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Items: 30


Targeting ALK in pediatric RMS does not induce antitumor activity in vivo.

Wierdl M, Tsurkan L, Chi L, Hatfield MJ, Tollemar V, Bradley C, Chen X, Qu C, Potter PM.

Cancer Chemother Pharmacol. 2018 Aug;82(2):251-263. doi: 10.1007/s00280-018-3615-7. Epub 2018 May 31.


Tumour-selective targeting of drug metabolizing enzymes to treat metastatic cancer.

Wierdl M, Tsurkan L, Hatfield MJ, Potter PM.

Br J Pharmacol. 2016 Oct;173(19):2811-8. doi: 10.1111/bph.13553. Epub 2016 Aug 22. Review.


Carboxylesterases: General detoxifying enzymes.

Hatfield MJ, Umans RA, Hyatt JL, Edwards CC, Wierdl M, Tsurkan L, Taylor MR, Potter PM.

Chem Biol Interact. 2016 Nov 25;259(Pt B):327-331. doi: 10.1016/j.cbi.2016.02.011. Epub 2016 Feb 15. Review.


Targeting oxidative stress in embryonal rhabdomyosarcoma.

Chen X, Stewart E, Shelat AA, Qu C, Bahrami A, Hatley M, Wu G, Bradley C, McEvoy J, Pappo A, Spunt S, Valentine MB, Valentine V, Krafcik F, Lang WH, Wierdl M, Tsurkan L, Tolleman V, Federico SM, Morton C, Lu C, Ding L, Easton J, Rusch M, Nagahawatte P, Wang J, Parker M, Wei L, Hedlund E, Finkelstein D, Edmonson M, Shurtleff S, Boggs K, Mulder H, Yergeau D, Skapek S, Hawkins DS, Ramirez N, Potter PM, Sandoval JA, Davidoff AM, Mardis ER, Wilson RK, Zhang J, Downing JR, Dyer MA; St. Jude Children’s Research Hospital–Washington University Pediatric Cancer Genome Project.

Cancer Cell. 2013 Dec 9;24(6):710-24. doi: 10.1016/j.ccr.2013.11.002.


Global and local molecular dynamics of a bacterial carboxylesterase provide insight into its catalytic mechanism.

Yu X, Sigler SC, Hossain D, Wierdl M, Gwaltney SR, Potter PM, Wadkins RM.

J Mol Model. 2012 Jun;18(6):2869-83. doi: 10.1007/s00894-011-1308-9. Epub 2011 Nov 30.


Nerve agent hydrolysis activity designed into a human drug metabolism enzyme.

Hemmert AC, Otto TC, Chica RA, Wierdl M, Edwards JS, Lewis SM, Edwards CC, Tsurkan L, Cadieux CL, Kasten SA, Cashman JR, Mayo SL, Potter PM, Cerasoli DM, Redinbo MR.

PLoS One. 2011 Mar 18;6(3):e17441. doi: 10.1371/journal.pone.0017441. Erratum in: PLoS One. 2012;7(1). doi:10.1371/annotation/c5953f27-95f8-4a1b-a46c-639d90e182ac. Lewis, Steven L [corrected to Lewis, Steven M].


Human carboxylesterase 1 stereoselectively binds the nerve agent cyclosarin and spontaneously hydrolyzes the nerve agent sarin.

Hemmert AC, Otto TC, Wierdl M, Edwards CC, Fleming CD, MacDonald M, Cashman JR, Potter PM, Cerasoli DM, Redinbo MR.

Mol Pharmacol. 2010 Apr;77(4):508-16. doi: 10.1124/mol.109.062356. Epub 2010 Jan 5.


Modifications of human carboxylesterase for improved prodrug activation.

Hatfield JM, Wierdl M, Wadkins RM, Potter PM.

Expert Opin Drug Metab Toxicol. 2008 Sep;4(9):1153-65. doi: 10.1517/17425255.4.9.1153 . Review.


An improved human carboxylesterase for enzyme/prodrug therapy with CPT-11.

Wierdl M, Tsurkan L, Hyatt JL, Edwards CC, Hatfield MJ, Morton CL, Houghton PJ, Danks MK, Redinbo MR, Potter PM.

Cancer Gene Ther. 2008 Mar;15(3):183-92. doi: 10.1038/sj.cgt.7701112. Epub 2008 Jan 11.


Evaluation of the 'side door' in carboxylesterase-mediated catalysis and inhibition.

Streit TM, Borazjani A, Lentz SE, Wierdl M, Potter PM, Gwaltney SR, Ross MK.

Biol Chem. 2008 Feb;389(2):149-62. doi: 10.1515/BC.2008.017.


Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.

Hicks LD, Hyatt JL, Moak T, Edwards CC, Tsurkan L, Wierdl M, Ferreira AM, Wadkins RM, Potter PM.

Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.


Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.

Hyatt JL, Moak T, Hatfield MJ, Tsurkan L, Edwards CC, Wierdl M, Danks MK, Wadkins RM, Potter PM.

J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.


Tumor-targeted enzyme/prodrug therapy mediates long-term disease-free survival of mice bearing disseminated neuroblastoma.

Danks MK, Yoon KJ, Bush RA, Remack JS, Wierdl M, Tsurkan L, Kim SU, Garcia E, Metz MZ, Najbauer J, Potter PM, Aboody KS.

Cancer Res. 2007 Jan 1;67(1):22-5.


Intracellular inhibition of carboxylesterases by benzil: modulation of CPT-11 cytotoxicity.

Hyatt JL, Tsurkan L, Wierdl M, Edwards CC, Danks MK, Potter PM.

Mol Cancer Ther. 2006 Sep;5(9):2281-8.


Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety.

Hyatt JL, Stacy V, Wadkins RM, Yoon KJ, Wierdl M, Edwards CC, Zeller M, Hunter AD, Danks MK, Crundwell G, Potter PM.

J Med Chem. 2005 Aug 25;48(17):5543-50.


Update on gene therapy approaches for cancer.

Wierdl M, Potter PM.

Curr Hematol Rep. 2005 Jul;4(4):294-9. Review.


Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.

Wadkins RM, Hyatt JL, Wei X, Yoon KJ, Wierdl M, Edwards CC, Morton CL, Obenauer JC, Damodaran K, Beroza P, Danks MK, Potter PM.

J Med Chem. 2005 Apr 21;48(8):2906-15.


Molecular modeling of CPT-11 metabolism by carboxylesterases (CEs): use of pnb CE as a model.

Wierdl M, Morton CL, Nguyen NK, Redinbo MR, Potter PM.

Biochemistry. 2004 Feb 24;43(7):1874-82.


Carboxylesterase-mediated sensitization of human tumor cells to CPT-11 cannot override ABCG2-mediated drug resistance.

Wierdl M, Wall A, Morton CL, Sampath J, Danks MK, Schuetz JD, Potter PM.

Mol Pharmacol. 2003 Aug;64(2):279-88.


p53-mediated regulation of expression of a rabbit liver carboxylesterase confers sensitivity to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11).

Wierdl M, Morton CL, Harris LC, Danks MK, Schuetz JD, Potter PM.

J Pharmacol Exp Ther. 2003 Feb;304(2):699-705.


Structural constraints affect the metabolism of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) by carboxylesterases.

Wadkins RM, Morton CL, Weeks JK, Oliver L, Wierdl M, Danks MK, Potter PM.

Mol Pharmacol. 2001 Aug;60(2):355-62.


A virus-directed enzyme prodrug therapy approach to purging neuroblastoma cells from hematopoietic cells using adenovirus encoding rabbit carboxylesterase and CPT-11.

Meck MM, Wierdl M, Wagner LM, Burger RA, Guichard SM, Krull EJ, Harris LC, Potter PM, Danks MK.

Cancer Res. 2001 Jul 1;61(13):5083-9.


Sensitization of human tumor cells to CPT-11 via adenoviral-mediated delivery of a rabbit liver carboxylesterase.

Wierdl M, Morton CL, Weeks JK, Danks MK, Harris LC, Potter PM.

Cancer Res. 2001 Jul 1;61(13):5078-82.


Activation of CPT-11 in mice: identification and analysis of a highly effective plasma esterase.

Morton CL, Wierdl M, Oliver L, Ma MK, Danks MK, Stewart CF, Eiseman JL, Potter PM.

Cancer Res. 2000 Aug 1;60(15):4206-10.


Isolation and characterization of a cDNA encoding a horse liver butyrylcholinesterase: evidence for CPT-11 drug activation.

Wierdl M, Morton CL, Danks MK, Potter PM.

Biochem Pharmacol. 2000 Apr 1;59(7):773-81.


Microsatellite instability in yeast: dependence on the length of the microsatellite.

Wierdl M, Dominska M, Petes TD.

Genetics. 1997 Jul;146(3):769-79.


Ergodic theorems along sequences and Hardy fields.

Boshernitzan M, Wierdl M.

Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8205-7.


Destabilization of simple repetitive DNA sequences by transcription in yeast.

Wierdl M, Greene CN, Datta A, Jinks-Robertson S, Petes TD.

Genetics. 1996 Jun;143(2):713-21.


DNA-binding protein RAP1 stimulates meiotic recombination at the HIS4 locus in yeast.

White MA, Wierdl M, Detloff P, Petes TD.

Proc Natl Acad Sci U S A. 1991 Nov 1;88(21):9755-9.

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