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Items: 25


Ataxin-3 Links NOD2 and TLR2 Mediated Innate Immune Sensing and Metabolism in Myeloid Cells.

Chapman TP, Corridoni D, Shiraishi S, Pandey S, Aulicino A, Wigfield S, do Carmo Costa M, Thézénas ML, Paulson H, Fischer R, Kessler BM, Simmons A.

Front Immunol. 2019 Jul 19;10:1495. doi: 10.3389/fimmu.2019.01495. eCollection 2019.


Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer.

Morotti M, Bridges E, Valli A, Choudhry H, Sheldon H, Wigfield S, Gray N, Zois CE, Grimm F, Jones D, Teoh EJ, Cheng WC, Lord S, Anastasiou D, Haider S, McIntyre A, Goberdhan DCI, Buffa F, Harris AL.

Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12452-12461. doi: 10.1073/pnas.1818521116. Epub 2019 May 31.


Integrated Pharmacodynamic Analysis Identifies Two Metabolic Adaption Pathways to Metformin in Breast Cancer.

Lord SR, Cheng WC, Liu D, Gaude E, Haider S, Metcalf T, Patel N, Teoh EJ, Gleeson F, Bradley K, Wigfield S, Zois C, McGowan DR, Ah-See ML, Thompson AM, Sharma A, Bidaut L, Pollak M, Roy PG, Karpe F, James T, English R, Adams RF, Campo L, Ayers L, Snell C, Roxanis I, Frezza C, Fenwick JD, Buffa FM, Harris AL.

Cell Metab. 2018 Nov 6;28(5):679-688.e4. doi: 10.1016/j.cmet.2018.08.021. Epub 2018 Sep 20.


Stem cell modeling of mitochondrial parkinsonism reveals key functions of OPA1.

Jonikas M, Madill M, Mathy A, Zekoll T, Zois CE, Wigfield S, Kurzawa-Akanbi M, Browne C, Sims D, Chinnery PF, Cowley SA, Tofaris GK.

Ann Neurol. 2018 May;83(5):915-925. doi: 10.1002/ana.25221. Epub 2018 Apr 25.


Is still there a role for IL-2 for solid tumors other than melanoma or renal cancer?

Roviello G, Zanotti L, Correale P, Gobbi A, Wigfield S, Guglielmi A, Pacifico C, Generali D.

Immunotherapy. 2017 Jan;9(1):25-32. doi: 10.2217/imt-2016-0107. Review.


Genomic alterations underlie a pan-cancer metabolic shift associated with tumour hypoxia.

Haider S, McIntyre A, van Stiphout RG, Winchester LM, Wigfield S, Harris AL, Buffa FM.

Genome Biol. 2016 Jun 29;17(1):140. doi: 10.1186/s13059-016-0999-8.


The BET inhibitor JQ1 selectively impairs tumour response to hypoxia and downregulates CA9 and angiogenesis in triple negative breast cancer.

da Motta LL, Ledaki I, Purshouse K, Haider S, De Bastiani MA, Baban D, Morotti M, Steers G, Wigfield S, Bridges E, Li JL, Knapp S, Ebner D, Klamt F, Harris AL, McIntyre A.

Oncogene. 2017 Jan 5;36(1):122-132. doi: 10.1038/onc.2016.184. Epub 2016 Jun 13.


Disrupting Hypoxia-Induced Bicarbonate Transport Acidifies Tumor Cells and Suppresses Tumor Growth.

McIntyre A, Hulikova A, Ledaki I, Snell C, Singleton D, Steers G, Seden P, Jones D, Bridges E, Wigfield S, Li JL, Russell A, Swietach P, Harris AL.

Cancer Res. 2016 Jul 1;76(13):3744-55. doi: 10.1158/0008-5472.CAN-15-1862. Epub 2016 May 17.


The Role of Oxygen in Avascular Tumor Growth.

Grimes DR, Kannan P, McIntyre A, Kavanagh A, Siddiky A, Wigfield S, Harris A, Partridge M.

PLoS One. 2016 Apr 18;11(4):e0153692. doi: 10.1371/journal.pone.0153692. eCollection 2016.


Carbonic anhydrase IX induction defines a heterogeneous cancer cell response to hypoxia and mediates stem cell-like properties and sensitivity to HDAC inhibition.

Ledaki I, McIntyre A, Wigfield S, Buffa F, McGowan S, Baban D, Li JL, Harris AL.

Oncotarget. 2015 Aug 14;6(23):19413-27.


Identification of a hypoxia-regulated miRNA signature in bladder cancer and a role for miR-145 in hypoxia-dependent apoptosis.

Blick C, Ramachandran A, McCormick R, Wigfield S, Cranston D, Catto J, Harris AL.

Br J Cancer. 2015 Aug 11;113(4):634-44. doi: 10.1038/bjc.2015.203. Epub 2015 Jul 21.


Fatty acid uptake and lipid storage induced by HIF-1α contribute to cell growth and survival after hypoxia-reoxygenation.

Bensaad K, Favaro E, Lewis CA, Peck B, Lord S, Collins JM, Pinnick KE, Wigfield S, Buffa FM, Li JL, Zhang Q, Wakelam MJO, Karpe F, Schulze A, Harris AL.

Cell Rep. 2014 Oct 9;9(1):349-365. doi: 10.1016/j.celrep.2014.08.056. Epub 2014 Sep 25.


Hypoxia regulates FGFR3 expression via HIF-1α and miR-100 and contributes to cell survival in non-muscle invasive bladder cancer.

Blick C, Ramachandran A, Wigfield S, McCormick R, Jubb A, Buffa FM, Turley H, Knowles MA, Cranston D, Catto J, Harris AL.

Br J Cancer. 2013 Jul 9;109(1):50-9. doi: 10.1038/bjc.2013.240. Epub 2013 Jun 18.


Dichloroacetate reverses the hypoxic adaptation to bevacizumab and enhances its antitumor effects in mouse xenografts.

Kumar K, Wigfield S, Gee HE, Devlin CM, Singleton D, Li JL, Buffa F, Huffman M, Sinn AL, Silver J, Turley H, Leek R, Harris AL, Ivan M.

J Mol Med (Berl). 2013 Jun;91(6):749-58. doi: 10.1007/s00109-013-0996-2. Epub 2013 Jan 30.


Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances anti-VEGF therapy.

McIntyre A, Patiar S, Wigfield S, Li JL, Ledaki I, Turley H, Leek R, Snell C, Gatter K, Sly WS, Vaughan-Jones RD, Swietach P, Harris AL.

Clin Cancer Res. 2012 Jun 1;18(11):3100-11. doi: 10.1158/1078-0432.CCR-11-1877. Epub 2012 Apr 12.


Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation.

Dubois L, Peeters S, Lieuwes NG, Geusens N, Thiry A, Wigfield S, Carta F, McIntyre A, Scozzafava A, Dogné JM, Supuran CT, Harris AL, Masereel B, Lambin P.

Radiother Oncol. 2011 Jun;99(3):424-31. doi: 10.1016/j.radonc.2011.05.045. Epub 2011 Jun 14.


Synchronised phosphorylation of BNIP3, Bcl-2 and Bcl-xL in response to microtubule-active drugs is JNK-independent and requires a mitotic kinase.

Mellor HR, Rouschop KM, Wigfield SM, Wouters BG, Harris AL.

Biochem Pharmacol. 2010 Jun 1;79(11):1562-72. doi: 10.1016/j.bcp.2010.01.019. Epub 2010 Jan 25.


PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer.

Wigfield SM, Winter SC, Giatromanolaki A, Taylor J, Koukourakis ML, Harris AL.

Br J Cancer. 2008 Jun 17;98(12):1975-84. doi: 10.1038/sj.bjc.6604356. Epub 2008 Jun 10.


Tumor-associated carbonic anhydrase 9 spatially coordinates intracellular pH in three-dimensional multicellular growths.

Swietach P, Wigfield S, Cobden P, Supuran CT, Harris AL, Vaughan-Jones RD.

J Biol Chem. 2008 Jul 18;283(29):20473-83. doi: 10.1074/jbc.M801330200. Epub 2008 May 15.


Cancer-associated, hypoxia-inducible carbonic anhydrase IX facilitates CO2 diffusion.

Swietach P, Wigfield S, Supuran CT, Harris AL, Vaughan-Jones RD.

BJU Int. 2008 Jun;101 Suppl 4:22-4. doi: 10.1111/j.1464-410X.2008.07644.x. No abstract available.


Role of carbonic anhydrase IX expression in prediction of the efficacy and outcome of primary epirubicin/tamoxifen therapy for breast cancer.

Generali D, Fox SB, Berruti A, Brizzi MP, Campo L, Bonardi S, Wigfield SM, Bruzzi P, Bersiga A, Allevi G, Milani M, Aguggini S, Dogliotti L, Bottini A, Harris AL.

Endocr Relat Cancer. 2006 Sep;13(3):921-30.


Hypoxia-inducible factor-1alpha expression predicts a poor response to primary chemoendocrine therapy and disease-free survival in primary human breast cancer.

Generali D, Berruti A, Brizzi MP, Campo L, Bonardi S, Wigfield S, Bersiga A, Allevi G, Milani M, Aguggini S, Gandolfi V, Dogliotti L, Bottini A, Harris AL, Fox SB.

Clin Cancer Res. 2006 Aug 1;12(15):4562-8.


The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins.

Harrington LS, Findlay GM, Gray A, Tolkacheva T, Wigfield S, Rebholz H, Barnett J, Leslie NR, Cheng S, Shepherd PR, Gout I, Downes CP, Lamb RF.

J Cell Biol. 2004 Jul 19;166(2):213-23. Epub 2004 Jul 12.


Identification of an immunodominant drug efflux pump in Burkholderia cepacia.

Wigfield SM, Rigg GP, Kavari M, Webb AK, Matthews RC, Burnie JP.

J Antimicrob Chemother. 2002 Apr;49(4):619-24.


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