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Items: 1 to 50 of 73

1.

Cancer Mutations in FGFR2 Prevent a Negative Feedback Loop Mediated by the ERK1/2 Pathway.

Szybowska P, Kostas M, Wesche J, Wiedlocha A, Haugsten EM.

Cells. 2019 May 29;8(6). pii: E518. doi: 10.3390/cells8060518.

2.

Crosstalk between p38 and Erk 1/2 in Downregulation of FGF1-Induced Signaling.

Zakrzewska M, Opalinski L, Haugsten EM, Otlewski J, Wiedlocha A.

Int J Mol Sci. 2019 Apr 12;20(8). pii: E1826. doi: 10.3390/ijms20081826.

3.

Translocation of Exogenous FGF1 and FGF2 Protects the Cell against Apoptosis Independently of Receptor Activation.

Kostas M, Lampart A, Bober J, Wiedlocha A, Tomala J, Krowarsch D, Otlewski J, Zakrzewska M.

J Mol Biol. 2018 Oct 19;430(21):4087-4101. doi: 10.1016/j.jmb.2018.08.004. Epub 2018 Aug 9.

4.

Cytotoxic Conjugates of Fibroblast Growth Factor 2 (FGF2) with Monomethyl Auristatin E for Effective Killing of Cells Expressing FGF Receptors.

Krzyscik MA, Zakrzewska M, Sørensen V, Sokolowska-Wedzina A, Lobocki M, Swiderska KW, Krowarsch D, Wiedlocha A, Otlewski J.

ACS Omega. 2017 Jul 31;2(7):3792-3805. doi: 10.1021/acsomega.7b00116. Epub 2017 Jul 21.

5.

Protein Tyrosine Phosphatase Receptor Type G (PTPRG) Controls Fibroblast Growth Factor Receptor (FGFR) 1 Activity and Influences Sensitivity to FGFR Kinase Inhibitors.

Kostas M, Haugsten EM, Zhen Y, Sørensen V, Szybowska P, Fiorito E, Lorenz S, Jones N, de Souza GA, Wiedlocha A, Wesche J.

Mol Cell Proteomics. 2018 May;17(5):850-870. doi: 10.1074/mcp.RA117.000538. Epub 2018 Jan 25.

6.

Proximity Labeling Reveals Molecular Determinants of FGFR4 Endosomal Transport.

Haugsten EM, Sørensen V, Kunova Bosakova M, de Souza GA, Krejci P, Wiedlocha A, Wesche J.

J Proteome Res. 2016 Oct 7;15(10):3841-3855. Epub 2016 Sep 26.

PMID:
27615514
7.

The novel HSP90 inhibitor NVP-AUY922 shows synergistic anti-leukemic activity with cytarabine in vivo.

Wendel T, Zhen Y, Suo Z, Bruheim S, Wiedlocha A.

Exp Cell Res. 2016 Jan 15;340(2):220-6. doi: 10.1016/j.yexcr.2015.12.017. Epub 2015 Dec 31.

PMID:
26748184
8.

Instability restricts signaling of multiple fibroblast growth factors.

Buchtova M, Chaloupkova R, Zakrzewska M, Vesela I, Cela P, Barathova J, Gudernova I, Zajickova R, Trantirek L, Martin J, Kostas M, Otlewski J, Damborsky J, Kozubik A, Wiedlocha A, Krejci P.

Cell Mol Life Sci. 2015 Jun;72(12):2445-59. doi: 10.1007/s00018-015-1856-8. Epub 2015 Feb 18.

PMID:
25854632
9.

Nucleolin regulates phosphorylation and nuclear export of fibroblast growth factor 1 (FGF1).

Sletten T, Kostas M, Bober J, Sorensen V, Yadollahi M, Olsnes S, Tomala J, Otlewski J, Zakrzewska M, Wiedlocha A.

PLoS One. 2014 Mar 4;9(3):e90687. doi: 10.1371/journal.pone.0090687. eCollection 2014.

10.

RSK2 regulates endocytosis of FGF receptor 1 by phosphorylation on serine 789.

Nadratowska-Wesolowska B, Haugsten EM, Zakrzewska M, Jakimowicz P, Zhen Y, Pajdzik D, Wesche J, Wiedlocha A.

Oncogene. 2014 Oct 2;33(40):4823-36. doi: 10.1038/onc.2013.425. Epub 2013 Oct 21.

PMID:
24141780
11.

ERK-mediated phosphorylation of fibroblast growth factor receptor 1 on Ser777 inhibits signaling.

Zakrzewska M, Haugsten EM, Nadratowska-Wesolowska B, Oppelt A, Hausott B, Jin Y, Otlewski J, Wesche J, Wiedlocha A.

Sci Signal. 2013 Feb 12;6(262):ra11. doi: 10.1126/scisignal.2003087.

PMID:
23405013
12.

FGF1-gold nanoparticle conjugates targeting FGFR efficiently decrease cell viability upon NIR irradiation.

Szlachcic A, Pala K, Zakrzewska M, Jakimowicz P, Wiedlocha A, Otlewski J.

Int J Nanomedicine. 2012;7:5915-27. doi: 10.2147/IJN.S36575. Epub 2012 Nov 29.

13.

Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnα1 and Kpnβ1.

Zhen Y, Sørensen V, Skjerpen CS, Haugsten EM, Jin Y, Wälchli S, Olsnes S, Wiedlocha A.

Traffic. 2012 May;13(5):650-64. doi: 10.1111/j.1600-0854.2012.01341.x. Epub 2012 Mar 4.

14.

Simultaneously targeting mitochondria and endoplasmic reticulum by photodynamic therapy induces apoptosis in human lymphoma cells.

Shahzidi S, Cunderlíková B, Więdłocha A, Zhen Y, Vasovič V, Nesland JM, Peng Q.

Photochem Photobiol Sci. 2011 Nov;10(11):1773-82. doi: 10.1039/c1pp05169e. Epub 2011 Sep 1.

PMID:
21881674
15.

The driver of malignancy in KG-1a leukemic cells, FGFR1OP2-FGFR1, encodes an HSP90 addicted oncoprotein.

Jin Y, Zhen Y, Haugsten EM, Wiedlocha A.

Cell Signal. 2011 Nov;23(11):1758-66. doi: 10.1016/j.cellsig.2011.06.010. Epub 2011 Jun 30.

PMID:
21745565
16.

Translocation of exogenous FGF1 into cytosol and nucleus is a periodic event independent of receptor kinase activity.

Zakrzewska M, Sørensen V, Jin Y, Wiedlocha A, Olsnes S.

Exp Cell Res. 2011 Apr 15;317(7):1005-15. doi: 10.1016/j.yexcr.2011.01.003. Epub 2011 Jan 8.

PMID:
21223966
17.

Roles of fibroblast growth factor receptors in carcinogenesis.

Haugsten EM, Wiedlocha A, Olsnes S, Wesche J.

Mol Cancer Res. 2010 Nov;8(11):1439-52. doi: 10.1158/1541-7786.MCR-10-0168. Epub 2010 Oct 13. Review.

18.

Increased protein stability of FGF1 can compensate for its reduced affinity for heparin.

Zakrzewska M, Wiedlocha A, Szlachcic A, Krowarsch D, Otlewski J, Olsnes S.

J Biol Chem. 2009 Sep 11;284(37):25388-403. doi: 10.1074/jbc.M109.001289. Epub 2009 Jul 2.

19.

Size limitation in translocation of fibroblast growth factor 1 fusion proteins across the endosomal membrane.

Zakrzewska M, Zhen Y, Wiedlocha A, Olsnes S, Wesche J.

Biochemistry. 2009 Aug 4;48(30):7209-18. doi: 10.1021/bi9007353.

PMID:
19558187
20.

Phosphorylation of fibroblast growth factor (FGF) receptor 1 at Ser777 by p38 mitogen-activated protein kinase regulates translocation of exogenous FGF1 to the cytosol and nucleus.

Sørensen V, Zhen Y, Zakrzewska M, Haugsten EM, Wälchli S, Nilsen T, Olsnes S, Wiedlocha A.

Mol Cell Biol. 2008 Jun;28(12):4129-41. doi: 10.1128/MCB.02117-07. Epub 2008 Apr 14.

21.

FGF-1: from biology through engineering to potential medical applications.

Zakrzewska M, Marcinkowska E, Wiedlocha A.

Crit Rev Clin Lab Sci. 2008;45(1):91-135. doi: 10.1080/10408360701713120 . Review.

PMID:
18293181
22.

A nuclear export sequence located on a beta-strand in fibroblast growth factor-1.

Nilsen T, Rosendal KR, Sørensen V, Wesche J, Olsnes S, Wiedłocha A.

J Biol Chem. 2007 Sep 7;282(36):26245-56. Epub 2007 Jul 6.

23.

Indirubin-3'-monoxime inhibits autophosphorylation of FGFR1 and stimulates ERK1/2 activity via p38 MAPK.

Zhen Y, Sørensen V, Jin Y, Suo Z, Wiedłocha A.

Oncogene. 2007 Sep 27;26(44):6372-85. Epub 2007 May 28.

PMID:
17533378
24.

Structural requirements of FGF-1 for receptor binding and translocation into cells.

Zakrzewska M, Krowarsch D, Wiedlocha A, Olsnes S, Otlewski J.

Biochemistry. 2006 Dec 26;45(51):15338-48.

PMID:
17176056
25.

Different abilities of the four FGFRs to mediate FGF-1 translocation are linked to differences in the receptor C-terminal tail.

Sørensen V, Wiedlocha A, Haugsten EM, Khnykin D, Wesche J, Olsnes S.

J Cell Sci. 2006 Oct 15;119(Pt 20):4332-41. Epub 2006 Sep 26.

26.

FGF-1 as a possible carrier for targeted drug delivery.

Marcinkowska E, Superat K, Wiedłocha A.

Oncol Res. 2006;16(1):27-34.

PMID:
16783965
27.

Functional diversity of FGF-2 isoforms by intracellular sorting.

Sørensen V, Nilsen T, Wiedłocha A.

Bioessays. 2006 May;28(5):504-14. Review.

PMID:
16615083
28.

FGF-1 and FGF-2 require the cytosolic chaperone Hsp90 for translocation into the cytosol and the cell nucleus.

Wesche J, Małecki J, Wiedłocha A, Skjerpen CS, Claus P, Olsnes S.

J Biol Chem. 2006 Apr 21;281(16):11405-12. Epub 2006 Feb 22.

29.

Highly stable mutants of human fibroblast growth factor-1 exhibit prolonged biological action.

Zakrzewska M, Krowarsch D, Wiedlocha A, Olsnes S, Otlewski J.

J Mol Biol. 2005 Sep 30;352(4):860-75.

PMID:
16126225
30.

Two nuclear localization signals required for transport from the cytosol to the nucleus of externally added FGF-1 translocated into cells.

Wesche J, Małecki J, Wiedłocha A, Ehsani M, Marcinkowska E, Nilsen T, Olsnes S.

Biochemistry. 2005 Apr 26;44(16):6071-80.

PMID:
15835896
31.

Signaling, internalization, and intracellular activity of fibroblast growth factor.

Wiedłocha A, Sørensen V.

Curr Top Microbiol Immunol. 2004;286:45-79. Review.

PMID:
15645710
32.

Phosphorylation-regulated nucleocytoplasmic trafficking of internalized fibroblast growth factor-1.

Wiedłocha A, Nilsen T, Wesche J, Sørensen V, Małecki J, Marcinkowska E, Olsnes S.

Mol Biol Cell. 2005 Feb;16(2):794-810. Epub 2004 Dec 1.

33.

Design of fully active FGF-1 variants with increased stability.

Zakrzewska M, Krowarsch D, Wiedlocha A, Otlewski J.

Protein Eng Des Sel. 2004 Aug;17(8):603-11. Epub 2004 Oct 6.

PMID:
15469994
34.
35.

Translocation of FGF-1 and FGF-2 across vesicular membranes occurs during G1-phase by a common mechanism.

Małecki J, Wesche J, Skjerpen CS, Wiedłocha A, Olsnes S.

Mol Biol Cell. 2004 Feb;15(2):801-14. Epub 2003 Dec 2.

36.

IL-7 receptor is present on human microvascular endothelial cells.

Duś D, Krawczenko A, Załecki P, Paprocka M, Wiedłocha A, Goupille C, Kieda C.

Immunol Lett. 2003 Apr 3;86(2):163-8.

PMID:
12644318
37.

Transport of exogenous growth factors and cytokines to the cytosol and to the nucleus.

Olsnes S, Klingenberg O, Wiedłocha A.

Physiol Rev. 2003 Jan;83(1):163-82. Review.

38.

Steroid signal transduction activated at the cell membrane: from plants to animals.

Marcinkowska E, Wiedłocha A.

Acta Biochim Pol. 2002;49(3):735-45. Review.

39.

Vesicle transmembrane potential is required for translocation to the cytosol of externally added FGF-1.

Małecki J, Wiedłocha A, Wesche J, Olsnes S.

EMBO J. 2002 Sep 2;21(17):4480-90.

40.

Expression of human protein tyrosine phosphatase epsilon in leucocytes: a potential ERK pathway-regulating phosphatase.

Wabakken T, Hauge H, Finne EF, Wiedlocha A, Aasheim H.

Scand J Immunol. 2002 Aug;56(2):195-203.

42.

Modulation of intracellular transport of acidic fibroblast growth factor by mutations in the cytoplasmic receptor domain.

Citores L, Khnykin D, Sørensen V, Wesche J, Klingenberg O, Wiedłocha A, Olsnes S.

J Cell Sci. 2001 May;114(Pt 9):1677-89.

43.

Externally added aFGF mutants do not require extensive unfolding for transport to the cytosol and the nucleus in NIH/3T3 cells.

Wesche J, Wiedłocha A, Falnes PO, Choe S, Olsnes S.

Biochemistry. 2000 Dec 12;39(49):15091-100.

PMID:
11106487
44.

Requirement for C-terminal end of fibroblast growth factor receptor 4 in translocation of acidic fibroblast growth factor to cytosol and nucleus.

Klingenberg O, Wiedlocha A, Rapak A, Khnykin D, Citores L, Olsnes S.

J Cell Sci. 2000 May;113 ( Pt 10):1827-38.

45.

Following angiogenin during angiogenesis: a journey from the cell surface to the nucleolus.

Wiedłocha A.

Arch Immunol Ther Exp (Warsz). 1999;47(5):299-305. Review.

PMID:
10604235
46.

Effects of mutations of a phosphorylation site in an exposed loop in acidic fibroblast growth factor.

Klingenberg O, Wiedlocha A, Olsnes S.

J Biol Chem. 1999 Jun 18;274(25):18081-6.

47.

[Activation of the cell proliferation program by acidic fibroblast growth factor (aFGF)].

Wiedłocha A.

Postepy Hig Med Dosw. 1999;53(2):277-89. Review. Polish.

PMID:
10355293
48.

Novel protein toxin-based strategy for development of cytotoxic T lymphocyte vaccines.

Wiedłocha A.

Arch Immunol Ther Exp (Warsz). 1998;46(6):341-6. Review.

PMID:
9883312
49.

Evidence that phosphatidylinositol 3-kinase and p70S6K protein are involved in differentiation of HL-60 cells induced by calcitriol.

Marcinkowska E, Wiedlocha A, Radzikowski C.

Anticancer Res. 1998 Sep-Oct;18(5A):3507-14.

PMID:
9858932
50.

Cloning of an intracellular protein that binds selectively to mitogenic acidic fibroblast growth factor.

Kolpakova E, Wiedłocha A, Stenmark H, Klingenberg O, Falnes PO, Olsnes S.

Biochem J. 1998 Nov 15;336 ( Pt 1):213-22.

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