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Items: 1 to 50 of 75

1.

Autophagy Inhibition Improves Sunitinib Efficacy in Pancreatic Neuroendocrine Tumors via a Lysosome-dependent Mechanism.

Wiedmer T, Blank A, Pantasis S, Normand L, Bill R, Krebs P, Tschan MP, Marinoni I, Perren A.

Mol Cancer Ther. 2017 Nov;16(11):2502-2515. doi: 10.1158/1535-7163.MCT-17-0136. Epub 2017 Jul 20.

2.

Genetic and epigenetic drivers of neuroendocrine tumours (NET).

Di Domenico A, Wiedmer T, Marinoni I, Perren A.

Endocr Relat Cancer. 2017 Sep;24(9):R315-R334. doi: 10.1530/ERC-17-0012. Epub 2017 Jul 14. Review.

PMID:
28710117
3.

Hypo-methylation mediates chromosomal instability in pancreatic NET.

Marinoni I, Wiederkeher A, Wiedmer T, Pantasis S, Di Domenico A, Frank R, Vassella E, Schmitt A, Perren A.

Endocr Relat Cancer. 2017 Mar;24(3):137-146. doi: 10.1530/ERC-16-0554. Epub 2017 Jan 23.

4.

The excited-state structure, vibrations, lifetimes, and nonradiative dynamics of jet-cooled 1-methylcytosine.

Trachsel MA, Wiedmer T, Blaser S, Frey HM, Li Q, Ruiz-Barragan S, Blancafort L, Leutwyler S.

J Chem Phys. 2016 Oct 7;145(13):134307.

PMID:
27782422
5.

Gas-Phase Cytosine and Cytosine-N1-Derivatives Have 0.1-1 ns Lifetimes Near the S1 State Minimum.

Blaser S, Trachsel MA, Lobsiger S, Wiedmer T, Frey HM, Leutwyler S.

J Phys Chem Lett. 2016 Mar 3;7(5):752-7. doi: 10.1021/acs.jpclett.6b00017. Epub 2016 Feb 12.

PMID:
26863095
6.

Regulation of the tyrosine phosphorylation of Phospholipid Scramblase 1 in mast cells that are stimulated through the high-affinity IgE receptor.

Kassas A, Moura IC, Yamashita Y, Scheffel J, Guérin-Marchand C, Blank U, Sims PJ, Wiedmer T, Monteiro RC, Rivera J, Charles N, Benhamou M.

PLoS One. 2014 Oct 7;9(10):e109800. doi: 10.1371/journal.pone.0109800. eCollection 2014.

7.

Identification of key regulatory pathways of myeloid differentiation using an mESC-based karyotypically normal cell model.

Li D, Yang H, Nan H, Liu P, Pang S, Zhao Q, Karni R, Kamps MP, Xu Y, Zhou J, Wiedmer T, Sims PJ, Wang F.

Blood. 2012 Dec 6;120(24):4712-9. doi: 10.1182/blood-2012-03-414979. Epub 2012 Oct 18.

8.

Nuclear phospholipid scramblase 1 prolongs the mitotic expansion of granulocyte precursors during G-CSF-induced granulopoiesis.

Chen CW, Sowden M, Zhao Q, Wiedmer T, Sims PJ.

J Leukoc Biol. 2011 Aug;90(2):221-33. doi: 10.1189/jlb.0111006. Epub 2011 Mar 29.

9.

Phospholipid scramblases and Tubby-like proteins belong to a new superfamily of membrane tethered transcription factors.

Bateman A, Finn RD, Sims PJ, Wiedmer T, Biegert A, Söding J.

Bioinformatics. 2009 Jan 15;25(2):159-62. doi: 10.1093/bioinformatics/btn595. Epub 2008 Nov 13.

10.

Expression of the phospholipid scramblase (PLSCR) gene family during the acute phase response.

Lu B, Sims PJ, Wiedmer T, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR.

Biochim Biophys Acta. 2007 Sep;1771(9):1177-85. Epub 2007 May 26.

PMID:
17590392
11.

Mobilization of pro-inflammatory lipids in obese Plscr3-deficient mice.

Mutch DM, O'Maille G, Wikoff WR, Wiedmer T, Sims PJ, Siuzdak G.

Genome Biol. 2007;8(3):R38.

12.

Antileukemic roles of human phospholipid scramblase 1 gene, evidence from inducible PLSCR1-expressing leukemic cells.

Huang Y, Zhao Q, Zhou CX, Gu ZM, Li D, Xu HZ, Wiedmer T, Sims PJ, Zhao KW, Chen GQ.

Oncogene. 2006 Oct 26;25(50):6618-27. Epub 2006 May 15. Erratum in: Oncogene. 2006 Nov 16;25(54):7224. Wiedmer, T [added].

PMID:
16702944
13.

Phospholipid scramblase 1 binds to the promoter region of the inositol 1,4,5-triphosphate receptor type 1 gene to enhance its expression.

Zhou Q, Ben-Efraim I, Bigcas JL, Junqueira D, Wiedmer T, Sims PJ.

J Biol Chem. 2005 Oct 14;280(41):35062-8. Epub 2005 Aug 9.

14.

Adiposity, dyslipidemia, and insulin resistance in mice with targeted deletion of phospholipid scramblase 3 (PLSCR3).

Wiedmer T, Zhao J, Li L, Zhou Q, Hevener A, Olefsky JM, Curtiss LK, Sims PJ.

Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13296-301. Epub 2004 Aug 24.

15.

Phospholipid scramblase 1 potentiates the antiviral activity of interferon.

Dong B, Zhou Q, Zhao J, Zhou A, Harty RN, Bose S, Banerjee A, Slee R, Guenther J, Williams BR, Wiedmer T, Sims PJ, Silverman RH.

J Virol. 2004 Sep;78(17):8983-93.

16.

Protein kinase Cdelta mediates retinoic acid and phorbol myristate acetate-induced phospholipid scramblase 1 gene expression: its role in leukemic cell differentiation.

Zhao KW, Li X, Zhao Q, Huang Y, Li D, Peng ZG, Shen WZ, Zhao J, Zhou Q, Chen Z, Sims PJ, Wiedmer T, Chen GQ.

Blood. 2004 Dec 1;104(12):3731-8. Epub 2004 Aug 12.

17.

Phospholipid scramblase 1 is imported into the nucleus by a receptor-mediated pathway and interacts with DNA.

Ben-Efraim I, Zhou Q, Wiedmer T, Gerace L, Sims PJ.

Biochemistry. 2004 Mar 30;43(12):3518-26.

PMID:
15035622
18.

Plasma membrane phospholipid scramblase 1 promotes EGF-dependent activation of c-Src through the epidermal growth factor receptor.

Nanjundan M, Sun J, Zhao J, Zhou Q, Sims PJ, Wiedmer T.

J Biol Chem. 2003 Sep 26;278(39):37413-8. Epub 2003 Jul 18.

19.

Caspase-independent exposure of aminophospholipids and tyrosine phosphorylation in bicarbonate responsive human sperm cells.

de Vries KJ, Wiedmer T, Sims PJ, Gadella BM.

Biol Reprod. 2003 Jun;68(6):2122-34. Epub 2003 Jan 22.

PMID:
12606386
20.

Palmitoylation of phospholipid scramblase 1 controls its distribution between nucleus and plasma membrane.

Wiedmer T, Zhao J, Nanjundan M, Sims PJ.

Biochemistry. 2003 Feb 11;42(5):1227-33.

PMID:
12564925
21.
22.

Plasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptor.

Sun J, Nanjundan M, Pike LJ, Wiedmer T, Sims PJ.

Biochemistry. 2002 May 21;41(20):6338-45.

PMID:
12009895
23.

Suppression of ovarian carcinoma cell growth in vivo by the interferon-inducible plasma membrane protein, phospholipid scramblase 1.

Silverman RH, Halloum A, Zhou A, Dong B, Al-Zoghaibi F, Kushner D, Zhou Q, Zhao J, Wiedmer T, Sims PJ.

Cancer Res. 2002 Jan 15;62(2):397-402.

24.

Unraveling the mysteries of phospholipid scrambling.

Sims PJ, Wiedmer T.

Thromb Haemost. 2001 Jul;86(1):266-75. Review.

PMID:
11487015
25.

c-Abl tyrosine kinase binds and phosphorylates phospholipid scramblase 1.

Sun J, Zhao J, Schwartz MA, Wang JY, Wiedmer T, Sims PJ.

J Biol Chem. 2001 Aug 3;276(31):28984-90. Epub 2001 Jun 4.

26.

Transcriptional control of the human plasma membrane phospholipid scramblase 1 gene is mediated by interferon-alpha.

Zhou Q, Zhao J, Al-Zoghaibi F, Zhou A, Wiedmer T, Silverman RH, Sims PJ.

Blood. 2000 Apr 15;95(8):2593-9.

27.

Identification of three new members of the phospholipid scramblase gene family.

Wiedmer T, Zhou Q, Kwoh DY, Sims PJ.

Biochim Biophys Acta. 2000 Jul 31;1467(1):244-53.

28.

Sphingomyelin hydrolysis to ceramide during the execution phase of apoptosis results from phospholipid scrambling and alters cell-surface morphology.

Tepper AD, Ruurs P, Wiedmer T, Sims PJ, Borst J, van Blitterswijk WJ.

J Cell Biol. 2000 Jul 10;150(1):155-64.

29.

Phosphatidylserine exposure during apoptosis is a cell-type-specific event and does not correlate with plasma membrane phospholipid scramblase expression.

Fadeel B, Gleiss B, Högstrand K, Chandra J, Wiedmer T, Sims PJ, Henter JI, Orrenius S, Samali A.

Biochem Biophys Res Commun. 1999 Dec 20;266(2):504-11.

PMID:
10600532
30.

Change in conformation of plasma membrane phospholipid scramblase induced by occupancy of its Ca2+ binding site.

Stout JG, Zhou Q, Wiedmer T, Sims PJ.

Biochemistry. 1998 Oct 20;37(42):14860-6.

PMID:
9778361
32.
33.
35.
36.

Production and characterization of a mutant cell line defective in aminophospholipid translocase.

Zhao J, Sims PJ, Wiedmer T.

Biochim Biophys Acta. 1997 Jun 5;1357(1):57-64.

37.
38.

Isolation of an erythrocyte membrane protein that mediates Ca2+-dependent transbilayer movement of phospholipid.

Bassé F, Stout JG, Sims PJ, Wiedmer T.

J Biol Chem. 1996 Jul 19;271(29):17205-10.

39.

Induction of cellular procoagulant activity by the membrane attack complex of complement.

Sims PJ, Wiedmer T.

Semin Cell Biol. 1995 Oct;6(5):275-82. Review.

PMID:
8562920
40.
41.

Production and characterization of transformed B-lymphocytes expressing the membrane defect of Scott syndrome.

Kojima H, Newton-Nash D, Weiss HJ, Zhao J, Sims PJ, Wiedmer T.

J Clin Invest. 1994 Dec;94(6):2237-44.

42.

Identity of a peptide domain of human C9 that is bound by the cell-surface complement inhibitor, CD59.

Chang CP, Hüsler T, Zhao J, Wiedmer T, Sims PJ.

J Biol Chem. 1994 Oct 21;269(42):26424-30.

43.
44.
45.

Binding of anticoagulant vitamin K-dependent protein S to platelet-derived microparticles.

Dahlbäck B, Wiedmer T, Sims PJ.

Biochemistry. 1992 Dec 29;31(51):12769-77.

PMID:
1463747
46.

Regulation of glycoprotein IIb-IIIa receptor function studied with platelets permeabilized by the pore-forming complement proteins C5b-9.

Shattil SJ, Cunningham M, Wiedmer T, Zhao J, Sims PJ, Brass LF.

J Biol Chem. 1992 Sep 15;267(26):18424-31.

47.

Inhibition of the complement membrane attack complex by the galactose-specific adhesion of Entamoeba histolytica.

Braga LL, Ninomiya H, McCoy JJ, Eacker S, Wiedmer T, Pham C, Wood S, Sims PJ, Petri WA Jr.

J Clin Invest. 1992 Sep;90(3):1131-7.

49.

Inhibition of the complement membrane attack complex by the galactose-specific adhesin of Entamoeba histolytica.

Braga LL, Ninomiya H, McCoy JJ, Adal K, Wiedmer T, Pham C, Sims PJ, Petri WA Jr.

Arch Med Res. 1992;23(2):133. No abstract available.

PMID:
1340275

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