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Items: 30

1.

Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides.

Clare RH, Bardelle C, Harper P, Hong WD, Börjesson U, Johnston KL, Collier M, Myhill L, Cassidy A, Plant D, Plant H, Clark R, Cook DAN, Steven A, Archer J, McGillan P, Charoensutthivarakul S, Bibby J, Sharma R, Nixon GL, Slatko BE, Cantin L, Wu B, Turner J, Ford L, Rich K, Wigglesworth M, Berry NG, O'Neill PM, Taylor MJ, Ward SA.

Nat Commun. 2019 Jan 2;10(1):11. doi: 10.1038/s41467-018-07826-2.

2.

Large Scale Synthetic Site Saturation GPCR Libraries Reveal Novel Mutations That Alter Glucose Signaling.

Öling D, Lawenius L, Shaw W, Clark S, Kettleborough R, Ellis T, Larsson N, Wigglesworth M.

ACS Synth Biol. 2018 Sep 21;7(9):2317-2321. doi: 10.1021/acssynbio.8b00118. Epub 2018 Sep 12.

PMID:
30114904
3.

Application of High-Throughput Flow Cytometry in Early Drug Discovery: An AstraZeneca Perspective.

Ding M, Clark R, Bardelle C, Backmark A, Norris T, Williams W, Wigglesworth M, Howes R.

SLAS Discov. 2018 Aug;23(7):719-731. doi: 10.1177/2472555218775074. Epub 2018 May 22.

PMID:
29787326
4.

Techniques to Enable 1536-Well Phenotypic Screening.

Knight S, Plant H, McWilliams L, Wigglesworth M.

Methods Mol Biol. 2018;1787:263-278. doi: 10.1007/978-1-4939-7847-2_20.

PMID:
29736725
5.

Enabling 1536-Well High-Throughput Cell-Based Screening through the Application of Novel Centrifugal Plate Washing.

Knight S, Plant H, McWilliams L, Murray D, Dixon-Steele R, Varghese A, Harper P, Ramne A, McArdle P, Engberg S, Bennett N, Blackett C, Wigglesworth M.

SLAS Discov. 2017 Jul;22(6):732-742. doi: 10.1177/2472555216683650. Epub 2016 Dec 27.

PMID:
28027450
6.

High affinity binding of the peptide agonist TIP-39 to the parathyroid hormone 2 (PTH2) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5.

Weaver RE, Mobarec JC, Wigglesworth MJ, Reynolds CA, Donnelly D.

Biochem Pharmacol. 2017 Mar 1;127:71-81. doi: 10.1016/j.bcp.2016.12.013. Epub 2016 Dec 22.

7.

Discovery and Optimization of Allosteric Inhibitors of Mutant Isocitrate Dehydrogenase 1 (R132H IDH1) Displaying Activity in Human Acute Myeloid Leukemia Cells.

Jones S, Ahmet J, Ayton K, Ball M, Cockerill M, Fairweather E, Hamilton N, Harper P, Hitchin J, Jordan A, Levy C, Lopez R, McKenzie E, Packer M, Plant D, Simpson I, Simpson P, Sinclair I, Somervaille TC, Small H, Spencer GJ, Thomson G, Tonge M, Waddell I, Walsh J, Waszkowycz B, Wigglesworth M, Wiseman DH, Ogilvie D.

J Med Chem. 2016 Dec 22;59(24):11120-11137. Epub 2016 Dec 5.

PMID:
28002956
8.

Understanding Cytotoxicity and Cytostaticity in a High-Throughput Screening Collection.

Mervin LH, Cao Q, Barrett IP, Firth MA, Murray D, McWilliams L, Haddrick M, Wigglesworth M, Engkvist O, Bender A.

ACS Chem Biol. 2016 Nov 18;11(11):3007-3023. Epub 2016 Sep 13.

9.

High-Throughput Cell Toxicity Assays.

Murray D, McWilliams L, Wigglesworth M.

Methods Mol Biol. 2016;1439:245-62. doi: 10.1007/978-1-4939-3673-1_16.

PMID:
27317000
10.

Artefacts at the liquid interface and their impact in miniaturized biochemical assay.

Litten B, Blackett C, Wigglesworth M, Goddard N, Fielden P.

Biomicrofluidics. 2015 Jul 21;9(5):052607. doi: 10.1063/1.4927324. eCollection 2015 Sep.

11.

Increasing the delivery of next generation therapeutics from high throughput screening libraries.

Wigglesworth MJ, Murray DC, Blackett CJ, Kossenjans M, Nissink JW.

Curr Opin Chem Biol. 2015 Jun;26:104-10. doi: 10.1016/j.cbpa.2015.04.006. Epub 2015 Apr 20. Review.

PMID:
25909818
12.

Validation of miniaturized one-step reverse transcription qPCR assays for high-throughput screening and comparison to a reporter gene methodology.

Bardelle C, McWilliams L, Mounfield S, Wigglesworth M, Rich K.

Assay Drug Dev Technol. 2015 Mar;13(2):94-101. doi: 10.1089/adt.2014.630.

PMID:
25785772
13.

A salt bridge between Arg-20 on parathyroid hormone (PTH) and Asp-137 on the PTH1 receptor is essential for full affinity.

Weaver RE, Wigglesworth MJ, Donnelly D.

Peptides. 2014 Nov;61:83-7. doi: 10.1016/j.peptides.2014.09.004. Epub 2014 Sep 13.

PMID:
25218037
14.

A low complexity rapid molecular method for detection of Clostridium difficile in stool.

McElgunn CJ, Pereira CR, Parham NJ, Smythe JE, Wigglesworth MJ, Smielewska A, Parmar SA, Gandelman OA, Brown NM, Tisi LC, Curran MD.

PLoS One. 2014 Jan 8;9(1):e83808. doi: 10.1371/journal.pone.0083808. eCollection 2014.

15.

Screening β-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors.

Southern C, Cook JM, Neetoo-Isseljee Z, Taylor DL, Kettleborough CA, Merritt A, Bassoni DL, Raab WJ, Quinn E, Wehrman TS, Davenport AP, Brown AJ, Green A, Wigglesworth MJ, Rees S.

J Biomol Screen. 2013 Jun;18(5):599-609. doi: 10.1177/1087057113475480. Epub 2013 Feb 8.

PMID:
23396314
16.

Novel spirotetracyclic zwitterionic dual H(1)/5-HT(2A) receptor antagonists for the treatment of sleep disorders.

Gianotti M, Botta M, Brough S, Carletti R, Castiglioni E, Corti C, Dal-Cin M, Delle Fratte S, Korajac D, Lovric M, Merlo G, Mesic M, Pavone F, Piccoli L, Rast S, Roscic M, Sava A, Smehil M, Stasi L, Togninelli A, Wigglesworth MJ.

J Med Chem. 2010 Nov 11;53(21):7778-95. doi: 10.1021/jm100856p.

PMID:
20942472
17.

Towards the discovery of new hypnotic agents: synthesis and preliminary pharmacological evaluation of a novel class of dibenzo[a,d]cycloheptene derivatives.

Castiglioni E, Di Fabio R, Togninelli A, Brough S, Brown F, Dal Cin M, Gianotti M, Marchioro C, Merlo G, Spinosa R, Wigglesworth MJ, Botta M.

ChemMedChem. 2010 Nov 8;5(11):1843-6. doi: 10.1002/cmdc.201000280. No abstract available.

PMID:
20922744
18.

Novel imidazobenzazepine derivatives as dual H1/5-HT2A antagonists for the treatment of sleep disorders.

Gianotti M, Corti C, Delle Fratte S, Di Fabio R, Leslie CP, Pavone F, Piccoli L, Stasi L, Wigglesworth MJ.

Bioorg Med Chem Lett. 2010 Sep 1;20(17):5069-73. doi: 10.1016/j.bmcl.2010.07.029. Epub 2010 Jul 11.

PMID:
20674357
19.

Non-peptidic antagonists of the CGRP receptor, BIBN4096BS and MK-0974, interact with the calcitonin receptor-like receptor via methionine-42 and RAMP1 via tryptophan-74.

Miller PS, Barwell J, Poyner DR, Wigglesworth MJ, Garland SL, Donnelly D.

Biochem Biophys Res Commun. 2010 Jan 1;391(1):437-42. doi: 10.1016/j.bbrc.2009.11.076. Epub 2009 Nov 13.

20.

Innovation leading the way: application of lean manufacturing to sample management.

Allen M, Wigglesworth MJ.

J Biomol Screen. 2009 Jun;14(5):515-22. doi: 10.1177/1087057109336587. Epub 2009 May 29.

PMID:
19483142
21.

The discovery of a selective, small molecule agonist for the MAS-related gene X1 receptor.

Wroblowski B, Wigglesworth MJ, Szekeres PG, Smith GD, Rahman SS, Nicholson NH, Muir AI, Hall A, Heer JP, Garland SL, Coates WJ.

J Med Chem. 2009 Feb 12;52(3):818-25. doi: 10.1021/jm800962k.

PMID:
19146417
22.
23.

Use of cryopreserved cells for enabling greater flexibility in compound profiling.

Wigglesworth MJ, Lawless KJ, Standing DJ, Mackenzie EK, Kitchen VR, McKay F, Ward E, Brough SJ, Stylianou M, Jewitt FR, McLaren-Douglas AM, Jowet MI, Tamayama N, Finnigan D, Ding J, Wise A.

J Biomol Screen. 2008 Jun;13(5):354-62. doi: 10.1177/1087057108317768. Epub 2008 May 8.

PMID:
18467669
24.

Identification of a novel asthma susceptibility gene on chromosome 1qter and its functional evaluation.

White JH, Chiano M, Wigglesworth M, Geske R, Riley J, White N, Hall S, Zhu G, Maurio F, Savage T, Anderson W, Cordy J, Ducceschi M; GAIN investigators, Vestbo J, Pillai SG.

Hum Mol Genet. 2008 Jul 1;17(13):1890-903. doi: 10.1093/hmg/ddn087. Epub 2008 Mar 15.

PMID:
18344558
25.

Orphan seven transmembrane receptor screening.

Wigglesworth MJ, Wolfe LA, Wise A.

Ernst Schering Found Symp Proc. 2006;(2):105-43. Review.

PMID:
17703580
26.

Considering the case for an antidepressant drug trial involving temporary deception: a qualitative enquiry of potential participants.

Dowrick CF, Hughes JG, Hiscock JJ, Wigglesworth M, Walley TJ.

BMC Health Serv Res. 2007 Apr 30;7:64.

27.

The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.

Brown AJ, Goldsworthy SM, Barnes AA, Eilert MM, Tcheang L, Daniels D, Muir AI, Wigglesworth MJ, Kinghorn I, Fraser NJ, Pike NB, Strum JC, Steplewski KM, Murdock PR, Holder JC, Marshall FH, Szekeres PG, Wilson S, Ignar DM, Foord SM, Wise A, Dowell SJ.

J Biol Chem. 2003 Mar 28;278(13):11312-9. Epub 2002 Dec 19.

28.

Trichinellosis in Papua New Guinea.

Owen IL, Sims LD, Wigglesworth MC, Puana I.

Aust Vet J. 2000 Oct;78(10):698-701.

PMID:
11098386
29.

On the role of 5-HT1B/1D receptors in modulating transmission in a spinal reflex pathway in the decerebrated rabbit.

Ogilvie J, Wigglesworth M, Appleby L, Kingston TO, Clarke RW.

Br J Pharmacol. 1999 Oct;128(3):781-7.

30.

Serological survey of human cysticercosis in Irianese refugee camps in Papua New Guinea.

Fritzsche M, Gottstein B, Wigglesworth MC, Eckert J.

Acta Trop. 1990 Feb;47(2):69-77.

PMID:
1969703

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