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Items: 25

1.

A Diacylglycerol Transferase 1 Inhibitor Is a Potent Hepatitis C Antiviral in Vitro but Not in Patients in a Randomized Clinical Trial.

Gane E, Stedman C, Dole K, Chen J, Meyers CD, Wiedmann B, Zhang J, Raman P, Colvin RA.

ACS Infect Dis. 2017 Feb 10;3(2):144-151. doi: 10.1021/acsinfecdis.6b00138. Epub 2016 Nov 8.

PMID:
27788579
2.

In Vitro Characterization of Human Cytomegalovirus-Targeting Therapeutic Monoclonal Antibodies LJP538 and LJP539.

Patel HD, Nikitin P, Gesner T, Lin JJ, Barkan DT, Ciferri C, Carfi A, Akbarnejad Yazdi T, Skewes-Cox P, Wiedmann B, Jarousse N, Zhong W, Feire A, Hebner CM.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):4961-71. doi: 10.1128/AAC.00382-16. Print 2016 Aug.

3.

Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition.

Fu J, Tjandra M, Becker C, Bednarczyk D, Capparelli M, Elling R, Hanna I, Fujimoto R, Furegati M, Karur S, Kasprzyk T, Knapp M, Leung K, Li X, Lu P, Mergo W, Miault C, Ng S, Parker D, Peng Y, Roggo S, Rivkin A, Simmons RL, Wang M, Wiedmann B, Weiss AH, Xiao L, Xie L, Xu W, Yifru A, Yang S, Zhou B, Sweeney ZK.

J Med Chem. 2014 Oct 23;57(20):8503-16. doi: 10.1021/jm500862r. Epub 2014 Oct 13.

PMID:
25310383
4.

2-Alkyloxazoles as potent and selective PI4KIIIβ inhibitors demonstrating inhibition of HCV replication.

Keaney EP, Connolly M, Dobler M, Karki R, Honda A, Sokup S, Karur S, Britt S, Patnaik A, Raman P, Hamann LG, Wiedmann B, LaMarche MJ.

Bioorg Med Chem Lett. 2014 Aug 15;24(16):3714-8. doi: 10.1016/j.bmcl.2014.07.015. Epub 2014 Jul 12.

PMID:
25065492
5.

From chemical tools to clinical medicines: nonimmunosuppressive cyclophilin inhibitors derived from the cyclosporin and sanglifehrin scaffolds.

Sweeney ZK, Fu J, Wiedmann B.

J Med Chem. 2014 Sep 11;57(17):7145-59. doi: 10.1021/jm500223x. Epub 2014 Jun 3.

PMID:
24831536
6.

Anti-hepatitis C virus activity and toxicity of type III phosphatidylinositol-4-kinase beta inhibitors.

Lamarche MJ, Borawski J, Bose A, Capacci-Daniel C, Colvin R, Dennehy M, Ding J, Dobler M, Drumm J, Gaither LA, Gao J, Jiang X, Lin K, McKeever U, Puyang X, Raman P, Thohan S, Tommasi R, Wagner K, Xiong X, Zabawa T, Zhu S, Wiedmann B.

Antimicrob Agents Chemother. 2012 Oct;56(10):5149-56. doi: 10.1128/AAC.00946-12. Epub 2012 Jul 23.

7.

Inhibition of cyclophilins alters lipid trafficking and blocks hepatitis C virus secretion.

Anderson LJ, Lin K, Compton T, Wiedmann B.

Virol J. 2011 Jun 28;8:329. doi: 10.1186/1743-422X-8-329.

8.

Mechanism of resistance of hepatitis C virus replicons to structurally distinct cyclophilin inhibitors.

Puyang X, Poulin DL, Mathy JE, Anderson LJ, Ma S, Fang Z, Zhu S, Lin K, Fujimoto R, Compton T, Wiedmann B.

Antimicrob Agents Chemother. 2010 May;54(5):1981-7. doi: 10.1128/AAC.01236-09. Epub 2010 Feb 22.

9.

Multiple cyclophilins involved in different cellular pathways mediate HCV replication.

Gaither LA, Borawski J, Anderson LJ, Balabanis KA, Devay P, Joberty G, Rau C, Schirle M, Bouwmeester T, Mickanin C, Zhao S, Vickers C, Lee L, Deng G, Baryza J, Fujimoto RA, Lin K, Compton T, Wiedmann B.

Virology. 2010 Feb 5;397(1):43-55. doi: 10.1016/j.virol.2009.10.043. Epub 2009 Nov 24.

10.

Class III phosphatidylinositol 4-kinase alpha and beta are novel host factor regulators of hepatitis C virus replication.

Borawski J, Troke P, Puyang X, Gibaja V, Zhao S, Mickanin C, Leighton-Davies J, Wilson CJ, Myer V, Cornellataracido I, Baryza J, Tallarico J, Joberty G, Bantscheff M, Schirle M, Bouwmeester T, Mathy JE, Lin K, Compton T, Labow M, Wiedmann B, Gaither LA.

J Virol. 2009 Oct;83(19):10058-74. doi: 10.1128/JVI.02418-08. Epub 2009 Jul 15.

11.

A peptide deformylase-ribosome complex reveals mechanism of nascent chain processing.

Bingel-Erlenmeyer R, Kohler R, Kramer G, Sandikci A, Antolić S, Maier T, Schaffitzel C, Wiedmann B, Bukau B, Ban N.

Nature. 2008 Mar 6;452(7183):108-11. doi: 10.1038/nature06683. Epub 2008 Feb 20.

PMID:
18288106
12.

LC-MALDI MS and MS/MS--an efficient tool in proteome analysis.

Mueller DR, Voshol H, Waldt A, Wiedmann B, Van Oostrum J.

Subcell Biochem. 2007;43:355-80. Review.

PMID:
17953403
13.

From proteomics to systems biology of bacterial pathogens: approaches, tools, and applications.

Plikat U, Voshol H, Dangendorf Y, Wiedmann B, Devay P, Müller D, Wirth U, Szustakowski J, Chirn GW, Inverardi B, Puyang X, Brown K, Kamp H, Hoving S, Ruchti A, Brendlen N, Peterson R, Buco J, Oostrum Jv, Peitsch MC.

Proteomics. 2007 Mar;7(6):992-1003.

PMID:
17370256
14.

Reduced susceptibility of Haemophilus influenzae to the peptide deformylase inhibitor LBM415 can result from target protein overexpression due to amplified chromosomal def gene copy number.

Dean CR, Narayan S, Richards J, Daigle DM, Esterow S, Leeds JA, Kamp H, Puyang X, Wiedmann B, Mueller D, Voshol H, van Oostrum J, Wall D, Koehn J, Dzink-Fox J, Ryder NS.

Antimicrob Agents Chemother. 2007 Mar;51(3):1004-10. Epub 2007 Jan 12.

15.

Reduced nitric oxide in sinus epithelium of patients with radiologic maxillary sinusitis and sepsis.

Deja M, Busch T, Bachmann S, Riskowski K, Campean V, Wiedmann B, Schwabe M, Hell B, Pfeilschifter J, Falke KJ, Lewandowski K.

Am J Respir Crit Care Med. 2003 Aug 1;168(3):281-6. Epub 2003 Apr 17.

PMID:
12702547
16.

Evidence for a nuclear passage of nascent polypeptide-associated complex subunits in yeast.

Franke J, Reimann B, Hartmann E, Köhlerl M, Wiedmann B.

J Cell Sci. 2001 Jul;114(Pt 14):2641-8.

18.

Initial characterization of the nascent polypeptide-associated complex in yeast.

Reimann B, Bradsher J, Franke J, Hartmann E, Wiedmann M, Prehn S, Wiedmann B.

Yeast. 1999 Mar 30;15(5):397-407.

19.

Nascent-polypeptide-associated complex: a bridge between ribosome and cytosol.

Lauring B, Wang S, Sakai H, Davis TA, Wiedmann B, Kreibich G, Wiedmann M.

Cold Spring Harb Symp Quant Biol. 1995;60:47-56. No abstract available.

PMID:
8824377
20.

A protein complex required for signal-sequence-specific sorting and translocation.

Wiedmann B, Sakai H, Davis TA, Wiedmann M.

Nature. 1994 Aug 11;370(6489):434-40.

PMID:
8047162
21.

Overexpression of the ER-membrane protein P-450 CYP52A3 mimics sec mutant characteristics in Saccharomyces cerevisiae.

Wiedmann B, Silver P, Schunck WH, Wiedmann M.

Biochim Biophys Acta. 1993 Dec 12;1153(2):267-76.

PMID:
8274497
22.

Molecular cloning and characterization of the primary structure of the alkane hydroxylating cytochrome P-450 from the yeast Candida maltosa.

Schunck WH, Kärgel E, Gross B, Wiedmann B, Mauersberger S, Köpke K, Kiessling U, Strauss M, Gaestel M, Müller HG.

Biochem Biophys Res Commun. 1989 Jun 15;161(2):843-50.

PMID:
2735924
23.

Post-translational transport of proteins into microsomal membranes of Candida maltosa.

Wiedmann M, Wiedmann B, Voigt S, Wachter E, Müller HG, Rapoport TA.

EMBO J. 1988 Jun;7(6):1763-8.

24.

Oxygen limitation induces indirectly the synthesis of cytochrome P-450 mRNA in alkane-growing Candida maltosa.

Wiedmann B, Wiedmann M, Mauersberger S, Schunck WH, Müller HG.

Biochem Biophys Res Commun. 1988 Jan 29;150(2):859-65.

PMID:
3342052
25.

N-alkanes induce the synthesis of cytochrome P-450 mRNA in Candida maltosa.

Wiedmann B, Wiedmann M, Kärgel E, Schunck WH, Müller HG.

Biochem Biophys Res Commun. 1986 May 14;136(3):1148-54.

PMID:
2424439

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