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Items: 31

1.

Myogenic vasoconstriction requires G12/G13 and LARG to maintain local and systemic vascular resistance.

Chennupati R, Wirth A, Favre J, Li R, Bonnavion R, Jin YJ, Wietelmann A, Schweda F, Wettschureck N, Henrion D, Offermanns S.

Elife. 2019 Sep 24;8. pii: e49374. doi: 10.7554/eLife.49374.

2.

Hyperoxia but not AOX expression mitigates pathological cardiac remodeling in a mouse model of inflammatory cardiomyopathy.

Dhandapani PK, Begines-Moreno IM, Brea-Calvo G, Gärtner U, Graeber TG, Javier Sanchez G, Morty RE, Schönig K, Hoeve JT, Wietelmann A, Braun T, Jacobs HT, Szibor M.

Sci Rep. 2019 Sep 4;9(1):12741. doi: 10.1038/s41598-019-49231-9.

3.

A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension.

Dabral S, Muecke C, Valasarajan C, Schmoranzer M, Wietelmann A, Semenza GL, Meister M, Muley T, Seeger-Nukpezah T, Samakovlis C, Weissmann N, Grimminger F, Seeger W, Savai R, Pullamsetti SS.

Nat Commun. 2019 May 13;10(1):2130. doi: 10.1038/s41467-019-10044-z.

4.

Response to: Comment on "Effect of Riociguat and Sildenafil on Right Heart Remodeling and Function in Pressure Overload Induced Model of Pulmonary Arterial Banding".

Rai N, Veeroju S, Schymura Y, Janssen W, Wietelmann A, Kojonazarov B, Weissmann N, Stasch JP, Ghofrani HA, Seeger W, Schermuly RT, Novoyatleva T.

Biomed Res Int. 2018 Dec 16;2018:7491284. doi: 10.1155/2018/7491284. eCollection 2018. No abstract available.

5.

Effect of Riociguat and Sildenafil on Right Heart Remodeling and Function in Pressure Overload Induced Model of Pulmonary Arterial Banding.

Rai N, Veeroju S, Schymura Y, Janssen W, Wietelmann A, Kojonazarov B, Weissmann N, Stasch JP, Ghofrani HA, Seeger W, Schermuly RT, Novoyatleva T.

Biomed Res Int. 2018 Jan 3;2018:3293584. doi: 10.1155/2018/3293584. eCollection 2018.

6.

Sirt7 promotes adipogenesis in the mouse by inhibiting autocatalytic activation of Sirt1.

Fang J, Ianni A, Smolka C, Vakhrusheva O, Nolte H, Krüger M, Wietelmann A, Simonet NG, Adrian-Segarra JM, Vaquero A, Braun T, Bober E.

Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8352-E8361. doi: 10.1073/pnas.1706945114. Epub 2017 Sep 18.

7.

Developmental vascular remodeling defects and postnatal kidney failure in mice lacking Gpr116 (Adgrf5) and Eltd1 (Adgrl4).

Lu S, Liu S, Wietelmann A, Kojonazarov B, Atzberger A, Tang C, Schermuly RT, Gröne HJ, Offermanns S.

PLoS One. 2017 Aug 14;12(8):e0183166. doi: 10.1371/journal.pone.0183166. eCollection 2017.

8.

Pressure overload leads to an increased accumulation and activity of mast cells in the right ventricle.

Luitel H, Sydykov A, Schymura Y, Mamazhakypov A, Janssen W, Pradhan K, Wietelmann A, Kosanovic D, Dahal BK, Weissmann N, Seeger W, Grimminger F, Ghofrani HA, Schermuly RT.

Physiol Rep. 2017 Mar;5(6). pii: e13146. doi: 10.14814/phy2.13146.

9.

Sex-specific, reciprocal regulation of ERα and miR-22 controls muscle lipid metabolism in male mice.

Schweisgut J, Schutt C, Wüst S, Wietelmann A, Ghesquière B, Carmeliet P, Dröse S, Korach KS, Braun T, Boettger T.

EMBO J. 2017 May 2;36(9):1199-1214. doi: 10.15252/embj.201695988. Epub 2017 Mar 17.

10.

Broad AOX expression in a genetically tractable mouse model does not disturb normal physiology.

Szibor M, Dhandapani PK, Dufour E, Holmström KM, Zhuang Y, Salwig I, Wittig I, Heidler J, Gizatullina Z, Gainutdinov T; German Mouse Clinic Consortium, Fuchs H, Gailus-Durner V, de Angelis MH, Nandania J, Velagapudi V, Wietelmann A, Rustin P, Gellerich FN, Jacobs HT, Braun T.

Dis Model Mech. 2017 Feb 1;10(2):163-171. doi: 10.1242/dmm.027839. Epub 2016 Dec 14.

11.

Increased apoptosis and browning of TAK1-deficient adipocytes protects against obesity.

Sassmann-Schweda A, Singh P, Tang C, Wietelmann A, Wettschureck N, Offermanns S.

JCI Insight. 2016 May 19;1(7):e81175. doi: 10.1172/jci.insight.81175.

12.

Targeted Ablation of Periostin-Expressing Activated Fibroblasts Prevents Adverse Cardiac Remodeling in Mice.

Kaur H, Takefuji M, Ngai CY, Carvalho J, Bayer J, Wietelmann A, Poetsch A, Hoelper S, Conway SJ, Möllmann H, Looso M, Troidl C, Offermanns S, Wettschureck N.

Circ Res. 2016 Jun 10;118(12):1906-17. doi: 10.1161/CIRCRESAHA.116.308643. Epub 2016 May 2. Erratum in: Circ Res. 2016 Sep 16;119(7):e109.

PMID:
27140435
13.

Myocardial healing requires Reg3β-dependent accumulation of macrophages in the ischemic heart.

Lörchner H, Pöling J, Gajawada P, Hou Y, Polyakova V, Kostin S, Adrian-Segarra JM, Boettger T, Wietelmann A, Warnecke H, Richter M, Kubin T, Braun T.

Nat Med. 2015 Apr;21(4):353-62. doi: 10.1038/nm.3816. Epub 2015 Mar 9.

PMID:
25751817
14.

Myostatin induces interstitial fibrosis in the heart via TAK1 and p38.

Biesemann N, Mendler L, Kostin S, Wietelmann A, Borchardt T, Braun T.

Cell Tissue Res. 2015 Sep;361(3):779-87. doi: 10.1007/s00441-015-2139-2. Epub 2015 Mar 1.

PMID:
25725788
15.

5-HT2B receptor antagonists inhibit fibrosis and protect from RV heart failure.

Janssen W, Schymura Y, Novoyatleva T, Kojonazarov B, Boehm M, Wietelmann A, Luitel H, Murmann K, Krompiec DR, Tretyn A, Pullamsetti SS, Weissmann N, Seeger W, Ghofrani HA, Schermuly RT.

Biomed Res Int. 2015;2015:438403. doi: 10.1155/2015/438403. Epub 2015 Feb 1.

16.

Macrophage and cancer cell cross-talk via CCR2 and CX3CR1 is a fundamental mechanism driving lung cancer.

Schmall A, Al-Tamari HM, Herold S, Kampschulte M, Weigert A, Wietelmann A, Vipotnik N, Grimminger F, Seeger W, Pullamsetti SS, Savai R.

Am J Respir Crit Care Med. 2015 Feb 15;191(4):437-47. doi: 10.1164/rccm.201406-1137OC.

PMID:
25536148
17.

MiRNA-1/133a clusters regulate adrenergic control of cardiac repolarization.

Besser J, Malan D, Wystub K, Bachmann A, Wietelmann A, Sasse P, Fleischmann BK, Braun T, Boettger T.

PLoS One. 2014 Nov 21;9(11):e113449. doi: 10.1371/journal.pone.0113449. eCollection 2014.

18.

Attenuation of Wnt/β-catenin activity reverses enhanced generation of cardiomyocytes and cardiac defects caused by the loss of emerin.

Stubenvoll A, Rice M, Wietelmann A, Wheeler M, Braun T.

Hum Mol Genet. 2015 Feb 1;24(3):802-13. doi: 10.1093/hmg/ddu498. Epub 2014 Sep 30.

PMID:
25274778
19.

Sham surgery and inter-individual heterogeneity are major determinants of monocyte subset kinetics in a mouse model of myocardial infarction.

Hoffmann J, Ospelt M, Troidl C, Voss S, Liebetrau C, Kim WK, Rolf A, Wietelmann A, Braun T, Troidl K, Sadayappan S, Barefield D, Hamm C, Nef H, Möllmann H.

PLoS One. 2014 Jun 3;9(6):e98456. doi: 10.1371/journal.pone.0098456. eCollection 2014.

20.

Myostatin regulates energy homeostasis in the heart and prevents heart failure.

Biesemann N, Mendler L, Wietelmann A, Hermann S, Schäfers M, Krüger M, Boettger T, Borchardt T, Braun T.

Circ Res. 2014 Jul 7;115(2):296-310. doi: 10.1161/CIRCRESAHA.115.304185. Epub 2014 May 7.

PMID:
24807786
21.

Therapeutic targeting of the oncostatin M receptor-β prevents inflammatory heart failure.

Pöling J, Gajawada P, Richter M, Lörchner H, Polyakova V, Kostin S, Shin J, Boettger T, Walther T, Rees W, Wietelmann A, Warnecke H, Kubin T, Braun T.

Basic Res Cardiol. 2014 Jan;109(1):396. doi: 10.1007/s00395-013-0396-3. Epub 2013 Nov 29.

PMID:
24292852
22.

TWEAK/Fn14 axis is a positive regulator of cardiac hypertrophy.

Novoyatleva T, Janssen W, Wietelmann A, Schermuly RT, Engel FB.

Cytokine. 2013 Oct;64(1):43-5. doi: 10.1016/j.cyto.2013.05.009. Epub 2013 Jun 10.

PMID:
23764551
23.

Deletion of Fn14 receptor protects from right heart fibrosis and dysfunction.

Novoyatleva T, Schymura Y, Janssen W, Strobl F, Swiercz JM, Patra C, Posern G, Wietelmann A, Zheng TS, Schermuly RT, Engel FB.

Basic Res Cardiol. 2013 Mar;108(2):325. doi: 10.1007/s00395-012-0325-x. Epub 2013 Jan 17.

24.

Bone marrow transplantation improves the outcome of Atm-deficient mice through the migration of ATM-competent cells.

Pietzner J, Baer PC, Duecker RP, Merscher MB, Satzger-Prodinger C, Bechmann I, Wietelmann A, Del Turco D, Doering C, Kuci S, Bader P, Schirmer S, Zielen S, Schubert R.

Hum Mol Genet. 2013 Feb 1;22(3):493-507. doi: 10.1093/hmg/dds448. Epub 2012 Oct 25.

PMID:
23100326
25.

Cardiomyocyte-specific IκB kinase (IKK)/NF-κB activation induces reversible inflammatory cardiomyopathy and heart failure.

Maier HJ, Schips TG, Wietelmann A, Krüger M, Brunner C, Sauter M, Klingel K, Böttger T, Braun T, Wirth T.

Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11794-9. doi: 10.1073/pnas.1116584109. Epub 2012 Jul 2.

26.

Oncostatin M is a major mediator of cardiomyocyte dedifferentiation and remodeling.

Kubin T, Pöling J, Kostin S, Gajawada P, Hein S, Rees W, Wietelmann A, Tanaka M, Lörchner H, Schimanski S, Szibor M, Warnecke H, Braun T.

Cell Stem Cell. 2011 Nov 4;9(5):420-32. doi: 10.1016/j.stem.2011.08.013.

27.

FoxO3 induces reversible cardiac atrophy and autophagy in a transgenic mouse model.

Schips TG, Wietelmann A, Höhn K, Schimanski S, Walther P, Braun T, Wirth T, Maier HJ.

Cardiovasc Res. 2011 Sep 1;91(4):587-97. doi: 10.1093/cvr/cvr144. Epub 2011 May 30.

PMID:
21628326
28.

Endogenous regeneration after collagenase-induced knee joint damage in the adult newt Notophthalmus viridescens.

Geyer M, Borchardt T, Schreiyäck C, Wietelmann A, Müller-Schrobsdorff F, Müller C, Müller-Ladner U, Dinser R.

Ann Rheum Dis. 2011 Jan;70(1):214-20. doi: 10.1136/ard.2009.126136. Epub 2010 Aug 31.

PMID:
20810393
29.

Identification of right heart-enriched genes in a murine model of chronic outflow tract obstruction.

Kreymborg Kg, Uchida S, Gellert P, Schneider A, Boettger T, Voswinckel R, Wietelmann A, Szibor M, Weissmann N, Ghofrani AH, Schermuly R, Schranz D, Seeger W, Braun T.

J Mol Cell Cardiol. 2010 Oct;49(4):598-605. doi: 10.1016/j.yjmcc.2010.07.014. Epub 2010 Jul 27.

PMID:
20673770
30.

Cardiac deletion of Smyd2 is dispensable for mouse heart development.

Diehl F, Brown MA, van Amerongen MJ, Novoyatleva T, Wietelmann A, Harriss J, Ferrazzi F, Böttger T, Harvey RP, Tucker PW, Engel FB.

PLoS One. 2010 Mar 17;5(3):e9748. doi: 10.1371/journal.pone.0009748.

31.

Sustained persistence of transplanted proangiogenic cells contributes to neovascularization and cardiac function after ischemia.

Ziebart T, Yoon CH, Trepels T, Wietelmann A, Braun T, Kiessling F, Stein S, Grez M, Ihling C, Muhly-Reinholz M, Carmona G, Urbich C, Zeiher AM, Dimmeler S.

Circ Res. 2008 Nov 21;103(11):1327-34. doi: 10.1161/CIRCRESAHA.108.180463. Epub 2008 Oct 16.

PMID:
18927463

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