.006. Review.


Multivariate Curve Resolution for Signal Isolation from Fast-Scan Cyclic Voltammetric Data.

Johnson JA, Gray JH, Rodeberg NT, Wightman RM.

Anal Chem. 2017 Oct 3;89(19):10547-10555. doi: 10.1021/acs.analchem.7b02771. Epub 2017 Sep 13.


Comparison of Spreading Depolarizations in the Motor Cortex and Nucleus Accumbens: Similar Patterns of Oxygen Responses and the Role of Dopamine.

Hobbs CN, Holzberg G, Min AS, Wightman RM.

ACS Chem Neurosci. 2017 Nov 15;8(11):2512-2521. doi: 10.1021/acschemneuro.7b00266. Epub 2017 Sep 5.


Removal of Differential Capacitive Interferences in Fast-Scan Cyclic Voltammetry.

Johnson JA, Hobbs CN, Wightman RM.

Anal Chem. 2017 Jun 6;89(11):6166-6174. doi: 10.1021/acs.analchem.7b01005. Epub 2017 May 18.


Effects of Glutamate Receptor Activation on Local Oxygen Changes.

Walton LR, Boustead NG, Carroll S, Wightman RM.

ACS Chem Neurosci. 2017 Jul 19;8(7):1598-1608. doi: 10.1021/acschemneuro.7b00088. Epub 2017 May 3.


Contrasting Regulation of Catecholamine Neurotransmission in the Behaving Brain: Pharmacological Insights from an Electrochemical Perspective.

Fox ME, Wightman RM.

Pharmacol Rev. 2017 Jan;69(1):12-32. doi: 10.1124/pr.116.012948. Review.


Hitchhiker's Guide to Voltammetry: Acute and Chronic Electrodes for in Vivo Fast-Scan Cyclic Voltammetry.

Rodeberg NT, Sandberg SG, Johnson JA, Phillips PE, Wightman RM.

ACS Chem Neurosci. 2017 Feb 15;8(2):221-234. doi: 10.1021/acschemneuro.6b00393. Epub 2017 Feb 9. Review.


Medullary Norepinephrine Projections Release Norepinephrine into the Contralateral Bed Nucleus of the Stria Terminalis.

Fox ME, Bucher ES, Johnson JA, Wightman RM.

ACS Chem Neurosci. 2016 Dec 21;7(12):1681-1689. doi: 10.1021/acschemneuro.6b00210. Epub 2016 Sep 27.


One month of cocaine abstinence potentiates rapid dopamine signaling in the nucleus accumbens core.

Cameron CM, Wightman RM, Carelli RM.

Neuropharmacology. 2016 Dec;111:223-230. doi: 10.1016/j.neuropharm.2016.09.006. Epub 2016 Sep 8.


Dopamine Dynamics during Continuous Intracranial Self-Stimulation: Effect of Waveform on Fast-Scan Cyclic Voltammetry Data.

Rodeberg NT, Johnson JA, Bucher ES, Wightman RM.

ACS Chem Neurosci. 2016 Nov 16;7(11):1508-1518. Epub 2016 Sep 1.


Reciprocal Catecholamine Changes during Opiate Exposure and Withdrawal.

Fox ME, Rodeberg NT, Wightman RM.

Neuropsychopharmacology. 2017 Feb;42(3):671-681. doi: 10.1038/npp.2016.135. Epub 2016 Jul 27.


Expanding neurochemical investigations with multi-modal recording: simultaneous fast-scan cyclic voltammetry, iontophoresis, and patch clamp measurements.

Kirkpatrick DC, McKinney CJ, Manis PB, Wightman RM.

Analyst. 2016 Aug 2;141(16):4902-11. doi: 10.1039/c6an00933f.


Cross-hemispheric dopamine projections have functional significance.

Fox ME, Mikhailova MA, Bass CE, Takmakov P, Gainetdinov RR, Budygin EA, Wightman RM.

Proc Natl Acad Sci U S A. 2016 Jun 21;113(25):6985-90. doi: 10.1073/pnas.1603629113. Epub 2016 Jun 13.


Cue-Evoked Dopamine Release Rapidly Modulates D2 Neurons in the Nucleus Accumbens During Motivated Behavior.

Owesson-White C, Belle AM, Herr NR, Peele JL, Gowrishankar P, Carelli RM, Wightman RM.

J Neurosci. 2016 Jun 1;36(22):6011-21. doi: 10.1523/JNEUROSCI.0393-16.2016.


Evaluation of Drug Concentrations Delivered by Microiontophoresis.

Kirkpatrick DC, Wightman RM.

Anal Chem. 2016 Jun 21;88(12):6492-9. doi: 10.1021/acs.analchem.6b01211. Epub 2016 May 27.


Design and characterization of a microfabricated hydrogen clearance blood flow sensor.

Walton LR, Edwards MA, McCarty GS, Wightman RM.

J Neurosci Methods. 2016 Jul 15;267:132-40. doi: 10.1016/j.jneumeth.2016.04.014. Epub 2016 Apr 19.


Quantitative analysis of iontophoretic drug delivery from micropipettes.

Kirkpatrick DC, Walton LR, Edwards MA, Wightman RM.

Analyst. 2016 Mar 21;141(6):1930-8. doi: 10.1039/c5an02530c.


Failure of Standard Training Sets in the Analysis of Fast-Scan Cyclic Voltammetry Data.

Johnson JA, Rodeberg NT, Wightman RM.

ACS Chem Neurosci. 2016 Mar 16;7(3):349-59. doi: 10.1021/acschemneuro.5b00302. Epub 2016 Jan 27.


Acute selective serotonin reuptake inhibitors regulate the dorsal raphe nucleus causing amplification of terminal serotonin release.

Dankoski EC, Carroll S, Wightman RM.

J Neurochem. 2016 Mar;136(6):1131-1141. doi: 10.1111/jnc.13528. Epub 2016 Jan 26.


Phasic dopamine signals: from subjective reward value to formal economic utility.

Schultz W, Carelli RM, Wightman RM.

Curr Opin Behav Sci. 2015 Oct;5:147-154.


Construction of Training Sets for Valid Calibration of in Vivo Cyclic Voltammetric Data by Principal Component Analysis.

Rodeberg NT, Johnson JA, Cameron CM, Saddoris MP, Carelli RM, Wightman RM.

Anal Chem. 2015 Nov 17;87(22):11484-91. doi: 10.1021/acs.analchem.5b03222. Epub 2015 Oct 27.


Microfabricated Collector-Generator Electrode Sensor for Measuring Absolute pH and Oxygen Concentrations.

Dengler AK, Wightman RM, McCarty GS.

Anal Chem. 2015 Oct 20;87(20):10556-64. doi: 10.1021/acs.analchem.5b02866. Epub 2015 Sep 29.


Differential Dopamine Release Dynamics in the Nucleus Accumbens Core and Shell Reveal Complementary Signals for Error Prediction and Incentive Motivation.

Saddoris MP, Cacciapaglia F, Wightman RM, Carelli RM.

J Neurosci. 2015 Aug 19;35(33):11572-82. doi: 10.1523/JNEUROSCI.2344-15.2015.


Electrochemical Analysis of Neurotransmitters.

Bucher ES, Wightman RM.

Annu Rev Anal Chem (Palo Alto Calif). 2015;8:239-61. doi: 10.1146/annurev-anchem-071114-040426. Epub 2015 May 4. Review.


Stress and Drug Dependence Differentially Modulate Norepinephrine Signaling in Animals with Varied HPA Axis Function.

Fox ME, Studebaker RI, Swofford NJ, Wightman RM.

Neuropsychopharmacology. 2015 Jun;40(7):1752-61. doi: 10.1038/npp.2015.23. Epub 2015 Jan 20.


Norepinephrine and dopamine transmission in 2 limbic regions differentially respond to acute noxious stimulation.

Park J, Bucher ES, Budygin EA, Wightman RM.

Pain. 2015 Feb;156(2):318-27. doi: 10.1097/01.j.pain.0000460312.79195.ed.


Monitoring molecules: insights and progress.

Wightman RM.

ACS Chem Neurosci. 2015 Jan 21;6(1):5-7. doi: 10.1021/cn500324m. Epub 2014 Dec 16.


Increased expression of the dopamine transporter leads to loss of dopamine neurons, oxidative stress and l-DOPA reversible motor deficits.

Masoud ST, Vecchio LM, Bergeron Y, Hossain MM, Nguyen LT, Bermejo MK, Kile B, Sotnikova TD, Siesser WB, Gainetdinov RR, Wightman RM, Caron MG, Richardson JR, Miller GW, Ramsey AJ, Cyr M, Salahpour A.

Neurobiol Dis. 2015 Feb;74:66-75. doi: 10.1016/j.nbd.2014.10.016. Epub 2014 Oct 30.


Dynamics of rapid dopamine release in the nucleus accumbens during goal-directed behaviors for cocaine versus natural rewards.

Cameron CM, Wightman RM, Carelli RM.

Neuropharmacology. 2014 Nov;86:319-28. doi: 10.1016/j.neuropharm.2014.08.006. Epub 2014 Aug 29.


Characterization of solute distribution following iontophoresis from a micropipet.

Kirkpatrick DC, Edwards MA, Flowers PA, Wightman RM.

Anal Chem. 2014 Oct 7;86(19):9909-16. doi: 10.1021/ac5026072. Epub 2014 Sep 10.


Facilitation of serotonin signaling by SSRIs is attenuated by social isolation.

Dankoski EC, Agster KL, Fox ME, Moy SS, Wightman RM.

Neuropsychopharmacology. 2014 Dec;39(13):2928-37. doi: 10.1038/npp.2014.162. Epub 2014 Jul 1.


Medullary norepinephrine neurons modulate local oxygen concentrations in the bed nucleus of the stria terminalis.

Bucher ES, Fox ME, Kim L, Kirkpatrick DC, Rodeberg NT, Belle AM, Wightman RM.

J Cereb Blood Flow Metab. 2014 Jul;34(7):1128-37. doi: 10.1038/jcbfm.2014.60. Epub 2014 Apr 9.


Flexible software platform for fast-scan cyclic voltammetry data acquisition and analysis.

Bucher ES, Brooks K, Verber MD, Keithley RB, Owesson-White C, Carroll S, Takmakov P, McKinney CJ, Wightman RM.

Anal Chem. 2013 Nov 5;85(21):10344-53. doi: 10.1021/ac402263x. Epub 2013 Oct 11.


Tissue-nonspecific alkaline phosphatase acts redundantly with PAP and NT5E to generate adenosine in the dorsal spinal cord.

Street SE, Kramer NJ, Walsh PL, Taylor-Blake B, Yadav MC, King IF, Vihko P, Wightman RM, Millán JL, Zylka MJ.

J Neurosci. 2013 Jul 3;33(27):11314-22. doi: 10.1523/JNEUROSCI.0133-13.2013.


Monitoring serotonin signaling on a subsecond time scale.

Dankoski EC, Wightman RM.

Front Integr Neurosci. 2013 Jun 5;7:44. doi: 10.3389/fnint.2013.00044. eCollection 2013.


Advances in studying phasic dopamine signaling in brain reward mechanisms.

Wickham RJ, Solecki W, Rathbun LR, Neugebauer NM, Wightman RM, Addy NA.

Front Biosci (Elite Ed). 2013 Jun 1;5:982-99. Review.


Controlled iontophoresis coupled with fast-scan cyclic voltammetry/electrophysiology in awake, freely moving animals.

Belle AM, Owesson-White C, Herr NR, Carelli RM, Wightman RM.

ACS Chem Neurosci. 2013 May 15;4(5):761-71. doi: 10.1021/cn400031v. Epub 2013 Mar 26.


Noradrenergic synaptic function in the bed nucleus of the stria terminalis varies in animal models of anxiety and addiction.

McElligott ZA, Fox ME, Walsh PL, Urban DJ, Ferrel MS, Roth BL, Wightman RM.

Neuropsychopharmacology. 2013 Aug;38(9):1665-73. doi: 10.1038/npp.2013.63. Epub 2013 Apr 3.


Improved techniques for examining rapid dopamine signaling with iontophoresis.

Herr NR, Wightman RM.

Front Biosci (Elite Ed). 2013 Jan 1;5:249-57. Review.


Opposing catecholamine changes in the bed nucleus of the stria terminalis during intracranial self-stimulation and its extinction.

Park J, Bucher ES, Fontillas K, Owesson-White C, Ariansen JL, Carelli RM, Wightman RM.

Biol Psychiatry. 2013 Jul 1;74(1):69-76. doi: 10.1016/j.biopsych.2012.11.008. Epub 2012 Dec 20.


Pathway-specific dopaminergic deficits in a mouse model of Angelman syndrome.

Riday TT, Dankoski EC, Krouse MC, Fish EW, Walsh PL, Han JE, Hodge CW, Wightman RM, Philpot BD, Malanga CJ.

J Clin Invest. 2012 Dec;122(12):4544-54. doi: 10.1172/JCI61888. Epub 2012 Nov 12.


Monitoring extracellular pH, oxygen, and dopamine during reward delivery in the striatum of primates.

Ariansen JL, Heien ML, Hermans A, Phillips PE, Hernadi I, Bermudez MA, Schultz W, Wightman RM.

Front Behav Neurosci. 2012 Jul 5;6:36. doi: 10.3389/fnbeh.2012.00036. eCollection 2012.


Brain dopamine and serotonin differ in regulation and its consequences.

Hashemi P, Dankoski EC, Lama R, Wood KM, Takmakov P, Wightman RM.

Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11510-5. doi: 10.1073/pnas.1201547109. Epub 2012 Jul 9.


Optimizing the Temporal Resolution of Fast-Scan Cyclic Voltammetry.

Kile BM, Walsh PL, McElligott ZA, Bucher ES, Guillot TS, Salahpour A, Caron MG, Wightman RM.

ACS Chem Neurosci. 2012 Apr 18;3(4):285-292. Epub 2012 Jan 30.


Sources contributing to the average extracellular concentration of dopamine in the nucleus accumbens.

Owesson-White CA, Roitman MF, Sombers LA, Belle AM, Keithley RB, Peele JL, Carelli RM, Wightman RM.

J Neurochem. 2012 Apr;121(2):252-62. doi: 10.1111/j.1471-4159.2012.07677.x. Epub 2012 Mar 13.


Differential dopamine release dynamics in the nucleus accumbens core and shell track distinct aspects of goal-directed behavior for sucrose.

Cacciapaglia F, Saddoris MP, Wightman RM, Carelli RM.

Neuropharmacology. 2012 Apr;62(5-6):2050-6. doi: 10.1016/j.neuropharm.2011.12.027. Epub 2012 Jan 12.


In vivo voltammetry monitoring of electrically evoked extracellular norepinephrine in subregions of the bed nucleus of the stria terminalis.

Herr NR, Park J, McElligott ZA, Belle AM, Carelli RM, Wightman RM.

J Neurophysiol. 2012 Mar;107(6):1731-7. doi: 10.1152/jn.00620.2011. Epub 2011 Dec 21.


Chronically Implanted, Nafion-Coated Ag/AgCl Reference Electrodes for Neurochemical Applications.

Hashemi P, Walsh PL, Guillot TS, Gras-Najjar J, Takmakov P, Crews FT, Wightman RM.

ACS Chem Neurosci. 2011 Nov 16;2(11):658-666.


Catecholamines in the bed nucleus of the stria terminalis reciprocally respond to reward and aversion.

Park J, Wheeler RA, Fontillas K, Keithley RB, Carelli RM, Wightman RM.

Biol Psychiatry. 2012 Feb 15;71(4):327-34. doi: 10.1016/j.biopsych.2011.10.017. Epub 2011 Nov 23.

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