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Items: 1 to 50 of 208


Probabilistic cell-type assignment of single-cell RNA-seq for tumor microenvironment profiling.

Zhang AW, O'Flanagan C, Chavez EA, Lim JLP, Ceglia N, McPherson A, Wiens M, Walters P, Chan T, Hewitson B, Lai D, Mottok A, Sarkozy C, Chong L, Aoki T, Wang X, Weng AP, McAlpine JN, Aparicio S, Steidl C, Campbell KR, Shah SP.

Nat Methods. 2019 Sep 9. doi: 10.1038/s41592-019-0529-1. [Epub ahead of print]


Exploring healthcare providers' perspectives of the paediatric discharge process in Uganda: a qualitative exploratory study.

Nemetchek B, Khowaja A, Kavuma A, Kabajaasi O, Olirus Owilli A, Ansermino JM, Fowler-Kerry S, Jacob ST, Kenya-Mugisha N, Kabakyenga J, Wiens MO.

BMJ Open. 2019 Sep 6;9(9):e029526. doi: 10.1136/bmjopen-2019-029526.


A transformation of oxygen saturation (the saturation virtual shunt) to improve clinical prediction model calibration and interpretation.

Zhou G, Karlen W, Brant R, Wiens M, Kissoon N, Ansermino JM.

Pediatr Res. 2019 Aug 5. doi: 10.1038/s41390-019-0525-2. [Epub ahead of print]


Very severe anemia and one year mortality outcome after hospitalization in Tanzanian children: A prospective cohort study.

Chami N, Hau DK, Masoza TS, Smart LR, Kayange NM, Hokororo A, Ambrose EE, Moschovis PP, Wiens MO, Peck RN.

PLoS One. 2019 Jun 20;14(6):e0214563. doi: 10.1371/journal.pone.0214563. eCollection 2019.


Re: "Investment Long Overdue in Primary Studies of HIV-exposed Uninfected Infant Infectious Morbidity".

Iroh Tam PY, Wiens MO, Moschovis PP.

Pediatr Infect Dis J. 2019 Jul;38(7):e165. doi: 10.1097/INF.0000000000002250. No abstract available.


Predictor variables for post-discharge mortality modelling in infants: a protocol development project.

Nemetchek BR, Liang LD, Kissoon N, Ansermino JM, Kabakyenga J, Lavoie PM, Fowler-Kerry S, Wiens MO.

Afr Health Sci. 2018 Dec;18(4):1214-1225. doi: 10.4314/ahs.v18i4.43.


Community health workers trained to conduct verbal autopsies provide better mortality measures than existing surveillance: Results from a cross-sectional study in rural western Uganda.

Nabukalu D, Ntaro M, Seviiri M, Reyes R, Wiens M, Sundararajan R, Mulogo E, Boyce RM.

PLoS One. 2019 Feb 13;14(2):e0211482. doi: 10.1371/journal.pone.0211482. eCollection 2019.


Active management of atrial fibrillation or flutter in emergency department patients with renal impairment is associated with a higher risk of adverse events and treatment failure.

Scheuermeyer FX, Wong H, Barrett TW, Christenson J, Grafstein E, Grunau B, Wiens M, Innes G.

CJEM. 2019 May;21(3):352-360. doi: 10.1017/cem.2018.475. Epub 2019 Feb 6.


Determining predictors of sepsis at triage among children under 5 years of age in resource-limited settings: A modified Delphi process.

Fung JST, Akech S, Kissoon N, Wiens MO, English M, Ansermino JM.

PLoS One. 2019 Jan 28;14(1):e0211274. doi: 10.1371/journal.pone.0211274. eCollection 2019.


A Locally Developed Electronic Health Platform in Uganda: Development and Implementation of Stre@mline.

Liang L, Wiens MO, Lubega P, Spillman I, Mugisha S.

JMIR Form Res. 2018 Sep 24;2(2):e20. doi: 10.2196/formative.9658.


Paediatric postdischarge mortality in developing countries: a systematic review.

Nemetchek B, English L, Kissoon N, Ansermino JM, Moschovis PP, Kabakyenga J, Fowler-Kerry S, Kumbakumba E, Wiens MO.

BMJ Open. 2018 Dec 28;8(12):e023445. doi: 10.1136/bmjopen-2018-023445.


Predictors of Mortality in Neonates and Infants Hospitalized With Sepsis or Serious Infections in Developing Countries: A Systematic Review.

Liang LD, Kotadia N, English L, Kissoon N, Ansermino JM, Kabakyenga J, Lavoie PM, Wiens MO.

Front Pediatr. 2018 Oct 4;6:277. doi: 10.3389/fped.2018.00277. eCollection 2018.


We need smarter trigger tools for diagnosing sepsis in children in Canada.

Ansermino JM, Wiens MO, Kissoon N.

CMAJ. 2018 Sep 10;190(36):E1060-E1061. doi: 10.1503/cmaj.180434. No abstract available.


Who Stays and Who Goes: Predictors of Admission among Patients Presenting with Febrile Illness and a Positive Malaria Rapid Diagnostic Test in a Rural Ugandan Health Center.

Chang JL, Reyes R, Matte M, Ntaro M, Mulogo E, Wiens MO, Meshnick SR, Siedner MJ, Boyce RM.

Am J Trop Med Hyg. 2018 Oct;99(4):1080-1088. doi: 10.4269/ajtmh.18-0338.


Enhancing fluorescent protein photostability through robot-assisted photobleaching.

Wiens MD, Hoffmann F, Chen Y, Campbell RE.

Integr Biol (Camb). 2018 Jul 16;10(7):419-428. doi: 10.1039/c8ib00063h.


Individual, maternal and household risk factors for anaemia among young children in sub-Saharan Africa: a cross-sectional study.

Moschovis PP, Wiens MO, Arlington L, Antsygina O, Hayden D, Dzik W, Kiwanuka JP, Christiani DC, Hibberd PL.

BMJ Open. 2018 May 14;8(5):e019654. doi: 10.1136/bmjopen-2017-019654.


Silicateins, silicatein interactors and cellular interplay in sponge skeletogenesis: formation of glass fiber-like spicules.

Wang X, Schloßmacher U, Wiens M, Batel R, Schröder HC, Müller WEG.

FEBS J. 2018 Apr;285(7):1373. doi: 10.1111/febs.14432. Epub 2018 Mar 23. No abstract available.


Corrigendum: A Tandem Green-Red Heterodimeric Fluorescent Protein with High FRET Efficiency.

Wiens MD, Shen Y, Li X, Salem MA, Smisdom N, Zhang W, Brown A, Campbell RE.

Chembiochem. 2018 Mar 16;19(6):647. doi: 10.1002/cbic.201600638. Epub 2016 Dec 7. No abstract available.


Pneumonia in HIV-exposed and Infected Children and Association With Malnutrition.

Iroh Tam PY, Wiens MO, Kabakyenga J, Kiwanuka J, Kumbakumba E, Moschovis PP.

Pediatr Infect Dis J. 2018 Oct;37(10):1011-1013. doi: 10.1097/INF.0000000000001971.


Smart Hospital Discharges to Address a Neglected Epidemic in Sepsis in Low- and Middle-Income Countries.

Wiens MO, Kissoon N, Kabakyenga J.

JAMA Pediatr. 2018 Mar 1;172(3):213-214. doi: 10.1001/jamapediatrics.2017.4519. No abstract available.


A genetically encoded Ca2+ indicator based on circularly permutated sea anemone red fluorescent protein eqFP578.

Shen Y, Dana H, Abdelfattah AS, Patel R, Shea J, Molina RS, Rawal B, Rancic V, Chang YF, Wu L, Chen Y, Qian Y, Wiens MD, Hambleton N, Ballanyi K, Hughes TE, Drobizhev M, Kim DS, Koyama M, Schreiter ER, Campbell RE.

BMC Biol. 2018 Jan 16;16(1):9. doi: 10.1186/s12915-018-0480-0.


Surveying the landscape of optogenetic methods for detection of protein-protein interactions.

Wiens MD, Campbell RE.

Wiley Interdiscip Rev Syst Biol Med. 2018 May;10(3):e1415. doi: 10.1002/wsbm.1415. Epub 2018 Jan 15. Review.


Uptake of polyphosphate microparticles in vitro (SaOS-2 and HUVEC cells) followed by an increase of the intracellular ATP pool size.

Müller WEG, Wang S, Wiens M, Neufurth M, Ackermann M, Relkovic D, Kokkinopoulou M, Feng Q, Schröder HC, Wang X.

PLoS One. 2017 Dec 29;12(12):e0188977. doi: 10.1371/journal.pone.0188977. eCollection 2017.


An evolutionary perspective on the role of mesencephalic astrocyte-derived neurotrophic factor (MANF): At the crossroads of poriferan innate immune and apoptotic pathways.

Sereno D, Müller WEG, Bausen M, Elkhooly TA, Markl JS, Wiens M.

Biochem Biophys Rep. 2017 Mar 18;11:161-173. doi: 10.1016/j.bbrep.2017.02.009. eCollection 2017 Sep.


Comparative efficacy and safety of second-line antiretroviral therapy for treatment of HIV/AIDS: a systematic review and network meta-analysis.

Kanters S, Socias ME, Paton NI, Vitoria M, Doherty M, Ayers D, Popoff E, Chan K, Cooper DA, Wiens MO, Calmy A, Ford N, Nsanzimana S, Mills EJ.

Lancet HIV. 2017 Oct;4(10):e433-e441. doi: 10.1016/S2352-3018(17)30109-1. Epub 2017 Aug 4. Review.


Effect of frequency of clinic visits and medication pick-up on antiretroviral treatment outcomes: a systematic literature review and meta-analysis.

Mutasa-Apollo T, Ford N, Wiens M, Socias ME, Negussie E, Wu P, Popoff E, Park J, Mills EJ, Kanters S.

J Int AIDS Soc. 2017 Jul 21;20(Suppl 4):21647. doi: 10.7448/IAS.20.5.21647. Review.


Alpha-defensin-dependent enhancement of enteric viral infection.

Wilson SS, Bromme BA, Holly MK, Wiens ME, Gounder AP, Sul Y, Smith JG.

PLoS Pathog. 2017 Jun 16;13(6):e1006446. doi: 10.1371/journal.ppat.1006446. eCollection 2017 Jun.


Pediatric out-of-hospital deaths following hospital discharge: a mixed-methods study.

English L, Kumbakumba E, Larson CP, Kabakyenga J, Singer J, Kissoon N, Ansermino JM, Wong H, Kiwanuka J, Wiens MO.

Afr Health Sci. 2016 Dec;16(4):883-891. doi: 10.4314/ahs.v16i4.2.


Two-Armed Activation of Bone Mineral Deposition by the Flavones Baicalin and Baicalein, Encapsulated in Polyphosphate Microparticles.

Wang XH, Guo YW, Tolba E, Kokkinopoulou M, Wiens M, Schröder HC, Müller WEG.

Am J Chin Med. 2017;45(3):533-555. doi: 10.1142/S0192415X1750032X. Epub 2017 Apr 2.


Optogenetic control with a photocleavable protein, PhoCl.

Zhang W, Lohman AW, Zhuravlova Y, Lu X, Wiens MD, Hoi H, Yaganoglu S, Mohr MA, Kitova EN, Klassen JS, Pantazis P, Thompson RJ, Campbell RE.

Nat Methods. 2017 Apr;14(4):391-394. doi: 10.1038/nmeth.4222. Epub 2017 Mar 13.


α-Defensin HD5 Inhibits Human Papillomavirus 16 Infection via Capsid Stabilization and Redirection to the Lysosome.

Wiens ME, Smith JG.

MBio. 2017 Jan 24;8(1). pii: e02304-16. doi: 10.1128/mBio.02304-16.


The authors reply.

Wiens MO, Kissoon N, Moschovis P, Kabakyenga J.

Pediatr Crit Care Med. 2017 Jan;18(1):99-100. doi: 10.1097/PCC.0000000000001022. No abstract available.


A Tandem Green-Red Heterodimeric Fluorescent Protein with High FRET Efficiency.

Wiens MD, Shen Y, Li X, Salem MA, Smisdom N, Zhang W, Brown A, Campbell RE.

Chembiochem. 2016 Dec 14;17(24):2361-2367. doi: 10.1002/cbic.201600492. Epub 2016 Nov 15. Erratum in: Chembiochem. 2018 Mar 16;19(6):647.


Scheduled Follow-Up Referrals and Simple Prevention Kits Including Counseling to Improve Post-Discharge Outcomes Among Children in Uganda: A Proof-of-Concept Study.

Wiens MO, Kumbakumba E, Larson CP, Moschovis PP, Barigye C, Kabakyenga J, Ndamira A, English L, Kissoon N, Zhou G, Ansermino JM.

Glob Health Sci Pract. 2016 Sep 29;4(3):422-34. doi: 10.9745/GHSP-D-16-00069. Print 2016 Sep 28.


Systematic Review and Meta-analysis of the Pharmacokinetics of Benznidazole in the Treatment of Chagas Disease.

Wiens MO, Kanters S, Mills E, Peregrina Lucano AA, Gold S, Ayers D, Ferrero L, Krolewiecki A.

Antimicrob Agents Chemother. 2016 Nov 21;60(12):7035-7042. Print 2016 Dec.


Dielectrophoresis of gold nanoparticles conjugated to DNA origami structures.

Henning-Knechtel A, Wiens M, Lakatos M, Heerwig A, Ostermaier F, Haufe N, Mertig M.

Beilstein J Nanotechnol. 2016 Jul 1;7:948-56. doi: 10.3762/bjnano.7.87. eCollection 2016.


Spying on Cells: Toward a Perfect Sleeper Agent.

Wiens MD, Lu X, Campbell RE.

Cell Chem Biol. 2016 Jul 21;23(7):756-758. doi: 10.1016/j.chembiol.2016.07.002.


Selecting candidate predictor variables for the modelling of post-discharge mortality from sepsis: a protocol development project.

Wiens MO, Kissoon N, Kumbakumba E, Singer J, Moschovis PP, Ansermino JM, Ndamira A, Kiwanuka J, Larson CP.

Afr Health Sci. 2016 Mar;16(1):162-9. doi: 10.4314/ahs.v16i1.22.


Prevalence of Ethanol Use Among Pregnant Women in Southwestern Uganda.

English LL, Mugyenyi G, Nightingale I, Kiwanuka G, Ngonzi J, Grunau BE, MacLeod S, Koren G, Delano K, Kabakyenga J, Wiens MO.

Matern Child Health J. 2016 Oct;20(10):2209-15. doi: 10.1007/s10995-016-2025-x.


Self-assembly and photocatalytic activity of branched silicatein/silintaphin filaments decorated with silicatein-synthesized TiO2 nanoparticles.

Gardères J, Elkhooly TA, Link T, Markl JS, Müller WE, Renkel J, Korzhev M, Wiens M.

Bioprocess Biosyst Eng. 2016 Sep;39(9):1477-86. doi: 10.1007/s00449-016-1619-4. Epub 2016 May 5.


Application of Sepsis Definitions to Pediatric Patients Admitted With Suspected Infections in Uganda.

Wiens MO, Larson CP, Kumbakumba E, Kissoon N, Ansermino JM, Singer J, Wong H, Ndamira A, Kabakyenga J, Moschovis P, Kiwanuka J.

Pediatr Crit Care Med. 2016 May;17(5):400-5. doi: 10.1097/PCC.0000000000000708.


Defensins at the Mucosal Surface: Latest Insights into Defensin-Virus Interactions.

Wilson SS, Wiens ME, Holly MK, Smith JG.

J Virol. 2016 May 12;90(11):5216-5218. doi: 10.1128/JVI.00904-15. Print 2016 Jun 1. Review.


Pediatric in-Hospital Death from Infectious Disease in Uganda: Derivation of Clinical Prediction Models.

Lowlaavar N, Larson CP, Kumbakumba E, Zhou G, Ansermino JM, Singer J, Kissoon N, Wong H, Ndamira A, Kabakyenga J, Kiwanuka J, Wiens MO.

PLoS One. 2016 Mar 10;11(3):e0150683. doi: 10.1371/journal.pone.0150683. eCollection 2016.


Defensins Potentiate a Neutralizing Antibody Response to Enteric Viral Infection.

Gounder AP, Myers ND, Treuting PM, Bromme BA, Wilson SS, Wiens ME, Lu W, Ouellette AJ, Spindler KR, Parks WC, Smith JG.

PLoS Pathog. 2016 Mar 2;12(3):e1005474. doi: 10.1371/journal.ppat.1005474. eCollection 2016 Mar.


The PAediatric Risk Assessment (PARA) Mobile App to Reduce Postdischarge Child Mortality: Design, Usability, and Feasibility for Health Care Workers in Uganda.

English LL, Dunsmuir D, Kumbakumba E, Ansermino JM, Larson CP, Lester R, Barigye C, Ndamira A, Kabakyenga J, Wiens MO.

JMIR Mhealth Uhealth. 2016 Feb 15;4(1):e16. doi: 10.2196/mhealth.5167.


Postdischarge mortality in children with acute infectious diseases: derivation of postdischarge mortality prediction models.

Wiens MO, Kumbakumba E, Larson CP, Ansermino JM, Singer J, Kissoon N, Wong H, Ndamira A, Kabakyenga J, Kiwanuka J, Zhou G.

BMJ Open. 2015 Nov 25;5(11):e009449. doi: 10.1136/bmjopen-2015-009449.


Prevalence of Ethanol Use Among Pregnant Women in Southwestern Uganda.

English L, Mugyenyi GR, Ngonzi J, Kiwanuka G, Nightingale I, Koren G, MacLeod S, Grunau BE, Wiens MO.

J Obstet Gynaecol Can. 2015 Oct;37(10):901-2. No abstract available.


Mobile health applications for HIV prevention and care in Africa.

Forrest JI, Wiens M, Kanters S, Nsanzimana S, Lester RT, Mills EJ.

Curr Opin HIV AIDS. 2015 Nov;10(6):464-71. doi: 10.1097/COH.0000000000000198. Review.


Critical appraisal of clinical practice guidelines in pediatric infectious diseases.

Wilby KJ, Black EK, MacLeod C, Wiens M, Lau TT, Paiva MA, Gorman S.

Int J Clin Pharm. 2015 Oct;37(5):799-807. doi: 10.1007/s11096-015-0123-2. Epub 2015 Apr 25.


Emergency Department Corticosteroid Use for Allergy or Anaphylaxis Is Not Associated With Decreased Relapses.

Grunau BE, Wiens MO, Rowe BH, McKay R, Li J, Yi TW, Stenstrom R, Schellenberg RR, Grafstein E, Scheuermeyer FX.

Ann Emerg Med. 2015 Oct;66(4):381-9. doi: 10.1016/j.annemergmed.2015.03.003. Epub 2015 Mar 25.


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