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Items: 50


Cas9 slide-and-seek for phage defense and genome engineering.

Santiago-Frangos A, Wiegand T, Wiedenheft B.

EMBO J. 2019 Feb 15;38(4). pii: e101474. doi: 10.15252/embj.2019101474. Epub 2019 Feb 7. No abstract available.


CRISPR RNA-guided autonomous delivery of Cas9.

Wilkinson RA, Martin C, Nemudryi AA, Wiedenheft B.

Nat Struct Mol Biol. 2019 Jan;26(1):14-24. doi: 10.1038/s41594-018-0173-y. Epub 2018 Dec 31. Review.


Bacteriophage Cooperation Suppresses CRISPR-Cas3 and Cas9 Immunity.

Borges AL, Zhang JY, Rollins MF, Osuna BA, Wiedenheft B, Bondy-Denomy J.

Cell. 2018 Aug 9;174(4):917-925.e10. doi: 10.1016/j.cell.2018.06.013. Epub 2018 Jul 19.


A PAX5-OCT4-PRDM1 developmental switch specifies human primordial germ cells.

Fang F, Angulo B, Xia N, Sukhwani M, Wang Z, Carey CC, Mazurie A, Cui J, Wilkinson R, Wiedenheft B, Irie N, Surani MA, Orwig KE, Reijo Pera RA.

Nat Cell Biol. 2018 Jun;20(6):655-665. doi: 10.1038/s41556-018-0094-3. Epub 2018 Apr 30.


Live imaging analysis of human gastric epithelial spheroids reveals spontaneous rupture, rotation and fusion events.

Sebrell TA, Sidar B, Bruns R, Wilkinson RA, Wiedenheft B, Taylor PJ, Perrino BA, Samuelson LC, Wilking JN, Bimczok D.

Cell Tissue Res. 2018 Feb;371(2):293-307. doi: 10.1007/s00441-017-2726-5. Epub 2017 Nov 25.


Conformational Dynamics of DNA Binding and Cas3 Recruitment by the CRISPR RNA-Guided Cascade Complex.

van Erp PBG, Patterson A, Kant R, Berry L, Golden SM, Forsman BL, Carter J, Jackson RN, Bothner B, Wiedenheft B.

ACS Chem Biol. 2018 Feb 16;13(2):481-490. doi: 10.1021/acschembio.7b00649. Epub 2017 Dec 12.


Conformational regulation of CRISPR-associated nucleases.

Jackson RN, van Erp PB, Sternberg SH, Wiedenheft B.

Curr Opin Microbiol. 2017 Jun;37:110-119. doi: 10.1016/j.mib.2017.05.010. Epub 2017 Jun 21. Review.


Cas1 and the Csy complex are opposing regulators of Cas2/3 nuclease activity.

Rollins MF, Chowdhury S, Carter J, Golden SM, Wilkinson RA, Bondy-Denomy J, Lander GC, Wiedenheft B.

Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):E5113-E5121. doi: 10.1073/pnas.1616395114. Epub 2017 Apr 24.


Structure Reveals Mechanisms of Viral Suppressors that Intercept a CRISPR RNA-Guided Surveillance Complex.

Chowdhury S, Carter J, Rollins MF, Golden SM, Jackson RN, Hoffmann C, Nosaka L, Bondy-Denomy J, Maxwell KL, Davidson AR, Fischer ER, Lander GC, Wiedenheft B.

Cell. 2017 Mar 23;169(1):47-57.e11. doi: 10.1016/j.cell.2017.03.012.


The Interfaces of Genetic Conflict Are Hot Spots for Innovation.

Carter J, Hoffman C, Wiedenheft B.

Cell. 2017 Jan 12;168(1-2):9-11. doi: 10.1016/j.cell.2016.12.007. Epub 2017 Jan 12.


CRISPR control of virulence in Pseudomonas aeruginosa.

Wiedenheft B, Bondy-Denomy J.

Cell Res. 2017 Feb;27(2):163-164. doi: 10.1038/cr.2017.6. Epub 2017 Jan 13.


The CRISPR RNA-guided surveillance complex in Escherichia coli accommodates extended RNA spacers.

Luo ML, Jackson RN, Denny SR, Tokmina-Lukaszewska M, Maksimchuk KR, Lin W, Bothner B, Wiedenheft B, Beisel CL.

Nucleic Acids Res. 2016 Sep 6;44(15):7385-94. doi: 10.1093/nar/gkw421. Epub 2016 May 12.


Programmed Self-Assembly of an Active P22-Cas9 Nanocarrier System.

Qazi S, Miettinen HM, Wilkinson RA, McCoy K, Douglas T, Wiedenheft B.

Mol Pharm. 2016 Mar 7;13(3):1191-6. doi: 10.1021/acs.molpharmaceut.5b00822. Epub 2016 Feb 22.


Structural basis for promiscuous PAM recognition in type I-E Cascade from E. coli.

Hayes RP, Xiao Y, Ding F, van Erp PB, Rajashankar K, Bailey S, Wiedenheft B, Ke A.

Nature. 2016 Feb 25;530(7591):499-503. doi: 10.1038/nature16995. Epub 2016 Feb 10.


Foreign DNA acquisition by the I-F CRISPR-Cas system requires all components of the interference machinery.

Vorontsova D, Datsenko KA, Medvedeva S, Bondy-Denomy J, Savitskaya EE, Pougach K, Logacheva M, Wiedenheft B, Davidson AR, Severinov K, Semenova E.

Nucleic Acids Res. 2015 Dec 15;43(22):10848-60. doi: 10.1093/nar/gkv1261. Epub 2015 Nov 19.


Surveillance and Processing of Foreign DNA by the Escherichia coli CRISPR-Cas System.

Redding S, Sternberg SH, Marshall M, Gibb B, Bhat P, Guegler CK, Wiedenheft B, Doudna JA, Greene EC.

Cell. 2015 Nov 5;163(4):854-65. doi: 10.1016/j.cell.2015.10.003.


Multiple mechanisms for CRISPR-Cas inhibition by anti-CRISPR proteins.

Bondy-Denomy J, Garcia B, Strum S, Du M, Rollins MF, Hidalgo-Reyes Y, Wiedenheft B, Maxwell KL, Davidson AR.

Nature. 2015 Oct 1;526(7571):136-9. doi: 10.1038/nature15254. Epub 2015 Sep 23.


SnapShot: CRISPR-RNA-guided adaptive immune systems.

Carter J, Wiedenheft B.

Cell. 2015 Sep 24;163(1):260-260.e1. doi: 10.1016/j.cell.2015.09.011.


Mechanism of CRISPR-RNA guided recognition of DNA targets in Escherichia coli.

van Erp PB, Jackson RN, Carter J, Golden SM, Bailey S, Wiedenheft B.

Nucleic Acids Res. 2015 Sep 30;43(17):8381-91. doi: 10.1093/nar/gkv793. Epub 2015 Aug 3.


X-ray structure determination using low-resolution electron microscopy maps for molecular replacement.

Jackson RN, McCoy AJ, Terwilliger TC, Read RJ, Wiedenheft B.

Nat Protoc. 2015 Sep;10(9):1275-84. doi: 10.1038/nprot.2015.069. Epub 2015 Jul 30.


A Conserved Structural Chassis for Mounting Versatile CRISPR RNA-Guided Immune Responses.

Jackson RN, Wiedenheft B.

Mol Cell. 2015 Jun 4;58(5):722-8. doi: 10.1016/j.molcel.2015.05.023. Epub 2015 May 28. Review.


The history and market impact of CRISPR RNA-guided nucleases.

van Erp PB, Bloomer G, Wilkinson R, Wiedenheft B.

Curr Opin Virol. 2015 Jun;12:85-90. doi: 10.1016/j.coviro.2015.03.011. Epub 2015 Apr 26.


Mechanism of foreign DNA recognition by a CRISPR RNA-guided surveillance complex from Pseudomonas aeruginosa.

Rollins MF, Schuman JT, Paulus K, Bukhari HS, Wiedenheft B.

Nucleic Acids Res. 2015 Feb 27;43(4):2216-22.


Structural biology. Crystal structure of the CRISPR RNA-guided surveillance complex from Escherichia coli.

Jackson RN, Golden SM, van Erp PB, Carter J, Westra ER, Brouns SJ, van der Oost J, Terwilliger TC, Read RJ, Wiedenheft B.

Science. 2014 Sep 19;345(6203):1473-9. doi: 10.1126/science.1256328. Epub 2014 Aug 7.


Unravelling the structural and mechanistic basis of CRISPR-Cas systems.

van der Oost J, Westra ER, Jackson RN, Wiedenheft B.

Nat Rev Microbiol. 2014 Jul;12(7):479-92. doi: 10.1038/nrmicro3279. Epub 2014 Jun 9. Review.


A CRISPR method for genome engineering.

Wilkinson R, Wiedenheft B.

F1000Prime Rep. 2014 Jan 2;6:3. doi: 10.12703/P6-3. eCollection 2014. Review.


Fitting CRISPR-associated Cas3 into the helicase family tree.

Jackson RN, Lavin M, Carter J, Wiedenheft B.

Curr Opin Struct Biol. 2014 Feb;24:106-14. doi: 10.1016/ Epub 2014 Jan 28. Review.


Type I-E CRISPR-cas systems discriminate target from non-target DNA through base pairing-independent PAM recognition.

Westra ER, Semenova E, Datsenko KA, Jackson RN, Wiedenheft B, Severinov K, Brouns SJ.

PLoS Genet. 2013;9(9):e1003742. doi: 10.1371/journal.pgen.1003742. Epub 2013 Sep 5.


CRISPR-mediated adaptive immune systems in bacteria and archaea.

Sorek R, Lawrence CM, Wiedenheft B.

Annu Rev Biochem. 2013;82:237-66. doi: 10.1146/annurev-biochem-072911-172315. Epub 2013 Mar 11. Review.


Native tandem and ion mobility mass spectrometry highlight structural and modular similarities in clustered-regularly-interspaced shot-palindromic-repeats (CRISPR)-associated protein complexes from Escherichia coli and Pseudomonas aeruginosa.

van Duijn E, Barbu IM, Barendregt A, Jore MM, Wiedenheft B, Lundgren M, Westra ER, Brouns SJ, Doudna JA, van der Oost J, Heck AJ.

Mol Cell Proteomics. 2012 Nov;11(11):1430-41. doi: 10.1074/mcp.M112.020263. Epub 2012 Aug 23.


Mechanism of foreign DNA selection in a bacterial adaptive immune system.

Sashital DG, Wiedenheft B, Doudna JA.

Mol Cell. 2012 Jun 8;46(5):606-15. doi: 10.1016/j.molcel.2012.03.020. Epub 2012 Apr 19.


RNA-guided genetic silencing systems in bacteria and archaea.

Wiedenheft B, Sternberg SH, Doudna JA.

Nature. 2012 Feb 15;482(7385):331-8. doi: 10.1038/nature10886. Review.


Structures of the RNA-guided surveillance complex from a bacterial immune system.

Wiedenheft B, Lander GC, Zhou K, Jore MM, Brouns SJJ, van der Oost J, Doudna JA, Nogales E.

Nature. 2011 Sep 21;477(7365):486-489. doi: 10.1038/nature10402.


RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions.

Wiedenheft B, van Duijn E, Bultema JB, Waghmare SP, Zhou K, Barendregt A, Westphal W, Heck AJ, Boekema EJ, Dickman MJ, Doudna JA.

Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10092-7. doi: 10.1073/pnas.1102716108. Epub 2011 May 2. Erratum in: Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):15010. Proc Natl Acad Sci U S A. 2011 Jun 21;108(25). doi:10.1073/pnas.1111854108. Bultema, Jelle [corrected to Bultema, Jelle B];Waghmare, Sakharam [corrected to Waghmare, Sakharam P]; Heck, Albert [corrected to Heck, Albert J R];Boekema, Egbert [corrected to Boekema, Egbert J]; Dickman, Mark [corrected to Dickman, Mark J].


Structural basis for CRISPR RNA-guided DNA recognition by Cascade.

Jore MM, Lundgren M, van Duijn E, Bultema JB, Westra ER, Waghmare SP, Wiedenheft B, Pul U, Wurm R, Wagner R, Beijer MR, Barendregt A, Zhou K, Snijders AP, Dickman MJ, Doudna JA, Boekema EJ, Heck AJ, van der Oost J, Brouns SJ.

Nat Struct Mol Biol. 2011 May;18(5):529-36. doi: 10.1038/nsmb.2019. Epub 2011 Apr 3.


Sequence- and structure-specific RNA processing by a CRISPR endonuclease.

Haurwitz RE, Jinek M, Wiedenheft B, Zhou K, Doudna JA.

Science. 2010 Sep 10;329(5997):1355-8. doi: 10.1126/science.1192272.


Something old, something new, something borrowed; how the thermoacidophilic archaeon Sulfolobus solfataricus responds to oxidative stress.

Maaty WS, Wiedenheft B, Tarlykov P, Schaff N, Heinemann J, Robison-Cox J, Valenzuela J, Dougherty A, Blum P, Lawrence CM, Douglas T, Young MJ, Bothner B.

PLoS One. 2009 Sep 16;4(9):e6964. doi: 10.1371/journal.pone.0006964.


Structural basis for DNase activity of a conserved protein implicated in CRISPR-mediated genome defense.

Wiedenheft B, Zhou K, Jinek M, Coyle SM, Ma W, Doudna JA.

Structure. 2009 Jun 10;17(6):904-12. doi: 10.1016/j.str.2009.03.019.


Virus movement maintains local virus population diversity.

Snyder JC, Wiedenheft B, Lavin M, Roberto FF, Spuhler J, Ortmann AC, Douglas T, Young M.

Proc Natl Acad Sci U S A. 2007 Nov 27;104(48):19102-7. Epub 2007 Nov 19.


Hot crenarchaeal viruses reveal deep evolutionary connections.

Ortmann AC, Wiedenheft B, Douglas T, Young M.

Nat Rev Microbiol. 2006 Jul;4(7):520-8. Epub 2006 Jun 6. Review.


Dps-like protein from the hyperthermophilic archaeon Pyrococcus furiosus.

Ramsay B, Wiedenheft B, Allen M, Gauss GH, Lawrence CM, Young M, Douglas T.

J Inorg Biochem. 2006 May;100(5-6):1061-8. Epub 2006 Jan 18.


An archaeal antioxidant: characterization of a Dps-like protein from Sulfolobus solfataricus.

Wiedenheft B, Mosolf J, Willits D, Yeager M, Dryden KA, Young M, Douglas T.

Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10551-6. Epub 2005 Jul 15.


Effects of culturing on the population structure of a hyperthermophilic virus.

Snyder JC, Spuhler J, Wiedenheft B, Roberto FF, Douglas T, Young MJ.

Microb Ecol. 2004 Nov;48(4):561-6. Epub 2004 Nov 4.


Crystal structure of F-93 from Sulfolobus spindle-shaped virus 1, a winged-helix DNA binding protein.

Kraft P, Oeckinghaus A, Kümmel D, Gauss GH, Gilmore J, Wiedenheft B, Young M, Lawrence CM.

J Virol. 2004 Nov;78(21):11544-50.


Structure of D-63 from sulfolobus spindle-shaped virus 1: surface properties of the dimeric four-helix bundle suggest an adaptor protein function.

Kraft P, Kümmel D, Oeckinghaus A, Gauss GH, Wiedenheft B, Young M, Lawrence CM.

J Virol. 2004 Jul;78(14):7438-42.


Comparative genomic analysis of hyperthermophilic archaeal Fuselloviridae viruses.

Wiedenheft B, Stedman K, Roberto F, Willits D, Gleske AK, Zoeller L, Snyder J, Douglas T, Young M.

J Virol. 2004 Feb;78(4):1954-61.


Viruses of hyperthermophilic Archaea.

Snyder JC, Stedman K, Rice G, Wiedenheft B, Spuhler J, Young MJ.

Res Microbiol. 2003 Sep;154(7):474-82. Review.


Viruses from extreme thermal environments.

Rice G, Stedman K, Snyder J, Wiedenheft B, Willits D, Brumfield S, McDermott T, Young MJ.

Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13341-5. Epub 2001 Oct 23.

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