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In vitro efficacies, ADME, and pharmacokinetic properties of phenoxazine derivatives active against Mycobacterium tuberculosis.

Tanner L, Evans JC, Seldon R, Jordaan A, Warner DF, Haynes RK, Parkinson CJ, Wiesner L.

Antimicrob Agents Chemother. 2019 Aug 19. pii: AAC.01010-19. doi: 10.1128/AAC.01010-19. [Epub ahead of print]


Is an obesity simulation suit in an undergraduate medical communication class a valuable teaching tool? A cross-sectional proof of concept study.

Herrmann-Werner A, Loda T, Wiesner LM, Erschens RS, Junne F, Zipfel S.

BMJ Open. 2019 Aug 5;9(8):e029738. doi: 10.1136/bmjopen-2019-029738.


Nonvascularized human skin chronic allograft rejection.

Rotman S, Koch N, Wiesner L, Aubert V, Rosales IA, Colvin RB, Raffoul W, Pascual M.

Am J Transplant. 2019 Jul 25. doi: 10.1111/ajt.15542. [Epub ahead of print]


Effect of first-line antituberculosis therapy on nevirapine pharmacokinetics in children younger than 3 years old.

Enimil A, Antwi S, Yang H, Dompreh A, Alghamdi WA, Gillani FS, Orstin A, Bosomtwe D, Opoku T, Norman J, Wiesner L, Langaee T, Peloquin CA, Court MH, Greenblatt DJ, Kwara A.

Antimicrob Agents Chemother. 2019 Jul 22. pii: AAC.00839-19. doi: 10.1128/AAC.00839-19. [Epub ahead of print]


Population pharmacokinetics of efavirenz in HIV and TB/HIV coinfected children: the significance of genotype-guided dosing.

Alghamdi WA, Antwi S, Enimil A, Yang H, Dompreh A, Wiesner L, Langaee T, Peloquin CA, Kwara A.

J Antimicrob Chemother. 2019 Sep 1;74(9):2698-2706. doi: 10.1093/jac/dkz238.


Ferroquine-derived polyamines that target resistant Plasmodium falciparum.

Stringer T, Wiesner L, Smith GS.

Eur J Med Chem. 2019 Oct 1;179:78-83. doi: 10.1016/j.ejmech.2019.06.023. Epub 2019 Jun 8.


Safety and tolerability of single low-dose primaquine in a low-intensity transmission area in South Africa: an open-label, randomized controlled trial.

Raman J, Allen E, Workman L, Mabuza A, Swanepoel H, Malatje G, Frean J, Wiesner L, Barnes KI.

Malar J. 2019 Jun 24;18(1):209. doi: 10.1186/s12936-019-2841-8.


Low-dose ritonavir-boosted darunavir once daily versus ritonavir-boosted lopinavir for participants with less than 50 HIV RNA copies per mL (WRHI 052): a randomised, open-label, phase 3, non-inferiority trial.

Venter WDF, Moorhouse M, Sokhela S, Serenata C, Akpomiemie G, Qavi A, Mashabane N, Arulappan N, Sim JW, Sinxadi PZ, Wiesner L, Maharaj E, Wallis C, Boyles T, Ripin D, Stacey S, Chitauri G, Hill A.

Lancet HIV. 2019 Jul;6(7):e428-e437. doi: 10.1016/S2352-3018(19)30081-5. Epub 2019 Jun 12.


Severe Acute Malnutrition Results in Lower Lumefantrine Exposure in Children Treated With Artemether-Lumefantrine for Uncomplicated Malaria.

Chotsiri P, Denoeud-Ndam L, Baudin E, Guindo O, Diawara H, Attaher O, Smit M, Guerin PJ, Doumbo OK, Wiesner L, Barnes KI, Hoglund RM, Dicko A, Etard JF, Tarning J.

Clin Pharmacol Ther. 2019 Jun 1. doi: 10.1002/cpt.1531. [Epub ahead of print]


Population pharmacokinetics of abacavir and lamivudine in severely malnourished human immunodeficiency virus-infected children in relation to treatment outcomes.

Archary M, Mcllleron H, Bobat R, LaRussa P, Sibaya T, Wiesner L, Hennig S.

Br J Clin Pharmacol. 2019 Sep;85(9):2066-2075. doi: 10.1111/bcp.13998. Epub 2019 Jul 7.


Pharmacokinetics of adjusted-dose 8-hourly lopinavir/ritonavir in HIV-infected children co-treated with rifampicin.

Rabie H, Rawizza H, Zuidewind P, Winckler J, Zar H, Van Rie A, Wiesner L, McIlleron H.

J Antimicrob Chemother. 2019 Aug 1;74(8):2347-2351. doi: 10.1093/jac/dkz171.


Correlation of hair and plasma efavirenz concentrations in HIV-positive South Africans.

Johnston J, Wiesner L, Smith P, Maartens G, Orrell C.

South Afr J HIV Med. 2019 Apr 29;20(1):881. doi: 10.4102/sajhivmed.v20i1.881. eCollection 2019.


Pharmacokinetics, optimal dosing, and safety of linezolid in children with multidrug-resistant tuberculosis: Combined data from two prospective observational studies.

Garcia-Prats AJ, Schaaf HS, Draper HR, Garcia-Cremades M, Winckler J, Wiesner L, Hesseling AC, Savic RM.

PLoS Med. 2019 Apr 30;16(4):e1002789. doi: 10.1371/journal.pmed.1002789. eCollection 2019 Apr.


Detectable prednisolone is delayed in pericardial fluid, compared with plasma of patients with tuberculous pericarditis: A pilot study.

Shenje J, Gumbo T, Wiesner L, Ntsekhe M, Mayosi B, Ross I.

Int J Cardiol Heart Vasc. 2019 Jan 11;22:105-110. doi: 10.1016/j.ijcha.2018.12.008. eCollection 2019 Mar.


Discovery of "false Elite Controllers": HIV antibody-positive RNA-negative blood donors found to be on antiretroviral treatment.

Sykes W, van den Berg K, Jacobs G, Jauregui A, Roubinian N, Wiesner L, Maartens G, Swanevelder R, Custer B, Busch M, Jentsch U, Murphy EL, Vermeulen M; NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III).

J Infect Dis. 2019 Apr 5. pii: jiz145. doi: 10.1093/infdis/jiz145. [Epub ahead of print]


A Comparison of Plasma Efavirenz and Tenofovir, Dried Blood Spot Tenofovir-Diphosphate, and Self-Reported Adherence to Predict Virologic Suppression Among South African Women.

Phillips TK, Sinxadi P, Abrams EJ, Zerbe A, Orrell C, Hu NC, Brittain K, Gomba Y, Norman J, Wiesner L, Myer L, Maartens G.

J Acquir Immune Defic Syndr. 2019 Jul 1;81(3):311-318. doi: 10.1097/QAI.0000000000002032.


An in vitro ADME and in vivo Pharmacokinetic Study of Novel TB-Active Decoquinate Derivatives.

Tanner L, Haynes RK, Wiesner L.

Front Pharmacol. 2019 Feb 18;10:120. doi: 10.3389/fphar.2019.00120. eCollection 2019.


The palladacycle complex AJ-5 induces apoptotic cell death while reducing autophagic flux in rhabdomyosarcoma cells.

Bleloch JS, du Toit A, Gibhard L, Kimani S, Ballim RD, Lee M, Blanckenberg A, Mapolie S, Wiesner L, Loos B, Prince S.

Cell Death Discov. 2019 Jan 28;5:60. doi: 10.1038/s41420-019-0139-9. eCollection 2019.


A Population Pharmacokinetic Analysis Shows that Arylacetamide Deacetylase (AADAC) Gene Polymorphism and HIV Infection Affect the Exposure of Rifapentine.

Francis J, Zvada SP, Denti P, Hatherill M, Charalambous S, Mungofa S, Dawson R, Dorman S, Gupte N, Wiesner L, Jindani A, Harrison TS, Olagunju A, Egan D, Owen A, McIlleron HM.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e01964-18. doi: 10.1128/AAC.01964-18. Print 2019 Apr.


Pharmacokinetics, Safety, and Dosing of Novel Pediatric Levofloxacin Dispersible Tablets in Children with Multidrug-Resistant Tuberculosis Exposure.

Garcia-Prats AJ, Purchase SE, Osman M, Draper HR, Schaaf HS, Wiesner L, Denti P, Hesseling AC.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e01865-18. doi: 10.1128/AAC.01865-18. Print 2019 Apr.


Linezolid Pharmacokinetics in South African Patients with Drug-Resistant Tuberculosis and a High Prevalence of HIV Coinfection.

Wasserman S, Denti P, Brust JCM, Abdelwahab M, Hlungulu S, Wiesner L, Norman J, Sirgel FA, Warren RM, Esmail A, Dheda K, Gandhi NR, Meintjes G, Maartens G.

Antimicrob Agents Chemother. 2019 Feb 26;63(3). pii: e02164-18. doi: 10.1128/AAC.02164-18. Print 2019 Mar.


Simple Synthesis of Elastomeric Photomechanical Switches That Self-Heal.

Li S, Tu Y, Bai H, Hibi Y, Wiesner LW, Pan W, Wang K, Giannelis EP, Shepherd RF.

Macromol Rapid Commun. 2019 Feb;40(4):e1800815. doi: 10.1002/marc.201800815. Epub 2019 Jan 2.


ART Denial: Results of a Home-Based Study to Validate Self-reported Antiretroviral Use in Rural South Africa.

Manne-Goehler J, Rohr J, Montana L, Siedner M, Harling G, Gómez-Olivé FX, Geldsetzer P, Wagner R, Wiesner L, Kahn K, Tollman S, Bärnighausen TW.

AIDS Behav. 2019 Aug;23(8):2072-2078. doi: 10.1007/s10461-018-2351-7.


Pharmacogenetics and pharmacokinetics of CNS penetration of efavirenz and its metabolites.

Decloedt EH, Sinxadi PZ, van Zyl GU, Wiesner L, Khoo S, Joska JA, Haas DW, Maartens G.

J Antimicrob Chemother. 2019 Mar 1;74(3):699-709. doi: 10.1093/jac/dky481.


Evaluation of PTA-derived ruthenium(II) and iridium(III) quinoline complexes against chloroquine-sensitive and resistant strains of the Plasmodium falciparum malaria parasite.

Stringer T, Quintero MAS, Wiesner L, Smith GS, Nordlander E.

J Inorg Biochem. 2019 Feb;191:164-173. doi: 10.1016/j.jinorgbio.2018.11.018. Epub 2018 Nov 27.


"A change would do you good": Training medical students in Motivational Interviewing using a blended-learning approach - A pilot evaluation.

Keifenheim KE, Velten-Schurian K, Fahse B, Erschens R, Loda T, Wiesner L, Zipfel S, Herrmann-Werner A.

Patient Educ Couns. 2019 Apr;102(4):663-669. doi: 10.1016/j.pec.2018.10.027. Epub 2018 Nov 1.


Effect of Rifampin-Isoniazid-Containing Antituberculosis Therapy on Efavirenz Pharmacokinetics in HIV-Infected Children 3 to 14 Years Old.

Kwara A, Yang H, Antwi S, Enimil A, Gillani FS, Dompreh A, Ortsin A, Opoku T, Bosomtwe D, Sarfo A, Wiesner L, Norman J, Alghamdi WA, Langaee T, Peloquin CA, Court MH, Greenblatt DJ.

Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01657-18. doi: 10.1128/AAC.01657-18. Print 2019 Jan.


Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria".

Brunschwig C, Lawrence N, Taylor D, Abay E, Njoroge M, Basarab GS, Le Manach C, Paquet T, Gonzàlez Cabrera D, Nchinda AT, de Kock C, Wiesner L, Denti P, Waterson D, Blasco B, Leroy D, Witty MJ, Donini C, Duffy J, Wittlin S, White KL, Charman SA, Jiménez-Díaz MB, Angulo-Barturen I, Herreros E, Gamo FJ, Rochford R, Mancama D, Coetzer TL, van der Watt ME, Reader J, Birkholtz LM, Marsh KC, Solapure SM, Burke JE, McPhail JA, Vanaerschot M, Fidock DA, Fish PV, Siegl P, Smith DA, Wirjanata G, Noviyanti R, Price RN, Marfurt J, Silue KD, Street LJ, Chibale K.

Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e01941-18. doi: 10.1128/AAC.01941-18. Print 2018 Nov. No abstract available.


Investigating Sulfoxide-to-Sulfone Conversion as a Prodrug Strategy for a Phosphatidylinositol 4-Kinase Inhibitor in a Humanized Mouse Model of Malaria.

Gibhard L, Njoroge M, Paquet T, Brunschwig C, Taylor D, Lawrence N, Abay E, Wittlin S, Wiesner L, Street LJ, Chibale K, Basarab GS.

Antimicrob Agents Chemother. 2018 Nov 26;62(12). pii: e00261-18. doi: 10.1128/AAC.00261-18. Print 2018 Dec.


Effect of efavirenz-based antiretroviral therapy and high-dose rifampicin on the pharmacokinetics of isoniazid and acetyl-isoniazid.

Chirehwa MT, McIlleron H, Wiesner L, Affolabi D, Bah-Sow O, Merle C, Denti P; RAFA team .

J Antimicrob Chemother. 2019 Jan 1;74(1):139-148. doi: 10.1093/jac/dky378.


Effect of lidocaine on kanamycin injection-site pain in patients with multidrug-resistant tuberculosis.

Court RG, Wiesner L, Chirehwa MT, Stewart A, de Vries N, Harding J, Gumbo T, McIlleron H, Maartens G.

Int J Tuberc Lung Dis. 2018 Aug 1;22(8):926-930. doi: 10.5588/ijtld.18.0091.


Relative bioavailability of bedaquiline tablets suspended in water: Implications for dosing in children.

Svensson EM, du Bois J, Kitshoff R, de Jager VR, Wiesner L, Norman J, Nachman S, Smith B, Diacon AH, Hesseling AC, Garcia-Prats AJ.

Br J Clin Pharmacol. 2018 Jun 27. doi: 10.1111/bcp.13696. [Epub ahead of print]


UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria.

Brunschwig C, Lawrence N, Taylor D, Abay E, Njoroge M, Basarab GS, Le Manach C, Paquet T, Cabrera DG, Nchinda AT, de Kock C, Wiesner L, Denti P, Waterson D, Blasco B, Leroy D, Witty MJ, Donini C, Duffy J, Wittlin S, White KL, Charman SA, Jiménez-Díaz MB, Angulo-Barturen I, Herreros E, Gamo FJ, Rochford R, Mancama D, Coetzer TL, van der Watt ME, Reader J, Birkholtz LM, Marsh KC, Solapure SM, Burke JE, McPhail JA, Vanaerschot M, Fidock DA, Fish PV, Siegl P, Smith DA, Wirjanata G, Noviyanti R, Price RN, Marfurt J, Silue KD, Street LJ, Chibale K.

Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e00012-18. doi: 10.1128/AAC.00012-18. Print 2018 Sep. Erratum in: Antimicrob Agents Chemother. 2018 Oct 24;62(11):.


Drug permeation and metabolism in Mycobacterium tuberculosis: Prioritising local exposure as essential criterion in new TB drug development.

Tanner L, Denti P, Wiesner L, Warner DF.

IUBMB Life. 2018 Sep;70(9):926-937. doi: 10.1002/iub.1866. Epub 2018 Jun 22. Review.


Evaluation of the Adequacy of WHO Revised Dosages of the First-Line Antituberculosis Drugs in Children with Tuberculosis Using Population Pharmacokinetic Modeling and Simulations.

Horita Y, Alsultan A, Kwara A, Antwi S, Enimil A, Ortsin A, Dompreh A, Yang H, Wiesner L, Peloquin CA.

Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e00008-18. doi: 10.1128/AAC.00008-18. Print 2018 Sep.


Artemisone and Artemiside Are Potent Panreactive Antimalarial Agents That Also Synergize Redox Imbalance in Plasmodium falciparum Transmissible Gametocyte Stages.

Coertzen D, Reader J, van der Watt M, Nondaba SH, Gibhard L, Wiesner L, Smith P, D'Alessandro S, Taramelli D, Wong HN, du Preez JL, Wu RWK, Birkholtz LM, Haynes RK.

Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e02214-17. doi: 10.1128/AAC.02214-17. Print 2018 Aug.


The determination of capreomycin in human plasma by LC-MS/MS using ion-pairing chromatography and solid-phase extraction.

Thuboy B, Kellermann T, Castel S, Norman J, Joubert A, Garcia-Prats AJ, Hesseling AC, Wiesner L.

Biomed Chromatogr. 2018 May 3:e4269. doi: 10.1002/bmc.4269. [Epub ahead of print]


The In Vitro and In Vivo Effects of Hypoxis hemerocallidea on Indinavir Pharmacokinetics: Modulation of Efflux.

Havenga K, Abay E, Wiesner L, Viljoen A, Steyn D, Hamman J.

Planta Med. 2018 Aug;84(12-13):895-901. doi: 10.1055/a-0607-2743. Epub 2018 Apr 19.


Quality assurance of rifampicin-containing fixed-drug combinations in South Africa: dosing implications.

Court R, Chirehwa MT, Wiesner L, Wright B, Smythe W, Kramer N, McIlleron H.

Int J Tuberc Lung Dis. 2018 May 1;22(5):537-543. doi: 10.5588/ijtld.17.0697.


Efficacy and safety of artemether-lumefantrine, artesunate-amodiaquine, and dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in three provinces in Angola, 2017.

Davlantes E, Dimbu PR, Ferreira CM, Florinda Joao M, Pode D, Félix J, Sanhangala E, Andrade BN, Dos Santos Souza S, Talundzic E, Udhayakumar V, Owens C, Mbounga E, Wiesner L, Halsey ES, Martins JF, Fortes F, Plucinski MM.

Malar J. 2018 Apr 3;17(1):144. doi: 10.1186/s12936-018-2290-9.


Progress towards the UNAIDS 90-90-90 goals by age and gender in a rural area of KwaZulu-Natal, South Africa: a household-based community cross-sectional survey.

Huerga H, Van Cutsem G, Ben Farhat J, Puren A, Bouhenia M, Wiesner L, Dlamini L, Maman D, Ellman T, Etard JF.

BMC Public Health. 2018 Mar 2;18(1):303. doi: 10.1186/s12889-018-5208-0.


A validated liquid chromatography/tandem mass spectrometry method for the analysis of efavirenz in 0.2 mg hair samples from human immunodeficiency virus infected patients.

Johnston J, Orrell C, Smith P, Joubert A, Wiesner L.

Rapid Commun Mass Spectrom. 2018 Apr 30;32(8):657-664. doi: 10.1002/rcm.8077.


Disaster Training in 24 Hours: Evaluation of a Novel Medical Student Curriculum in Disaster Medicine.

Wiesner L, Kappler S, Shuster A, DeLuca M, Ott J, Glasser E.

J Emerg Med. 2018 Mar;54(3):348-353. doi: 10.1016/j.jemermed.2017.12.008. Epub 2018 Feb 13.


Steady state pharmacokinetics of cycloserine in patients on terizidone for multidrug-resistant tuberculosis.

Court R, Wiesner L, Stewart A, de Vries N, Harding J, Maartens G, Gumbo T, McIlleron H.

Int J Tuberc Lung Dis. 2018 Jan 1;22(1):30-33. doi: 10.5588/ijtld.17.0475.


Population Pharmacokinetics of Lopinavir in Severely Malnourished HIV-infected Children and the Effect on Treatment Outcomes.

Archary M, Mcllleron H, Bobat R, La Russa P, Sibaya T, Wiesner L, Hennig S.

Pediatr Infect Dis J. 2018 Apr;37(4):349-355. doi: 10.1097/INF.0000000000001867.


4-Aminoquinoline Antimalarials Containing a Benzylmethylpyridylmethylamine Group Are Active against Drug Resistant Plasmodium falciparum and Exhibit Oral Activity in Mice.

Joshi MC, Okombo J, Nsumiwa S, Ndove J, Taylor D, Wiesner L, Hunter R, Chibale K, Egan TJ.

J Med Chem. 2017 Dec 28;60(24):10245-10256. doi: 10.1021/acs.jmedchem.7b01537. Epub 2017 Dec 7.


Levofloxacin Population Pharmacokinetics in South African Children Treated for Multidrug-Resistant Tuberculosis.

Denti P, Garcia-Prats AJ, Draper HR, Wiesner L, Winckler J, Thee S, Dooley KE, Savic RM, McIlleron HM, Schaaf HS, Hesseling AC.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e01521-17. doi: 10.1128/AAC.01521-17. Print 2018 Feb.


Pharmacokinetics and Drug-Drug Interactions of Lopinavir-Ritonavir Administered with First- and Second-Line Antituberculosis Drugs in HIV-Infected Children Treated for Multidrug-Resistant Tuberculosis.

van der Laan LE, Garcia-Prats AJ, Schaaf HS, Tikiso T, Wiesner L, de Kock M, Winckler J, Norman J, McIlleron H, Denti P, Hesseling AC.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e00420-17. doi: 10.1128/AAC.00420-17. Print 2018 Feb.


Therapeutic drug monitoring of amlodipine and the Z-FHL/HHL ratio: Adherence tools in patients referred for apparent treatment-resistant hypertension.

Jones ESW, Lesosky M, Blockman M, Castel S, Decloedt EH, Schwager SLU, Sturrock ED, Wiesner L, Rayner BL.

S Afr Med J. 2017 Sep 22;107(10):887-891. doi: 10.7196/SAMJ.2017.v107i10.12268.


Evaluation of the Adequacy of the 2010 Revised World Health Organization Recommended Dosages of the First-line Antituberculosis Drugs for Children: Adequacy of Revised Dosages of TB Drugs for Children.

Yang H, Enimil A, Gillani FS, Antwi S, Dompreh A, Ortsin A, Adu Awhireng E, Owusu M, Wiesner L, Peloquin CA, Kwara A.

Pediatr Infect Dis J. 2018 Jan;37(1):43-51. doi: 10.1097/INF.0000000000001687.

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