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Items: 1 to 50 of 94

1.

Respiratory chain inactivation links cartilage-mediated growth retardation to mitochondrial diseases.

Holzer T, Probst K, Etich J, Auler M, Georgieva VS, Bluhm B, Frie C, Heilig J, Niehoff A, Nüchel J, Plomann M, Seeger JM, Kashkar H, Baris OR, Wiesner RJ, Brachvogel B.

J Cell Biol. 2019 May 13. pii: jcb.201809056. doi: 10.1083/jcb.201809056. [Epub ahead of print]

PMID:
31085560
2.

MRPS25 mutations impair mitochondrial translation and cause encephalomyopathy.

Bugiardini E, Mitchell AL, Rosa ID, Horning-Do HT, Pitmann A, Poole OV, Holton JL, Shah S, Woodward C, Hargreaves I, Quinlivan R, Amunts A, Wiesner RJ, Houlden H, Holt IJ, Hanna MG, Pitceathly RDS, Spinazzola A.

Hum Mol Genet. 2019 Apr 30. pii: ddz093. doi: 10.1093/hmg/ddz093. [Epub ahead of print]

PMID:
31039582
3.

Fasting-Induced Transcription Factors Repress Vitamin D Bioactivation, a Mechanism for Vitamin D Deficiency in Diabetes.

Aatsinki SM, Elkhwanky MS, Kummu O, Karpale M, Buler M, Viitala P, Rinne V, Mutikainen M, Tavi P, Franko A, Wiesner RJ, Chambers KT, Finck BN, Hakkola J.

Diabetes. 2019 May;68(5):918-931. doi: 10.2337/db18-1050. Epub 2019 Mar 4.

PMID:
30833469
4.

Augmented contractility of murine femoral arteries in a streptozotocin diabetes model is related to increased phosphorylation of MYPT1.

Lubomirov LT, Gagov H, Schroeter MM, Wiesner RJ, Franko A.

Physiol Rep. 2019 Feb;7(3):e13975. doi: 10.14814/phy2.13975.

5.

Imbalance of Mitochondrial Respiratory Chain Complexes in the Epidermis Induces Severe Skin Inflammation.

Weiland D, Brachvogel B, Hornig-Do HT, Neuhaus JFG, Holzer T, Tobin DJ, Niessen CM, Wiesner RJ, Baris OR.

J Invest Dermatol. 2018 Jan;138(1):132-140. doi: 10.1016/j.jid.2017.08.019. Epub 2017 Sep 1.

6.

Aging-related mitochondrial dysfunction facilitates the occurrence of serious arrhythmia after myocardial infarction.

Stöckigt F, Beiert T, Knappe V, Baris OR, Wiesner RJ, Clemen CS, Nickenig G, Andrié RP, Schrickel JW.

Biochem Biophys Res Commun. 2017 Nov 4;493(1):604-610. doi: 10.1016/j.bbrc.2017.08.145. Epub 2017 Sep 1.

PMID:
28867191
7.

Metformin causes a futile intestinal-hepatic cycle which increases energy expenditure and slows down development of a type 2 diabetes-like state.

Schommers P, Thurau A, Bultmann-Mellin I, Guschlbauer M, Klatt AR, Rozman J, Klingenspor M, de Angelis MH, Alber J, Gründemann D, Sterner-Kock A, Wiesner RJ.

Mol Metab. 2017 May 5;6(7):737-747. doi: 10.1016/j.molmet.2017.05.002. eCollection 2017 Jul.

8.

Impaired Insulin Signaling is Associated with Hepatic Mitochondrial Dysfunction in IR+/--IRS-1+/- Double Heterozygous (IR-IRS1dh) Mice.

Franko A, Kunze A, Böse M, von Kleist-Retzow JC, Paulsson M, Hartmann U, Wiesner RJ.

Int J Mol Sci. 2017 May 30;18(6). pii: E1156. doi: 10.3390/ijms18061156.

9.

Catecholamine Metabolism Induces Mitochondrial DNA Deletions and Leads to Severe Adrenal Degeneration during Aging.

Neuhaus JF, Baris OR, Kittelmann A, Becker K, Rothschild MA, Wiesner RJ.

Neuroendocrinology. 2017;104(1):72-84. Epub 2016 Feb 20.

PMID:
26895241
10.

CLPP coordinates mitoribosomal assembly through the regulation of ERAL1 levels.

Szczepanowska K, Maiti P, Kukat A, Hofsetz E, Nolte H, Senft K, Becker C, Ruzzenente B, Hornig-Do HT, Wibom R, Wiesner RJ, Krüger M, Trifunovic A.

EMBO J. 2016 Dec 1;35(23):2566-2583. Epub 2016 Oct 20.

11.

FGF21 is a biomarker for mitochondrial translation and mtDNA maintenance disorders.

Lehtonen JM, Forsström S, Bottani E, Viscomi C, Baris OR, Isoniemi H, Höckerstedt K, Österlund P, Hurme M, Jylhävä J, Leppä S, Markkula R, Heliö T, Mombelli G, Uusimaa J, Laaksonen R, Laaksovirta H, Auranen M, Zeviani M, Smeitink J, Wiesner RJ, Nakada K, Isohanni P, Suomalainen A.

Neurology. 2016 Nov 29;87(22):2290-2299. Epub 2016 Oct 28.

12.

Bezafibrate Improves Insulin Sensitivity and Metabolic Flexibility in STZ-Induced Diabetic Mice.

Franko A, Huypens P, Neschen S, Irmler M, Rozman J, Rathkolb B, Neff F, Prehn C, Dubois G, Baumann M, Massinger R, Gradinger D, Przemeck GK, Repp B, Aichler M, Feuchtinger A, Schommers P, Stöhr O, Sanchez-Lasheras C, Adamski J, Peter A, Prokisch H, Beckers J, Walch AK, Fuchs H, Wolf E, Schubert M, Wiesner RJ, Hrabě de Angelis M.

Diabetes. 2016 Sep;65(9):2540-52. doi: 10.2337/db15-1670. Epub 2016 Jun 9.

13.

Correction: A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity.

Kumar V, Bouameur JE, Bär J, Rice RH, Hornig-Do HT, Roop DR, Schwarz N, Brodesser S, Thiering S, Leube RE, Wiesner RJ, Vijayaraj P, Brazel CB, Heller S, Binder H, Löffler-Wirth H, Seibel P, Magin TM.

J Cell Biol. 2016 Mar 28;212(7):877. doi: 10.1083/jcb.20140414703042016c. Epub 2016 Mar 21. No abstract available.

14.

A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity.

Kumar V, Bouameur JE, Bär J, Rice RH, Hornig-Do HT, Roop DR, Schwarz N, Brodesser S, Thiering S, Leube RE, Wiesner RJ, Vijayaraj P, Brazel CB, Heller S, Binder H, Löffler-Wirth H, Seibel P, Magin TM.

J Cell Biol. 2015 Dec 7;211(5):1057-75. doi: 10.1083/jcb.201404147. Erratum in: J Cell Biol. 2016 Mar 28;212(7):877.

15.

High glucose uptake unexpectedly is accompanied by high levels of the mitochondrial ß-F1-ATPase subunit in head and neck squamous cell carcinoma.

Huebbers CU, Adam AC, Preuss SF, Schiffer T, Schilder S, Guntinas-Lichius O, Schmidt M, Klussmann JP, Wiesner RJ.

Oncotarget. 2015 Nov 3;6(34):36172-84. doi: 10.18632/oncotarget.5459.

16.

Mosaic Deficiency in Mitochondrial Oxidative Metabolism Promotes Cardiac Arrhythmia during Aging.

Baris OR, Ederer S, Neuhaus JF, von Kleist-Retzow JC, Wunderlich CM, Pal M, Wunderlich FT, Peeva V, Zsurka G, Kunz WS, Hickethier T, Bunck AC, Stöckigt F, Schrickel JW, Wiesner RJ.

Cell Metab. 2015 May 5;21(5):667-77. doi: 10.1016/j.cmet.2015.04.005.

17.

Cytochrome c oxidase deficiency accelerates mitochondrial apoptosis by activating ceramide synthase 6.

Schüll S, Günther SD, Brodesser S, Seeger JM, Tosetti B, Wiegmann K, Pongratz C, Diaz F, Witt A, Andree M, Brinkmann K, Krönke M, Wiesner RJ, Kashkar H.

Cell Death Dis. 2015 Mar 12;6:e1691. doi: 10.1038/cddis.2015.62.

18.

Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure.

Ising C, Koehler S, Brähler S, Merkwirth C, Höhne M, Baris OR, Hagmann H, Kann M, Fabretti F, Dafinger C, Bloch W, Schermer B, Linkermann A, Brüning JC, Kurschat CE, Müller RU, Wiesner RJ, Langer T, Benzing T, Brinkkoetter PT.

EMBO Mol Med. 2015 Mar;7(3):275-87. doi: 10.15252/emmm.201404916.

19.

Mitochondrial function in murine skin epithelium is crucial for hair follicle morphogenesis and epithelial-mesenchymal interactions.

Kloepper JE, Baris OR, Reuter K, Kobayashi K, Weiland D, Vidali S, Tobin DJ, Niemann C, Wiesner RJ, Paus R.

J Invest Dermatol. 2015 Mar;135(3):679-689. doi: 10.1038/jid.2014.475. Epub 2014 Nov 5.

20.

Methionine restriction slows down senescence in human diploid fibroblasts.

Kozieł R, Ruckenstuhl C, Albertini E, Neuhaus M, Netzberger C, Bust M, Madeo F, Wiesner RJ, Jansen-Dürr P.

Aging Cell. 2014 Dec;13(6):1038-48. doi: 10.1111/acel.12266. Epub 2014 Oct 1.

21.

Embelin inhibits endothelial mitochondrial respiration and impairs neoangiogenesis during tumor growth and wound healing.

Coutelle O, Hornig-Do HT, Witt A, Andree M, Schiffmann LM, Piekarek M, Brinkmann K, Seeger JM, Liwschitz M, Miwa S, Hallek M, Krönke M, Trifunovic A, Eming SA, Wiesner RJ, Hacker UT, Kashkar H.

EMBO Mol Med. 2014 May;6(5):624-39. doi: 10.1002/emmm.201303016.

22.

Efficient isolation of pure and functional mitochondria from mouse tissues using automated tissue disruption and enrichment with anti-TOM22 magnetic beads.

Franko A, Baris OR, Bergschneider E, von Toerne C, Hauck SM, Aichler M, Walch AK, Wurst W, Wiesner RJ, Johnston IC, de Angelis MH.

PLoS One. 2013 Dec 12;8(12):e82392. doi: 10.1371/journal.pone.0082392. eCollection 2013.

23.

Liver adapts mitochondrial function to insulin resistant and diabetic states in mice.

Franko A, von Kleist-Retzow JC, Neschen S, Wu M, Schommers P, Böse M, Kunze A, Hartmann U, Sanchez-Lasheras C, Stoehr O, Huntgeburth M, Brodesser S, Irmler M, Beckers J, de Angelis MH, Paulsson M, Schubert M, Wiesner RJ.

J Hepatol. 2014 Apr;60(4):816-23. doi: 10.1016/j.jhep.2013.11.020. Epub 2013 Nov 28.

PMID:
24291365
24.

Lifelong obesity in a polygenic mouse model prevents age- and diet-induced glucose intolerance- obesity is no road to late-onset diabetes in mice.

Renne U, Langhammer M, Brenmoehl J, Walz C, Zeissler A, Tuchscherer A, Piechotta M, Wiesner RJ, Bielohuby M, Hoeflich A.

PLoS One. 2013 Nov 13;8(11):e79788. doi: 10.1371/journal.pone.0079788. eCollection 2013.

25.

It's all in the brain-2 neurons mediate increased life span upon various stressors in C. elegans.

Wiesner RJ.

Mol Metab. 2013 Mar 14;2(2):62. doi: 10.1016/j.molmet.2013.02.004. eCollection 2013. No abstract available.

26.

Catecholamine metabolism drives generation of mitochondrial DNA deletions in dopaminergic neurons.

Neuhaus JF, Baris OR, Hess S, Moser N, Schröder H, Chinta SJ, Andersen JK, Kloppenburg P, Wiesner RJ.

Brain. 2014 Feb;137(Pt 2):354-65. doi: 10.1093/brain/awt291. Epub 2013 Oct 24.

PMID:
24163249
27.

Negative regulation of mitochondrial transcription by mitochondrial topoisomerase I.

Sobek S, Dalla Rosa I, Pommier Y, Bornholz B, Kalfalah F, Zhang H, Wiesner RJ, von Kleist-Retzow JC, Hillebrand F, Schaal H, Mielke C, Christensen MO, Boege F.

Nucleic Acids Res. 2013 Nov;41(21):9848-57. doi: 10.1093/nar/gkt768. Epub 2013 Aug 27.

28.

Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission.

Freyer C, Cree LM, Mourier A, Stewart JB, Koolmeister C, Milenkovic D, Wai T, Floros VI, Hagström E, Chatzidaki EE, Wiesner RJ, Samuels DC, Larsson NG, Chinnery PF.

Nat Genet. 2012 Nov;44(11):1282-5. doi: 10.1038/ng.2427. Epub 2012 Oct 7.

29.

Complete failure of insulin-transmitted signaling, but not obesity-induced insulin resistance, impairs respiratory chain function in muscle.

Franko A, von Kleist-Retzow JC, Böse M, Sanchez-Lasheras C, Brodesser S, Krut O, Kunz WS, Wiedermann D, Hoehn M, Stöhr O, Moll L, Freude S, Krone W, Schubert M, Wiesner RJ.

J Mol Med (Berl). 2012 Oct;90(10):1145-60. doi: 10.1007/s00109-012-0887-y. Epub 2012 Mar 13.

PMID:
22411022
30.

Nonsense mutations in the COX1 subunit impair the stability of respiratory chain complexes rather than their assembly.

Hornig-Do HT, Tatsuta T, Buckermann A, Bust M, Kollberg G, Rötig A, Hellmich M, Nijtmans L, Wiesner RJ.

EMBO J. 2012 Mar 7;31(5):1293-307. doi: 10.1038/emboj.2011.477. Epub 2012 Jan 17.

31.

Central FoxO3a and FoxO6 expression is down-regulated in obesity induced diabetes but not in aging.

Zemva J, Schilbach K, Stöhr O, Moll L, Franko A, Krone W, Wiesner RJ, Schubert M.

Exp Clin Endocrinol Diabetes. 2012 Jun;120(6):340-50. doi: 10.1055/s-0031-1297970. Epub 2011 Dec 20.

PMID:
22187289
32.

The mitochondrial electron transport chain is dispensable for proliferation and differentiation of epidermal progenitor cells.

Baris OR, Klose A, Kloepper JE, Weiland D, Neuhaus JF, Schauen M, Wille A, Müller A, Merkwirth C, Langer T, Larsson NG, Krieg T, Tobin DJ, Paus R, Wiesner RJ.

Stem Cells. 2011 Sep;29(9):1459-68. doi: 10.1002/stem.695.

33.

The Ras related GTPase Miro is not required for mitochondrial transport in Dictyostelium discoideum.

Vlahou G, Eliáš M, von Kleist-Retzow JC, Wiesner RJ, Rivero F.

Eur J Cell Biol. 2011 Apr;90(4):342-55. doi: 10.1016/j.ejcb.2010.10.012. Epub 2010 Dec 4.

PMID:
21131095
34.

Thyrotropin powers human mitochondria.

Poeggeler B, Knuever J, Gáspár E, Bíró T, Klinger M, Bodó E, Wiesner RJ, Wenzel BE, Paus R.

FASEB J. 2010 May;24(5):1525-31. doi: 10.1096/fj.09-147728. Epub 2010 Jan 14.

PMID:
20075194
35.

Isolation of functional pure mitochondria by superparamagnetic microbeads.

Hornig-Do HT, Günther G, Bust M, Lehnartz P, Bosio A, Wiesner RJ.

Anal Biochem. 2009 Jun 1;389(1):1-5. doi: 10.1016/j.ab.2009.02.040. Epub 2009 Mar 11.

PMID:
19285029
36.

Clonal expansion of different mtDNA variants without selective advantage in solid tumors.

Gekeler J, Zsurka G, Kunz WS, Preuss SF, Klussmann JP, Guntinas-Lichius O, Wiesner RJ.

Mutat Res. 2009 Mar 9;662(1-2):28-32. doi: 10.1016/j.mrfmmm.2008.11.020. Epub 2008 Dec 9.

PMID:
19114048
37.

Concerted action of two novel tRNA mtDNA point mutations in chronic progressive external ophthalmoplegia.

Kornblum C, Zsurka G, Wiesner RJ, Schröder R, Kunz WS.

Biosci Rep. 2008 Apr;28(2):89-96. doi: 10.1042/BSR20080004.

PMID:
18384291
38.

CREB-1alpha is recruited to and mediates upregulation of the cytochrome c promoter during enhanced mitochondrial biogenesis accompanying skeletal muscle differentiation.

Franko A, Mayer S, Thiel G, Mercy L, Arnould T, Hornig-Do HT, Wiesner RJ, Goffart S.

Mol Cell Biol. 2008 Apr;28(7):2446-59. doi: 10.1128/MCB.00980-07. Epub 2008 Jan 28.

39.

Impaired mitochondrial Ca2+ homeostasis in respiratory chain-deficient cells but efficient compensation of energetic disadvantage by enhanced anaerobic glycolysis due to low ATP steady state levels.

von Kleist-Retzow JC, Hornig-Do HT, Schauen M, Eckertz S, Dinh TA, Stassen F, Lottmann N, Bust M, Galunska B, Wielckens K, Hein W, Beuth J, Braun JM, Fischer JH, Ganitkevich VY, Maniura-Weber K, Wiesner RJ.

Exp Cell Res. 2007 Aug 15;313(14):3076-89. Epub 2007 Apr 19.

PMID:
17509565
40.

Mitochondrial electron transport chain activity is not involved in ultraviolet A (UVA)-induced cell death.

Schauen M, Hornig-Do HT, Schomberg S, Herrmann G, Wiesner RJ.

Free Radic Biol Med. 2007 Feb 15;42(4):499-509. Epub 2006 Nov 17.

PMID:
17275682
41.

Human epidermal keratinocytes accumulate superoxide due to low activity of Mn-SOD, leading to mitochondrial functional impairment.

Hornig-Do HT, von Kleist-Retzow JC, Lanz K, Wickenhauser C, Kudin AP, Kunz WS, Wiesner RJ, Schauen M.

J Invest Dermatol. 2007 May;127(5):1084-93. Epub 2006 Dec 21.

42.

Molecular dysfunction associated with the human mitochondrial 3302A>G mutation in the MTTL1 (mt-tRNALeu(UUR)) gene.

Maniura-Weber K, Helm M, Engemann K, Eckertz S, Möllers M, Schauen M, Hayrapetyan A, von Kleist-Retzow JC, Lightowlers RN, Bindoff LA, Wiesner RJ.

Nucleic Acids Res. 2006;34(22):6404-15. Epub 2006 Nov 27.

43.

Mitochondrial DNA damage and the aging process: facts and imaginations.

Wiesner RJ, Zsurka G, Kunz WS.

Free Radic Res. 2006 Dec;40(12):1284-94. Review.

PMID:
17090418
44.

Increased Ca2+ sensitivity and protein expression of SERCA 2a in situations of chronic beta3-adrenoceptor deficiency.

Ziskoven C, Grafweg S, Bölck B, Wiesner RJ, Jimenez M, Giacobino JP, Bloch W, Schwinger RH, Brixius K.

Pflugers Arch. 2007 Jan;453(4):443-53. Epub 2006 Sep 22.

PMID:
17021799
45.

Respiratory chain deficiency slows down cell-cycle progression via reduced ROS generation and is associated with a reduction of p21CIP1/WAF1.

Schauen M, Spitkovsky D, Schubert J, Fischer JH, Hayashi J, Wiesner RJ.

J Cell Physiol. 2006 Oct;209(1):103-12.

PMID:
16775840
46.

Alpha-actinin 4 and BAT1 interaction with the cytochrome c promoter upon skeletal muscle differentiation.

Goffart S, Franko A, Clemen CS, Wiesner RJ.

Curr Genet. 2006 Feb;49(2):125-35. Epub 2005 Dec 6.

PMID:
16331456
47.

Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice.

Thierbach R, Schulz TJ, Isken F, Voigt A, Mietzner B, Drewes G, von Kleist-Retzow JC, Wiesner RJ, Magnuson MA, Puccio H, Pfeiffer AF, Steinberg P, Ristow M.

Hum Mol Genet. 2005 Dec 15;14(24):3857-64. Epub 2005 Nov 8. Erratum in: Hum Mol Genet. 2007 Dec 1;16(23):2987.

PMID:
16278235
48.

A new mechanism for mtDNA pathogenesis: impairment of post-transcriptional maturation leads to severe depletion of mitochondrial tRNASer(UCN) caused by T7512C and G7497A point mutations.

Möllers M, Maniura-Weber K, Kiseljakovic E, Bust M, Hayrapetyan A, Jaksch M, Helm M, Wiesner RJ, von Kleist-Retzow JC.

Nucleic Acids Res. 2005 Sep 30;33(17):5647-58. Print 2005.

49.

Tissue dependent co-segregation of the novel pathogenic G12276A mitochondrial tRNALeu(CUN) mutation with the A185G D-loop polymorphism.

Zsurka G, Schröder R, Kornblum C, Rudolph J, Wiesner RJ, Elger CE, Kunz WS.

J Med Genet. 2004 Dec;41(12):e124. No abstract available.

50.

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