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Differential Metabolism of Medium-Chain Fatty Acids in Differentiated Human-Induced Pluripotent Stem Cell-Derived Astrocytes.

Sonnay S, Chakrabarti A, Thevenet J, Wiederkehr A, Christinat N, Masoodi M.

Front Physiol. 2019 Jun 4;10:657. doi: 10.3389/fphys.2019.00657. eCollection 2019.


The plant product quinic acid activates Ca2+ -dependent mitochondrial function and promotes insulin secretion from pancreatic beta cells.

Heikkilä E, Hermant A, Thevenet J, Bermont F, Kulkarni SS, Ratajczak J, Santo-Domingo J, Dioum EH, Canto C, Barron D, Wiederkehr A, De Marchi U.

Br J Pharmacol. 2019 Sep;176(17):3250-3263. doi: 10.1111/bph.14757. Epub 2019 Jul 15.


Macroencapsulated Human iPSC-Derived Pancreatic Progenitors Protect against STZ-Induced Hyperglycemia in Mice.

Haller C, Piccand J, De Franceschi F, Ohi Y, Bhoumik A, Boss C, De Marchi U, Jacot G, Metairon S, Descombes P, Wiederkehr A, Palini A, Bouche N, Steiner P, Kelly OG, R-C Kraus M.

Stem Cell Reports. 2019 Apr 9;12(4):787-800. doi: 10.1016/j.stemcr.2019.02.002. Epub 2019 Mar 7.


Glucose-dependent phosphorylation signaling pathways and crosstalk to mitochondrial respiration in insulin secreting cells.

Santo-Domingo J, Galindo AN, Cominetti O, De Marchi U, Cutillas P, Dayon L, Wiederkehr A.

Cell Commun Signal. 2019 Feb 20;17(1):14. doi: 10.1186/s12964-019-0326-6.


Mitochondrial lysine deacetylation promotes energy metabolism and calcium signaling in insulin-secreting cells.

De Marchi U, Galindo AN, Thevenet J, Hermant A, Bermont F, Lassueur S, Domingo JS, Kussmann M, Dayon L, Wiederkehr A.

FASEB J. 2019 Apr;33(4):4660-4674. doi: 10.1096/fj.201801424R. Epub 2018 Dec 27.


Regulation of inositol 1,4,5-trisphosphate-induced Ca2+ release from the endoplasmic reticulum by AMP-activated kinase modulators.

Arias-Del-Val J, Santo-Domingo J, García-Casas P, Alvarez-Illera P, Núñez Galindo A, Wiederkehr A, Fonteriz RI, Montero M, Alvarez J.

Cell Calcium. 2019 Jan;77:68-76. doi: 10.1016/j.ceca.2018.12.004. Epub 2018 Dec 11.


Keratinocytes Isolated From Individual Cleft Lip/Palate Patients Display Variations in Their Differentiation Potential in vitro.

Degen M, Wiederkehr A, La Scala GC, Carmann C, Schnyder I, Katsaros C.

Front Physiol. 2018 Nov 29;9:1703. doi: 10.3389/fphys.2018.01703. eCollection 2018.


Cellular stress is a prerequisite for glucose-induced mitochondrial matrix alkalinization in pancreatic β-cells.

Chareyron I, Wall C, Thevenet J, Santo-Domingo J, Wiederkehr A.

Mol Cell Endocrinol. 2019 Feb 5;481:71-83. doi: 10.1016/j.mce.2018.11.011. Epub 2018 Nov 23.


Illuminating redox biology using NADH- and NADPH-specific sensors.

Wiederkehr A, Demaurex N.

Nat Methods. 2017 Jun 29;14(7):671-672. doi: 10.1038/nmeth.4336. No abstract available.


Antibiotics induce mitonuclear protein imbalance but fail to inhibit respiration and nutrient activation in pancreatic β-cells.

Santo-Domingo J, Chareyron I, Broenimann C, Lassueur S, Wiederkehr A.

Exp Cell Res. 2017 Aug 15;357(2):170-180. doi: 10.1016/j.yexcr.2017.05.013. Epub 2017 May 17.


Corrigendum: Advances in pancreatic islet monolayer culture on glass surfaces enable super-resolution microscopy and insights into beta cell ciliogenesis and proliferation.

Phelps EA, Cianciaruso C, Santo-Domingo J, Pasquier M, Galliverti G, Piemonti L, Berishvili E, Burri O, Wiederkehr A, Hubbell JA, Baekkeskov S.

Sci Rep. 2017 May 9;7:46801. doi: 10.1038/srep46801. No abstract available.


MitoRS, a method for high throughput, sensitive, and accurate detection of mitochondrial DNA heteroplasmy.

Marquis J, Lefebvre G, Kourmpetis YAI, Kassam M, Ronga F, De Marchi U, Wiederkehr A, Descombes P.

BMC Genomics. 2017 Apr 26;18(1):326. doi: 10.1186/s12864-017-3695-5.


A novel ATP-synthase-independent mechanism coupling mitochondrial activation to exocytosis in insulin-secreting cells.

De Marchi U, Hermant A, Thevenet J, Ratinaud Y, Santo-Domingo J, Barron D, Wiederkehr A.

J Cell Sci. 2017 Jun 1;130(11):1929-1939. doi: 10.1242/jcs.200741. Epub 2017 Apr 12.


Advances in pancreatic islet monolayer culture on glass surfaces enable super-resolution microscopy and insights into beta cell ciliogenesis and proliferation.

Phelps EA, Cianciaruso C, Santo-Domingo J, Pasquier M, Galliverti G, Piemonti L, Berishvili E, Burri O, Wiederkehr A, Hubbell JA, Baekkeskov S.

Sci Rep. 2017 Apr 12;7:45961. doi: 10.1038/srep45961. Erratum in: Sci Rep. 2017 May 09;7:46801.


Oxidative stress and calcium dysregulation by palmitate in type 2 diabetes.

Ly LD, Xu S, Choi SK, Ha CM, Thoudam T, Cha SK, Wiederkehr A, Wollheim CB, Lee IK, Park KS.

Exp Mol Med. 2017 Feb 3;49(2):e291. doi: 10.1038/emm.2016.157. Review.


Encapsulation of Insulin-Secreting Cells Expressing a Genetically Encoded Fluorescent Calcium Indicator for Cell-Based Sensing In Vivo.

Boss C, De Marchi U, Hermant A, Conrad M, Sizzano F, Palini A, Wiederkehr A, Bouche N.

Adv Healthc Mater. 2017 Feb;6(4). doi: 10.1002/adhm.201600869. Epub 2016 Dec 20.


Coordinated activation of mitochondrial respiration and exocytosis mediated by PKC signaling in pancreatic β cells.

Santo-Domingo J, Chareyron I, Dayon L, Núñez Galindo A, Cominetti O, Pilar Giner Giménez M, De Marchi U, Canto C, Kussmann M, Wiederkehr A.

FASEB J. 2017 Mar;31(3):1028-1045. doi: 10.1096/fj.201600837R. Epub 2016 Dec 7.


Medium-chain fatty acids inhibit mitochondrial metabolism in astrocytes promoting astrocyte-neuron lactate and ketone body shuttle systems.

Thevenet J, De Marchi U, Domingo JS, Christinat N, Bultot L, Lefebvre G, Sakamoto K, Descombes P, Masoodi M, Wiederkehr A.

FASEB J. 2016 May;30(5):1913-26. doi: 10.1096/fj.201500182. Epub 2016 Feb 2.


Modulation of the matrix redox signaling by mitochondrial Ca(2.).

Santo-Domingo J, Wiederkehr A, De Marchi U.

World J Biol Chem. 2015 Nov 26;6(4):310-23. doi: 10.4331/wjbc.v6.i4.310. Review.


Palmitate induces ER calcium depletion and apoptosis in mouse podocytes subsequent to mitochondrial oxidative stress.

Xu S, Nam SM, Kim JH, Das R, Choi SK, Nguyen TT, Quan X, Choi SJ, Chung CH, Lee EY, Lee IK, Wiederkehr A, Wollheim CB, Cha SK, Park KS.

Cell Death Dis. 2015 Nov 19;6:e1976. doi: 10.1038/cddis.2015.331.


Mitochondrial oxidative stress mediates high-phosphate-induced secretory defects and apoptosis in insulin-secreting cells.

Nguyen TT, Quan X, Hwang KH, Xu S, Das R, Choi SK, Wiederkehr A, Wollheim CB, Cha SK, Park KS.

Am J Physiol Endocrinol Metab. 2015 Jun 1;308(11):E933-41. doi: 10.1152/ajpendo.00009.2015. Epub 2015 Apr 7.


Essential role of mitochondrial Ca2+ uniporter in the generation of mitochondrial pH gradient and metabolism-secretion coupling in insulin-releasing cells.

Quan X, Nguyen TT, Choi SK, Xu S, Das R, Cha SK, Kim N, Han J, Wiederkehr A, Wollheim CB, Park KS.

J Biol Chem. 2015 Feb 13;290(7):4086-96. doi: 10.1074/jbc.M114.632547. Epub 2014 Dec 29.


NCLX protein, but not LETM1, mediates mitochondrial Ca2+ extrusion, thereby limiting Ca2+-induced NAD(P)H production and modulating matrix redox state.

De Marchi U, Santo-Domingo J, Castelbou C, Sekler I, Wiederkehr A, Demaurex N.

J Biol Chem. 2014 Jul 18;289(29):20377-85. doi: 10.1074/jbc.M113.540898. Epub 2014 Jun 4.


Calcium co-regulates oxidative metabolism and ATP synthase-dependent respiration in pancreatic beta cells.

De Marchi U, Thevenet J, Hermant A, Dioum E, Wiederkehr A.

J Biol Chem. 2014 Mar 28;289(13):9182-94. doi: 10.1074/jbc.M113.513184. Epub 2014 Feb 19.


Mitochondrial phosphate transport during nutrient stimulation of INS-1E insulinoma cells.

Quan X, Das R, Xu S, Cline GW, Wiederkehr A, Wollheim CB, Park KS.

Mol Cell Endocrinol. 2013 Dec 5;381(1-2):198-209. doi: 10.1016/j.mce.2013.08.003. Epub 2013 Aug 9.


Pyruvate dehydrogenase E1α phosphorylation is induced by glucose but does not control metabolism-secretion coupling in INS-1E clonal β-cells.

Akhmedov D, De Marchi U, Wollheim CB, Wiederkehr A.

Biochim Biophys Acta. 2012 Oct;1823(10):1815-24. doi: 10.1016/j.bbamcr.2012.07.005. Epub 2012 Jul 15.


Defective mitochondrial function and motility due to mitofusin 1 overexpression in insulin secreting cells.

Park KS, Wiederkehr A, Wollheim CB.

Korean J Physiol Pharmacol. 2012 Feb;16(1):71-7. doi: 10.4196/kjpp.2012.16.1.71. Epub 2012 Feb 28.


Multistage Zeeman deceleration of metastable neon.

Wiederkehr AW, Motsch M, Hogan SD, Andrist M, Schmutz H, Lambillotte B, Agner JA, Merkt F.

J Chem Phys. 2011 Dec 7;135(21):214202. doi: 10.1063/1.3662141.


Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice.

Thorel F, Damond N, Chera S, Wiederkehr A, Thorens B, Meda P, Wollheim CB, Herrera PL.

Diabetes. 2011 Nov;60(11):2872-82. doi: 10.2337/db11-0876. Epub 2011 Sep 16.


Hepatic nuclear factor 1alpha (HNF1alpha) dysfunction down-regulates X-box-binding protein 1 (XBP1) and sensitizes beta-cells to endoplasmic reticulum stress.

Kirkpatrick CL, Wiederkehr A, Baquié M, Akhmedov D, Wang H, Gauthier BR, Akerman I, Ishihara H, Ferrer J, Wollheim CB.

J Biol Chem. 2011 Sep 16;286(37):32300-12. doi: 10.1074/jbc.M111.247866. Epub 2011 Jul 22.


Mitochondrial signals drive insulin secretion in the pancreatic β-cell.

Wiederkehr A, Wollheim CB.

Mol Cell Endocrinol. 2012 Apr 28;353(1-2):128-37. doi: 10.1016/j.mce.2011.07.016. Epub 2011 Jul 19. Review.


Mitochondrial matrix calcium is an activating signal for hormone secretion.

Wiederkehr A, Szanda G, Akhmedov D, Mataki C, Heizmann CW, Schoonjans K, Pozzan T, Spät A, Wollheim CB.

Cell Metab. 2011 May 4;13(5):601-11. doi: 10.1016/j.cmet.2011.03.015.


Reduction of plasma membrane glutamate transport potentiates insulin but not glucagon secretion in pancreatic islet cells.

Feldmann N, del Rio RM, Gjinovci A, Tamarit-Rodriguez J, Wollheim CB, Wiederkehr A.

Mol Cell Endocrinol. 2011 May 16;338(1-2):46-57. doi: 10.1016/j.mce.2011.02.019. Epub 2011 Mar 1.


Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal beta cells.

Akhmedov D, Braun M, Mataki C, Park KS, Pozzan T, Schoonjans K, Rorsman P, Wollheim CB, Wiederkehr A.

FASEB J. 2010 Nov;24(11):4613-26. doi: 10.1096/fj.10-162222. Epub 2010 Jul 20.


Linking fatty acid stress to beta-cell mitochondrial dynamics.

Wiederkehr A, Wollheim CB.

Diabetes. 2009 Oct;58(10):2185-6. doi: 10.2337/db09-0967. No abstract available.


Matrix alkalinisation unleashes β-cell mitochondria.

Wiederkehr A.

Islets. 2009 Sep-Oct;1(2):154-6. doi: 10.4161/isl.1.2.9058.


PDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppression.

Gauthier BR, Wiederkehr A, Baquié M, Dai C, Powers AC, Kerr-Conte J, Pattou F, MacDonald RJ, Ferrer J, Wollheim CB.

Cell Metab. 2009 Aug;10(2):110-8. doi: 10.1016/j.cmet.2009.07.002.


Matrix alkalinization: a novel mitochondrial signal for sustained pancreatic beta-cell activation.

Wiederkehr A, Park KS, Dupont O, Demaurex N, Pozzan T, Cline GW, Wollheim CB.

EMBO J. 2009 Feb 18;28(4):417-28. doi: 10.1038/emboj.2008.302. Epub 2009 Jan 22.


Requirement for aralar and its Ca2+-binding sites in Ca2+ signal transduction in mitochondria from INS-1 clonal beta-cells.

Mármol P, Pardo B, Wiederkehr A, del Arco A, Wollheim CB, Satrústegui J.

J Biol Chem. 2009 Jan 2;284(1):515-24. doi: 10.1074/jbc.M806729200. Epub 2008 Nov 7.


Magnetic trapping of hydrogen after multistage Zeeman deceleration.

Hogan SD, Wiederkehr AW, Schmutz H, Merkt F.

Phys Rev Lett. 2008 Oct 3;101(14):143001. Epub 2008 Sep 29.


Selective actions of mitochondrial fission/fusion genes on metabolism-secretion coupling in insulin-releasing cells.

Park KS, Wiederkehr A, Kirkpatrick C, Mattenberger Y, Martinou JC, Marchetti P, Demaurex N, Wollheim CB.

J Biol Chem. 2008 Nov 28;283(48):33347-56. doi: 10.1074/jbc.M806251200. Epub 2008 Oct 2.


Impact of mitochondrial calcium on the coupling of metabolism to insulin secretion in the pancreatic beta-cell.

Wiederkehr A, Wollheim CB.

Cell Calcium. 2008 Jul;44(1):64-76. doi: 10.1016/j.ceca.2007.11.004. Epub 2008 Jan 8. Review.


Minireview: implication of mitochondria in insulin secretion and action.

Wiederkehr A, Wollheim CB.

Endocrinology. 2006 Jun;147(6):2643-9. Epub 2006 Mar 23. Review.


Functional specialization within a vesicle tethering complex: bypass of a subset of exocyst deletion mutants by Sec1p or Sec4p.

Wiederkehr A, De Craene JO, Ferro-Novick S, Novick P.

J Cell Biol. 2004 Dec 6;167(5):875-87.


Sec3p is needed for the spatial regulation of secretion and for the inheritance of the cortical endoplasmic reticulum.

Wiederkehr A, Du Y, Pypaert M, Ferro-Novick S, Novick P.

Mol Biol Cell. 2003 Dec;14(12):4770-82. Epub 2003 Sep 5.


Skp1p and the F-box protein Rcy1p form a non-SCF complex involved in recycling of the SNARE Snc1p in yeast.

Galan JM, Wiederkehr A, Seol JH, Haguenauer-Tsapis R, Deshaies RJ, Riezman H, Peter M.

Mol Cell Biol. 2001 May;21(9):3105-17.


A novel EH domain protein of Saccharomyces cerevisiae, Ede1p, involved in endocytosis.

Gagny B, Wiederkehr A, Dumoulin P, Winsor B, Riezman H, Haguenauer-Tsapis R.

J Cell Sci. 2000 Sep;113 ( Pt 18):3309-19.


The F-box protein Rcy1p is involved in endocytic membrane traffic and recycling out of an early endosome in Saccharomyces cerevisiae.

Wiederkehr A, Avaro S, Prescianotto-Baschong C, Haguenauer-Tsapis R, Riezman H.

J Cell Biol. 2000 Apr 17;149(2):397-410.

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