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Items: 35

1.

The Bri2 and Bri3 BRICHOS Domains Interact Differently with Aβ42 and Alzheimer Amyloid Plaques.

Dolfe L, Tambaro S, Tigro H, Del Campo M, Hoozemans JJM, Wiehager B, Graff C, Winblad B, Ankarcrona M, Kaldmäe M, Teunissen CE, Rönnbäck A, Johansson J, Presto J.

J Alzheimers Dis Rep. 2018 Feb 16;2(1):27-39. doi: 10.3233/ADR-170051.

2.

TOM70 Sustains Cell Bioenergetics by Promoting IP3R3-Mediated ER to Mitochondria Ca2+ Transfer.

Filadi R, Leal NS, Schreiner B, Rossi A, Dentoni G, Pinho CM, Wiehager B, Cieri D, Calì T, Pizzo P, Ankarcrona M.

Curr Biol. 2018 Feb 5;28(3):369-382.e6. doi: 10.1016/j.cub.2017.12.047. Epub 2018 Jan 27.

3.

Monoamine oxidase B is elevated in Alzheimer disease neurons, is associated with γ-secretase and regulates neuronal amyloid β-peptide levels.

Schedin-Weiss S, Inoue M, Hromadkova L, Teranishi Y, Yamamoto NG, Wiehager B, Bogdanovic N, Winblad B, Sandebring-Matton A, Frykman S, Tjernberg LO.

Alzheimers Res Ther. 2017 Aug 1;9(1):57. doi: 10.1186/s13195-017-0279-1.

4.

Mitofusin-2 knockdown increases ER-mitochondria contact and decreases amyloid β-peptide production.

Leal NS, Schreiner B, Pinho CM, Filadi R, Wiehager B, Karlström H, Pizzo P, Ankarcrona M.

J Cell Mol Med. 2016 Sep;20(9):1686-95. doi: 10.1111/jcmm.12863. Epub 2016 May 20.

5.

Proton myo-inositol cotransporter is a novel γ-secretase associated protein that regulates Aβ production without affecting Notch cleavage.

Teranishi Y, Inoue M, Yamamoto NG, Kihara T, Wiehager B, Ishikawa T, Winblad B, Schedin-Weiss S, Frykman S, Tjernberg LO.

FEBS J. 2015 Sep;282(17):3438-51. doi: 10.1111/febs.13353. Epub 2015 Jul 14. Review.

6.

Human brain proteins showing neuron-specific interactions with γ-secretase.

Inoue M, Hur JY, Kihara T, Teranishi Y, Yamamoto NG, Ishikawa T, Wiehager B, Winblad B, Tjernberg LO, Schedin-Weiss S.

FEBS J. 2015 Jul;282(14):2587-99. doi: 10.1111/febs.13303. Epub 2015 Jul 2.

7.

Stress Conditions Increase Vimentin Cleavage by Omi/HtrA2 Protease in Human Primary Neurons and Differentiated Neuroblastoma Cells.

Lucotte B, Tajhizi M, Alkhatib D, Samuelsson EB, Wiehager B, Schedin-Weiss S, Sundström E, Winblad B, Tjernberg LO, Behbahani H.

Mol Neurobiol. 2015 Dec;52(3):1077-1092. doi: 10.1007/s12035-014-8906-3. Epub 2014 Oct 8.

PMID:
25288153
8.

Amyloid-β peptides are generated in mitochondria-associated endoplasmic reticulum membranes.

Schreiner B, Hedskog L, Wiehager B, Ankarcrona M.

J Alzheimers Dis. 2015;43(2):369-74. doi: 10.3233/JAD-132543.

PMID:
25096627
9.

Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models.

Hedskog L, Pinho CM, Filadi R, Rönnbäck A, Hertwig L, Wiehager B, Larssen P, Gellhaar S, Sandebring A, Westerlund M, Graff C, Winblad B, Galter D, Behbahani H, Pizzo P, Glaser E, Ankarcrona M.

Proc Natl Acad Sci U S A. 2013 May 7;110(19):7916-21. doi: 10.1073/pnas.1300677110. Epub 2013 Apr 25.

10.

Biochemical studies of poly-T variants in the Alzheimer's disease associated TOMM40 gene.

Hedskog L, Brohede J, Wiehager B, Pinho CM, Revathikumar P, Lilius L, Glaser E, Graff C, Karlström H, Ankarcrona M.

J Alzheimers Dis. 2012;31(3):527-36. doi: 10.3233/JAD-2012-120580.

PMID:
22596268
11.

Mitochondrial γ-secretase participates in the metabolism of mitochondria-associated amyloid precursor protein.

Pavlov PF, Wiehager B, Sakai J, Frykman S, Behbahani H, Winblad B, Ankarcrona M.

FASEB J. 2011 Jan;25(1):78-88. doi: 10.1096/fj.10-157230. Epub 2010 Sep 10.

PMID:
20833873
12.

Association of Omi/HtrA2 with γ-secretase in mitochondria.

Behbahani H, Pavlov PF, Wiehager B, Nishimura T, Winblad B, Ankarcrona M.

Neurochem Int. 2010 Nov;57(6):668-75. doi: 10.1016/j.neuint.2010.08.004. Epub 2010 Aug 10.

PMID:
20705111
13.

The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae.

Hansson Petersen CA, Alikhani N, Behbahani H, Wiehager B, Pavlov PF, Alafuzoff I, Leinonen V, Ito A, Winblad B, Glaser E, Ankarcrona M.

Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13145-50. doi: 10.1073/pnas.0806192105. Epub 2008 Aug 29.

14.

Differential role of Presenilin-1 and -2 on mitochondrial membrane potential and oxygen consumption in mouse embryonic fibroblasts.

Behbahani H, Shabalina IG, Wiehager B, Concha H, Hultenby K, Petrovic N, Nedergaard J, Winblad B, Cowburn RF, Ankarcrona M.

J Neurosci Res. 2006 Sep;84(4):891-902.

PMID:
16883555
15.

Presenilin expression during induced differentiation of the human neuroblastoma SH-SY5Y cell line.

Flood F, Sundström E, Samuelsson EB, Wiehager B, Seiger A, Johnston JA, Cowburn RF.

Neurochem Int. 2004 Jun;44(7):487-96.

PMID:
15209417
16.
18.

Protein kinase C and amyloid precursor protein processing in skin fibroblasts from sporadic and familial Alzheimer's disease cases.

Vestling M, Cedazo-Mínguez A, Adem A, Wiehager B, Racchi M, Lannfelt L, Cowburn RF.

Biochim Biophys Acta. 1999 Mar 30;1453(3):341-50.

19.

Amyloid precursor protein heat shock response in lymphoblastoid cell lines bearing presenilin-1 mutations.

Johnston JA, Lannfelt L, Wiehager B, O'Neill C, Cowburn RF.

Biochim Biophys Acta. 1997 Dec 31;1362(2-3):183-92.

20.

Intracellular inositol (1,4,5)-trisphosphate receptor levels are preserved in Alzheimer's disease platelets.

Garlind A, Wiehager B, Winblad B, Fowler CJ.

Neurobiol Aging. 1997 Sep-Oct;18(5):559-61.

PMID:
9390785
22.
23.

Impaired G-protein-stimulated adenylyl cyclase activity in Alzheimer's disease brain is not accompanied by reduced cyclic-AMP-dependent protein kinase A activity.

Bonkale WL, Fastbom J, Wiehager B, Ravid R, Winblad B, Cowburn RF.

Brain Res. 1996 Oct 21;737(1-2):155-61.

PMID:
8930361
24.
26.

Preservation of kappa 1 opioid receptor recognition site density and regulation by G-proteins in the temporal cortex of patients with Alzheimer's disease.

Garlind A, Cowburn RF, Wiehager B, Ravid R, Winblad B, Fowler CJ.

Neurosci Lett. 1995 Feb 9;185(2):131-4.

PMID:
7746504
27.

Increased beta-amyloid release and levels of amyloid precursor protein (APP) in fibroblast cell lines from family members with the Swedish Alzheimer's disease APP670/671 mutation.

Johnston JA, Cowburn RF, Norgren S, Wiehager B, Venizelos N, Winblad B, Vigo-Pelfrey C, Schenk D, Lannfelt L, O'Neill C.

FEBS Lett. 1994 Nov 14;354(3):274-8.

28.

Regionally selective alterations in G protein subunit levels in the Alzheimer's disease brain.

O'Neill C, Wiehager B, Fowler CJ, Ravid R, Winblad B, Cowburn RF.

Brain Res. 1994 Feb 14;636(2):193-201.

PMID:
8012802
29.

Adenylyl cyclase activity and G-protein subunit levels in postmortem frontal cortex of suicide victims.

Cowburn RF, Marcusson JO, Eriksson A, Wiehager B, O'Neill C.

Brain Res. 1994 Jan 7;633(1-2):297-304.

PMID:
8137164
30.

Preservation of 5-hydroxytryptamine1A receptor-G protein interactions in the cerebral cortex of patients with Alzheimer's disease.

O'Neill C, Cowburn RF, Wiehager B, Alafuzoff I, Winblad B, Fowler CJ.

Neurosci Lett. 1991 Nov 25;133(1):15-9.

PMID:
1838799
31.

Coupling of human brain cerebral cortical alpha 2-adrenoceptors to GTP-binding proteins in Alzheimer's disease.

O'Neill C, Fowler CJ, Wiehager B, Cowburn RF, Alafuzoff I, Winblad B.

Brain Res. 1991 Nov 1;563(1-2):39-43.

PMID:
1664776
32.

Assay of a phosphatidylinositol bisphosphate phospholipase C activity in postmortem human brain.

O'Neill C, Fowler CJ, Wiehager B, Alafuzoff I, Winblad B.

Brain Res. 1991 Mar 15;543(2):307-14.

PMID:
1647835
33.

Effect of monovalent ions upon G proteins coupling muscarinic receptors to phosphoinositide hydrolysis in the rat cerebral cortex.

Tiger G, Björklund PE, Cowburn RF, Garlind A, O'Neill C, Wiehager B, Fowler CJ.

Eur J Pharmacol. 1990 Jan 23;188(1):51-62.

PMID:
2155122
34.

Studies on brain monoamine and neuropeptide systems after neonatal intracerebroventricular 6-hydroxydopamine treatment.

Luthman J, Brodin E, Sundström E, Wiehager B.

Int J Dev Neurosci. 1990;8(5):549-60.

PMID:
1704172
35.

Muscarinic receptors coupled to inositol phospholipid breakdown in human SH-SY5Y neuroblastoma cells: Effect of retinoic acid-induced differentiation.

Fowler CJ, O'Neill C, Almqvist P, Nilsson S, Wiehager B, Winblad B.

Neurochem Int. 1989;15(1):73-9.

PMID:
20504467

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