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Combined Treatment with L-Carnitine and Nicotinamide Riboside Improves Hepatic Metabolism and Attenuates Obesity and Liver Steatosis.

Salic K, Gart E, Seidel F, Verschuren L, Caspers M, van Duyvenvoorde W, Wong KE, Keijer J, Bobeldijk-Pastorova I, Wielinga PY, Kleemann R.

Int J Mol Sci. 2019 Sep 5;20(18). pii: E4359. doi: 10.3390/ijms20184359.


Obeticholic Acid Modulates Serum Metabolites and Gene Signatures Characteristic of Human NASH and Attenuates Inflammation and Fibrosis Progression in Ldlr-/-.Leiden Mice.

Morrison MC, Verschuren L, Salic K, Verheij J, Menke A, Wielinga PY, Iruarrizaga-Lejarreta M, Gole L, Yu WM, Turner S, Caspers MPM, Martínez-Arranz I, Pieterman E, Stoop R, van Koppen A, van den Hoek AM, Mato JM, Hanemaaijer R, Alonso C, Kleemann R.

Hepatol Commun. 2018 Oct 29;2(12):1513-1532. doi: 10.1002/hep4.1270. eCollection 2018 Dec.


CAT-2003: A novel sterol regulatory element-binding protein inhibitor that reduces steatohepatitis, plasma lipids, and atherosclerosis in apolipoprotein E*3-Leiden mice.

Zimmer M, Bista P, Benson EL, Lee DY, Liu F, Picarella D, Vega RB, Vu CB, Yeager M, Ding M, Liang G, Horton JD, Kleemann R, Kooistra T, Morrison MC, Wielinga PY, Milne JC, Jirousek MR, Nichols AJ.

Hepatol Commun. 2017 May 12;1(4):311-325. doi: 10.1002/hep4.1042. eCollection 2017 Jun.


A casein hydrolysate based formulation attenuates obesity and associated non-alcoholic fatty liver disease and atherosclerosis in LDLr-/-.Leiden mice.

Schoemaker MH, Kleemann R, Morrison MC, Verheij J, Salic K, van Tol EAF, Kooistra T, Wielinga PY.

PLoS One. 2017 Jul 5;12(7):e0180648. doi: 10.1371/journal.pone.0180648. eCollection 2017.


Protective effect of rosiglitazone on kidney function in high-fat challenged human-CRP transgenic mice: a possible role for adiponectin and miR-21?

Morrison MC, Yakala GK, Liang W, Wielinga PY, Salic K, van Koppen A, Tomar T, Kleemann R, Heeringa P, Kooistra T.

Sci Rep. 2017 Jun 6;7(1):2915. doi: 10.1038/s41598-017-02444-2.


Butyrate restores HFD-induced adaptations in brain function and metabolism in mid-adult obese mice.

Arnoldussen IAC, Wiesmann M, Pelgrim CE, Wielemaker EM, van Duyvenvoorde W, Amaral-Santos PL, Verschuren L, Keijser BJF, Heerschap A, Kleemann R, Wielinga PY, Kiliaan AJ.

Int J Obes (Lond). 2017 Jun;41(6):935-944. doi: 10.1038/ijo.2017.52. Epub 2017 Feb 21.


Reduction of obesity-associated white adipose tissue inflammation by rosiglitazone is associated with reduced non-alcoholic fatty liver disease in LDLr-deficient mice.

Mulder P, Morrison MC, Verschuren L, Liang W, van Bockel JH, Kooistra T, Wielinga PY, Kleemann R.

Sci Rep. 2016 Aug 22;6:31542. doi: 10.1038/srep31542.


Resolvin E1 attenuates atherosclerosis in absence of cholesterol-lowering effects and on top of atorvastatin.

Salic K, Morrison MC, Verschuren L, Wielinga PY, Wu L, Kleemann R, Gjorstrup P, Kooistra T.

Atherosclerosis. 2016 Jul;250:158-65. doi: 10.1016/j.atherosclerosis.2016.05.001. Epub 2016 May 2.


Intervention with a caspase-1 inhibitor reduces obesity-associated hyperinsulinemia, non-alcoholic steatohepatitis and hepatic fibrosis in LDLR-/-.Leiden mice.

Morrison MC, Mulder P, Salic K, Verheij J, Liang W, van Duyvenvoorde W, Menke A, Kooistra T, Kleemann R, Wielinga PY.

Int J Obes (Lond). 2016 Sep;40(9):1416-23. doi: 10.1038/ijo.2016.74. Epub 2016 May 28.


Early intake of long-chain polyunsaturated fatty acids preserves brain structure and function in diet-induced obesity.

Arnoldussen IA, Zerbi V, Wiesmann M, Noordman RH, Bolijn S, Mutsaers MP, Dederen PJ, Kleemann R, Kooistra T, van Tol EA, Gross G, Schoemaker MH, Heerschap A, Wielinga PY, Kiliaan AJ.

J Nutr Biochem. 2016 Apr;30:177-88. doi: 10.1016/j.jnutbio.2015.12.011. Epub 2016 Jan 21.


Surgical removal of inflamed epididymal white adipose tissue attenuates the development of non-alcoholic steatohepatitis in obesity.

Mulder P, Morrison MC, Wielinga PY, van Duyvenvoorde W, Kooistra T, Kleemann R.

Int J Obes (Lond). 2016 Apr;40(4):675-84. doi: 10.1038/ijo.2015.226. Epub 2015 Oct 26.


Replacement of Dietary Saturated Fat by PUFA-Rich Pumpkin Seed Oil Attenuates Non-Alcoholic Fatty Liver Disease and Atherosclerosis Development, with Additional Health Effects of Virgin over Refined Oil.

Morrison MC, Mulder P, Stavro PM, Suárez M, Arola-Arnal A, van Duyvenvoorde W, Kooistra T, Wielinga PY, Kleemann R.

PLoS One. 2015 Sep 25;10(9):e0139196. doi: 10.1371/journal.pone.0139196. eCollection 2015.


Mirtoselect, an anthocyanin-rich bilberry extract, attenuates non-alcoholic steatohepatitis and associated fibrosis in ApoE(∗)3Leiden mice.

Morrison MC, Liang W, Mulder P, Verschuren L, Pieterman E, Toet K, Heeringa P, Wielinga PY, Kooistra T, Kleemann R.

J Hepatol. 2015 May;62(5):1180-6. doi: 10.1016/j.jhep.2014.12.011. Epub 2014 Dec 13.


A systems biology approach to understand the pathophysiological mechanisms of cardiac pathological hypertrophy associated with rosiglitazone.

Verschuren L, Wielinga PY, Kelder T, Radonjic M, Salic K, Kleemann R, van Ommen B, Kooistra T.

BMC Med Genomics. 2014 Jun 17;7:35. doi: 10.1186/1755-8794-7-35.


Detecting bioterrorism: how to detect the unexpected?

Wielinga PR.

Biosecur Bioterror. 2013 Sep;11 Suppl 1:S123. doi: 10.1089/bsp.2013.0863. No abstract available.


Coordinated and interactive expression of genes of lipid metabolism and inflammation in adipose tissue and liver during metabolic overload.

Liang W, Tonini G, Mulder P, Kelder T, van Erk M, van den Hoek AM, Mariman R, Wielinga PY, Baccini M, Kooistra T, Biggeri A, Kleemann R.

PLoS One. 2013 Sep 25;8(9):e75290. doi: 10.1371/journal.pone.0075290. eCollection 2013.


Effects of chocolate supplementation on metabolic and cardiovascular parameters in ApoE3L mice fed a high-cholesterol atherogenic diet.

Yakala GK, Wielinga PY, Suarez M, Bunschoten A, van Golde JM, Arola L, Keijer J, Kleemann R, Kooistra T, Heeringa P.

Mol Nutr Food Res. 2013 Nov;57(11):2039-48. doi: 10.1002/mnfr.201200858. Epub 2013 Aug 15.


Differential effects of drug interventions and dietary lifestyle in developing type 2 diabetes and complications: a systems biology analysis in LDLr-/- mice.

Radonjic M, Wielinga PY, Wopereis S, Kelder T, Goelela VS, Verschuren L, Toet K, van Duyvenvoorde W, van der Werff van der Vat B, Stroeve JH, Cnubben N, Kooistra T, van Ommen B, Kleemann R.

PLoS One. 2013;8(2):e56122. doi: 10.1371/journal.pone.0056122. Epub 2013 Feb 15.


Systems biology analysis unravels the complementary action of combined rosuvastatin and ezetimibe therapy.

Verschuren L, Radonjic M, Wielinga PY, Kelder T, Kooistra T, van Ommen B, Kleemann R.

Pharmacogenet Genomics. 2012 Dec;22(12):837-45. doi: 10.1097/FPC.0b013e328359d274.


Beneficial effects of an alternating high- fat dietary regimen on systemic insulin resistance, hepatic and renal inflammation and renal function.

Yakala GK, van der Heijden R, Molema G, Schipper M, Wielinga PY, Kleemann R, Kooistra T, Heeringa P.

PLoS One. 2012;7(9):e45866. doi: 10.1371/journal.pone.0045866. Epub 2012 Sep 25.


Food Safety: at the center of a One Health approach for combating zoonoses.

Wielinga PR, Schlundt J.

Curr Top Microbiol Immunol. 2013;366:3-17. doi: 10.1007/82_2012_238. Review.


Arachidonic acid/docosahexaenoic acid-supplemented diet in early life reduces body weight gain, plasma lipids, and adiposity in later life in ApoE*3Leiden mice.

Wielinga PY, Harthoorn LF, Verschuren L, Schoemaker MH, Jouni ZE, van Tol EA, Kleemann R, Kooistra T.

Mol Nutr Food Res. 2012 Jul;56(7):1081-9. doi: 10.1002/mnfr.201100762. Epub 2012 May 18.


Metabolic stress-induced inflammation plays a major role in the development of osteoarthritis in mice.

Gierman LM, van der Ham F, Koudijs A, Wielinga PY, Kleemann R, Kooistra T, Stoop R, Kloppenburg M, van Osch GJ, Stojanovic-Susulic V, Huizinga TW, Zuurmond AM.

Arthritis Rheum. 2012 Apr;64(4):1172-81. doi: 10.1002/art.33443. Epub 2011 Oct 27.


Evaluation of DNA extraction methods for Bacillus anthracis spores spiked to food and feed matrices at biosafety level 3 conditions.

Wielinga PR, de Heer L, de Groot A, Hamidjaja RA, Bruggeman G, Jordan K, van Rotterdam BJ.

Int J Food Microbiol. 2011 Nov 1;150(2-3):122-7. doi: 10.1016/j.ijfoodmicro.2011.07.023. Epub 2011 Jul 29.


A systems biology strategy for predicting similarities and differences of drug effects: evidence for drug-specific modulation of inflammation in atherosclerosis.

Kleemann R, Bureeva S, Perlina A, Kaput J, Verschuren L, Wielinga PY, Hurt-Camejo E, Nikolsky Y, van Ommen B, Kooistra T.

BMC Syst Biol. 2011 Aug 12;5:125. doi: 10.1186/1752-0509-5-125.


Detection of Coxiella burnetii in complex matrices by using multiplex quantitative PCR during a major Q fever outbreak in The Netherlands.

de Bruin A, de Groot A, de Heer L, Bok J, Wielinga PR, Hamans M, van Rotterdam BJ, Janse I.

Appl Environ Microbiol. 2011 Sep;77(18):6516-23. doi: 10.1128/AEM.05097-11. Epub 2011 Jul 22.


Anti-inflammatory, anti-proliferative and anti-atherosclerotic effects of quercetin in human in vitro and in vivo models.

Kleemann R, Verschuren L, Morrison M, Zadelaar S, van Erk MJ, Wielinga PY, Kooistra T.

Atherosclerosis. 2011 Sep;218(1):44-52. doi: 10.1016/j.atherosclerosis.2011.04.023. Epub 2011 May 5.


Beneficial effects of alternate dietary regimen on liver inflammation, atherosclerosis and renal activation.

Wielinga PY, Yakala GK, Heeringa P, Kleemann R, Kooistra T.

PLoS One. 2011 Mar 31;6(3):e18432. doi: 10.1371/journal.pone.0018432.


A dietary mixture containing fish oil, resveratrol, lycopene, catechins, and vitamins E and C reduces atherosclerosis in transgenic mice.

Verschuren L, Wielinga PY, van Duyvenvoorde W, Tijani S, Toet K, van Ommen B, Kooistra T, Kleemann R.

J Nutr. 2011 May;141(5):863-9. doi: 10.3945/jn.110.133751. Epub 2011 Mar 16.


Towards an international standard for detection and typing botulinum neurotoxin-producing Clostridia types A, B, E and F in food, feed and environmental samples: a European ring trial study to evaluate a real-time PCR assay.

Fenicia L, Fach P, van Rotterdam BJ, Anniballi F, Segerman B, Auricchio B, Delibato E, Hamidjaja RA, Wielinga PR, Woudstra C, Agren J, De Medici D, Knutsson R.

Int J Food Microbiol. 2011 Mar 1;145 Suppl 1:S152-7. doi: 10.1016/j.ijfoodmicro.2011.02.001. Epub 2011 Feb 24.


Accidental and deliberate microbiological contamination in the feed and food chains--how biotraceability may improve the response to bioterrorism.

Knutsson R, van Rotterdam B, Fach P, De Medici D, Fricker M, Löfström C, Agren J, Segerman B, Andersson G, Wielinga P, Fenicia L, Skiby J, Schultz AC, Ehling-Schulz M.

Int J Food Microbiol. 2011 Mar 1;145 Suppl 1:S123-8. doi: 10.1016/j.ijfoodmicro.2010.10.011. Epub 2010 Oct 21.


Anti-inflammatory salicylate beneficially modulates pre-existing atherosclerosis through quenching of NF-κB activity and lowering of cholesterol.

de Vries-van der Weij J, Toet K, Zadelaar S, Wielinga PY, Kleemann R, Rensen PC, Kooistra T.

Atherosclerosis. 2010 Nov;213(1):241-6. doi: 10.1016/j.atherosclerosis.2010.09.006. Epub 2010 Sep 21.


A multiplex real-time PCR for identifying and differentiating B. anthracis virulent types.

Wielinga PR, Hamidjaja RA, Agren J, Knutsson R, Segerman B, Fricker M, Ehling-Schulz M, de Groot A, Burton J, Brooks T, Janse I, van Rotterdam B.

Int J Food Microbiol. 2011 Mar 1;145 Suppl 1:S137-44. doi: 10.1016/j.ijfoodmicro.2010.07.039. Epub 2010 Aug 10.


Bioinformatic tools for using whole genome sequencing as a rapid high resolution diagnostic typing tool when tracing bioterror organisms in the food and feed chain.

Segerman B, De Medici D, Ehling Schulz M, Fach P, Fenicia L, Fricker M, Wielinga P, Van Rotterdam B, Knutsson R.

Int J Food Microbiol. 2011 Mar 1;145 Suppl 1:S167-76. doi: 10.1016/j.ijfoodmicro.2010.06.027. Epub 2010 Sep 7.


An innovative molecular detection tool for tracking and tracing Clostridium botulinum types A, B, E, F and other botulinum neurotoxin producing Clostridia based on the GeneDisc cycler.

Fach P, Fenicia L, Knutsson R, Wielinga PR, Anniballi F, Delibato E, Auricchio B, Woudstra C, Agren J, Segerman B, de Medici D, van Rotterdam BJ.

Int J Food Microbiol. 2011 Mar 1;145 Suppl 1:S145-51. doi: 10.1016/j.ijfoodmicro.2010.04.006. Epub 2010 Apr 8.


Central amylin acts as an adiposity signal to control body weight and energy expenditure.

Wielinga PY, Löwenstein C, Muff S, Munz M, Woods SC, Lutz TA.

Physiol Behav. 2010 Aug 4;101(1):45-52. doi: 10.1016/j.physbeh.2010.04.012. Epub 2010 Apr 21.


Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet.

Ehses JA, Meier DT, Wueest S, Rytka J, Boller S, Wielinga PY, Schraenen A, Lemaire K, Debray S, Van Lommel L, Pospisilik JA, Tschopp O, Schultze SM, Malipiero U, Esterbauer H, Ellingsgaard H, Rütti S, Schuit FC, Lutz TA, Böni-Schnetzler M, Konrad D, Donath MY.

Diabetologia. 2010 Aug;53(8):1795-806. doi: 10.1007/s00125-010-1747-3. Epub 2010 Apr 21.


Time-resolved and tissue-specific systems analysis of the pathogenesis of insulin resistance.

Kleemann R, van Erk M, Verschuren L, van den Hoek AM, Koek M, Wielinga PY, Jie A, Pellis L, Bobeldijk-Pastorova I, Kelder T, Toet K, Wopereis S, Cnubben N, Evelo C, van Ommen B, Kooistra T.

PLoS One. 2010 Jan 21;5(1):e8817. doi: 10.1371/journal.pone.0008817.


Ixodes ricinus ticks are reservoir hosts for Rickettsia helvetica and potentially carry flea-borne Rickettsia species.

Sprong H, Wielinga PR, Fonville M, Reusken C, Brandenburg AH, Borgsteede F, Gaasenbeek C, van der Giessen JW.

Parasit Vectors. 2009 Sep 4;2(1):41. doi: 10.1186/1756-3305-2-41.


The passive coping Roman Low Avoidance rat, a non-obese rat model for insulin resistance.

Boersma GJ, Scheurink AJ, Wielinga PY, Steimer TJ, Benthem L.

Physiol Behav. 2009 Jun 22;97(3-4):353-8. doi: 10.1016/j.physbeh.2009.03.005. Epub 2009 Mar 16.


[Small risk of developing Lyme borreliosis following a tick bite on Ameland: research in a general practice].

Jacobs JJ, Noordhoek GT, Brouwers JM, Wielinga PR, Jacobs JP, Brandenburg AH.

Ned Tijdschr Geneeskd. 2008 Sep 13;152(37):2022-6. Dutch.


Vaccination against GIP for the treatment of obesity.

Fulurija A, Lutz TA, Sladko K, Osto M, Wielinga PY, Bachmann MF, Saudan P.

PLoS One. 2008 Sep 9;3(9):e3163. doi: 10.1371/journal.pone.0003163.


Persistent detection of Babesia EU1 and Babesia microti in Ixodes ricinus in the Netherlands during a 5-year surveillance: 2003-2007.

Wielinga PR, Fonville M, Sprong H, Gaasenbeek C, Borgsteede F, van der Giessen JW.

Vector Borne Zoonotic Dis. 2009 Feb;9(1):119-22. doi: 10.1089/vbz.2008.0047. Epub 2008 Aug 30.


In-vitro and in-vivo antagonistic action of an anti-amylin Spiegelmer.

Bilik KU, Ergüven E, Klussmann S, Jarosch F, Wielinga PY, Lutz TA, Riediger T.

Neuroreport. 2007 Nov 19;18(17):1855-9.


Molecular epidemiology of Cryptosporidium in humans and cattle in The Netherlands.

Wielinga PR, de Vries A, van der Goot TH, Mank T, Mars MH, Kortbeek LM, van der Giessen JW.

Int J Parasitol. 2008 Jun;38(7):809-17. Epub 2007 Nov 4.


Modulation of the satiating effect of amylin by central ghrelin, leptin and insulin.

Osto M, Wielinga PY, Alder B, Walser N, Lutz TA.

Physiol Behav. 2007 Aug 15;91(5):566-72. Epub 2007 Mar 30.


The acute effect of amylin and salmon calcitonin on energy expenditure.

Wielinga PY, Alder B, Lutz TA.

Physiol Behav. 2007 Jun 8;91(2-3):212-7. Epub 2007 Mar 2.


cGMP transport by vesicles from human and mouse erythrocytes.

de Wolf CJ, Yamaguchi H, van der Heijden I, Wielinga PR, Hundscheid SL, Ono N, Scheffer GL, de Haas M, Schuetz JD, Wijnholds J, Borst P.

FEBS J. 2007 Jan;274(2):439-50.


Longitudinal analysis of tick densities and Borrelia, Anaplasma, and Ehrlichia infections of Ixodes ricinus ticks in different habitat areas in The Netherlands.

Wielinga PR, Gaasenbeek C, Fonville M, de Boer A, de Vries A, Dimmers W, Akkerhuis Op Jagers G, Schouls LM, Borgsteede F, van der Giessen JW.

Appl Environ Microbiol. 2006 Dec;72(12):7594-601. Epub 2006 Oct 6.


Lyme borreliosis in the Netherlands: strong increase in GP consultations and hospital admissions in past 10 years.

Hofhuis A, van der Giessen JW, Borgsteede FH, Wielinga PR, Notermans DW, van Pelt W.

Euro Surveill. 2006 Jun 22;11(6):E060622.2. No abstract available. Erratum in: Euro Surveill. 2006 Jun;11(6):E060629.5.


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