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Targeting the Extracellular Matrix Promotes Healing Following Myocardial Infarction.

Wight TN, Vernon RB.

Circ Res. 2019 Oct 11;125(9):802-804. doi: 10.1161/CIRCRESAHA.119.315902. Epub 2019 Oct 10. No abstract available.


Cardiac Hyaluronan Synthesis Is Critically Involved in the Cardiac Macrophage Response and Promotes Healing After Ischemia Reperfusion Injury.

Petz A, Grandoch M, Gorski DJ, Abrams M, Piroth M, Schneckmann R, Homann S, Müller J, Hartwig S, Lehr S, Yamaguchi Y, Wight TN, Gorressen S, Ding Z, Kötter S, Krüger M, Heinen A, Kelm M, Gödecke A, Flögel U, Fischer JW.

Circ Res. 2019 May 10;124(10):1433-1447. doi: 10.1161/CIRCRESAHA.118.313285.


Increased Hyaluronan and TSG-6 in Association with Neuropathologic Changes of Alzheimer's Disease.

Reed MJ, Damodarasamy M, Pathan JL, Chan CK, Spiekerman C, Wight TN, Banks WA, Day AJ, Vernon RB, Keene CD.

J Alzheimers Dis. 2019;67(1):91-102. doi: 10.3233/JAD-180797.


Fibroblast gene expression following asthmatic bronchial epithelial cell conditioning correlates with epithelial donor lung function and exacerbation history.

Reeves SR, Barrow KA, Kolstad TK, White MP, Rich LM, Wight TN, Debley JS.

Sci Rep. 2018 Oct 25;8(1):15768. doi: 10.1038/s41598-018-34021-6.


Versican is differentially regulated in the adventitial and medial layers of human vein grafts.

Kenagy RD, Kikuchi S, Evanko SP, Ruiter MS, Piola M, Longchamp A, Pesce M, Soncini M, Deglise S, Fiore GB, Haefliger JA, Schmidt TA, Majesky MW, Sobel M, Wight TN.

PLoS One. 2018 Sep 28;13(9):e0204045. doi: 10.1371/journal.pone.0204045. eCollection 2018.


A Role for Extracellular Matrix in Atherosclerotic Plaque Erosion.

Wight TN.

J Am Coll Cardiol. 2018 Sep 25;72(13):1504-1505. doi: 10.1016/j.jacc.2018.07.031. No abstract available.


Hyaluronan levels are increased systemically in human type 2 but not type 1 diabetes independently of glycemic control.

Nagy N, Sunkari VG, Kaber G, Hasbun S, Lam DN, Speake C, Sanda S, McLaughlin TL, Wight TN, Long SR, Bollyky PL.

Matrix Biol. 2019 Jul;80:46-58. doi: 10.1016/j.matbio.2018.09.003. Epub 2018 Sep 6.


Immune Checkpoint Ligand PD-L1 Is Upregulated in Pulmonary Lymphangioleiomyomatosis.

Maisel K, Merrilees MJ, Atochina-Vasserman EN, Lian L, Obraztsova K, Rue R, Vasserman AN, Zuo N, Angel LF, Gow AJ, Kang I, Wight TN, Eruslanov E, Swartz MA, Krymskaya VP.

Am J Respir Cell Mol Biol. 2018 Dec;59(6):723-732. doi: 10.1165/rcmb.2018-0123OC.


Asthmatic bronchial epithelial cells promote the establishment of a Hyaluronan-enriched, leukocyte-adhesive extracellular matrix by lung fibroblasts.

Reeves SR, Kang I, Chan CK, Barrow KA, Kolstad TK, White MP, Ziegler SF, Wight TN, Debley JS.

Respir Res. 2018 Aug 2;19(1):146. doi: 10.1186/s12931-018-0849-1.


Clinical factors that influence the cellular responses of saphenous veins used for arterial bypass.

Sobel M, Kikuchi S, Chen L, Tang GL, Wight TN, Kenagy RD.

J Vasc Surg. 2018 Dec;68(6S):165S-176S.e6. doi: 10.1016/j.jvs.2018.03.436. Epub 2018 Jun 15.


Smooth muscle glucose metabolism promotes monocyte recruitment and atherosclerosis in a mouse model of metabolic syndrome.

Wall VZ, Barnhart S, Kanter JE, Kramer F, Shimizu-Albergine M, Adhikari N, Wight TN, Hall JL, Bornfeldt KE.

JCI Insight. 2018 Jun 7;3(11). pii: 96544. doi: 10.1172/jci.insight.96544. eCollection 2018 Jun 7.


A role for proteoglycans in vascular disease.

Wight TN.

Matrix Biol. 2018 Oct;71-72:396-420. doi: 10.1016/j.matbio.2018.02.019. Epub 2018 Feb 27. Review.


Proteoglycans as Immunomodulators of the Innate Immune Response to Lung Infection.

Kang I, Chang MY, Wight TN, Frevert CW.

J Histochem Cytochem. 2018 Apr;66(4):241-259. doi: 10.1369/0022155417751880. Epub 2018 Jan 12. Review.


The biochemistry and immunohistochemistry of versican.

Evanko SP, Chan CK, Johnson PY, Frevert CW, Wight TN.

Methods Cell Biol. 2018;143:261-279. doi: 10.1016/bs.mcb.2017.08.015. Epub 2017 Nov 26.


Hyaluronan content governs tissue stiffness in pancreatic islet inflammation.

Nagy N, de la Zerda A, Kaber G, Johnson PY, Hu KH, Kratochvil MJ, Yadava K, Zhao W, Cui Y, Navarro G, Annes JP, Wight TN, Heilshorn SC, Bollyky PL, Butte MJ.

J Biol Chem. 2018 Jan 12;293(2):567-578. doi: 10.1074/jbc.RA117.000148. Epub 2017 Nov 28.


Versican is produced by Trif- and type I interferon-dependent signaling in macrophages and contributes to fine control of innate immunity in lungs.

Chang MY, Kang I, Gale M Jr, Manicone AM, Kinsella MG, Braun KR, Wigmosta T, Parks WC, Altemeier WA, Wight TN, Frevert CW.

Am J Physiol Lung Cell Mol Physiol. 2017 Dec 1;313(6):L1069-L1086. doi: 10.1152/ajplung.00353.2017. Epub 2017 Sep 14.


Smooth muscle cells of human veins show an increased response to injury at valve sites.

Kikuchi S, Chen L, Xiong K, Saito Y, Azuma N, Tang G, Sobel M, Wight TN, Kenagy RD.

J Vasc Surg. 2018 May;67(5):1556-1570.e9. doi: 10.1016/j.jvs.2017.03.447. Epub 2017 Jun 21.


Microvasculature of the Mouse Cerebral Cortex Exhibits Increased Accumulation and Synthesis of Hyaluronan With Aging.

Reed MJ, Vernon RB, Damodarasamy M, Chan CK, Wight TN, Bentov I, Banks WA.

J Gerontol A Biol Sci Med Sci. 2017 Jun 1;72(6):740-746. doi: 10.1093/gerona/glw213.


A pilot randomised clinical trial of mepolizumab in COPD with eosinophilic bronchitis.

Dasgupta A, Kjarsgaard M, Capaldi D, Radford K, Aleman F, Boylan C, Altman LC, Wight TN, Parraga G, O'Byrne PM, Nair P.

Eur Respir J. 2017 Mar 15;49(3). pii: 1602486. doi: 10.1183/13993003.02486-2016. Print 2017 Mar. No abstract available.


Interplay of extracellular matrix and leukocytes in lung inflammation.

Wight TN, Frevert CW, Debley JS, Reeves SR, Parks WC, Ziegler SF.

Cell Immunol. 2017 Feb;312:1-14. doi: 10.1016/j.cellimm.2016.12.003. Epub 2016 Dec 23. Review.


Crosstalk Between T Lymphocytes and Lung Fibroblasts: Generation of a Hyaluronan-Enriched Extracellular Matrix Adhesive for Monocytes.

Gaucherand L, Falk BA, Evanko SP, Workman G, Chan CK, Wight TN.

J Cell Biochem. 2017 Aug;118(8):2118-2130. doi: 10.1002/jcb.25842. Epub 2017 Apr 18.


Provisional matrix: A role for versican and hyaluronan.

Wight TN.

Matrix Biol. 2017 Jul;60-61:38-56. doi: 10.1016/j.matbio.2016.12.001. Epub 2016 Dec 6. Review.


Interleukin-10-mediated regenerative postnatal tissue repair is dependent on regulation of hyaluronan metabolism via fibroblast-specific STAT3 signaling.

Balaji S, Wang X, King A, Le LD, Bhattacharya SS, Moles CM, Butte MJ, de Jesus Perez VA, Liechty KW, Wight TN, Crombleholme TM, Bollyky PL, Keswani SG.

FASEB J. 2017 Mar;31(3):868-881. doi: 10.1096/fj.201600856R. Epub 2016 Nov 30.


Versican Deficiency Significantly Reduces Lung Inflammatory Response Induced by Polyinosine-Polycytidylic Acid Stimulation.

Kang I, Harten IA, Chang MY, Braun KR, Sheih A, Nivison MP, Johnson PY, Workman G, Kaber G, Evanko SP, Chan CK, Merrilees MJ, Ziegler SF, Kinsella MG, Frevert CW, Wight TN.

J Biol Chem. 2017 Jan 6;292(1):51-63. doi: 10.1074/jbc.M116.753186. Epub 2016 Nov 28.


Versican accumulates in vascular lesions in pulmonary arterial hypertension.

Chang YT, Chan CK, Eriksson I, Johnson PY, Cao X, Westöö C, Norvik C, Andersson-Sjöland A, Westergren-Thorsson G, Johansson S, Hedin U, Kjellén L, Wight TN, Tran-Lundmark K.

Pulm Circ. 2016 Sep;6(3):347-59. doi: 10.1086/686994.


Enhanced T cell responses to IL-6 in type 1 diabetes are associated with early clinical disease and increased IL-6 receptor expression.

Hundhausen C, Roth A, Whalen E, Chen J, Schneider A, Long SA, Wei S, Rawlings R, Kinsman M, Evanko SP, Wight TN, Greenbaum CJ, Cerosaletti K, Buckner JH.

Sci Transl Med. 2016 Sep 14;8(356):356ra119. doi: 10.1126/scitranslmed.aad9943.


The pharmacokinetics and dosing of oral 4-methylumbelliferone for inhibition of hyaluronan synthesis in mice.

Kuipers HF, Nagy N, Ruppert SM, Sunkari VG, Marshall PL, Gebe JA, Ishak HD, Keswani SG, Bollyky J, Frymoyer AR, Wight TN, Steinman L, Bollyky PL.

Clin Exp Immunol. 2016 Sep;185(3):372-81. doi: 10.1111/cei.12815.


Subepithelial Accumulation of Versican in a Cockroach Antigen-Induced Murine Model of Allergic Asthma.

Reeves SR, Kaber G, Sheih A, Cheng G, Aronica MA, Merrilees MJ, Debley JS, Frevert CW, Ziegler SF, Wight TN.

J Histochem Cytochem. 2016 Jun;64(6):364-80. doi: 10.1369/0022155416642989. Epub 2016 Apr 28.


G1 Domain of Versican Regulates Hyaluronan Organization and the Phenotype of Cultured Human Dermal Fibroblasts.

Merrilees MJ, Zuo N, Evanko SP, Day AJ, Wight TN.

J Histochem Cytochem. 2016 Jun;64(6):353-63. doi: 10.1369/0022155416643913. Epub 2016 Apr 28.


Serum amyloid A impairs the antiinflammatory properties of HDL.

Han CY, Tang C, Guevara ME, Wei H, Wietecha T, Shao B, Subramanian S, Omer M, Wang S, O'Brien KD, Marcovina SM, Wight TN, Vaisar T, de Beer MC, de Beer FC, Osborne WR, Elkon KB, Chait A.

J Clin Invest. 2016 Feb;126(2):796. doi: 10.1172/JCI86401. Epub 2016 Feb 1. No abstract available.


Hyaluronan synthesis is necessary for autoreactive T-cell trafficking, activation, and Th1 polarization.

Kuipers HF, Rieck M, Gurevich I, Nagy N, Butte MJ, Negrin RS, Wight TN, Steinman L, Bollyky PL.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1339-44. doi: 10.1073/pnas.1525086113. Epub 2016 Jan 19.


Inhibition of versican expression by siRNA facilitates tropoelastin synthesis and elastic fiber formation by human SK-LMS-1 leiomyosarcoma smooth muscle cells in vitro and in vivo.

Keire PA, Bressler SL, Mulvihill ER, Starcher BC, Kang I, Wight TN.

Matrix Biol. 2016 Mar;50:67-81. doi: 10.1016/j.matbio.2015.12.010. Epub 2015 Dec 23.


Serum amyloid A impairs the antiinflammatory properties of HDL.

Han CY, Tang C, Guevara ME, Wei H, Wietecha T, Shao B, Subramanian S, Omer M, Wang S, O'Brien KD, Marcovina SM, Wight TN, Vaisar T, de Beer MC, de Beer FC, Osborne WR, Elkon KB, Chait A.

J Clin Invest. 2016 Jan;126(1):266-81. doi: 10.1172/JCI83475. Epub 2015 Dec 7. Erratum in: J Clin Invest. 2016 Feb;126(2):796.


Postnatal Deletion of the Type II Transforming Growth Factor-β Receptor in Smooth Muscle Cells Causes Severe Aortopathy in Mice.

Hu JH, Wei H, Jaffe M, Airhart N, Du L, Angelov SN, Yan J, Allen JK, Kang I, Wight TN, Fox K, Smith A, Enstrom R, Dichek DA.

Arterioscler Thromb Vasc Biol. 2015 Dec;35(12):2647-56. doi: 10.1161/ATVBAHA.115.306573. Epub 2015 Oct 22.


Inhibition of hyaluronan synthesis restores immune tolerance during autoimmune insulitis.

Nagy N, Kaber G, Johnson PY, Gebe JA, Preisinger A, Falk BA, Sunkari VG, Gooden MD, Vernon RB, Bogdani M, Kuipers HF, Day AJ, Campbell DJ, Wight TN, Bollyky PL.

J Clin Invest. 2015 Oct 1;125(10):3928-40. doi: 10.1172/JCI79271. Epub 2015 Sep 14.


Hyaluronan: A Mediator of Islet Dysfunction and Destruction in Diabetes?

Hull RL, Bogdani M, Nagy N, Johnson PY, Wight TN.

J Histochem Cytochem. 2015 Aug;63(8):592-603. doi: 10.1369/0022155415576542. Review.


Expression of V3 Versican by Rat Arterial Smooth Muscle Cells Promotes Differentiated and Anti-inflammatory Phenotypes.

Kang I, Barth JL, Sproul EP, Yoon DW, Workman GA, Braun KR, Argraves WS, Wight TN.

J Biol Chem. 2015 Aug 28;290(35):21629-41. doi: 10.1074/jbc.M115.657486. Epub 2015 Jul 7.


Natural progression of atherosclerosis from pathologic intimal thickening to late fibroatheroma in human coronary arteries: A pathology study.

Otsuka F, Kramer MC, Woudstra P, Yahagi K, Ladich E, Finn AV, de Winter RJ, Kolodgie FD, Wight TN, Davis HR, Joner M, Virmani R.

Atherosclerosis. 2015 Aug;241(2):772-82. doi: 10.1016/j.atherosclerosis.2015.05.011. Epub 2015 May 19.


Surgical marking pen dye inhibits saphenous vein cell proliferation and migration in saphenous vein graft tissue.

Kikuchi S, Kenagy RD, Gao L, Wight TN, Azuma N, Sobel M, Clowes AW.

J Vasc Surg. 2016 Apr;63(4):1044-50. doi: 10.1016/j.jvs.2014.10.017. Epub 2015 Apr 30.


4-methylumbelliferone treatment and hyaluronan inhibition as a therapeutic strategy in inflammation, autoimmunity, and cancer.

Nagy N, Kuipers HF, Frymoyer AR, Ishak HD, Bollyky JB, Wight TN, Bollyky PL.

Front Immunol. 2015 Mar 23;6:123. doi: 10.3389/fimmu.2015.00123. eCollection 2015. Review.


Pivotal role for decorin in angiogenesis.

Järveläinen H, Sainio A, Wight TN.

Matrix Biol. 2015 Apr;43:15-26. doi: 10.1016/j.matbio.2015.01.023. Epub 2015 Feb 7. Review.


Hyaluronan Controls the Deposition of Fibronectin and Collagen and Modulates TGF-β1 Induction of Lung Myofibroblasts.

Evanko SP, Potter-Perigo S, Petty LJ, Workman GA, Wight TN.

Matrix Biol. 2015 Mar;42:74-92. doi: 10.1016/j.matbio.2014.12.001. Epub 2014 Dec 27.


Extracellular matrix components in the pathogenesis of type 1 diabetes.

Bogdani M, Korpos E, Simeonovic CJ, Parish CR, Sorokin L, Wight TN.

Curr Diab Rep. 2014 Dec;14(12):552. doi: 10.1007/s11892-014-0552-7. Review.


The detection of glycosaminoglycans in pancreatic islets and lymphoid tissues.

Bogdani M, Simeonovic C, Nagy N, Johnson PY, Chan CK, Wight TN.

Methods Mol Biol. 2015;1229:413-30. doi: 10.1007/978-1-4939-1714-3_32.


A role for versican in the development of leiomyosarcoma.

Keire PA, Bressler SL, Lemire JM, Edris B, Rubin BP, Rahmani M, McManus BM, van de Rijn M, Wight TN.

J Biol Chem. 2014 Dec 5;289(49):34089-103. doi: 10.1074/jbc.M114.607168. Epub 2014 Oct 15.


Hyaluronan in aged collagen matrix increases prostate epithelial cell proliferation.

Damodarasamy M, Vernon RB, Chan CK, Plymate SR, Wight TN, Reed MJ.

In Vitro Cell Dev Biol Anim. 2015 Jan;51(1):50-8. doi: 10.1007/s11626-014-9800-z. Epub 2014 Aug 15.


Use of versican variant V3 and versican antisense expression to engineer cultured human skin containing increased content of insoluble elastin.

Merrilees MJ, Falk BA, Zuo N, Dickinson ME, May BC, Wight TN.

J Tissue Eng Regen Med. 2017 Jan;11(1):295-305. doi: 10.1002/term.1913. Epub 2014 Jun 19.


Asthmatic airway epithelial cells differentially regulate fibroblast expression of extracellular matrix components.

Reeves SR, Kolstad T, Lien TY, Elliott M, Ziegler SF, Wight TN, Debley JS.

J Allergy Clin Immunol. 2014 Sep;134(3):663-670.e1. doi: 10.1016/j.jaci.2014.04.007. Epub 2014 May 27.


Reprint of: A rapid increase in macrophage-derived versican and hyaluronan in infectious lung disease.

Chang MY, Tanino Y, Vidova V, Kinsella MG, Chan CK, Johnson PY, Wight TN, Frevert CW.

Matrix Biol. 2014 Apr;35:162-73. doi: 10.1016/j.matbio.2014.04.003. Epub 2014 Apr 12.

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