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Na+/Ca2+ exchanger overexpression in smooth muscle augments cytosolic Ca2+ in femoral arteries of living mice.

Zhang J, Wang Y, Chen L, Wier WG, Blaustein MP.

Am J Physiol Heart Circ Physiol. 2019 Feb 1;316(2):H298-H310. doi: 10.1152/ajpheart.00185.2018. Epub 2018 Nov 21. Erratum in: Am J Physiol Heart Circ Physiol. 2019 Mar 1;316(3):H762-H763.


Hypoxia selectively upregulates cation channels and increases cytosolic [Ca2+] in pulmonary, but not coronary, arterial smooth muscle cells.

He X, Song S, Ayon RJ, Balisterieri A, Black SM, Makino A, Wier WG, Zang WJ, Yuan JX.

Am J Physiol Cell Physiol. 2018 Apr 1;314(4):C504-C517. doi: 10.1152/ajpcell.00272.2017. Epub 2018 Jan 3.


Imaging sympathetic neurogenic Ca2+ signaling in blood vessels.

Wier WG, Mauban JRH.

Auton Neurosci. 2017 Nov;207:59-66. doi: 10.1016/j.autneu.2017.07.007. Epub 2017 Jul 29. Review.


Pivotal role of α2 Na+ pumps and their high affinity ouabain binding site in cardiovascular health and disease.

Blaustein MP, Chen L, Hamlyn JM, Leenen FH, Lingrel JB, Wier WG, Zhang J.

J Physiol. 2016 Nov 1;594(21):6079-6103. doi: 10.1113/JP272419. Epub 2016 Jul 31. Review.


Reduction of Mitochondria-Endoplasmic Reticulum Interactions by Acetylcholine Protects Human Umbilical Vein Endothelial Cells From Hypoxia/Reoxygenation Injury.

He X, Bi XY, Lu XZ, Zhao M, Yu XJ, Sun L, Xu M, Wier WG, Zang WJ.

Arterioscler Thromb Vasc Biol. 2015 Jul;35(7):1623-34. doi: 10.1161/ATVBAHA.115.305469. Epub 2015 May 14.


PC-PLC/sphingomyelin synthase activity plays a central role in the development of myogenic tone in murine resistance arteries.

Mauban JR, Zacharia J, Fairfax S, Wier WG.

Am J Physiol Heart Circ Physiol. 2015 Jun 15;308(12):H1517-24. doi: 10.1152/ajpheart.00594.2014. Epub 2015 Apr 17.


Ca(2+) signaling in arterioles and small arteries of conscious, restrained, optical biosensor mice.

Fairfax ST, Mauban JR, Hao S, Rizzo MA, Zhang J, Wier WG.

Front Physiol. 2014 Oct 7;5:387. doi: 10.3389/fphys.2014.00387. eCollection 2014.


More in vivo experimentation is needed in cardiovascular physiology.

Wier WG.

Am J Physiol Heart Circ Physiol. 2014 Jul 15;307(2):H121-3. doi: 10.1152/ajpheart.00326.2014. Epub 2014 May 23. No abstract available.


A method for noninvasive longitudinal measurements of [Ca2+] in arterioles of hypertensive optical biosensor mice.

Mauban JR, Fairfax ST, Rizzo MA, Zhang J, Wier WG.

Am J Physiol Heart Circ Physiol. 2014 Jul 15;307(2):H173-81. doi: 10.1152/ajpheart.00182.2014. Epub 2014 May 23.


High vascular tone of mouse femoral arteries in vivo is determined by sympathetic nerve activity via α1A- and α1D-adrenoceptor subtypes.

Zacharia J, Mauban JR, Raina H, Fisher SA, Wier WG.

PLoS One. 2013 Jun 12;8(6):e65969. doi: 10.1371/journal.pone.0065969. Print 2013.


Vascular tone and Ca(2+) signaling in murine cremaster muscle arterioles in vivo.

Mauban JR, Zacharia J, Zhang J, Wier WG.

Microcirculation. 2013 Apr;20(3):269-77. doi: 10.1111/micc.12025.


Increased arterial smooth muscle Ca2+ signaling, vasoconstriction, and myogenic reactivity in Milan hypertensive rats.

Linde CI, Karashima E, Raina H, Zulian A, Wier WG, Hamlyn JM, Ferrari P, Blaustein MP, Golovina VA.

Am J Physiol Heart Circ Physiol. 2012 Feb 1;302(3):H611-20. doi: 10.1152/ajpheart.00950.2011. Epub 2011 Dec 2.


How NaCl raises blood pressure: a new paradigm for the pathogenesis of salt-dependent hypertension.

Blaustein MP, Leenen FH, Chen L, Golovina VA, Hamlyn JM, Pallone TL, Van Huysse JW, Zhang J, Wier WG.

Am J Physiol Heart Circ Physiol. 2012 Mar 1;302(5):H1031-49. doi: 10.1152/ajpheart.00899.2011. Epub 2011 Nov 4. Review.


Gender differences in myogenic regulation along the vascular tree of the gerbil cochlea.

Reimann K, Krishnamoorthy G, Wier WG, Wangemann P.

PLoS One. 2011;6(9):e25659. doi: 10.1371/journal.pone.0025659. Epub 2011 Sep 29.


Endothelial dysfunction in rat mesenteric artery after regional cardiac ischaemia-reperfusion.

Zhao M, He X, Wier WG, Zhang HL, Zhao M, Yu XJ, Zang WJ.

Exp Physiol. 2012 Jan;97(1):70-9. doi: 10.1113/expphysiol.2011.059360. Epub 2011 Sep 23.


Exercise improves the dilatation function of mesenteric arteries in postmyocardial infarction rats via a PI3K/Akt/eNOS pathway-mediated mechanism.

Wang Y, Wang S, Wier WG, Zhang Q, Jiang H, Li Q, Chen S, Tian Z, Li Y, Yu X, Zhao M, Liu J, Yang J, Zhang J, Zang W.

Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H2097-106. doi: 10.1152/ajpheart.00701.2010. Epub 2010 Oct 8.


Tumor necrosis factor-α enhances microvascular tone and reduces blood flow in the cochlea via enhanced sphingosine-1-phosphate signaling.

Scherer EQ, Yang J, Canis M, Reimann K, Ivanov K, Diehl CD, Backx PH, Wier WG, Strieth S, Wangemann P, Voigtlaender-Bolz J, Lidington D, Bolz SS.

Stroke. 2010 Nov;41(11):2618-24. doi: 10.1161/STROKEAHA.110.593327. Epub 2010 Oct 7.


In vivo assessment of artery smooth muscle [Ca2+]i and MLCK activation in FRET-based biosensor mice.

Zhang J, Chen L, Raina H, Blaustein MP, Wier WG.

Am J Physiol Heart Circ Physiol. 2010 Sep;299(3):H946-56. doi: 10.1152/ajpheart.00359.2010. Epub 2010 Jul 9.


Sympathetic nerves and the endothelium influence the vasoconstrictor effect of low concentrations of ouabain in pressurized small arteries.

Raina H, Zhang Q, Rhee AY, Pallone TL, Wier WG.

Am J Physiol Heart Circ Physiol. 2010 Jun;298(6):H2093-101. doi: 10.1152/ajpheart.01045.2009. Epub 2010 Apr 9.


Knockout of Na+/Ca2+ exchanger in smooth muscle attenuates vasoconstriction and L-type Ca2+ channel current and lowers blood pressure.

Zhang J, Ren C, Chen L, Navedo MF, Antos LK, Kinsey SP, Iwamoto T, Philipson KD, Kotlikoff MI, Santana LF, Wier WG, Matteson DR, Blaustein MP.

Am J Physiol Heart Circ Physiol. 2010 May;298(5):H1472-83. doi: 10.1152/ajpheart.00964.2009. Epub 2010 Feb 19.


Low-dose ouabain constricts small arteries from ouabain-hypertensive rats: implications for sustained elevation of vascular resistance.

Zhang J, Hamlyn JM, Karashima E, Raina H, Mauban JR, Izuka M, Berra-Romani R, Zulian A, Wier WG, Blaustein MP.

Am J Physiol Heart Circ Physiol. 2009 Sep;297(3):H1140-50. doi: 10.1152/ajpheart.00436.2009. Epub 2009 Jul 17.


Role of store-operated Ca(2+) entry in adenosine-induced vasodilatation of rat small mesenteric artery.

Wang S, Zhang Y, Wier WG, Yu X, Zhao M, Hu H, Sun L, He X, Wang Y, Wang B, Zang W.

Am J Physiol Heart Circ Physiol. 2009 Jul;297(1):H347-54. doi: 10.1152/ajpheart.00060.2009. Epub 2009 May 8.


Activation by Ca2+/calmodulin of an exogenous myosin light chain kinase in mouse arteries.

Raina H, Zacharia J, Li M, Wier WG.

J Physiol. 2009 Jun 1;587(Pt 11):2599-612. doi: 10.1113/jphysiol.2008.165258. Epub 2009 Apr 29.


The pump, the exchanger, and endogenous ouabain: signaling mechanisms that link salt retention to hypertension.

Blaustein MP, Zhang J, Chen L, Song H, Raina H, Kinsey SP, Izuka M, Iwamoto T, Kotlikoff MI, Lingrel JB, Philipson KD, Wier WG, Hamlyn JM.

Hypertension. 2009 Feb;53(2):291-8. doi: 10.1161/HYPERTENSIONAHA.108.119974. Epub 2008 Dec 22. Review. No abstract available.


Sympathetic neurogenic Ca2+ signalling in rat arteries: ATP, noradrenaline and neuropeptide Y.

Wier WG, Zang WJ, Lamont C, Raina H.

Exp Physiol. 2009 Jan;94(1):31-7. doi: 10.1113/expphysiol.2008.043638. Epub 2008 Oct 17.


Effects of siRNA knock-down of TRPC6 and InsP(3)R1 in vasopressin-induced Ca(2+) oscillations of A7r5 vascular smooth muscle cells.

Li M, Zacharia J, Sun X, Wier WG.

Pharmacol Res. 2008 Nov-Dec;58(5-6):308-15. doi: 10.1016/j.phrs.2008.09.004. Epub 2008 Sep 13.


A technique for simultaneous measurement of Ca2+, FRET fluorescence and force in intact mouse small arteries.

Wier WG, Rizzo MA, Raina H, Zacharia J.

J Physiol. 2008 May 15;586(10):2437-43. doi: 10.1113/jphysiol.2008.151522. Epub 2008 Mar 27.


Membrane current oscillations in descending vasa recta pericytes.

Zhang Q, Cao C, Zhang Z, Wier WG, Edwards A, Pallone TL.

Am J Physiol Renal Physiol. 2008 Mar;294(3):F656-66. doi: 10.1152/ajprenal.00493.2007. Epub 2008 Jan 9.


Local sodium, global reach: filling the gap between salt and hypertension.

Blaustein MP, Wier WG.

Circ Res. 2007 Nov 9;101(10):959-61. No abstract available.


Gain and cardiac E-C coupling: revisited and revised.

Wier WG.

Circ Res. 2007 Sep 14;101(6):533-5. No abstract available.


Ca2+ signaling in mouse mesenteric small arteries: myogenic tone and adrenergic vasoconstriction.

Zacharia J, Zhang J, Wier WG.

Am J Physiol Heart Circ Physiol. 2007 Mar;292(3):H1523-32. Epub 2006 Nov 17.


Sympathetically evoked Ca2+ signaling in arterial smooth muscle.

Zang WJ, Zacharia J, Lamont C, Wier WG.

Acta Pharmacol Sin. 2006 Dec;27(12):1515-25. Review.


P2X1 receptors mediate sympathetic postjunctional Ca2+ transients in mesenteric small arteries.

Lamont C, Vial C, Evans RJ, Wier WG.

Am J Physiol Heart Circ Physiol. 2006 Dec;291(6):H3106-13. Epub 2006 Aug 18.


On the mechanism of myogenic tone in small arteries.

Blaustein MP, Zhang J, Wier WG.

J Muscle Res Cell Motil. 2004;25(8):615. No abstract available.


Sodium pump alpha2 subunits control myogenic tone and blood pressure in mice.

Zhang J, Lee MY, Cavalli M, Chen L, Berra-Romani R, Balke CW, Bianchi G, Ferrari P, Hamlyn JM, Iwamoto T, Lingrel JB, Matteson DR, Wier WG, Blaustein MP.

J Physiol. 2005 Nov 15;569(Pt 1):243-56. Epub 2005 Sep 15.


Essential role of EDHF in the initiation and maintenance of adrenergic vasomotion in rat mesenteric arteries.

Mauban JR, Wier WG.

Am J Physiol Heart Circ Physiol. 2004 Aug;287(2):H608-16. Epub 2004 Apr 1.


Ca2+-sensing transgenic mice: postsynaptic signaling in smooth muscle.

Ji G, Feldman ME, Deng KY, Greene KS, Wilson J, Lee JC, Johnston RC, Rishniw M, Tallini Y, Zhang J, Wier WG, Blaustein MP, Xin HB, Nakai J, Kotlikoff MI.

J Biol Chem. 2004 May 14;279(20):21461-8. Epub 2004 Feb 29.


Alpha1-adrenergic signaling mechanisms in contraction of resistance arteries.

Wier WG, Morgan KG.

Rev Physiol Biochem Pharmacol. 2003;150:91-139. Epub 2003 Jul 17. Review.


Purinergic and adrenergic Ca2+ transients during neurogenic contractions of rat mesenteric small arteries.

Lamont C, Vainorius E, Wier WG.

J Physiol. 2003 Jun 15;549(Pt 3):801-8. Epub 2003 May 9.


Role of the transverse-axial tubule system in generating calcium sparks and calcium transients in rat atrial myocytes.

Kirk MM, Izu LT, Chen-Izu Y, McCulle SL, Wier WG, Balke CW, Shorofsky SR.

J Physiol. 2003 Mar 1;547(Pt 2):441-51. Epub 2003 Jan 31.


Mg2+ blocks myogenic tone but not K+-induced constriction: role for SOCs in small arteries.

Zhang J, Wier WG, Blaustein MP.

Am J Physiol Heart Circ Physiol. 2002 Dec;283(6):H2692-705. Epub 2002 Aug 15.


Organization of Ca2+ stores in vascular smooth muscle: functional implications.

Blaustein MP, Golovina VA, Song H, Choate J, Lencesova L, Robinson SW, Wier WG.

Novartis Found Symp. 2002;246:125-37; discussion 137-41, 221-7. Review.


I(Ca(TTX)) channels are distinct from those generating the classical cardiac Na(+) current.

Chen-Izu Y, Sha Q, Shorofsky SR, Robinson SW, Wier WG, Goldman L, Balke CW.

Biophys J. 2001 Nov;81(5):2647-59.


Adrenergic stimulation of rat resistance arteries affects Ca(2+) sparks, Ca(2+) waves, and Ca(2+) oscillations.

Mauban JR, Lamont C, Balke CW, Wier WG.

Am J Physiol Heart Circ Physiol. 2001 May;280(5):H2399-405.


Evolution of cardiac calcium waves from stochastic calcium sparks.

Izu LT, Wier WG, Balke CW.

Biophys J. 2001 Jan;80(1):103-20.


Large currents generate cardiac Ca2+ sparks.

Izu LT, Mauban JR, Balke CW, Wier WG.

Biophys J. 2001 Jan;80(1):88-102.

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