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RPL22L1 induction in colorectal cancer is associated with poor prognosis and 5-FU resistance.

Rao S, Peri S, Hoffmann J, Cai KQ, Harris B, Rhodes M, Connolly DC, Testa JR, Wiest DL.

PLoS One. 2019 Oct 3;14(10):e0222392. doi: 10.1371/journal.pone.0222392. eCollection 2019.


TCR Signaling Circuits in αβ/γδ T Lineage Choice.

Fahl SP, Kappes DJ, Wiest DL.

In: Soboloff J, Kappes DJ, editors. Signaling Mechanisms Regulating T Cell Diversity and Function. Boca Raton (FL): CRC Press/Taylor & Francis; 2018. Chapter 6.


Gadd45 stress sensors in suppression of leukemia.

Wiest DL.

Oncotarget. 2018 Sep 28;9(76):34191-34192. doi: 10.18632/oncotarget.26154. eCollection 2018 Sep 28. No abstract available.


Functional genomic landscape of acute myeloid leukaemia.

Tyner JW, Tognon CE, Bottomly D, Wilmot B, Kurtz SE, Savage SL, Long N, Schultz AR, Traer E, Abel M, Agarwal A, Blucher A, Borate U, Bryant J, Burke R, Carlos A, Carpenter R, Carroll J, Chang BH, Coblentz C, d'Almeida A, Cook R, Danilov A, Dao KT, Degnin M, Devine D, Dibb J, Edwards DK 5th, Eide CA, English I, Glover J, Henson R, Ho H, Jemal A, Johnson K, Johnson R, Junio B, Kaempf A, Leonard J, Lin C, Liu SQ, Lo P, Loriaux MM, Luty S, Macey T, MacManiman J, Martinez J, Mori M, Nelson D, Nichols C, Peters J, Ramsdill J, Rofelty A, Schuff R, Searles R, Segerdell E, Smith RL, Spurgeon SE, Sweeney T, Thapa A, Visser C, Wagner J, Watanabe-Smith K, Werth K, Wolf J, White L, Yates A, Zhang H, Cogle CR, Collins RH, Connolly DC, Deininger MW, Drusbosky L, Hourigan CS, Jordan CT, Kropf P, Lin TL, Martinez ME, Medeiros BC, Pallapati RR, Pollyea DA, Swords RT, Watts JM, Weir SJ, Wiest DL, Winters RM, McWeeney SK, Druker BJ.

Nature. 2018 Oct;562(7728):526-531. doi: 10.1038/s41586-018-0623-z. Epub 2018 Oct 17.


Id3 Restricts γδ NKT Cell Expansion by Controlling Egr2 and c-Myc Activity.

Zhang B, Jiao A, Dai M, Wiest DL, Zhuang Y.

J Immunol. 2018 Sep 1;201(5):1452-1459. doi: 10.4049/jimmunol.1800106. Epub 2018 Jul 16.


Integration of T-cell receptor, Notch and cytokine signals programs mouse γδ T-cell effector differentiation.

Zarin P, In TS, Chen EL, Singh J, Wong GW, Mohtashami M, Wiest DL, Anderson MK, Zúñiga-Pflücker JC.

Immunol Cell Biol. 2018 Oct;96(9):994-1007. doi: 10.1111/imcb.12164. Epub 2018 Jun 28.


Reply to Chien: Clarification of the effect of ligand on γδ-TCR repertoire selection.

Fahl SP, Wiest DL.

Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):E3607-E3608. doi: 10.1073/pnas.1804193115. Epub 2018 Apr 3. No abstract available.


Role of a selecting ligand in shaping the murine γδ-TCR repertoire.

Fahl SP, Coffey F, Kain L, Zarin P, Dunbrack RL Jr, Teyton L, Zúñiga-Pflücker JC, Kappes DJ, Wiest DL.

Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1889-1894. doi: 10.1073/pnas.1718328115. Epub 2018 Feb 5.


HEB is required for the specification of fetal IL-17-producing γδ T cells.

In TSH, Trotman-Grant A, Fahl S, Chen ELY, Zarin P, Moore AJ, Wiest DL, Zúñiga-Pflücker JC, Anderson MK.

Nat Commun. 2017 Dec 8;8(1):2004. doi: 10.1038/s41467-017-02225-5.


Disruption of Thrombocyte and T Lymphocyte Development by a Mutation in ARPC1B.

Somech R, Lev A, Lee YN, Simon AJ, Barel O, Schiby G, Avivi C, Barshack I, Rhodes M, Yin J, Wang M, Yang Y, Rhodes J, Marcus N, Garty BZ, Stein J, Amariglio N, Rechavi G, Wiest DL, Zhang Y.

J Immunol. 2017 Dec 15;199(12):4036-4045. doi: 10.4049/jimmunol.1700460. Epub 2017 Nov 10.


Non-coding Transcription Instructs Chromatin Folding and Compartmentalization to Dictate Enhancer-Promoter Communication and T Cell Fate.

Isoda T, Moore AJ, He Z, Chandra V, Aida M, Denholtz M, Piet van Hamburg J, Fisch KM, Chang AN, Fahl SP, Wiest DL, Murre C.

Cell. 2017 Sep 21;171(1):103-119.e18. doi: 10.1016/j.cell.2017.09.001.


THEMIS-tery is solved.

Wiest DL.

Nat Immunol. 2017 Mar 22;18(4):368-370. doi: 10.1038/ni.3708. No abstract available.


The homeoprotein Dlx5 drives murine T-cell lymphomagenesis by directly transactivating Notch and upregulating Akt signaling.

Tan Y, Sementino E, Xu J, Pei J, Liu Z, Ito TK, Cai KQ, Peri S, Klein-Szanto AJ, Wiest DL, Testa JR.

Oncotarget. 2017 Feb 28;8(9):14941-14956. doi: 10.18632/oncotarget.14784.


Ribosomal Proteins Rpl22 and Rpl22l1 Control Morphogenesis by Regulating Pre-mRNA Splicing.

Zhang Y, O'Leary MN, Peri S, Wang M, Zha J, Melov S, Kappes DJ, Feng Q, Rhodes J, Amieux PS, Morris DR, Kennedy BK, Wiest DL.

Cell Rep. 2017 Jan 10;18(2):545-556. doi: 10.1016/j.celrep.2016.12.034.


Multisystem Anomalies in Severe Combined Immunodeficiency with Mutant BCL11B.

Punwani D, Zhang Y, Yu J, Cowan MJ, Rana S, Kwan A, Adhikari AN, Lizama CO, Mendelsohn BA, Fahl SP, Chellappan A, Srinivasan R, Brenner SE, Wiest DL, Puck JM.

N Engl J Med. 2016 Dec 1;375(22):2165-2176.


JUN is a key transcriptional regulator of the unfolded protein response in acute myeloid leukemia.

Zhou C, Martinez E, Di Marcantonio D, Solanki-Patel N, Aghayev T, Peri S, Ferraro F, Skorski T, Scholl C, Fröhling S, Balachandran S, Wiest DL, Sykes SM.

Leukemia. 2017 May;31(5):1196-1205. doi: 10.1038/leu.2016.329. Epub 2016 Nov 14.


Rpl22 Loss Selectively Impairs αβ T Cell Development by Dysregulating Endoplasmic Reticulum Stress Signaling.

Solanki NR, Stadanlick JE, Zhang Y, Duc AC, Lee SY, Lauritsen JP, Zhang Z, Wiest DL.

J Immunol. 2016 Sep 15;197(6):2280-9. doi: 10.4049/jimmunol.1600815. Epub 2016 Aug 3.


Mutations in STN1 cause Coats plus syndrome and are associated with genomic and telomere defects.

Simon AJ, Lev A, Zhang Y, Weiss B, Rylova A, Eyal E, Kol N, Barel O, Cesarkas K, Soudack M, Greenberg-Kushnir N, Rhodes M, Wiest DL, Schiby G, Barshack I, Katz S, Pras E, Poran H, Reznik-Wolf H, Ribakovsky E, Simon C, Hazou W, Sidi Y, Lahad A, Katzir H, Sagie S, Aqeilan HA, Glousker G, Amariglio N, Tzfati Y, Selig S, Rechavi G, Somech R.

J Exp Med. 2016 Jul 25;213(8):1429-40. doi: 10.1084/jem.20151618. Epub 2016 Jul 18.


The BRCA1-Δ11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin.

Wang Y, Bernhardy AJ, Cruz C, Krais JJ, Nacson J, Nicolas E, Peri S, van der Gulden H, van der Heijden I, O'Brien SW, Zhang Y, Harrell MI, Johnson SF, Candido Dos Reis FJ, Pharoah PD, Karlan B, Gourley C, Lambrechts D, Chenevix-Trench G, Olsson H, Benitez JJ, Greene MH, Gore M, Nussbaum R, Sadetzki S, Gayther SA, Kjaer SK; kConFab Investigators, D'Andrea AD, Shapiro GI, Wiest DL, Connolly DC, Daly MB, Swisher EM, Bouwman P, Jonkers J, Balmaña J, Serra V, Johnson N.

Cancer Res. 2016 May 1;76(9):2778-90. doi: 10.1158/0008-5472.CAN-16-0186.


Ribosomal Protein Rpl22 Controls the Dissemination of T-cell Lymphoma.

Rao S, Cai KQ, Stadanlick JE, Greenberg-Kushnir N, Solanki-Patel N, Lee SY, Fahl SP, Testa JR, Wiest DL.

Cancer Res. 2016 Jun 1;76(11):3387-96. doi: 10.1158/0008-5472.CAN-15-2698. Epub 2016 Apr 5.


Regulatory Roles of Rpl22 in Hematopoiesis: An Old Dog with New Tricks.

Fahl SP, Wang M, Zhang Y, Duc AC, Wiest DL.

Crit Rev Immunol. 2015;35(5):379-400. Review.


Appl1 and Appl2 are Expendable for Mouse Development But Are Essential for HGF-Induced Akt Activation and Migration in Mouse Embryonic Fibroblasts.

Tan Y, Xin X, Coffey FJ, Wiest DL, Dong LQ, Testa JR.

J Cell Physiol. 2016 May;231(5):1142-50. doi: 10.1002/jcp.25211. Epub 2015 Oct 21.


Using the Zebrafish Model to Study T Cell Development.

Zhang Y, Wiest DL.

Methods Mol Biol. 2016;1323:273-92. doi: 10.1007/978-1-4939-2809-5_22.


Development of γδ T Cells, the Special-Force Soldiers of the Immune System.

Wiest DL.

Methods Mol Biol. 2016;1323:23-32. doi: 10.1007/978-1-4939-2809-5_2. Review.


Mutagenesis Screen Identifies agtpbp1 and eps15L1 as Essential for T lymphocyte Development in Zebrafish.

Seiler C, Gebhart N, Zhang Y, Shinton SA, Li YS, Ross NL, Liu X, Li Q, Bilbee AN, Varshney GK, LaFave MC, Burgess SM, Balciuniene J, Balciunas D, Hardy RR, Kappes DJ, Wiest DL, Rhodes J.

PLoS One. 2015 Jul 10;10(7):e0131908. doi: 10.1371/journal.pone.0131908. eCollection 2015.


Noncanonical mode of ERK action controls alternative αβ and γδ T cell lineage fates.

Lee SY, Coffey F, Fahl SP, Peri S, Rhodes M, Cai KQ, Carleton M, Hedrick SM, Fehling HJ, Zúñiga-Pflücker JC, Kappes DJ, Wiest DL.

Immunity. 2014 Dec 18;41(6):934-46. doi: 10.1016/j.immuni.2014.10.021. Epub 2014 Nov 28.


Rpl22 Loss Impairs the Development of B Lymphocytes by Activating a p53-Dependent Checkpoint.

Fahl SP, Harris B, Coffey F, Wiest DL.

J Immunol. 2015 Jan 1;194(1):200-9.


Origins of γδ T cell effector subsets: a riddle wrapped in an enigma.

Fahl SP, Coffey F, Wiest DL.

J Immunol. 2014 Nov 1;193(9):4289-94. doi: 10.4049/jimmunol.1401813. Review.


Fli-1 regulates the DN2 to DN3 thymocyte transition and promotes γδ T-cell commitment by enhancing TCR signal strength.

Smeets MF, Wiest DL, Izon DJ.

Eur J Immunol. 2014 Sep;44(9):2617-24. doi: 10.1002/eji.201444442. Epub 2014 Jul 24.


Enforcement of γδ-lineage commitment by the pre-T-cell receptor in precursors with weak γδ-TCR signals.

Zarin P, Wong GW, Mohtashami M, Wiest DL, Zúñiga-Pflücker JC.

Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5658-63. doi: 10.1073/pnas.1312872111. Epub 2014 Mar 31.


The TCR ligand-inducible expression of CD73 marks γδ lineage commitment and a metastable intermediate in effector specification.

Coffey F, Lee SY, Buus TB, Lauritsen JP, Wong GW, Joachims ML, Thompson LF, Zúñiga-Pflücker JC, Kappes DJ, Wiest DL.

J Exp Med. 2014 Feb 10;211(2):329-43. doi: 10.1084/jem.20131540. Epub 2014 Feb 3.


The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1.

O'Leary MN, Schreiber KH, Zhang Y, Duc AC, Rao S, Hale JS, Academia EC, Shah SR, Morton JF, Holstein CA, Martin DB, Kaeberlein M, Ladiges WC, Fink PJ, Mackay VL, Wiest DL, Kennedy BK.

PLoS Genet. 2013;9(8):e1003708. doi: 10.1371/journal.pgen.1003708. Epub 2013 Aug 22.


Control of hematopoietic stem cell emergence by antagonistic functions of ribosomal protein paralogs.

Zhang Y, Duc AC, Rao S, Sun XL, Bilbee AN, Rhodes M, Li Q, Kappes DJ, Rhodes J, Wiest DL.

Dev Cell. 2013 Feb 25;24(4):411-25. doi: 10.1016/j.devcel.2013.01.018.


A role for Ly108 in the induction of promyelocytic zinc finger transcription factor in developing thymocytes.

Dutta M, Kraus ZJ, Gomez-Rodriguez J, Hwang SH, Cannons JL, Cheng J, Lee SY, Wiest DL, Wakeland EK, Schwartzberg PL.

J Immunol. 2013 Mar 1;190(5):2121-8. doi: 10.4049/jimmunol.1202145. Epub 2013 Jan 25.


Development of promyelocytic leukemia zinc finger-expressing innate CD4 T cells requires stronger T-cell receptor signals than conventional CD4 T cells.

Qiao Y, Zhu L, Sofi H, Lapinski PE, Horai R, Mueller K, Stritesky GL, He X, Teh HS, Wiest DL, Kappes DJ, King PD, Hogquist KA, Schwartzberg PL, Sant'Angelo DB, Chang CH.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16264-9. doi: 10.1073/pnas.1207528109. Epub 2012 Sep 17.


Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B.

Rao S, Lee SY, Gutierrez A, Perrigoue J, Thapa RJ, Tu Z, Jeffers JR, Rhodes M, Anderson S, Oravecz T, Hunger SP, Timakhov RA, Zhang R, Balachandran S, Zambetti GP, Testa JR, Look AT, Wiest DL.

Blood. 2012 Nov 1;120(18):3764-73. doi: 10.1182/blood-2012-03-415349. Epub 2012 Sep 13.


CD45-deficient severe combined immunodeficiency caused by uniparental disomy.

Roberts JL, Buckley RH, Luo B, Pei J, Lapidus A, Peri S, Wei Q, Shin J, Parrott RE, Dunbrack RL Jr, Testa JR, Zhong XP, Wiest DL.

Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10456-61. doi: 10.1073/pnas.1202249109. Epub 2012 Jun 11.


Tcra enhancer activation by inducible transcription factors downstream of pre-TCR signaling.

del Blanco B, García-Mariscal A, Wiest DL, Hernández-Munain C.

J Immunol. 2012 Apr 1;188(7):3278-93. doi: 10.4049/jimmunol.1100271. Epub 2012 Feb 22.


Developmental arrest of T cells in Rpl22-deficient mice is dependent upon multiple p53 effectors.

Stadanlick JE, Zhang Z, Lee SY, Hemann M, Biery M, Carleton MO, Zambetti GP, Anderson SJ, Oravecz T, Wiest DL.

J Immunol. 2011 Jul 15;187(2):664-75. doi: 10.4049/jimmunol.1100029. Epub 2011 Jun 20.


Cutting edge: Intrinsic programming of thymic γδT cells for specific peripheral tissue localization.

Jin Y, Xia M, Saylor CM, Narayan K, Kang J, Wiest DL, Wang Y, Xiong N.

J Immunol. 2010 Dec 15;185(12):7156-60. doi: 10.4049/jimmunol.1002781. Epub 2010 Nov 10.


Appl1 is dispensable for Akt signaling in vivo and mouse T-cell development.

Tan Y, You H, Coffey FJ, Wiest DL, Testa JR.

Genesis. 2010 Sep;48(9):531-9. doi: 10.1002/dvg.20657.


Differential roles of IL-2-inducible T cell kinase-mediated TCR signals in tissue-specific localization and maintenance of skin intraepithelial T cells.

Xia M, Qi Q, Jin Y, Wiest DL, August A, Xiong N.

J Immunol. 2010 Jun 15;184(12):6807-14. doi: 10.4049/jimmunol.1000453. Epub 2010 May 17.


Origins of gammadeltaT cells: a forum for opposing perspectives.

Wiest DL.

Semin Immunol. 2010 Aug;22(4):191-2. doi: 10.1016/j.smim.2010.04.009. Epub 2010 May 14. No abstract available.


Towards a molecular understanding of the differential signals regulating alphabeta/gammadelta T lineage choice.

Lee SY, Stadanlick J, Kappes DJ, Wiest DL.

Semin Immunol. 2010 Aug;22(4):237-46. doi: 10.1016/j.smim.2010.04.008. Epub 2010 May 14. Review.


Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functional maturation Notch independent.

Lauritsen JP, Wong GW, Lee SY, Lefebvre JM, Ciofani M, Rhodes M, Kappes DJ, Zúñiga-Pflücker JC, Wiest DL.

Immunity. 2009 Oct 16;31(4):565-75. doi: 10.1016/j.immuni.2009.07.010.


Recurrent chromosomal rearrangements implicate oncogenes contributing to T-cell lymphomagenesis in Lck-MyrAkt2 transgenic mice.

Timakhov RA, Tan Y, Rao M, Liu Z, Altomare DA, Pei J, Wiest DL, Favorova OO, Knepper JE, Testa JR.

Genes Chromosomes Cancer. 2009 Sep;48(9):786-94. doi: 10.1002/gcc.20683.


Identification of the last cog in a ligand-independent signaling machine?

Wiest DL.

J Immunol. 2009 May 1;182(9):5163-4. doi: 10.4049/jimmunol.0990028. No abstract available.


Disruption of Supv3L1 damages the skin and causes sarcopenia, loss of fat, and death.

Paul E, Cronan R, Weston PJ, Boekelheide K, Sedivy JM, Lee SY, Wiest DL, Resnick MB, Klysik JE.

Mamm Genome. 2009 Feb;20(2):92-108. doi: 10.1007/s00335-008-9168-z. Epub 2009 Jan 15.


Sustained expression of pre-TCR induced beta-catenin in post-beta-selection thymocytes blocks T cell development.

Xu M, Sharma A, Hossain MZ, Wiest DL, Sen JM.

J Immunol. 2009 Jan 15;182(2):759-65.


Pre-TCR-induced beta-catenin facilitates traversal through beta-selection.

Xu M, Sharma A, Wiest DL, Sen JM.

J Immunol. 2009 Jan 15;182(2):751-8.

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