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Items: 38

1.

Transcriptional Categorization of the Etiology of Pneumonia Syndrome in Pediatric Patients in Malaria-Endemic Areas.

Silterra J, Gillette MA, Lanaspa M, Pellé KG, Valim C, Ahmad R, Acácio S, Almendinger KD, Tan Y, Madrid L, Alonso PL, Carr SA, Wiegand RC, Bassat Q, Mesirov JP, Milner DA Jr, Wirth DF.

J Infect Dis. 2017 Jan 15;215(2):312-320. doi: 10.1093/infdis/jiw531.

2.

Responses to Bacteria, Virus, and Malaria Distinguish the Etiology of Pediatric Clinical Pneumonia.

Valim C, Ahmad R, Lanaspa M, Tan Y, Acácio S, Gillette MA, Almendinger KD, Milner DA Jr, Madrid L, Pellé K, Harezlak J, Silterra J, Alonso PL, Carr SA, Mesirov JP, Wirth DF, Wiegand RC, Bassat Q.

Am J Respir Crit Care Med. 2016 Feb 15;193(4):448-59. doi: 10.1164/rccm.201506-1100OC.

3.

Malaria. A forward genetic screen identifies erythrocyte CD55 as essential for Plasmodium falciparum invasion.

Egan ES, Jiang RH, Moechtar MA, Barteneva NS, Weekes MP, Nobre LV, Gygi SP, Paulo JA, Frantzreb C, Tani Y, Takahashi J, Watanabe S, Goldberg J, Paul AS, Brugnara C, Root DE, Wiegand RC, Doench JG, Duraisingh MT.

Science. 2015 May 8;348(6235):711-4. doi: 10.1126/science.aaa3526.

4.

Diversity-oriented synthesis probe targets Plasmodium falciparum cytochrome b ubiquinone reduction site and synergizes with oxidation site inhibitors.

Lukens AK, Heidebrecht RW Jr, Mulrooney C, Beaudoin JA, Comer E, Duvall JR, Fitzgerald ME, Masi D, Galinsky K, Scherer CA, Palmer M, Munoz B, Foley M, Schreiber SL, Wiegand RC, Wirth DF.

J Infect Dis. 2015 Apr 1;211(7):1097-103. doi: 10.1093/infdis/jiu565. Epub 2014 Oct 21.

5.

Diversity-oriented synthesis-facilitated medicinal chemistry: toward the development of novel antimalarial agents.

Comer E, Beaudoin JA, Kato N, Fitzgerald ME, Heidebrecht RW, Lee Md 4th, Masi D, Mercier M, Mulrooney C, Muncipinto G, Rowley A, Crespo-Llado K, Serrano AE, Lukens AK, Wiegand RC, Wirth DF, Palmer MA, Foley MA, Munoz B, Scherer CA, Duvall JR, Schreiber SL.

J Med Chem. 2014 Oct 23;57(20):8496-502. doi: 10.1021/jm500994n. Epub 2014 Oct 13.

6.

In vitro resistance selections for Plasmodium falciparum dihydroorotate dehydrogenase inhibitors give mutants with multiple point mutations in the drug-binding site and altered growth.

Ross LS, Gamo FJ, Lafuente-Monasterio MJ, Singh OM, Rowland P, Wiegand RC, Wirth DF.

J Biol Chem. 2014 Jun 27;289(26):17980-95. doi: 10.1074/jbc.M114.558353. Epub 2014 Apr 29.

7.

Harnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistance.

Lukens AK, Ross LS, Heidebrecht R, Javier Gamo F, Lafuente-Monasterio MJ, Booker ML, Hartl DL, Wiegand RC, Wirth DF.

Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):799-804. doi: 10.1073/pnas.1320886110. Epub 2013 Dec 31.

8.

Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite.

Park DJ, Lukens AK, Neafsey DE, Schaffner SF, Chang HH, Valim C, Ribacke U, Van Tyne D, Galinsky K, Galligan M, Becker JS, Ndiaye D, Mboup S, Wiegand RC, Hartl DL, Sabeti PC, Wirth DF, Volkman SK.

Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):13052-7. doi: 10.1073/pnas.1210585109. Epub 2012 Jul 23.

9.

Genomic sequencing of Plasmodium falciparum malaria parasites from Senegal reveals the demographic history of the population.

Chang HH, Park DJ, Galinsky KJ, Schaffner SF, Ndiaye D, Ndir O, Mboup S, Wiegand RC, Volkman SK, Sabeti PC, Wirth DF, Neafsey DE, Hartl DL.

Mol Biol Evol. 2012 Nov;29(11):3427-39. doi: 10.1093/molbev/mss161. Epub 2012 Jun 24.

10.

Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria.

Heidebrecht RW Jr, Mulrooney C, Austin CP, Barker RH Jr, Beaudoin JA, Cheng KC, Comer E, Dandapani S, Dick J, Duvall JR, Ekland EH, Fidock DA, Fitzgerald ME, Foley M, Guha R, Hinkson P, Kramer M, Lukens AK, Masi D, Marcaurelle LA, Su XZ, Thomas CJ, Weïwer M, Wiegand RC, Wirth D, Xia M, Yuan J, Zhao J, Palmer M, Munoz B, Schreiber S.

ACS Med Chem Lett. 2012 Feb 9;3(2):112-117. Epub 2011 Dec 22.

11.

Human cerebral malaria and Plasmodium falciparum genotypes in Malawi.

Milner DA Jr, Vareta J, Valim C, Montgomery J, Daniels RF, Volkman SK, Neafsey DE, Park DJ, Schaffner SF, Mahesh NC, Barnes KG, Rosen DM, Lukens AK, Van Tyne D, Wiegand RC, Sabeti PC, Seydel KB, Glover SJ, Kamiza S, Molyneux ME, Taylor TE, Wirth DF.

Malar J. 2012 Feb 7;11:35. doi: 10.1186/1475-2875-11-35.

12.

Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum.

Van Tyne D, Park DJ, Schaffner SF, Neafsey DE, Angelino E, Cortese JF, Barnes KG, Rosen DM, Lukens AK, Daniels RF, Milner DA Jr, Johnson CA, Shlyakhter I, Grossman SR, Becker JS, Yamins D, Karlsson EK, Ndiaye D, Sarr O, Mboup S, Happi C, Furlotte NA, Eskin E, Kang HM, Hartl DL, Birren BW, Wiegand RC, Lander ES, Wirth DF, Volkman SK, Sabeti PC.

PLoS Genet. 2011 Apr;7(4):e1001383. doi: 10.1371/journal.pgen.1001383. Epub 2011 Apr 21.

13.

A high-throughput screen targeting malaria transmission stages opens new avenues for drug development.

Buchholz K, Burke TA, Williamson KC, Wiegand RC, Wirth DF, Marti M.

J Infect Dis. 2011 May 15;203(10):1445-53. doi: 10.1093/infdis/jir037.

14.

Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum.

Barker RH Jr, Urgaonkar S, Mazitschek R, Celatka C, Skerlj R, Cortese JF, Tyndall E, Liu H, Cromwell M, Sidhu AB, Guerrero-Bravo JE, Crespo-Llado KN, Serrano AE, Lin JW, Janse CJ, Khan SM, Duraisingh M, Coleman BI, Angulo-Barturen I, Jiménez-Díaz MB, Magán N, Gomez V, Ferrer S, Martínez MS, Wittlin S, Papastogiannidis P, O'Shea T, Klinger JD, Bree M, Lee E, Levine M, Wiegand RC, Munoz B, Wirth DF, Clardy J, Bathurst I, Sybertz E.

Antimicrob Agents Chemother. 2011 Jun;55(6):2612-22. doi: 10.1128/AAC.01714-10. Epub 2011 Mar 21.

15.

SNP genotyping defines complex gene-flow boundaries among African malaria vector mosquitoes.

Neafsey DE, Lawniczak MKN, Park DJ, Redmond SN, Coulibaly MB, Traoré SF, Sagnon N, Costantini C, Johnson C, Wiegand RC, Collins FH, Lander ES, Wirth DF, Kafatos FC, Besansky NJ, Christophides GK, Muskavitch MAT.

Science. 2010 Oct 22;330(6003):514-517. doi: 10.1126/science.1193036. Erratum in: Science. 2010 Dec 10;330(6010):1477.

16.

Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence.

Neafsey DE, Schaffner SF, Volkman SK, Park D, Montgomery P, Milner DA Jr, Lukens A, Rosen D, Daniels R, Houde N, Cortese JF, Tyndall E, Gates C, Stange-Thomann N, Sarr O, Ndiaye D, Ndir O, Mboup S, Ferreira MU, Moraes Sdo L, Dash AP, Chitnis CE, Wiegand RC, Hartl DL, Birren BW, Lander ES, Sabeti PC, Wirth DF.

Genome Biol. 2008;9(12):R171. doi: 10.1186/gb-2008-9-12-r171. Epub 2008 Dec 15.

17.

A general SNP-based molecular barcode for Plasmodium falciparum identification and tracking.

Daniels R, Volkman SK, Milner DA, Mahesh N, Neafsey DE, Park DJ, Rosen D, Angelino E, Sabeti PC, Wirth DF, Wiegand RC.

Malar J. 2008 Oct 29;7:223. doi: 10.1186/1475-2875-7-223.

18.

A genome-wide map of diversity in Plasmodium falciparum.

Volkman SK, Sabeti PC, DeCaprio D, Neafsey DE, Schaffner SF, Milner DA Jr, Daily JP, Sarr O, Ndiaye D, Ndir O, Mboup S, Duraisingh MT, Lukens A, Derr A, Stange-Thomann N, Waggoner S, Onofrio R, Ziaugra L, Mauceli E, Gnerre S, Jaffe DB, Zainoun J, Wiegand RC, Birren BW, Hartl DL, Galagan JE, Lander ES, Wirth DF.

Nat Genet. 2007 Jan;39(1):113-9. Epub 2006 Dec 10.

PMID:
17159979
19.

Three-dimensional structure of human cytomegalovirus protease.

Shieh HS, Kurumbail RG, Stevens AM, Stegeman RA, Sturman EJ, Pak JY, Wittwer AJ, Palmier MO, Wiegand RC, Holwerda BC, Stallings WC.

Nature. 1996 Sep 19;383(6597):279-82. Erratum in: Nature 1996 Nov 21;384(6606):288.

PMID:
8805708
20.

Activity of two-chain recombinant human cytomegalovirus protease.

Holwerda BC, Wittwer AJ, Duffin KL, Smith C, Toth MV, Carr LS, Wiegand RC, Bryant ML.

J Biol Chem. 1994 Oct 14;269(41):25911-5.

21.

Characterization of the structure of preproguanylin.

Kato J, Wiegand RC, Currie MG.

Adv Second Messenger Phosphoprotein Res. 1993;28:139-42. No abstract available.

PMID:
8398395
22.

Human guanylin: cDNA isolation, structure, and activity.

Wiegand RC, Kato J, Huang MD, Fok KF, Kachur JF, Currie MG.

FEBS Lett. 1992 Oct 19;311(2):150-4.

23.

Polyamine spider toxins are potent un-competitive antagonists of rat cortex excitatory amino acid receptors.

Davies MS, Baganoff MP, Grishin EV, Lanthorn TH, Volkova TM, Watson GB, Wiegand RC.

Eur J Pharmacol. 1992 Sep 1;227(1):51-6.

PMID:
1385187
24.

Rat guanylin cDNA: characterization of the precursor of an endogenous activator of intestinal guanylate cyclase.

Wiegand RC, Kato J, Currie MG.

Biochem Biophys Res Commun. 1992 Jun 30;185(3):812-7.

PMID:
1378267
25.

The Candida albicans myristoyl-CoA:protein N-myristoyltransferase gene. Isolation and expression in Saccharomyces cerevisiae and Escherichia coli.

Wiegand RC, Carr C, Minnerly JC, Pauley AM, Carron CP, Langner CA, Duronio RJ, Gordon JI.

J Biol Chem. 1992 Apr 25;267(12):8591-8.

26.

Cloning of the bovine pancreatic cholesterol esterase/lysophospholipase.

Kyger EM, Wiegand RC, Lange LG.

Biochem Biophys Res Commun. 1989 Nov 15;164(3):1302-9.

PMID:
2590203
27.

Reversible induction of right ventricular atriopeptin synthesis in hypertrophy due to hypoxia.

Stockmann PT, Will DH, Sides SD, Brunnert SR, Wilner GD, Leahy KM, Wiegand RC, Needleman P.

Circ Res. 1988 Jul;63(1):207-13.

PMID:
2968194
28.

Developmental changes in the rat atriopeptin hormonal system.

Wei YF, Rodi CP, Day ML, Wiegand RC, Needleman LD, Cole BR, Needleman P.

J Clin Invest. 1987 May;79(5):1325-9.

29.

Ventricular atriopeptin. Unmasking of messenger RNA and peptide synthesis by hypertrophy or dexamethasone.

Day ML, Schwartz D, Wiegand RC, Stockman PT, Brunnert SR, Tolunay HE, Currie MG, Standaert DG, Needleman P.

Hypertension. 1987 May;9(5):485-91.

PMID:
2952591
30.

Cloning and expression of a cDNA encoding a maize glutathione-S-transferase in E. coli.

Moore RE, Davies MS, O'Connell KM, Harding EI, Wiegand RC, Tiemeier DC.

Nucleic Acids Res. 1986 Sep 25;14(18):7227-35.

31.

Structural analysis of a maize gene coding for glutathione-S-transferase involved in herbicide detoxification.

Shah DM, Hironaka CM, Wiegand RC, Harding EI, Krivi GG, Tiemeier DC.

Plant Mol Biol. 1986 Jul;6(4):203-11. doi: 10.1007/BF00015226.

PMID:
24307319
32.

Messenger RNA encoding a glutathione-S-transferase responsible for herbicide tolerance in maize is induced in response to safener treatment.

Wiegand RC, Shah DM, Mozer TJ, Harding EI, Diaz-Collier J, Saunders C, Jaworski EG, Tiemeier DC.

Plant Mol Biol. 1986 Jul;7(4):235-43. doi: 10.1007/BF00752897.

PMID:
24302366
33.

Histone acetylase from Drosophila melanogaster specific for H4.

Wiegand RC, Brutlag DL.

J Biol Chem. 1981 May 10;256(9):4578-83.

34.

Interferon, double-stranded RNA and RNA degradation. Fractionation of the endonucleaseINT system into two macromolecular components; role of a small molecule in nuclease activation.

Ratner L, Wiegand RC, Farrell PJ, Sen GC, Cabrer B, Lengyel P.

Biochem Biophys Res Commun. 1978 Apr 14;81(3):947-54. No abstract available.

PMID:
566549
35.

Uptake of homologous single-stranded fragments by superhelical DNA. IV. Branch migration.

Radding CM, Beattie KL, Holloman WK, Wiegand RC.

J Mol Biol. 1977 Nov;116(4):825-39. No abstract available.

PMID:
592403
36.

Uptake of homologous single-stranded fragments by superhelical DNA. III. The product and its enzymic conversion to a recombinant molecule.

Wiegand RC, Beattie KL, Holloman WK, Radding CM.

J Mol Biol. 1977 Nov;116(4):805-24. No abstract available.

PMID:
592402
37.

Uptake of homologous single-stranded fragments by superhelical DNA. II. Characterization of the reaction.

Beattie KL, Wiegand RC, Radding CM.

J Mol Biol. 1977 Nov;116(4):783-803. No abstract available.

PMID:
592401
38.

Specificity of the S1 nuclease from Aspergillus oryzae.

Wiegand RC, Godson GN, Radding CM.

J Biol Chem. 1975 Nov 25;250(22):8848-55.

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