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Items: 8

1.

Identification of compounds that rescue otic and myelination defects in the zebrafish adgrg6 (gpr126) mutant.

Diamantopoulou E, Baxendale S, de la Vega de León A, Asad A, Holdsworth CJ, Abbas L, Gillet VJ, Wiggin GR, Whitfield TT.

Elife. 2019 Jun 10;8. pii: e44889. doi: 10.7554/eLife.44889.

2.

Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile).

Christopher JA, Aves SJ, Bennett KA, Doré AS, Errey JC, Jazayeri A, Marshall FH, Okrasa K, Serrano-Vega MJ, Tehan BG, Wiggin GR, Congreve M.

J Med Chem. 2015 Aug 27;58(16):6653-64. doi: 10.1021/acs.jmedchem.5b00892. Epub 2015 Aug 12.

PMID:
26225459
3.

Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain.

Doré AS, Okrasa K, Patel JC, Serrano-Vega M, Bennett K, Cooke RM, Errey JC, Jazayeri A, Khan S, Tehan B, Weir M, Wiggin GR, Marshall FH.

Nature. 2014 Jul 31;511(7511):557-62. doi: 10.1038/nature13396. Epub 2014 Jul 6.

PMID:
25042998
4.

MSK regulate TCR-induced CREB phosphorylation but not immediate early gene transcription.

Kaiser M, Wiggin GR, Lightfoot K, Arthur JS, Macdonald A.

Eur J Immunol. 2007 Sep;37(9):2583-95.

5.

Polarity proteins in axon specification and synaptogenesis.

Wiggin GR, Fawcett JP, Pawson T.

Dev Cell. 2005 Jun;8(6):803-16. Review.

6.

MSKs are required for the transcription of the nuclear orphan receptors Nur77, Nurr1 and Nor1 downstream of MAPK signalling.

Darragh J, Soloaga A, Beardmore VA, Wingate AD, Wiggin GR, Peggie M, Arthur JS.

Biochem J. 2005 Sep 15;390(Pt 3):749-59.

7.

MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14.

Soloaga A, Thomson S, Wiggin GR, Rampersaud N, Dyson MH, Hazzalin CA, Mahadevan LC, Arthur JS.

EMBO J. 2003 Jun 2;22(11):2788-97.

8.

MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts.

Wiggin GR, Soloaga A, Foster JM, Murray-Tait V, Cohen P, Arthur JS.

Mol Cell Biol. 2002 Apr;22(8):2871-81.

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