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Stability and Efficiency of Mixed Aryl Phosphonate Prodrugs.

Foust BJ, Li J, Hsiao CC, Wiemer DF, Wiemer AJ.

ChemMedChem. 2019 Jun 21. doi: 10.1002/cmdc.201900344. [Epub ahead of print]


Screening for Carbapenemases in Ertapenem-Resistant Enterobacteriaceae Collected at a Tunisian Hospital Between 2014 and 2018.

Kollenda H, Frickmann H, Ben Helal R, Wiemer DF, Naija H, El Asli MS, Egold M, Bugert JJ, Handrick S, Wölfel R, Barguellil F, Ben Moussa M.

Eur J Microbiol Immunol (Bp). 2019 Feb 13;9(1):9-13. doi: 10.1556/1886.2018.00033. eCollection 2019 Mar 18.


Loop-mediated isothermal amplification for paratyphoid fever - a proof-of-principle analysis.

Rojak S, Wiemer DF, Wille A, Loderstädt U, Wassill L, Hinz R, Hagen RM, Frickmann H.

Lett Appl Microbiol. 2019 Jun;68(6):509-513. doi: 10.1111/lam.13130. Epub 2019 Apr 25.


Loop-mediated isothermal amplification-based detection of typhoid fever on an automated Genie II Mk2 system - A case-control-based approach.

Frickmann H, Wiemer DF, Wassill L, Hinz R, Rojak S, Wille A, Loderstädt U, Schwarz NG, von Kalckreuth V, Im J, Jin Jeon H, Marks F, Owusu-Dabo E, Sarpong N, May J, Eibach D, Dekker D.

Acta Trop. 2019 Feb;190:293-295. doi: 10.1016/j.actatropica.2018.12.004. Epub 2018 Dec 5.


Phosphonamidate Prodrugs of a Butyrophilin Ligand Display Plasma Stability and Potent Vγ9 Vδ2 T Cell Stimulation.

Lentini NA, Foust BJ, Hsiao CC, Wiemer AJ, Wiemer DF.

J Med Chem. 2018 Oct 11;61(19):8658-8669. doi: 10.1021/acs.jmedchem.8b00655. Epub 2018 Sep 26.


Chemo-enzymatic synthesis of the exocyclic olefin isomer of thymidine monophosphate.

Mondal D, Koehn EM, Yao J, Wiemer DF, Kohen A.

Bioorg Med Chem. 2018 May 15;26(9):2365-2371. doi: 10.1016/j.bmc.2018.03.032. Epub 2018 Mar 22.


Quantitative determination of a potent geranylgeranyl diphosphate synthase inhibitor using LC-MS/MS: Derivatization and application.

Chhonker YS, Haney SL, Matthiesen RA, Wiemer DF, Holstein SA, Murry DJ.

J Pharm Biomed Anal. 2018 May 10;153:22-28. doi: 10.1016/j.jpba.2018.02.010. Epub 2018 Feb 6.


Pharmaceutical interactions between antiretroviral and antimalarial drugs used in chemoprophylaxis.

Zautner AE, Herchenröder O, Moussi AE, Schwarz NG, Wiemer DF, Groß U, Frickmann H.

Acta Trop. 2018 Mar;179:25-35. doi: 10.1016/j.actatropica.2017.12.021. Epub 2017 Dec 19. Review.


α-Methylation enhances the potency of isoprenoid triazole bisphosphonates as geranylgeranyl diphosphate synthase inhibitors.

Matthiesen RA, Varney ML, Xu PC, Rier AS, Wiemer DF, Holstein SA.

Bioorg Med Chem. 2018 Jan 15;26(2):376-385. doi: 10.1016/j.bmc.2017.10.023. Epub 2017 Oct 19.


Mixed Aryl Phosphonate Prodrugs of a Butyrophilin Ligand.

Foust BJ, Poe MM, Lentini NA, Hsiao CC, Wiemer AJ, Wiemer DF.

ACS Med Chem Lett. 2017 Aug 9;8(9):914-918. doi: 10.1021/acsmedchemlett.7b00245. eCollection 2017 Sep 14.


Synthesis of amide isosteres of schweinfurthin-based stilbenes.

Stockdale DP, Beutler JA, Wiemer DF.

Bioorg Med Chem. 2017 Oct 15;25(20):5483-5489. doi: 10.1016/j.bmc.2017.08.016. Epub 2017 Aug 9.


Selective opioid growth factor receptor antagonists based on a stilbene isostere.

Stockdale DP, Titunick MB, Biegler JM, Reed JL, Hartung AM, Wiemer DF, McLaughlin PJ, Neighbors JD.

Bioorg Med Chem. 2017 Aug 15;25(16):4464-4474. doi: 10.1016/j.bmc.2017.06.035. Epub 2017 Jun 27.


Colonization with Multidrug-Resistant Bacteria - On the Efficiency of Local Decolonization Procedures.

Münch J, Hagen RM, Müller M, Kellert V, Wiemer DF, Hinz R, Schwarz NG, Frickmann H.

Eur J Microbiol Immunol (Bp). 2017 May 31;7(2):99-111. doi: 10.1556/1886.2017.00008. eCollection 2017 Jun.


Recent Advances in the Development of Mammalian Geranylgeranyl Diphosphate Synthase Inhibitors.

Haney SL, Wills VS, Wiemer DF, Holstein SA.

Molecules. 2017 May 27;22(6). pii: E886. doi: 10.3390/molecules22060886. Review.


Bishomoisoprenoid triazole bisphosphonates as inhibitors of geranylgeranyl diphosphate synthase.

Wills VS, Metzger JI, Allen C, Varney ML, Wiemer DF, Holstein SA.

Bioorg Med Chem. 2017 Apr 15;25(8):2437-2444. doi: 10.1016/j.bmc.2017.02.066. Epub 2017 Mar 4.


Phosphinophosphonates and Their Tris-pivaloyloxymethyl Prodrugs Reveal a Negatively Cooperative Butyrophilin Activation Mechanism.

Shippy RR, Lin X, Agabiti SS, Li J, Zangari BM, Foust BJ, Poe MM, Hsiao CC, Vinogradova O, Wiemer DF, Wiemer AJ.

J Med Chem. 2017 Mar 23;60(6):2373-2382. doi: 10.1021/acs.jmedchem.6b00965. Epub 2017 Mar 1.


Olefin Isomers of a Triazole Bisphosphonate Synergistically Inhibit Geranylgeranyl Diphosphate Synthase.

Allen C, Kortagere S, Tong H, Matthiesen RA, Metzger JI, Wiemer DF, Holstein SA.

Mol Pharmacol. 2017 Mar;91(3):229-236. doi: 10.1124/mol.116.107326. Epub 2017 Jan 5.


Stereoselective Synthesis of Homoneryl and Homogeranyl Triazole Bisphosphonates.

Matthiesen RA, Wills VS, Metzger JI, Holstein SA, Wiemer DF.

J Org Chem. 2016 Oct 7;81(19):9438-9442. Epub 2016 Sep 20.


A new motif for inhibitors of geranylgeranyl diphosphate synthase.

Foust BJ, Allen C, Holstein SA, Wiemer DF.

Bioorg Med Chem. 2016 Aug 15;24(16):3734-41. doi: 10.1016/j.bmc.2016.06.019. Epub 2016 Jun 10.


Corrigendum to "A selective delta opioid receptor antagonist based on a stilbene core" [Bioorg. Med. Chem. Lett. 25 (2015) 5532-5535].

Hartung AM, Navarro HA, Wiemer DF, Neighbors JD.

Bioorg Med Chem Lett. 2016 Mar 15;26(6):1645. doi: 10.1016/j.bmcl.2016.02.014. Epub 2016 Feb 11. No abstract available.


Stereocontrolled regeneration of olefins from epoxides.

Wills VS, Zhou X, Allen C, Holstein SA, Wiemer DF.

Tetrahedron Lett. 2016 Mar 23;57(12):1335-1337.


Selective Prenylation of Protected Phenols for Synthesis of Pawhuskin A Analogues.

Gardner KD, Wiemer DF.

J Org Chem. 2016 Feb 19;81(4):1585-92. doi: 10.1021/acs.joc.5b02756. Epub 2016 Jan 28.


Potent Triazole Bisphosphonate Inhibitor of Geranylgeranyl Diphosphate Synthase.

Wills VS, Allen C, Holstein SA, Wiemer DF.

ACS Med Chem Lett. 2015 Oct 28;6(12):1195-8. doi: 10.1021/acsmedchemlett.5b00334. eCollection 2015 Dec 10.


A selective delta opioid receptor antagonist based on a stilbene core.

Hartung AM, Navarro HA, Wiemer DF, Neighbors JD.

Bioorg Med Chem Lett. 2015 Dec 1;25(23):5532-5. doi: 10.1016/j.bmcl.2015.10.059. Epub 2015 Oct 23. Erratum in: Bioorg Med Chem Lett. 2016 Mar 15;26(6):1645. Bioorg Med Chem Lett. 2016 Mar 15;26(6):1645.


Evaluation of a 7-Methoxycoumarin-3-carboxylic Acid Ester Derivative as a Fluorescent, Cell-Cleavable, Phosphonate Protecting Group.

Wiemer AJ, Shippy RR, Kilcollins AM, Li J, Hsiao CH, Barney RJ, Geng ML, Wiemer DF.

Chembiochem. 2016 Jan 1;17(1):52-5. doi: 10.1002/cbic.201500484. Epub 2015 Nov 19.


3-Deoxyschweinfurthin B Lowers Cholesterol Levels by Decreasing Synthesis and Increasing Export in Cultured Cancer Cell Lines.

Kuder CH, Weivoda MM, Zhang Y, Zhu J, Neighbors JD, Wiemer DF, Hohl RJ.

Lipids. 2015 Dec;50(12):1195-207. doi: 10.1007/s11745-015-4083-z. Epub 2015 Oct 22.


In vitro studies in a myelogenous leukemia cell line suggest an organized binding of geranylgeranyl diphosphate synthase inhibitors.

Reilly JE, Zhou X, Tong H, Kuder CH, Wiemer DF, Hohl RJ.

Biochem Pharmacol. 2015 Jul 15;96(2):83-92. doi: 10.1016/j.bcp.2015.04.009. Epub 2015 May 4.


N-Oxide derivatives of 3-(3-pyridyl)-2-phosphonopropanoic acids as potential inhibitors of Rab geranylgeranylation.

Zhou X, Born EJ, Allen C, Holstein SA, Wiemer DF.

Bioorg Med Chem Lett. 2015 Jun 1;25(11):2331-4. doi: 10.1016/j.bmcl.2015.04.021. Epub 2015 Apr 17.


Prodrugs of phosphonates and phosphates: crossing the membrane barrier.

Wiemer AJ, Wiemer DF.

Top Curr Chem. 2015;360:115-60. doi: 10.1007/128_2014_561. Review.


Synthesis of isoprenoid bisphosphonate ethers through C-P bond formations: Potential inhibitors of geranylgeranyl diphosphate synthase.

Zhou X, Reilly JE, Loerch KA, Hohl RJ, Wiemer DF.

Beilstein J Org Chem. 2014 Jul 18;10:1645-50. doi: 10.3762/bjoc.10.171. eCollection 2014.


Synthesis of a phosphoantigen prodrug that potently activates Vγ9Vδ2 T-lymphocytes.

Hsiao CH, Lin X, Barney RJ, Shippy RR, Li J, Vinogradova O, Wiemer DF, Wiemer AJ.

Chem Biol. 2014 Aug 14;21(8):945-54. doi: 10.1016/j.chembiol.2014.06.006. Epub 2014 Jul 24.


Geranyl and neryl triazole bisphosphonates as inhibitors of geranylgeranyl diphosphate synthase.

Zhou X, Ferree SD, Wills VS, Born EJ, Tong H, Wiemer DF, Holstein SA.

Bioorg Med Chem. 2014 May 1;22(9):2791-8. doi: 10.1016/j.bmc.2014.03.014. Epub 2014 Mar 24.


Opportunities and challenges in development of phosphoantigens as Vγ9Vδ2 T cell agonists.

Wiemer DF, Wiemer AJ.

Biochem Pharmacol. 2014 Jun 1;89(3):301-12. doi: 10.1016/j.bcp.2014.03.009. Epub 2014 Mar 26.


Synthesis and structure activity relationships of schweinfurthin indoles.

Kodet JG, Beutler JA, Wiemer DF.

Bioorg Med Chem. 2014 Apr 15;22(8):2542-52. doi: 10.1016/j.bmc.2014.02.043. Epub 2014 Mar 6.


Electrophilic aromatic prenylation via cascade cyclization.

Kodet JG, Topczewski JJ, Gardner KD, Wiemer DF.

Tetrahedron. 2013 Oct 4;69(44):9212-9218.


Stilbenes as κ-selective, non-nitrogenous opioid receptor antagonists.

Hartung AM, Beutler JA, Navarro HA, Wiemer DF, Neighbors JD.

J Nat Prod. 2014 Feb 28;77(2):311-9. doi: 10.1021/np4009046. Epub 2014 Jan 23.


Food and drinking water hygiene and intestinal protozoa in deployed German soldiers.

Frickmann H, Schwarz NG, Wiemer DF, Fischer M, Tannich E, Scheid PL, Müller M, Schotte U, Bock W, Hagen RM.

Eur J Microbiol Immunol (Bp). 2013 Mar;3(1):53-60. doi: 10.1556/EuJMI.3.2013.1.8. Epub 2013 Mar 13.


Synthesis of indole analogues of the natural schweinfurthins.

Kodet JG, Wiemer DF.

J Org Chem. 2013 Sep 20;78(18):9291-302. doi: 10.1021/jo4014244. Epub 2013 Sep 5.


Increased detection of invasive enteropathogenic bacteria in pre-incubated blood culture materials by real-time PCR in comparison with automated incubation in Sub-Saharan Africa.

Frickmann H, Dekker D, Boahen K, Acquah S, Sarpong N, Adu-Sarkodie Y, Schwarz NG, May J, Marks F, Poppert S, Wiemer DF, Hagen RM.

Scand J Infect Dis. 2013 Aug;45(8):616-22. doi: 10.3109/00365548.2013.777777. Epub 2013 Apr 3.


Triazole-based inhibitors of geranylgeranyltransferase II.

Zhou X, Hartman SV, Born EJ, Smits JP, Holstein SA, Wiemer DF.

Bioorg Med Chem Lett. 2013 Feb 1;23(3):764-6. doi: 10.1016/j.bmcl.2012.11.089. Epub 2012 Dec 1.


Functional evaluation of a fluorescent schweinfurthin: mechanism of cytotoxicity and intracellular quantification.

Kuder CH, Sheehy RM, Neighbors JD, Wiemer DF, Hohl RJ.

Mol Pharmacol. 2012 Jul;82(1):9-16. doi: 10.1124/mol.111.077107. Epub 2012 Mar 29.


Relevance of the C-5 position to schweinfurthin induced cytotoxicity.

Topczewski JJ, Callahan MP, Kodet JG, Inbarasu JD, Mente NR, Beutler JA, Wiemer DF.

Bioorg Med Chem. 2011 Dec 15;19(24):7570-81. doi: 10.1016/j.bmc.2011.10.034. Epub 2011 Oct 19.


First total synthesis of (+)-Vedelianin, a potent antiproliferative agent.

Topczewski JJ, Wiemer DF.

Tetrahedron Lett. 2011 Apr 6;52(14):1628-1630.


Geranylgeranyl diphosphate synthase: an emerging therapeutic target.

Wiemer AJ, Wiemer DF, Hohl RJ.

Clin Pharmacol Ther. 2011 Dec;90(6):804-12. doi: 10.1038/clpt.2011.215. Epub 2011 Nov 2. Review.


Synthesis and reactivity of alkyl-1,1,1-trisphosphonate esters.

Smits JP, Wiemer DF.

J Org Chem. 2011 Nov 4;76(21):8807-13. doi: 10.1021/jo201523w. Epub 2011 Oct 4.


A novel bisphosphonate inhibitor of squalene synthase combined with a statin or a nitrogenous bisphosphonate in vitro.

Wasko BM, Smits JP, Shull LW, Wiemer DF, Hohl RJ.

J Lipid Res. 2011 Nov;52(11):1957-64. doi: 10.1194/jlr.M016089. Epub 2011 Sep 8.


Direct conversion of benzylic and allylic alcohols to phosphonates.

Barney RJ, Richardson RM, Wiemer DF.

J Org Chem. 2011 Apr 15;76(8):2875-9. doi: 10.1021/jo200137k. Epub 2011 Mar 15.


Exploration of cascade cyclizations terminated by tandem aromatic substitution: total synthesis of (+)-schweinfurthin A.

Topczewski JJ, Kodet JG, Wiemer DF.

J Org Chem. 2011 Feb 4;76(3):909-19. doi: 10.1021/jo1022102. Epub 2011 Jan 12.


Biologically active biotin derivatives of schweinfurthin F.

Ulrich NC, Kuder CH, Hohl RJ, Wiemer DF.

Bioorg Med Chem Lett. 2010 Nov 15;20(22):6716-20. doi: 10.1016/j.bmcl.2010.08.143. Epub 2010 Sep 6.


Synthesis and biological evaluation of a series of aromatic bisphosphonates.

Barney RJ, Wasko BM, Dudakovic A, Hohl RJ, Wiemer DF.

Bioorg Med Chem. 2010 Oct 15;18(20):7212-20. doi: 10.1016/j.bmc.2010.08.036. Epub 2010 Aug 19.


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