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Items: 1 to 50 of 101

1.

Pten controls B-cell responsiveness and germinal center reaction by regulating the expression of IgD BCR.

Setz CS, Khadour A, Renna V, Iype J, Gentner E, He X, Datta M, Young M, Nitschke L, Wienands J, Maity PC, Reth M, Jumaa H.

EMBO J. 2019 Jun 3;38(11). pii: e100249. doi: 10.15252/embj.2018100249. Epub 2019 Apr 23.

2.

Memory control by the B cell antigen receptor.

Engels N, Wienands J.

Immunol Rev. 2018 May;283(1):150-160. doi: 10.1111/imr.12651. Review.

PMID:
29664567
3.

Germline deletion of CIN85 in humans with X chromosome-linked antibody deficiency.

Keller B, Shoukier M, Schulz K, Bhatt A, Heine I, Strohmeier V, Speckmann C, Engels N, Warnatz K, Wienands J.

J Exp Med. 2018 May 7;215(5):1327-1336. doi: 10.1084/jem.20170534. Epub 2018 Apr 10.

4.

Grb2 and GRAP connect the B cell antigen receptor to Erk MAP kinase activation in human B cells.

Vanshylla K, Bartsch C, Hitzing C, Krümpelmann L, Wienands J, Engels N.

Sci Rep. 2018 Mar 9;8(1):4244. doi: 10.1038/s41598-018-22544-x.

5.

Sensitivity-Enhanced Four-Dimensional Amide-Amide Correlation NMR Experiments for Sequential Assignment of Proline-Rich Disordered Proteins.

Wong LE, Maier J, Wienands J, Becker S, Griesinger C.

J Am Chem Soc. 2018 Mar 14;140(10):3518-3522. doi: 10.1021/jacs.8b00215. Epub 2018 Mar 6.

PMID:
29489342
6.

The extracellular membrane-proximal domain of membrane-bound IgE restricts B cell activation by limiting B cell antigen receptor surface expression.

Vanshylla K, Opazo F, Gronke K, Wienands J, Engels N.

Eur J Immunol. 2018 Mar;48(3):441-453. doi: 10.1002/eji.201747196. Epub 2017 Dec 1.

7.

Guidelines for the use of flow cytometry and cell sorting in immunological studies.

Cossarizza A, Chang HD, Radbruch A, Akdis M, Andrä I, Annunziato F, Bacher P, Barnaba V, Battistini L, Bauer WM, Baumgart S, Becher B, Beisker W, Berek C, Blanco A, Borsellino G, Boulais PE, Brinkman RR, Büscher M, Busch DH, Bushnell TP, Cao X, Cavani A, Chattopadhyay PK, Cheng Q, Chow S, Clerici M, Cooke A, Cosma A, Cosmi L, Cumano A, Dang VD, Davies D, De Biasi S, Del Zotto G, Della Bella S, Dellabona P, Deniz G, Dessing M, Diefenbach A, Di Santo J, Dieli F, Dolf A, Donnenberg VS, Dörner T, Ehrhardt GRA, Endl E, Engel P, Engelhardt B, Esser C, Everts B, Dreher A, Falk CS, Fehniger TA, Filby A, Fillatreau S, Follo M, Förster I, Foster J, Foulds GA, Frenette PS, Galbraith D, Garbi N, García-Godoy MD, Geginat J, Ghoreschi K, Gibellini L, Goettlinger C, Goodyear CS, Gori A, Grogan J, Gross M, Grützkau A, Grummitt D, Hahn J, Hammer Q, Hauser AE, Haviland DL, Hedley D, Herrera G, Herrmann M, Hiepe F, Holland T, Hombrink P, Houston JP, Hoyer BF, Huang B, Hunter CA, Iannone A, Jäck HM, Jávega B, Jonjic S, Juelke K, Jung S, Kaiser T, Kalina T, Keller B, Khan S, Kienhöfer D, Kroneis T, Kunkel D, Kurts C, Kvistborg P, Lannigan J, Lantz O, Larbi A, LeibundGut-Landmann S, Leipold MD, Levings MK, Litwin V, Liu Y, Lohoff M, Lombardi G, Lopez L, Lovett-Racke A, Lubberts E, Ludewig B, Lugli E, Maecker HT, Martrus G, Matarese G, Maueröder C, McGrath M, McInnes I, Mei HE, Melchers F, Melzer S, Mielenz D, Mills K, Mirrer D, Mjösberg J, Moore J, Moran B, Moretta A, Moretta L, Mosmann TR, Müller S, Müller W, Münz C, Multhoff G, Munoz LE, Murphy KM, Nakayama T, Nasi M, Neudörfl C, Nolan J, Nourshargh S, O'Connor JE, Ouyang W, Oxenius A, Palankar R, Panse I, Peterson P, Peth C, Petriz J, Philips D, Pickl W, Piconese S, Pinti M, Pockley AG, Podolska MJ, Pucillo C, Quataert SA, Radstake TRDJ, Rajwa B, Rebhahn JA, Recktenwald D, Remmerswaal EBM, Rezvani K, Rico LG, Robinson JP, Romagnani C, Rubartelli A, Ruckert B, Ruland J, Sakaguchi S, Sala-de-Oyanguren F, Samstag Y, Sanderson S, Sawitzki B, Scheffold A, Schiemann M, Schildberg F, Schimisky E, Schmid SA, Schmitt S, Schober K, Schüler T, Schulz AR, Schumacher T, Scotta C, Shankey TV, Shemer A, Simon AK, Spidlen J, Stall AM, Stark R, Stehle C, Stein M, Steinmetz T, Stockinger H, Takahama Y, Tarnok A, Tian Z, Toldi G, Tornack J, Traggiai E, Trotter J, Ulrich H, van der Braber M, van Lier RAW, Veldhoen M, Vento-Asturias S, Vieira P, Voehringer D, Volk HD, von Volkmann K, Waisman A, Walker R, Ward MD, Warnatz K, Warth S, Watson JV, Watzl C, Wegener L, Wiedemann A, Wienands J, Willimsky G, Wing J, Wurst P, Yu L, Yue A, Zhang Q, Zhao Y, Ziegler S, Zimmermann J.

Eur J Immunol. 2017 Oct;47(10):1584-1797. doi: 10.1002/eji.201646632. No abstract available.

8.

Unperturbed Immune Function despite Mutation of C-Terminal Tyrosines in Syk Previously Implicated in Signaling and Activity Regulation.

Weis V, Königsberger S, Amler S, Wienands J, Kiefer F.

Mol Cell Biol. 2017 Oct 13;37(21). pii: e00216-17. doi: 10.1128/MCB.00216-17. Print 2017 Nov 1.

9.

The Dok-3/Grb2 adaptor module promotes inducible association of the lipid phosphatase SHIP with the BCR in a coreceptor-independent manner.

Manno B, Oellerich T, Schnyder T, Corso J, Lösing M, Neumann K, Urlaub H, Batista FD, Engelke M, Wienands J.

Eur J Immunol. 2016 Nov;46(11):2520-2530. doi: 10.1002/eji.201646431. Epub 2016 Sep 14.

10.

Identification of Novel Nuclear Factor of Activated T Cell (NFAT)-associated Proteins in T Cells.

Gabriel CH, Gross F, Karl M, Stephanowitz H, Hennig AF, Weber M, Gryzik S, Bachmann I, Hecklau K, Wienands J, Schuchhardt J, Herzel H, Radbruch A, Krause E, Baumgrass R.

J Biol Chem. 2016 Nov 11;291(46):24172-24187. Epub 2016 Sep 16.

11.

The adaptor protein CIN85 assembles intracellular signaling clusters for B cell activation.

Kühn J, Wong LE, Pirkuliyeva S, Schulz K, Schwiegk C, Fünfgeld KG, Keppler S, Batista FD, Urlaub H, Habeck M, Becker S, Griesinger C, Wienands J.

Sci Signal. 2016 Jun 28;9(434):ra66. doi: 10.1126/scisignal.aad6275.

PMID:
27353366
12.

Control of memory B cell responses by extrinsic and intrinsic mechanisms.

Wienands J, Engels N.

Immunol Lett. 2016 Oct;178:27-30. doi: 10.1016/j.imlet.2016.05.010. Epub 2016 Jun 23. Review.

PMID:
27345519
13.

Elucidation of tonic and activated B-cell receptor signaling in Burkitt's lymphoma provides insights into regulation of cell survival.

Corso J, Pan KT, Walter R, Doebele C, Mohr S, Bohnenberger H, Ströbel P, Lenz C, Slabicki M, Hüllein J, Comoglio F, Rieger MA, Zenz T, Wienands J, Engelke M, Serve H, Urlaub H, Oellerich T.

Proc Natl Acad Sci U S A. 2016 May 17;113(20):5688-93. doi: 10.1073/pnas.1601053113. Epub 2016 May 6.

14.

Autoantibody-boosted T-cell reactivation in the target organ triggers manifestation of autoimmune CNS disease.

Flach AC, Litke T, Strauss J, Haberl M, Gómez CC, Reindl M, Saiz A, Fehling HJ, Wienands J, Odoardi F, Lühder F, Flügel A.

Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3323-8. doi: 10.1073/pnas.1519608113. Epub 2016 Mar 8.

15.

Preface. Regulatory signal networks of the B cell antigen receptor.

Kurosaki T, Wienands J.

Curr Top Microbiol Immunol. 2016;393:v-vi. No abstract available.

PMID:
26933697
16.

Reactivation of IgG-switched memory B cells by BCR-intrinsic signal amplification promotes IgG antibody production.

Lutz J, Dittmann K, Bösl MR, Winkler TH, Wienands J, Engels N.

Nat Commun. 2015 Oct 13;6:8575. doi: 10.1038/ncomms9575.

17.

The Memory Function of the B Cell Antigen Receptor.

Wienands J, Engels N.

Curr Top Microbiol Immunol. 2016;393:107-121. doi: 10.1007/82_2015_480. Review.

PMID:
26362935
18.

Tyrphostin AG126 exerts neuroprotection in CNS inflammation by a dual mechanism.

Menzfeld C, John M, van Rossum D, Regen T, Scheffel J, Janova H, Götz A, Ribes S, Nau R, Borisch A, Boutin P, Neumann K, Bremes V, Wienands J, Reichardt HM, Lühder F, Tischner D, Waetzig V, Herdegen T, Teismann P, Greig I, Müller M, Pukrop T, Mildner A, Kettenmann H, Brück W, Prinz M, Rotshenker S, Weber MS, Hanisch UK.

Glia. 2015 Jun;63(6):1083-99. doi: 10.1002/glia.22803. Epub 2015 Mar 2.

PMID:
25731696
19.

The immunoglobulin tail tyrosine motif upgrades memory-type BCRs by incorporating a Grb2-Btk signalling module.

Engels N, König LM, Schulze W, Radtke D, Vanshylla K, Lutz J, Winkler TH, Nitschke L, Wienands J.

Nat Commun. 2014 Nov 21;5:5456. doi: 10.1038/ncomms6456.

20.

STAT3: A Novel Molecular Mediator of Resistance to Chemoradiotherapy.

Spitzner M, Ebner R, Wolff HA, Ghadimi BM, Wienands J, Grade M.

Cancers (Basel). 2014 Sep 29;6(4):1986-2011. doi: 10.3390/cancers6041986. Review.

21.

Macromolecular assembly of the adaptor SLP-65 at intracellular vesicles in resting B cells.

Engelke M, Pirkuliyeva S, Kühn J, Wong L, Boyken J, Herrmann N, Becker S, Griesinger C, Wienands J.

Sci Signal. 2014 Aug 19;7(339):ra79. doi: 10.1126/scitranslmed.2005104.

PMID:
25140054
22.

Seroprevalence of autoantibodies against brain antigens in health and disease.

Dahm L, Ott C, Steiner J, Stepniak B, Teegen B, Saschenbrecker S, Hammer C, Borowski K, Begemann M, Lemke S, Rentzsch K, Probst C, Martens H, Wienands J, Spalletta G, Weissenborn K, Stöcker W, Ehrenreich H.

Ann Neurol. 2014 Jul;76(1):82-94. doi: 10.1002/ana.24189. Epub 2014 Jun 23.

PMID:
24853231
23.

Reprint of: Environments of B cell development.

Tsuneto M, Kajikhina E, Seiler K, Reimer A, Tornack J, Bouquet C, Simmons S, Knoll M, Wolf I, Tokoyoda K, Hauser A, Hara T, Tani-ichi S, Ikuta K, Grün JR, Grützkau A, Engels N, Wienands J, Yanagisawa Y, Ohnishi K, Melchers F.

Immunol Lett. 2014 Aug;160(2):109-12. doi: 10.1016/j.imlet.2014.05.005. Epub 2014 May 20.

PMID:
24852107
24.

Inactivation of patched1 in murine chondrocytes causes spinal fusion without inflammation.

Dittmann K, Wuelling M, Uhmann A, Dullin C, Hahn H, Schweyer S, Vortkamp A, Wienands J.

Arthritis Rheumatol. 2014 Apr;66(4):831-40. doi: 10.1002/art.38325.

25.

The intramembrane proteases signal Peptide peptidase-like 2a and 2b have distinct functions in vivo.

Schneppenheim J, Hüttl S, Mentrup T, Lüllmann-Rauch R, Rothaug M, Engelke M, Dittmann K, Dressel R, Araki M, Araki K, Wienands J, Fluhrer R, Saftig P, Schröder B.

Mol Cell Biol. 2014 Apr;34(8):1398-411. doi: 10.1128/MCB.00038-14. Epub 2014 Feb 3.

26.

Environments of B cell development.

Tsuneto M, Kajikhina E, Seiler K, Reimer A, Tornack J, Bouquet C, Simmons S, Knoll M, Wolf I, Tokoyoda K, Hauser A, Hara T, Tani-ichi S, Ikuta K, Grün JR, Grützkau A, Engels N, Wienands J, Yanagisawa Y, Ohnishi K, Melchers F.

Immunol Lett. 2014 Jan-Feb;157(1-2):60-3. doi: 10.1016/j.imlet.2013.11.011. Epub 2013 Nov 24. Review.

PMID:
24284375
27.

Cutting edge: feed-forward activation of phospholipase Cγ2 via C2 domain-mediated binding to SLP65.

Engelke M, Oellerich T, Dittmann K, Hsiao HH, Urlaub H, Serve H, Griesinger C, Wienands J.

J Immunol. 2013 Dec 1;191(11):5354-8. doi: 10.4049/jimmunol.1301326. Epub 2013 Oct 28.

28.

STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapy in vitro and in vivo.

Spitzner M, Roesler B, Bielfeld C, Emons G, Gaedcke J, Wolff HA, Rave-Fränk M, Kramer F, Beissbarth T, Kitz J, Wienands J, Ghadimi BM, Ebner R, Ried T, Grade M.

Int J Cancer. 2014 Feb 15;134(4):997-1007. doi: 10.1002/ijc.28429. Epub 2013 Sep 3.

29.

Empty liposomes induce antitumoral effects associated with macrophage responses distinct from those of the TLR1/2 agonist Pam3CSK 4 (BLP).

König S, Regen T, Dittmann K, Engelke M, Wienands J, Schwendener R, Hanisch UK, Pukrop T, Hahn H.

Cancer Immunol Immunother. 2013 Oct;62(10):1587-97. doi: 10.1007/s00262-013-1444-4. Epub 2013 Aug 6.

30.

Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells.

Castello A, Gaya M, Tucholski J, Oellerich T, Lu KH, Tafuri A, Pawson T, Wienands J, Engelke M, Batista FD.

Nat Immunol. 2013 Sep;14(9):966-75. doi: 10.1038/ni.2685. Epub 2013 Aug 4.

PMID:
23913047
31.

PDK1 controls upstream PI3K expression and PIP3 generation.

Dieterle AM, Böhler P, Keppeler H, Alers S, Berleth N, Drießen S, Hieke N, Pietkiewicz S, Löffler AS, Peter C, Gray A, Leslie NR, Shinohara H, Kurosaki T, Engelke M, Wienands J, Bonin M, Wesselborg S, Stork B.

Oncogene. 2014 Jun 5;33(23):3043-53. doi: 10.1038/onc.2013.266. Epub 2013 Jul 29.

PMID:
23893244
32.

β2 integrin-derived signals induce cell survival and proliferation of AML blasts by activating a Syk/STAT signaling axis.

Oellerich T, Oellerich MF, Engelke M, Münch S, Mohr S, Nimz M, Hsiao HH, Corso J, Zhang J, Bohnenberger H, Berg T, Rieger MA, Wienands J, Bug G, Brandts C, Urlaub H, Serve H.

Blood. 2013 May 9;121(19):3889-99, S1-66. doi: 10.1182/blood-2012-09-457887. Epub 2013 Mar 18.

33.

PI3K inhibition enhances doxorubicin-induced apoptosis in sarcoma cells.

Marklein D, Graab U, Naumann I, Yan T, Ridzewski R, Nitzki F, Rosenberger A, Dittmann K, Wienands J, Wojnowski L, Fulda S, Hahn H.

PLoS One. 2012;7(12):e52898. doi: 10.1371/journal.pone.0052898. Epub 2012 Dec 31.

34.

The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain.

Schneppenheim J, Dressel R, Hüttl S, Lüllmann-Rauch R, Engelke M, Dittmann K, Wienands J, Eskelinen EL, Hermans-Borgmeyer I, Fluhrer R, Saftig P, Schröder B.

J Exp Med. 2013 Jan 14;210(1):41-58. doi: 10.1084/jem.20121069. Epub 2012 Dec 24.

35.

The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclusters.

Lösing M, Goldbeck I, Manno B, Oellerich T, Schnyder T, Bohnenberger H, Stork B, Urlaub H, Batista FD, Wienands J, Engelke M.

J Biol Chem. 2013 Jan 25;288(4):2303-13. doi: 10.1074/jbc.M112.406546. Epub 2012 Dec 5.

36.

Inactivation of Patched1 in mice leads to development of gastrointestinal stromal-like tumors that express Pdgfrα but not kit.

Pelczar P, Zibat A, van Dop WA, Heijmans J, Bleckmann A, Gruber W, Nitzki F, Uhmann A, Guijarro MV, Hernando E, Dittmann K, Wienands J, Dressel R, Wojnowski L, Binder C, Taguchi T, Beissbarth T, Hogendoorn PC, Antonescu CR, Rubin BP, Schulz-Schaeffer W, Aberger F, van den Brink GR, Hahn H.

Gastroenterology. 2013 Jan;144(1):134-144.e6. doi: 10.1053/j.gastro.2012.09.061. Epub 2012 Oct 3.

37.

Spatiotemporal resolution of Ca2+ signaling events by real time imaging of single B cells.

Junek S, Engelke M, Schild D, Wienands J.

FEBS Lett. 2012 May 21;586(10):1452-8. doi: 10.1016/j.febslet.2012.03.057. Epub 2012 Apr 13.

38.

The non-Ig parts of the VpreB and λ5 proteins of the surrogate light chain play opposite roles in the surface representation of the precursor B cell receptor.

Knoll M, Yanagisawa Y, Simmons S, Engels N, Wienands J, Melchers F, Ohnishi K.

J Immunol. 2012 Jun 15;188(12):6010-7. doi: 10.4049/jimmunol.1200071. Epub 2012 May 7.

39.

Epstein-Barr virus LMP2A signaling in statu nascendi mimics a B cell antigen receptor-like activation signal.

Engels N, Yigit G, Emmerich CH, Czesnik D, Schild D, Wienands J.

Cell Commun Signal. 2012 Apr 3;10:9. doi: 10.1186/1478-811X-10-9.

40.

Occurrence of acute lymphoblastic leukemia and juvenile myelomonocytic leukemia in a patient with Noonan syndrome carrying the germline PTPN11 mutation p.E139D.

Pauli S, Steinemann D, Dittmann K, Wienands J, Shoukier M, Möschner M, Burfeind P, Manukjan G, Göhring G, Escherich G.

Am J Med Genet A. 2012 Mar;158A(3):652-8. doi: 10.1002/ajmg.a.34439. Epub 2012 Feb 7.

PMID:
22315187
41.

The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85.

Oellerich T, Bremes V, Neumann K, Bohnenberger H, Dittmann K, Hsiao HH, Engelke M, Schnyder T, Batista FD, Urlaub H, Wienands J.

EMBO J. 2011 Aug 5;30(17):3620-34. doi: 10.1038/emboj.2011.251.

42.

Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells.

Sela M, Bogin Y, Beach D, Oellerich T, Lehne J, Smith-Garvin JE, Okumura M, Starosvetsky E, Kosoff R, Libman E, Koretzky G, Kambayashi T, Urlaub H, Wienands J, Chernoff J, Yablonski D.

EMBO J. 2011 Jul 1;30(15):3160-72. doi: 10.1038/emboj.2011.213.

43.

B cell receptor-mediated antigen gathering requires ubiquitin ligase Cbl and adaptors Grb2 and Dok-3 to recruit dynein to the signaling microcluster.

Schnyder T, Castello A, Feest C, Harwood NE, Oellerich T, Urlaub H, Engelke M, Wienands J, Bruckbauer A, Batista FD.

Immunity. 2011 Jun 24;34(6):905-18. doi: 10.1016/j.immuni.2011.06.001.

44.

Complex phosphorylation dynamics control the composition of the Syk interactome in B cells.

Bohnenberger H, Oellerich T, Engelke M, Hsiao HH, Urlaub H, Wienands J.

Eur J Immunol. 2011 Jun;41(6):1550-62. doi: 10.1002/eji.201041326. Epub 2011 May 25.

45.

The signaling tool box for tyrosine-based costimulation of lymphocytes.

Engels N, Wienands J.

Curr Opin Immunol. 2011 Jun;23(3):324-9. doi: 10.1016/j.coi.2011.01.005. Epub 2011 Feb 14. Review.

PMID:
21324660
46.

T cell development critically depends on prethymic stromal patched expression.

Uhmann A, van den Brandt J, Dittmann K, Hess I, Dressel R, Binder C, Lühder F, Christiansen H, Fassnacht M, Bhandoola A, Wienands J, Reichardt HM, Hahn H.

J Immunol. 2011 Mar 15;186(6):3383-91. doi: 10.4049/jimmunol.1001939. Epub 2011 Feb 11.

47.

B-lymphoma cells escape rituximab-triggered elimination by NK cells through increased HLA class I expression.

Borgerding A, Hasenkamp J, Engelke M, Burkhart N, Trümper L, Wienands J, Glass B.

Exp Hematol. 2010 Mar;38(3):213-21. doi: 10.1016/j.exphem.2009.12.007. Epub 2010 Jan 6.

PMID:
20056126
48.

The B-lymphoid Grb2 interaction code.

Neumann K, Oellerich T, Urlaub H, Wienands J.

Immunol Rev. 2009 Nov;232(1):135-49. doi: 10.1111/j.1600-065X.2009.00845.x. Review.

PMID:
19909361
49.

Non-T cell activation linker regulates ERK activation in Helicobacter pylori-infected epithelial cells.

Rieke C, Kähne T, Schweitzer K, Schraven B, Wienands J, Engelke M, Naumann M.

Cell Signal. 2010 Mar;22(3):395-403. doi: 10.1016/j.cellsig.2009.10.010.

PMID:
19879355
50.

Comment on "Direct hematological toxicity and illegitimate chromosomal recombination caused by the systemic activation of CreER(T2)".

Uhmann A, Dittmann K, Wienands J, Hahn H.

J Immunol. 2009 Sep 1;183(5):2891; author reply 2891-2. doi: 10.4049/jimmunol.0990063. No abstract available.

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