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Items: 26

1.

A stemness screen reveals C3orf54/INKA1 as a promoter of human leukemia stem cell latency.

Kaufmann KB, Garcia-Prat L, Liu Q, Ng SWK, Takayanagi SI, Mitchell A, Wienholds E, van Galen P, Cumbaa CA, Tsay MJ, Pastrello C, Wagenblast E, Krivdova G, Minden MD, Lechman ER, Zandi S, Jurisica I, Wang JCY, Xie SZ, Dick JE.

Blood. 2019 May 16;133(20):2198-2211. doi: 10.1182/blood-2018-10-881441. Epub 2019 Feb 22.

PMID:
30796022
2.

A novel method for detecting the cellular stemness state in normal and leukemic human hematopoietic cells can predict disease outcome and drug sensitivity.

Yassin M, Aqaqe N, Yassin AA, van Galen P, Kugler E, Bernstein BE, Koren-Michowitz M, Canaani J, Nagler A, Lechman ER, Dick JE, Wienholds E, Izraeli S, Milyavsky M.

Leukemia. 2019 Aug;33(8):2061-2077. doi: 10.1038/s41375-019-0386-z. Epub 2019 Jan 31.

PMID:
30705411
3.

Deregulation of DUX4 and ERG in acute lymphoblastic leukemia.

Zhang J, McCastlain K, Yoshihara H, Xu B, Chang Y, Churchman ML, Wu G, Li Y, Wei L, Iacobucci I, Liu Y, Qu C, Wen J, Edmonson M, Payne-Turner D, Kaufmann KB, Takayanagi SI, Wienholds E, Waanders E, Ntziachristos P, Bakogianni S, Wang J, Aifantis I, Roberts KG, Ma J, Song G, Easton J, Mulder HL, Chen X, Newman S, Ma X, Rusch M, Gupta P, Boggs K, Vadodaria B, Dalton J, Liu Y, Valentine ML, Ding L, Lu C, Fulton RS, Fulton L, Tabib Y, Ochoa K, Devidas M, Pei D, Cheng C, Yang J, Evans WE, Relling MV, Pui CH, Jeha S, Harvey RC, Chen IL, Willman CL, Marcucci G, Bloomfield CD, Kohlschmidt J, Mrózek K, Paietta E, Tallman MS, Stock W, Foster MC, Racevskis J, Rowe JM, Luger S, Kornblau SM, Shurtleff SA, Raimondi SC, Mardis ER, Wilson RK, Dick JE, Hunger SP, Loh ML, Downing JR, Mullighan CG; St. Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project.

Nat Genet. 2016 Dec;48(12):1481-1489. doi: 10.1038/ng.3691. Epub 2016 Oct 24.

4.

Ectopic miR-125a Expression Induces Long-Term Repopulating Stem Cell Capacity in Mouse and Human Hematopoietic Progenitors.

Wojtowicz EE, Lechman ER, Hermans KG, Schoof EM, Wienholds E, Isserlin R, van Veelen PA, Broekhuis MJ, Janssen GM, Trotman-Grant A, Dobson SM, Krivdova G, Elzinga J, Kennedy J, Gan OI, Sinha A, Ignatchenko V, Kislinger T, Dethmers-Ausema B, Weersing E, Alemdehy MF, de Looper HW, Bader GD, Ritsema M, Erkeland SJ, Bystrykh LV, Dick JE, de Haan G.

Cell Stem Cell. 2016 Sep 1;19(3):383-96. doi: 10.1016/j.stem.2016.06.008. Epub 2016 Jul 14.

5.

Substrate requirements for let-7 function in the developing zebrafish embryo.

Kloosterman WP, Wienholds E, Ketting RF, Plasterk RH.

Nucleic Acids Res. 2016 Jul 8;44(12):5993. doi: 10.1093/nar/gkw173. Epub 2016 Mar 11. No abstract available.

6.

Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia.

Cole A, Wang Z, Coyaud E, Voisin V, Gronda M, Jitkova Y, Mattson R, Hurren R, Babovic S, Maclean N, Restall I, Wang X, Jeyaraju DV, Sukhai MA, Prabha S, Bashir S, Ramakrishnan A, Leung E, Qia YH, Zhang N, Combes KR, Ketela T, Lin F, Houry WA, Aman A, Al-Awar R, Zheng W, Wienholds E, Xu CJ, Dick J, Wang JC, Moffat J, Minden MD, Eaves CJ, Bader GD, Hao Z, Kornblau SM, Raught B, Schimmer AD.

Cancer Cell. 2015 Jun 8;27(6):864-76. doi: 10.1016/j.ccell.2015.05.004.

7.

The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress.

van Galen P, Kreso A, Mbong N, Kent DG, Fitzmaurice T, Chambers JE, Xie S, Laurenti E, Hermans K, Eppert K, Marciniak SJ, Goodall JC, Green AR, Wouters BG, Wienholds E, Dick JE.

Nature. 2014 Jun 12;510(7504):268-72. doi: 10.1038/nature13228. Epub 2014 Apr 28.

PMID:
24776803
8.

Reduced lymphoid lineage priming promotes human hematopoietic stem cell expansion.

van Galen P, Kreso A, Wienholds E, Laurenti E, Eppert K, Lechman ER, Mbong N, Hermans K, Dobson S, April C, Fan JB, Dick JE.

Cell Stem Cell. 2014 Jan 2;14(1):94-106. doi: 10.1016/j.stem.2013.11.021.

9.

Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors.

Yu W, Chory EJ, Wernimont AK, Tempel W, Scopton A, Federation A, Marineau JJ, Qi J, Barsyte-Lovejoy D, Yi J, Marcellus R, Iacob RE, Engen JR, Griffin C, Aman A, Wienholds E, Li F, Pineda J, Estiu G, Shatseva T, Hajian T, Al-Awar R, Dick JE, Vedadi M, Brown PJ, Arrowsmith CH, Bradner JE, Schapira M.

Nat Commun. 2012;3:1288. doi: 10.1038/ncomms2304. Erratum in: Nat Commun. 2013;4:1893.

PMID:
23250418
10.

Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer.

Kreso A, O'Brien CA, van Galen P, Gan OI, Notta F, Brown AM, Ng K, Ma J, Wienholds E, Dunant C, Pollett A, Gallinger S, McPherson J, Mullighan CG, Shibata D, Dick JE.

Science. 2013 Feb 1;339(6119):543-8. doi: 10.1126/science.1227670. Epub 2012 Dec 13.

11.

Zebrafish Tie-2 shares a redundant role with Tie-1 in heart development and regulates vessel integrity.

Gjini E, Hekking LH, Küchler A, Saharinen P, Wienholds E, Post JA, Alitalo K, Schulte-Merker S.

Dis Model Mech. 2011 Jan;4(1):57-66. doi: 10.1242/dmm.005033. Epub 2010 Nov 2.

12.

T-cell factor 4 (Tcf7l2) maintains proliferative compartments in zebrafish intestine.

Muncan V, Faro A, Haramis AP, Hurlstone AF, Wienholds E, van Es J, Korving J, Begthel H, Zivkovic D, Clevers H.

EMBO Rep. 2007 Oct;8(10):966-73. Epub 2007 Sep 7.

13.

In situ detection of miRNAs in animal embryos using LNA-modified oligonucleotide probes.

Kloosterman WP, Wienholds E, de Bruijn E, Kauppinen S, Plasterk RH.

Nat Methods. 2006 Jan;3(1):27-9.

PMID:
16369549
14.

The zebrafish mutants dre, uki, and lep encode negative regulators of the hedgehog signaling pathway.

Koudijs MJ, den Broeder MJ, Keijser A, Wienholds E, Houwing S, van Rooijen EM, Geisler R, van Eeden FJ.

PLoS Genet. 2005 Aug;1(2):e19. Epub 2005 Aug 19.

15.

MicroRNA function in animal development.

Wienholds E, Plasterk RH.

FEBS Lett. 2005 Oct 31;579(26):5911-22. Epub 2005 Aug 10. Review.

16.

MicroRNA expression in zebrafish embryonic development.

Wienholds E, Kloosterman WP, Miska E, Alvarez-Saavedra E, Berezikov E, de Bruijn E, Horvitz HR, Kauppinen S, Plasterk RH.

Science. 2005 Jul 8;309(5732):310-1. Epub 2005 May 26.

17.

Phylogenetic shadowing and computational identification of human microRNA genes.

Berezikov E, Guryev V, van de Belt J, Wienholds E, Plasterk RH, Cuppen E.

Cell. 2005 Jan 14;120(1):21-4.

18.

tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors.

Berghmans S, Murphey RD, Wienholds E, Neuberg D, Kutok JL, Fletcher CD, Morris JP, Liu TX, Schulte-Merker S, Kanki JP, Plasterk R, Zon LI, Look AT.

Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):407-12. Epub 2005 Jan 3.

19.

Target-selected gene inactivation in zebrafish.

Wienholds E, Plasterk RH.

Methods Cell Biol. 2004;77:69-90. No abstract available.

PMID:
15602906
20.

Substrate requirements for let-7 function in the developing zebrafish embryo.

Kloosterman WP, Wienholds E, Ketting RF, Plasterk RH.

Nucleic Acids Res. 2004 Dec 7;32(21):6284-91. Print 2004.

21.

Efficient target-selected mutagenesis in zebrafish.

Wienholds E, van Eeden F, Kosters M, Mudde J, Plasterk RH, Cuppen E.

Genome Res. 2003 Dec;13(12):2700-7. Epub 2003 Nov 12.

22.

The Wnt/beta-catenin pathway regulates cardiac valve formation.

Hurlstone AF, Haramis AP, Wienholds E, Begthel H, Korving J, Van Eeden F, Cuppen E, Zivkovic D, Plasterk RH, Clevers H.

Nature. 2003 Oct 9;425(6958):633-7.

23.

The microRNA-producing enzyme Dicer1 is essential for zebrafish development.

Wienholds E, Koudijs MJ, van Eeden FJ, Cuppen E, Plasterk RH.

Nat Genet. 2003 Nov;35(3):217-8. Epub 2003 Oct 5.

24.
25.

Target-selected inactivation of the zebrafish rag1 gene.

Wienholds E, Schulte-Merker S, Walderich B, Plasterk RH.

Science. 2002 Jul 5;297(5578):99-102.

26.

Regulated transposition of a fish transposon in the mouse germ line.

Fischer SE, Wienholds E, Plasterk RH.

Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6759-64. Epub 2001 May 29.

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