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Items: 15

1.

Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq.

Wienert B, Wyman SK, Richardson CD, Yeh CD, Akcakaya P, Porritt MJ, Morlock M, Vu JT, Kazane KR, Watry HL, Judge LM, Conklin BR, Maresca M, Corn JE.

Science. 2019 Apr 19;364(6437):286-289. doi: 10.1126/science.aav9023. Epub 2019 Apr 18.

2.

A natural regulatory mutation in the proximal promoter elevates fetal globin expression by creating a de novo GATA1 site.

Martyn GE, Wienert B, Kurita R, Nakamura Y, Quinlan KGR, Crossley M.

Blood. 2019 Feb 21;133(8):852-856. doi: 10.1182/blood-2018-07-863951. Epub 2019 Jan 7.

PMID:
30617196
3.

Wake-up Sleepy Gene: Reactivating Fetal Globin for β-Hemoglobinopathies.

Wienert B, Martyn GE, Funnell APW, Quinlan KGR, Crossley M.

Trends Genet. 2018 Dec;34(12):927-940. doi: 10.1016/j.tig.2018.09.004. Epub 2018 Oct 1. Review.

PMID:
30287096
4.

In vitro-transcribed guide RNAs trigger an innate immune response via the RIG-I pathway.

Wienert B, Shin J, Zelin E, Pestal K, Corn JE.

PLoS Biol. 2018 Jul 16;16(7):e2005840. doi: 10.1371/journal.pbio.2005840. eCollection 2018 Jul.

5.

Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding.

Martyn GE, Wienert B, Yang L, Shah M, Norton LJ, Burdach J, Kurita R, Nakamura Y, Pearson RCM, Funnell APW, Quinlan KGR, Crossley M.

Nat Genet. 2018 Apr;50(4):498-503. doi: 10.1038/s41588-018-0085-0. Epub 2018 Apr 2.

PMID:
29610478
6.

KLF1 directly activates expression of the novel fetal globin repressor ZBTB7A/LRF in erythroid cells.

Norton LJ, Funnell APW, Burdach J, Wienert B, Kurita R, Nakamura Y, Philipsen S, Pearson RCM, Quinlan KGR, Crossley M.

Blood Adv. 2017 Apr 25;1(11):685-692. doi: 10.1182/bloodadvances.2016002303. eCollection 2017 Apr 25.

7.

METTL21B Is a Novel Human Lysine Methyltransferase of Translation Elongation Factor 1A: Discovery by CRISPR/Cas9 Knockout.

Hamey JJ, Wienert B, Quinlan KGR, Wilkins MR.

Mol Cell Proteomics. 2017 Dec;16(12):2229-2242. doi: 10.1074/mcp.M116.066308. Epub 2017 Jun 29.

8.

KLF1 drives the expression of fetal hemoglobin in British HPFH.

Wienert B, Martyn GE, Kurita R, Nakamura Y, Quinlan KGR, Crossley M.

Blood. 2017 Aug 10;130(6):803-807. doi: 10.1182/blood-2017-02-767400. Epub 2017 Jun 28.

PMID:
28659276
9.

Editing the genome to introduce a beneficial naturally occurring mutation associated with increased fetal globin.

Wienert B, Funnell AP, Norton LJ, Pearson RC, Wilkinson-White LE, Lester K, Vadolas J, Porteus MH, Matthews JM, Quinlan KG, Crossley M.

Nat Commun. 2015 May 14;6:7085. doi: 10.1038/ncomms8085.

PMID:
25971621
10.

Phosphorylation of Krüppel-like factor 3 (KLF3/BKLF) and C-terminal binding protein 2 (CtBP2) by homeodomain-interacting protein kinase 2 (HIPK2) modulates KLF3 DNA binding and activity.

Dewi V, Kwok A, Lee S, Lee MM, Tan YM, Nicholas HR, Isono K, Wienert B, Mak KS, Knights AJ, Quinlan KG, Cordwell SJ, Funnell AP, Pearson RC, Crossley M.

J Biol Chem. 2015 Mar 27;290(13):8591-605. doi: 10.1074/jbc.M115.638338. Epub 2015 Feb 6.

11.

Differential regulation of the α-globin locus by Krüppel-like Factor 3 in erythroid and non-erythroid cells.

Funnell AP, Vernimmen D, Lim WF, Mak KS, Wienert B, Martyn GE, Artuz CM, Burdach J, Quinlan KG, Higgs DR, Whitelaw E, Pearson RC, Crossley M.

BMC Mol Biol. 2014 May 16;15:8. doi: 10.1186/1471-2199-15-8.

12.

Regions outside the DNA-binding domain are critical for proper in vivo specificity of an archetypal zinc finger transcription factor.

Burdach J, Funnell AP, Mak KS, Artuz CM, Wienert B, Lim WF, Tan LY, Pearson RC, Crossley M.

Nucleic Acids Res. 2014 Jan;42(1):276-89. doi: 10.1093/nar/gkt895. Epub 2013 Oct 7.

13.

Nitrogen- and phosphorus-co-doped carbons with tunable enhanced surface areas promoted by the doping additives.

Paraknowitsch JP, Zhang Y, Wienert B, Thomas A.

Chem Commun (Camb). 2013 Feb 11;49(12):1208-10. doi: 10.1039/c2cc37398j.

PMID:
23295742
14.

Intrinsically sulfur- and nitrogen-co-doped carbons from thiazolium salts.

Paraknowitsch JP, Wienert B, Zhang Y, Thomas A.

Chemistry. 2012 Nov 26;18(48):15416-23. doi: 10.1002/chem.201202445. Epub 2012 Oct 10.

PMID:
23055452
15.

Structural basis of simultaneous recruitment of the transcriptional regulators LMO2 and FOG1/ZFPM1 by the transcription factor GATA1.

Wilkinson-White L, Gamsjaeger R, Dastmalchi S, Wienert B, Stokes PH, Crossley M, Mackay JP, Matthews JM.

Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):14443-8. doi: 10.1073/pnas.1105898108. Epub 2011 Aug 15.

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