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Items: 1 to 50 of 307

1.

Carbon irradiation overcomes glioma radioresistance by eradicating stem cells and forming an antiangiogenic and immunopermissive niche.

Chiblak S, Tang Z, Lemke D, Knoll M, Dokic I, Warta R, Moustafa M, Mier W, Brons S, Rapp C, Muschal S, Seidel P, Bendszus M, Adeberg S, Wiestler OD, Haberkorn U, Debus J, Herold-Mende C, Wick W, Abdollahi A.

JCI Insight. 2019 Jan 24;4(2). pii: 123837. doi: 10.1172/jci.insight.123837. [Epub ahead of print]

2.

Randomized, Prospective Double-Blinded Study Comparing 3 Different Doses of 5-Aminolevulinic Acid for Fluorescence-Guided Resections of Malignant Gliomas.

Stummer W, Stepp H, Wiestler OD, Pichlmeier U.

Neurosurgery. 2017 Aug 1;81(2):230-239. doi: 10.1093/neuros/nyx074.

3.

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary.

Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P, Ellison DW.

Acta Neuropathol. 2016 Jun;131(6):803-20. doi: 10.1007/s00401-016-1545-1. Epub 2016 May 9. Review.

PMID:
27157931
4.

The mutational pattern of primary lymphoma of the central nervous system determined by whole-exome sequencing.

Vater I, Montesinos-Rongen M, Schlesner M, Haake A, Purschke F, Sprute R, Mettenmeyer N, Nazzal I, Nagel I, Gutwein J, Richter J, Buchhalter I, Russell RB, Wiestler OD, Eils R, Deckert M, Siebert R.

Leukemia. 2015 Mar;29(3):677-85. doi: 10.1038/leu.2014.264. Epub 2014 Sep 5.

PMID:
25189415
5.

Assessing CpG island methylator phenotype, 1p/19q codeletion, and MGMT promoter methylation from epigenome-wide data in the biomarker cohort of the NOA-04 trial.

Wiestler B, Capper D, Hovestadt V, Sill M, Jones DT, Hartmann C, Felsberg J, Platten M, Feiden W, Keyvani K, Pfister SM, Wiestler OD, Meyermann R, Reifenberger G, Pietsch T, von Deimling A, Weller M, Wick W.

Neuro Oncol. 2014 Dec;16(12):1630-8. doi: 10.1093/neuonc/nou138. Epub 2014 Jul 15.

6.

Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion and can be diagnosed by nuclear expression of STAT6 protein.

Schweizer L, Koelsche C, Sahm F, Piro RM, Capper D, Reuss DE, Pusch S, Habel A, Meyer J, Göck T, Jones DT, Mawrin C, Schittenhelm J, Becker A, Heim S, Simon M, Herold-Mende C, Mechtersheimer G, Paulus W, König R, Wiestler OD, Pfister SM, von Deimling A.

Acta Neuropathol. 2013 May;125(5):651-8. doi: 10.1007/s00401-013-1117-6. Epub 2013 Apr 11.

PMID:
23575898
7.

Secretory meningiomas are defined by combined KLF4 K409Q and TRAF7 mutations.

Reuss DE, Piro RM, Jones DT, Simon M, Ketter R, Kool M, Becker A, Sahm F, Pusch S, Meyer J, Hagenlocher C, Schweizer L, Capper D, Kickingereder P, Mucha J, Koelsche C, Jäger N, Santarius T, Tarpey PS, Stephens PJ, Andrew Futreal P, Wellenreuther R, Kraus J, Lenartz D, Herold-Mende C, Hartmann C, Mawrin C, Giese N, Eils R, Collins VP, König R, Wiestler OD, Pfister SM, von Deimling A.

Acta Neuropathol. 2013 Mar;125(3):351-8. doi: 10.1007/s00401-013-1093-x. Epub 2013 Feb 12.

PMID:
23404370
8.

Notch1 signaling promotes survival of glioblastoma cells via EGFR-mediated induction of anti-apoptotic Mcl-1.

Fassl A, Tagscherer KE, Richter J, Berriel Diaz M, Alcantara Llaguno SR, Campos B, Kopitz J, Herold-Mende C, Herzig S, Schmidt MHH, Parada LF, Wiestler OD, Roth W.

Oncogene. 2012 Nov 1;31(44):4698-708. doi: 10.1038/onc.2011.615. Epub 2012 Jan 16.

PMID:
22249262
9.

Activating L265P mutations of the MYD88 gene are common in primary central nervous system lymphoma.

Montesinos-Rongen M, Godlewska E, Brunn A, Wiestler OD, Siebert R, Deckert M.

Acta Neuropathol. 2011 Dec;122(6):791-2. doi: 10.1007/s00401-011-0891-2. Epub 2011 Oct 22. No abstract available.

PMID:
22020631
10.

Modern concepts in the biology, diagnosis, differential diagnosis and treatment of primary central nervous system lymphoma.

Deckert M, Engert A, Brück W, Ferreri AJ, Finke J, Illerhaus G, Klapper W, Korfel A, Küppers R, Maarouf M, Montesinos-Rongen M, Paulus W, Schlegel U, Lassmann H, Wiestler OD, Siebert R, DeAngelis LM.

Leukemia. 2011 Dec;25(12):1797-807. doi: 10.1038/leu.2011.169. Epub 2011 Aug 5. Review.

PMID:
21818113
11.

Danger signaling protein HMGB1 induces a distinct form of cell death accompanied by formation of giant mitochondria.

Gdynia G, Keith M, Kopitz J, Bergmann M, Fassl A, Weber AN, George J, Kees T, Zentgraf HW, Wiestler OD, Schirmacher P, Roth W.

Cancer Res. 2010 Nov 1;70(21):8558-68. doi: 10.1158/0008-5472.CAN-10-0204. Epub 2010 Oct 19.

12.

Mutations of CARD11 but not TNFAIP3 may activate the NF-kappaB pathway in primary CNS lymphoma.

Montesinos-Rongen M, Schmitz R, Brunn A, Gesk S, Richter J, Hong K, Wiestler OD, Siebert R, Küppers R, Deckert M.

Acta Neuropathol. 2010 Oct;120(4):529-35. doi: 10.1007/s00401-010-0709-7. Epub 2010 Jun 11.

PMID:
20544211
13.

Molecular signatures classify astrocytic gliomas by IDH1 mutation status.

Toedt G, Barbus S, Wolter M, Felsberg J, Tews B, Blond F, Sabel MC, Hofmann S, Becker N, Hartmann C, Ohgaki H, von Deimling A, Wiestler OD, Hahn M, Lichter P, Reifenberger G, Radlwimmer B.

Int J Cancer. 2011 Mar 1;128(5):1095-103. doi: 10.1002/ijc.25448.

14.

Focal genomic amplification at 19q13.42 comprises a powerful diagnostic marker for embryonal tumors with ependymoblastic rosettes.

Korshunov A, Remke M, Gessi M, Ryzhova M, Hielscher T, Witt H, Tobias V, Buccoliero AM, Sardi I, Gardiman MP, Bonnin J, Scheithauer B, Kulozik AE, Witt O, Mork S, von Deimling A, Wiestler OD, Giangaspero F, Rosenblum M, Pietsch T, Lichter P, Pfister SM.

Acta Neuropathol. 2010 Aug;120(2):253-60. doi: 10.1007/s00401-010-0688-8. Epub 2010 Apr 21.

PMID:
20407781
15.

Epigenetic downregulation of mitogen-activated protein kinase phosphatase MKP-2 relieves its growth suppressive activity in glioma cells.

Waha A, Felsberg J, Hartmann W, von dem Knesebeck A, Mikeska T, Joos S, Wolter M, Koch A, Yan PS, Endl E, Wiestler OD, Reifenberger G, Pietsch T, Waha A.

Cancer Res. 2010 Feb 15;70(4):1689-99. doi: 10.1158/0008-5472.CAN-09-3218. Epub 2010 Feb 2.

16.

Array-based DNA methylation profiling of primary lymphomas of the central nervous system.

Richter J, Ammerpohl O, Martín-Subero JI, Montesinos-Rongen M, Bibikova M, Wickham-Garcia E, Wiestler OD, Deckert M, Siebert R.

BMC Cancer. 2009 Dec 21;9:455. doi: 10.1186/1471-2407-9-455.

17.

NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with procarbazine, lomustine, and vincristine or temozolomide.

Wick W, Hartmann C, Engel C, Stoffels M, Felsberg J, Stockhammer F, Sabel MC, Koeppen S, Ketter R, Meyermann R, Rapp M, Meisner C, Kortmann RD, Pietsch T, Wiestler OD, Ernemann U, Bamberg M, Reifenberger G, von Deimling A, Weller M.

J Clin Oncol. 2009 Dec 10;27(35):5874-80. doi: 10.1200/JCO.2009.23.6497. Epub 2009 Nov 9. Erratum in: J Clin Oncol. 2010 Feb 1;28(4):708.

PMID:
19901110
18.

Preferential expression of truncated isoforms of FOXP1 in primary central nervous system lymphoma.

Courts C, Brunn A, Montesinos-Rongen M, Siemer D, Hans V, Paulus W, Wiestler OD, Küppers R, Siebert R, Deckert M.

J Neuropathol Exp Neurol. 2009 Sep;68(9):972-6. doi: 10.1097/NEN.0b013e3181b31cd6.

PMID:
19680146
19.

Chromosomal imbalances and partial uniparental disomies in primary central nervous system lymphoma.

Schwindt H, Vater I, Kreuz M, Montesinos-Rongen M, Brunn A, Richter J, Gesk S, Ammerpohl O, Wiestler OD, Hasenclever D, Deckert M, Siebert R.

Leukemia. 2009 Oct;23(10):1875-84. doi: 10.1038/leu.2009.120. Epub 2009 Jun 4.

PMID:
19494841
20.

Outcome prediction in pediatric medulloblastoma based on DNA copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN loci.

Pfister S, Remke M, Benner A, Mendrzyk F, Toedt G, Felsberg J, Wittmann A, Devens F, Gerber NU, Joos S, Kulozik A, Reifenberger G, Rutkowski S, Wiestler OD, Radlwimmer B, Scheurlen W, Lichter P, Korshunov A.

J Clin Oncol. 2009 Apr 1;27(10):1627-36. doi: 10.1200/JCO.2008.17.9432. Epub 2009 Mar 2.

PMID:
19255330
21.

Troglitazone-mediated sensitization to TRAIL-induced apoptosis is regulated by proteasome-dependent degradation of FLIP and ERK1/2-dependent phosphorylation of BAD.

Grund K, Ahmadi R, Jung F, Funke V, Gdynia G, Benner A, Sykora J, Walczak H, Joos S, Felsberg J, Reifenberger G, Wiestler OD, Herold-Mende C, Roth W.

Cancer Biol Ther. 2008 Dec;7(12):1982-90.

PMID:
19158480
22.

Apoptosis-based treatment of glioblastomas with ABT-737, a novel small molecule inhibitor of Bcl-2 family proteins.

Tagscherer KE, Fassl A, Campos B, Farhadi M, Kraemer A, Böck BC, Macher-Goeppinger S, Radlwimmer B, Wiestler OD, Herold-Mende C, Roth W.

Oncogene. 2008 Nov 6;27(52):6646-56. doi: 10.1038/onc.2008.259. Epub 2008 Jul 28.

PMID:
18663354
23.

Recurrent inactivation of the PRDM1 gene in primary central nervous system lymphoma.

Courts C, Montesinos-Rongen M, Brunn A, Bug S, Siemer D, Hans V, Blümcke I, Klapper W, Schaller C, Wiestler OD, Küppers R, Siebert R, Deckert M.

J Neuropathol Exp Neurol. 2008 Jul;67(7):720-7. doi: 10.1097/NEN.0b013e31817dd02d.

PMID:
18596541
24.

Mechanisms of Disease: cancer stem cells--targeting the evil twin.

Trumpp A, Wiestler OD.

Nat Clin Pract Oncol. 2008 Jun;5(6):337-47. doi: 10.1038/ncponc1110. Epub 2008 Apr 22. Review.

PMID:
18431377
25.

[The PEA-15 protein induces resistance against glucose deprivation-induced cell death via the ERK/MAP kinase pathway].

Roth W, Eckert A, Böck B, Schirmacher P, Wiestler OD.

Verh Dtsch Ges Pathol. 2007;91:343-50. German.

PMID:
18314633
26.

[The anti-diabetic drug troglitazone sensitizes colon cancer cells to TRAIL-induced apoptosis by down-regulating FLIP].

Roth W, Grund K, Wiestler OD, Schirmacher P.

Verh Dtsch Ges Pathol. 2007;91:294-301. German.

PMID:
18314627
27.

Basal caspase activity promotes migration and invasiveness in glioblastoma cells.

Gdynia G, Grund K, Eckert A, Böck BC, Funke B, Macher-Goeppinger S, Sieber S, Herold-Mende C, Wiestler B, Wiestler OD, Roth W.

Mol Cancer Res. 2007 Dec;5(12):1232-40. doi: 10.1158/1541-7786.MCR-07-0343.

28.

Gene expression profiling suggests primary central nervous system lymphomas to be derived from a late germinal center B cell.

Montesinos-Rongen M, Brunn A, Bentink S, Basso K, Lim WK, Klapper W, Schaller C, Reifenberger G, Rubenstein J, Wiestler OD, Spang R, Dalla-Favera R, Siebert R, Deckert M.

Leukemia. 2008 Feb;22(2):400-5. Epub 2007 Nov 8.

29.

The PEA-15/PED protein protects glioblastoma cells from glucose deprivation-induced apoptosis via the ERK/MAP kinase pathway.

Eckert A, Böck BC, Tagscherer KE, Haas TL, Grund K, Sykora J, Herold-Mende C, Ehemann V, Hollstein M, Chneiweiss H, Wiestler OD, Walczak H, Roth W.

Oncogene. 2008 Feb 14;27(8):1155-66. Epub 2007 Aug 13.

PMID:
17700518
30.

The 2007 WHO classification of tumours of the central nervous system.

Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW, Kleihues P.

Acta Neuropathol. 2007 Aug;114(2):97-109. Epub 2007 Jul 6. Review. Erratum in: Acta Neuropathol. 2007 Nov;114(5):547.

31.

Microsatellite instability in pediatric and adult high-grade gliomas.

Eckert A, Kloor M, Giersch A, Ahmadi R, Herold-Mende C, Hampl JA, Heppner FL, Zoubaa S, Holinski-Feder E, Pietsch T, Wiestler OD, von Knebel Doeberitz M, Roth W, Gebert J.

Brain Pathol. 2007 Apr;17(2):146-50.

PMID:
17388945
32.

Mutations of the Wnt antagonist AXIN2 (Conductin) result in TCF-dependent transcription in medulloblastomas.

Koch A, Hrychyk A, Hartmann W, Waha A, Mikeska T, Waha A, Schüller U, Sörensen N, Berthold F, Goodyer CG, Wiestler OD, Birchmeier W, Behrens J, Pietsch T.

Int J Cancer. 2007 Jul 15;121(2):284-91.

33.

Transcriptional profiling of the nuclear factor-kappaB pathway identifies a subgroup of primary lymphoma of the central nervous system with low BCL10 expression.

Courts C, Montesinos-Rongen M, Martin-Subero JI, Brunn A, Siemer D, Zühlke-Jenisch R, Pels H, Jürgens A, Schlegel U, Schmidt-Wolf IG, Schaller C, Reifenberger G, Sabel M, Warnecke-Eberz U, Wiestler OD, Küppers R, Siebert R, Deckert M.

J Neuropathol Exp Neurol. 2007 Mar;66(3):230-7.

PMID:
17356384
34.

SGNE1/7B2 is epigenetically altered and transcriptionally downregulated in human medulloblastomas.

Waha A, Koch A, Hartmann W, Milde U, Felsberg J, Hübner A, Mikeska T, Goodyer CG, Sörensen N, Lindberg I, Wiestler OD, Pietsch T, Waha A.

Oncogene. 2007 Aug 16;26(38):5662-8. Epub 2007 Mar 5.

PMID:
17334394
35.

Identification of genomic aberrations associated with shorter overall survival in patients with oligodendroglial tumors.

Trost D, Ehrler M, Fimmers R, Felsberg J, Sabel MC, Kirsch L, Schramm J, Wiestler OD, Reifenberger G, Weber RG.

Int J Cancer. 2007 Jun 1;120(11):2368-76.

36.

DNA methylation and allelic losses on chromosome arm 14q in oligodendroglial tumours.

Felsberg J, Yan PS, Huang TH, Milde U, Schramm J, Wiestler OD, Reifenberger G, Pietsch T, Waha A.

Neuropathol Appl Neurobiol. 2006 Oct;32(5):517-24.

PMID:
16972885
37.

Frequent loss of chromosome 9, homozygous CDKN2A/p14(ARF)/CDKN2B deletion and low TSC1 mRNA expression in pleomorphic xanthoastrocytomas.

Weber RG, Hoischen A, Ehrler M, Zipper P, Kaulich K, Blaschke B, Becker AJ, Weber-Mangal S, Jauch A, Radlwimmer B, Schramm J, Wiestler OD, Lichter P, Reifenberger G.

Oncogene. 2007 Feb 15;26(7):1088-97. Epub 2006 Aug 7.

PMID:
16909113
38.

Selective vulnerability of different types of commissural neurons for amyloid beta-protein-induced neurodegeneration in APP23 mice correlates with dendritic tree morphology.

Capetillo-Zarate E, Staufenbiel M, Abramowski D, Haass C, Escher A, Stadelmann C, Yamaguchi H, Wiestler OD, Thal DR.

Brain. 2006 Nov;129(Pt 11):2992-3005. Epub 2006 Jul 14.

PMID:
16844716
39.

Phosphatidylinositol 3'-kinase/AKT signaling is activated in medulloblastoma cell proliferation and is associated with reduced expression of PTEN.

Hartmann W, Digon-Söntgerath B, Koch A, Waha A, Endl E, Dani I, Denkhaus D, Goodyer CG, Sörensen N, Wiestler OD, Pietsch T.

Clin Cancer Res. 2006 May 15;12(10):3019-27.

40.

Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial.

Stummer W, Pichlmeier U, Meinel T, Wiestler OD, Zanella F, Reulen HJ; ALA-Glioma Study Group.

Lancet Oncol. 2006 May;7(5):392-401.

PMID:
16648043
41.

Molecular genetic analysis of central nervous system germ cell tumors with comparative genomic hybridization.

Schneider DT, Zahn S, Sievers S, Alemazkour K, Reifenberger G, Wiestler OD, Calaminus G, Göbel U, Perlman EJ.

Mod Pathol. 2006 Jun;19(6):864-73.

42.

[Cancer research at the transition from bench to bedside].

Wiestler OD, Rautenstrauch J.

Med Klin (Munich). 2006 Feb 15;101(2):153-9. German.

PMID:
16501913
43.

Distinct allelic variants of TSC1 and TSC2 in epilepsy-associated cortical malformations without balloon cells.

Majores M, Blümcke I, Urbach H, Meroni A, Hans V, Holthausen H, Elger CE, Schramm J, Galli C, Spreafico R, Wiestler OD, Becker AJ.

J Neuropathol Exp Neurol. 2005 Jul;64(7):629-37.

PMID:
16042315
44.

Curbing tobacco's toll starts with the professionals: World No Tobacco Day.

Boyle P, Ariyaratne M, Bartelink H, Baselga J, Berns A, Brawley OW, Burns H, Davidov M, Dinshaw KA, Dresler C, Eggermont AM, Gajurel D, Gordina G, Gray N, Kakizoe T, Karki BS, Kásler M, Kerr DJ, Khayat D, Kiselev A, Khuhaprema T, Klocker H, Levshin V, Martin-Moreno JM, McVie JG, Mendelsohn J, Napalkov NP, Ngoma TA, Park JG, Philip T, Pötschke-Langer M, Poudal HN, Rajan B, Ringborg U, Rodger A, Seffrin JR, Shanta V, Shrestha MM, Thomas R, Tursz T, de Valeriola D, Veronesi U, Wiestler OD, Zaridze D, Zatonski W, Zeng YX.

Lancet. 2005 Jun 11-17;365(9476):1990-2. No abstract available.

PMID:
15950704
45.

Absence of immunoglobulin class switch in primary lymphomas of the central nervous system.

Montesinos-Rongen M, Schmitz R, Courts C, Stenzel W, Bechtel D, Niedobitek G, Blümcke I, Reifenberger G, von Deimling A, Jungnickel B, Wiestler OD, Küppers R, Deckert M.

Am J Pathol. 2005 Jun;166(6):1773-9.

46.

The impact of argyrophilic grain disease on the development of dementia and its relationship to concurrent Alzheimer's disease-related pathology.

Thal DR, Schultz C, Botez G, Del Tredici K, Mrak RE, Griffin WS, Wiestler OD, Braak H, Ghebremedhin E.

Neuropathol Appl Neurobiol. 2005 Jun;31(3):270-9.

PMID:
15885064
47.

Subtype-specific expression and genetic alterations of the chemokinereceptor gene CXCR4 in medulloblastomas.

Schüller U, Koch A, Hartmann W, Garrè ML, Goodyer CG, Cama A, Sörensen N, Wiestler OD, Pietsch T.

Int J Cancer. 2005 Oct 20;117(1):82-9.

48.

AFP/beta-HCG secreting CNS germ cell tumors: long-term outcome with respect to initial symptoms and primary tumor resection. Results of the cooperative trial MAKEI 89.

Calaminus G, Bamberg M, Harms D, Jürgens H, Kortmann RD, Sörensen N, Wiestler OD, Göbel U.

Neuropediatrics. 2005 Apr;36(2):71-7.

PMID:
15822019
49.

Epigenetic silencing of the protocadherin family member PCDH-gamma-A11 in astrocytomas.

Waha A, Güntner S, Huang TH, Yan PS, Arslan B, Pietsch T, Wiestler OD, Waha A.

Neoplasia. 2005 Mar;7(3):193-9.

50.

Insulin-like growth factor II is involved in the proliferation control of medulloblastoma and its cerebellar precursor cells.

Hartmann W, Koch A, Brune H, Waha A, Schüller U, Dani I, Denkhaus D, Langmann W, Bode U, Wiestler OD, Schilling K, Pietsch T.

Am J Pathol. 2005 Apr;166(4):1153-62.

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