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Items: 31

1.

Influence of Stereochemistry on the Bioactivation and Glucuronidation of 4-Ipomeanol.

Teitelbaum AM, McDonald MG, Kowalski JP, Parkinson OT, Scian M, Whittington D, Roellecke K, Hanenberg H, Wiek C, Rettie AE.

J Pharmacol Exp Ther. 2018 Nov 8. pii: jpet.118.249771. doi: 10.1124/jpet.118.249771. [Epub ahead of print]

2.

i3 signaling is associated with sexual dimorphic expression of the clock-controlled output gene Dbp in murine liver.

Singh M, Bergmann L, Lang A, Pexa K, Kuck F, Stibane D, Janke L, Ezzahoini H, Lindecke A, Wiek C, Hanenberg H, Köhrer K, von Gall C, Reinke H, Piekorz RP.

Oncotarget. 2018 Jul 13;9(54):30213-30224. doi: 10.18632/oncotarget.25727. eCollection 2018 Jul 13.

3.

Effects of novel HDAC inhibitors on urothelial carcinoma cells.

Kaletsch A, Pinkerneil M, Hoffmann MJ, Jaguva Vasudevan AA, Wang C, Hansen FK, Wiek C, Hanenberg H, Gertzen C, Gohlke H, Kassack MU, Kurz T, Schulz WA, Niegisch G.

Clin Epigenetics. 2018 Jul 31;10(1):100. doi: 10.1186/s13148-018-0531-y.

4.

Systematic Methodological Evaluation of a Multiplex Bead-Based Flow Cytometry Assay for Detection of Extracellular Vesicle Surface Signatures.

Wiklander OPB, Bostancioglu RB, Welsh JA, Zickler AM, Murke F, Corso G, Felldin U, Hagey DW, Evertsson B, Liang XM, Gustafsson MO, Mohammad DK, Wiek C, Hanenberg H, Bremer M, Gupta D, Björnstedt M, Giebel B, Nordin JZ, Jones JC, El Andaloussi S, Görgens A.

Front Immunol. 2018 Jun 13;9:1326. doi: 10.3389/fimmu.2018.01326. eCollection 2018.

5.

Mutational and Functional Analysis of FANCB as a Candidate Gene for Sporadic Head and Neck Squamous Cell Carcinomas.

Glaas MF, Wiek C, Wolter LM, Roellecke K, Balz V, Okpanyi V, Wagenmann M, Hoffmann TK, Grässlin R, Plettenberg C, Schipper J, Hanenberg H, Scheckenbach K.

Anticancer Res. 2018 Mar;38(3):1317-1325.

PMID:
29491055
6.

FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response.

Thompson EL, Yeo JE, Lee EA, Kan Y, Raghunandan M, Wiek C, Hanenberg H, Schärer OD, Hendrickson EA, Sobeck A.

Nucleic Acids Res. 2017 Nov 16;45(20):11837-11857. doi: 10.1093/nar/gkx847.

7.

The role of apoptosis repressor with a CARD domain (ARC) in the therapeutic resistance of renal cell carcinoma (RCC): the crucial role of ARC in the inhibition of extrinsic and intrinsic apoptotic signalling.

Toth C, Funke S, Nitsche V, Liverts A, Zlachevska V, Gasis M, Wiek C, Hanenberg H, Mahotka C, Schirmacher P, Heikaus S.

Cell Commun Signal. 2017 May 2;15(1):16. doi: 10.1186/s12964-017-0170-5.

8.

Targeting Ewing sarcoma with activated and GD2-specific chimeric antigen receptor-engineered human NK cells induces upregulation of immune-inhibitory HLA-G.

Kailayangiri S, Altvater B, Spurny C, Jamitzky S, Schelhaas S, Jacobs AH, Wiek C, Roellecke K, Hanenberg H, Hartmann W, Wiendl H, Pankratz S, Meltzer J, Farwick N, Greune L, Fluegge M, Rossig C.

Oncoimmunology. 2016 Oct 28;6(1):e1250050. doi: 10.1080/2162402X.2016.1250050. eCollection 2017.

9.

Ligand characterization of CYP4B1 isoforms modified for high-level expression in Escherichia coli and HepG2 cells.

Roellecke K, Jäger VD, Gyurov VH, Kowalski JP, Mielke S, Rettie AE, Hanenberg H, Wiek C, Girhard M.

Protein Eng Des Sel. 2017 Mar 1;30(3):205-216. doi: 10.1093/protein/gzw075.

10.

Stem Cell Genetic Therapy for Fanconi Anemia - A New Hope.

Hanenberg H, Roellecke K, Wiek C.

Curr Gene Ther. 2017;16(5):309-320. doi: 10.2174/1566523217666170109111958. Review.

PMID:
28067166
11.

Complementation of hypersensitivity to DNA interstrand crosslinking agents demonstrates that XRCC2 is a Fanconi anaemia gene.

Park JY, Virts EL, Jankowska A, Wiek C, Othman M, Chakraborty SC, Vance GH, Alkuraya FS, Hanenberg H, Andreassen PR.

J Med Genet. 2016 Oct;53(10):672-680. doi: 10.1136/jmedgenet-2016-103847. Epub 2016 May 20.

12.

Optimized human CYP4B1 in combination with the alkylator prodrug 4-ipomeanol serves as a novel suicide gene system for adoptive T-cell therapies.

Roellecke K, Virts EL, Einholz R, Edson KZ, Altvater B, Rossig C, von Laer D, Scheckenbach K, Wagenmann M, Reinhardt D, Kramm CM, Rettie AE, Wiek C, Hanenberg H.

Gene Ther. 2016 Jul;23(7):615-26. doi: 10.1038/gt.2016.38. Epub 2016 May 19.

PMID:
27092941
13.

Bile salt export pump-reactive antibodies form a polyclonal, multi-inhibitory response in antibody-induced bile salt export pump deficiency.

Stindt J, Kluge S, Dröge C, Keitel V, Stross C, Baumann U, Brinkert F, Dhawan A, Engelmann G, Ganschow R, Gerner P, Grabhorn E, Knisely AS, Noli KA, Pukite I, Shepherd RW, Ueno T, Schmitt L, Wiek C, Hanenberg H, Häussinger D, Kubitz R.

Hepatology. 2016 Feb;63(2):524-37. doi: 10.1002/hep.28311. Epub 2015 Dec 15.

PMID:
26516723
14.

Characterization of an Additional Splice Acceptor Site Introduced into CYP4B1 in Hominoidae during Evolution.

Schmidt EM, Wiek C, Parkinson OT, Roellecke K, Freund M, Gombert M, Lottmann N, Steward CA, Kramm CM, Yarov-Yarovoy V, Rettie AE, Hanenberg H.

PLoS One. 2015 Sep 10;10(9):e0137110. doi: 10.1371/journal.pone.0137110. eCollection 2015.

15.

AluY-mediated germline deletion, duplication and somatic stem cell reversion in UBE2T defines a new subtype of Fanconi anemia.

Virts EL, Jankowska A, Mackay C, Glaas MF, Wiek C, Kelich SL, Lottmann N, Kennedy FM, Marchal C, Lehnert E, Scharf RE, Dufour C, Lanciotti M, Farruggia P, Santoro A, Savasan S, Scheckenbach K, Schipper J, Wagenmann M, Lewis T, Leffak M, Farlow JL, Foroud TM, Honisch E, Niederacher D, Chakraborty SC, Vance GH, Pruss D, Timms KM, Lanchbury JS, Alpi AF, Hanenberg H.

Hum Mol Genet. 2015 Sep 15;24(18):5093-108. doi: 10.1093/hmg/ddv227. Epub 2015 Jun 17.

16.

Identification of amino acid determinants in CYP4B1 for optimal catalytic processing of 4-ipomeanol.

Wiek C, Schmidt EM, Roellecke K, Freund M, Nakano M, Kelly EJ, Kaisers W, Yarov-Yarovoy V, Kramm CM, Rettie AE, Hanenberg H.

Biochem J. 2015 Jan 1;465(1):103-14. doi: 10.1042/BJ20140813.

17.

Peptide-independent stabilization of MHC class I molecules breaches cellular quality control.

Hein Z, Uchtenhagen H, Abualrous ET, Saini SK, Janßen L, Van Hateren A, Wiek C, Hanenberg H, Momburg F, Achour A, Elliott T, Springer S, Boulanger D.

J Cell Sci. 2014 Jul 1;127(Pt 13):2885-97. doi: 10.1242/jcs.145334. Epub 2014 May 7.

18.

Design, synthesis, and evaluation of curcumin-derived arylheptanoids for glioblastoma and neuroblastoma cytotoxicity.

Campos CA, Gianino JB, Bailey BJ, Baluyut ME, Wiek C, Hanenberg H, Shannon HE, Pollok KE, Ashfeld BL.

Bioorg Med Chem Lett. 2013 Dec 15;23(24):6874-8. doi: 10.1016/j.bmcl.2013.09.095. Epub 2013 Oct 11.

19.

Evidence for a novel anti-apoptotic pathway in human keratinocytes involving the aryl hydrocarbon receptor, E2F1, and checkpoint kinase 1.

Frauenstein K, Sydlik U, Tigges J, Majora M, Wiek C, Hanenberg H, Abel J, Esser C, Fritsche E, Krutmann J, Haarmann-Stemmann T.

Cell Death Differ. 2013 Oct;20(10):1425-34. doi: 10.1038/cdd.2013.102. Epub 2013 Aug 2.

20.

A natural tapasin isoform lacking exon 3 modifies peptide loading complex function.

Beutler N, Hauka S, Niepel A, Kowalewski DJ, Uhlmann J, Ghanem E, Erkelenz S, Wiek C, Hanenberg H, Schaal H, Stevanović S, Springer S, Momburg F, Hengel H, Halenius A.

Eur J Immunol. 2013 Jun;43(6):1459-69. doi: 10.1002/eji.201242725. Epub 2013 May 10.

21.

Characterization and manipulation of foamy virus membrane interactions.

Swiersy A, Wiek C, Zentgraf H, Lindemann D.

Cell Microbiol. 2013 Feb;15(2):227-36. doi: 10.1111/cmi.12042. Epub 2012 Nov 6.

PMID:
23051660
22.

A novel MCPH1 isoform complements the defective chromosome condensation of human MCPH1-deficient cells.

Gavvovidis I, Rost I, Trimborn M, Kaiser FJ, Purps J, Wiek C, Hanenberg H, Neitzel H, Schindler D.

PLoS One. 2012;7(8):e40387. doi: 10.1371/journal.pone.0040387. Epub 2012 Aug 30.

23.
24.

Orthoretroviral-like prototype foamy virus Gag-Pol expression is compatible with viral replication.

Swiersy A, Wiek C, Reh J, Zentgraf H, Lindemann D.

Retrovirology. 2011 Aug 15;8:66. doi: 10.1186/1742-4690-8-66.

25.

Human cytomegalovirus disrupts the major histocompatibility complex class I peptide-loading complex and inhibits tapasin gene transcription.

Halenius A, Hauka S, Dölken L, Stindt J, Reinhard H, Wiek C, Hanenberg H, Koszinowski UH, Momburg F, Hengel H.

J Virol. 2011 Apr;85(7):3473-85. doi: 10.1128/JVI.01923-10. Epub 2011 Jan 19.

26.

The centrosome and mitotic spindle apparatus in cancer and senescence.

Schmidt S, Essmann F, Cirstea IC, Kuck F, Thakur HC, Singh M, Kletke A, Jänicke RU, Wiek C, Hanenberg H, Ahmadian MR, Schulze-Osthoff K, Nürnberg B, Piekorz RP.

Cell Cycle. 2010 Nov 15;9(22):4469-73.

PMID:
21088502
27.

The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program.

Schmidt S, Schneider L, Essmann F, Cirstea IC, Kuck F, Kletke A, Jänicke RU, Wiek C, Hanenberg H, Ahmadian MR, Schulze-Osthoff K, Nürnberg B, Piekorz RP.

Oncogene. 2010 Nov 18;29(46):6184-92. doi: 10.1038/onc.2010.354. Epub 2010 Aug 23.

PMID:
20729911
28.

Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene.

Meindl A, Hellebrand H, Wiek C, Erven V, Wappenschmidt B, Niederacher D, Freund M, Lichtner P, Hartmann L, Schaal H, Ramser J, Honisch E, Kubisch C, Wichmann HE, Kast K, Deissler H, Engel C, Müller-Myhsok B, Neveling K, Kiechle M, Mathew CG, Schindler D, Schmutzler RK, Hanenberg H.

Nat Genet. 2010 May;42(5):410-4. doi: 10.1038/ng.569. Epub 2010 Apr 18.

PMID:
20400964
29.

Mutation of the RAD51C gene in a Fanconi anemia-like disorder.

Vaz F, Hanenberg H, Schuster B, Barker K, Wiek C, Erven V, Neveling K, Endt D, Kesterton I, Autore F, Fraternali F, Freund M, Hartmann L, Grimwade D, Roberts RG, Schaal H, Mohammed S, Rahman N, Schindler D, Mathew CG.

Nat Genet. 2010 May;42(5):406-9. doi: 10.1038/ng.570. Epub 2010 Apr 18.

PMID:
20400963
30.

DLK-1 as a marker to distinguish unrestricted somatic stem cells and mesenchymal stromal cells in cord blood.

Kluth SM, Buchheiser A, Houben AP, Geyh S, Krenz T, Radke TF, Wiek C, Hanenberg H, Reinecke P, Wernet P, Kögler G.

Stem Cells Dev. 2010 Oct;19(10):1471-83. doi: 10.1089/scd.2010.0070.

PMID:
20331358
31.

Adaptation of topoisomerase I paralogs to nuclear and mitochondrial DNA.

Dalla Rosa I, Goffart S, Wurm M, Wiek C, Essmann F, Sobek S, Schroeder P, Zhang H, Krutmann J, Hanenberg H, Schulze-Osthoff K, Mielke C, Pommier Y, Boege F, Christensen MO.

Nucleic Acids Res. 2009 Oct;37(19):6414-28. doi: 10.1093/nar/gkp708. Epub 2009 Aug 31.

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