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Items: 1 to 50 of 59

1.

L1 Cell Adhesion Molecule Overexpression Down Regulates Phosphacan and Up Regulates Structural Plasticity-Related Genes Rostral and Caudal to the Complete Spinal Cord Transection.

Płatek R, Grycz K, Więckowska A, Czarkowska-Bauch J, Skup M.

J Neurotrauma. 2019 Sep 25. doi: 10.1089/neu.2018.6103. [Epub ahead of print]

PMID:
31426714
2.

Anti-Alzheimer's multitarget-directed ligands with serotonin 5-HT6 antagonist, butyrylcholinesterase inhibitory, and antioxidant activity.

Marcinkowska M, Bucki A, Panek D, Siwek A, Fajkis N, Bednarski M, Zygmunt M, Godyń J, Del Rio Valdivieso A, Kotańska M, Kołaczkowski M, Więckowska A.

Arch Pharm (Weinheim). 2019 Jul;352(7):e1900041. doi: 10.1002/ardp.201900041. Epub 2019 Jun 4.

PMID:
31162703
3.

The influence of metal-complexing macrocycle size on intramolecular movement in rotaxanes.

Woźny M, Tomczyk KM, Więckowska A, Sutuła S, Trzybiński D, Woźniak K, Korybut-Daszkiewicz B.

Dalton Trans. 2019 May 15;48(19):6546-6557. doi: 10.1039/c9dt00083f.

PMID:
31011729
4.

Novel Aryloxyethyl Derivatives of 1-(1-Benzoylpiperidin-4-yl)methanamine as the Extracellular Regulated Kinases 1/2 (ERK1/2) Phosphorylation-Preferring Serotonin 5-HT1A Receptor-Biased Agonists with Robust Antidepressant-like Activity.

Sniecikowska J, Gluch-Lutwin M, Bucki A, Więckowska A, Siwek A, Jastrzebska-Wiesek M, Partyka A, Wilczyńska D, Pytka K, Pociecha K, Cios A, Wyska E, Wesołowska A, Pawłowski M, Varney MA, Newman-Tancredi A, Kolaczkowski M.

J Med Chem. 2019 Mar 14;62(5):2750-2771. doi: 10.1021/acs.jmedchem.9b00062. Epub 2019 Mar 2.

PMID:
30721053
5.

[3]rotaxanes composed of two dibenzo-24-crown-8 ether wheels and an azamacrocyclic complex.

Woźny M, Więckowska A, Trzybiński D, Sutuła S, Domagała S, Woźniak K.

Dalton Trans. 2018 Nov 13;47(44):15845-15856. doi: 10.1039/c8dt03225d.

PMID:
30358785
6.

Spinalization and locomotor training differentially affect muscarinic acetylcholine receptor type 2 abutting on α-motoneurons innervating the ankle extensor and flexor muscles.

Więckowska A, Gajewska-Woźniak O, Głowacka A, Ji B, Grycz K, Czarkowska-Bauch J, Skup M.

J Neurochem. 2018 Nov;147(3):361-379. doi: 10.1111/jnc.14567.

7.

A novel live-cell imaging system reveals a reversible hydrostatic pressure impact on cell-cycle progression.

Brooker HR, Gyamfi IA, Wieckowska A, Brooks NJ, Mulvihill DP, Geeves MA.

J Cell Sci. 2018 Aug 6;131(15). pii: jcs212167. doi: 10.1242/jcs.212167.

8.

Design, Synthesis, and Biological Evaluation of 2-(Benzylamino-2-Hydroxyalkyl)Isoindoline-1,3-Diones Derivatives as Potential Disease-Modifying Multifunctional Anti-Alzheimer Agents.

Panek D, Więckowska A, Pasieka A, Godyń J, Jończyk J, Bajda M, Knez D, Gobec S, Malawska B.

Molecules. 2018 Feb 7;23(2). pii: E347. doi: 10.3390/molecules23020347.

9.

Novel Multitarget-Directed Ligands Aiming at Symptoms and Causes of Alzheimer's Disease.

Więckowska A, Wichur T, Godyń J, Bucki A, Marcinkowska M, Siwek A, Więckowski K, Zaręba P, Knez D, Głuch-Lutwin M, Kazek G, Latacz G, Mika K, Kołaczkowski M, Korabecny J, Soukup O, Benkova M, Kieć-Kononowicz K, Gobec S, Malawska B.

ACS Chem Neurosci. 2018 May 16;9(5):1195-1214. doi: 10.1021/acschemneuro.8b00024. Epub 2018 Feb 13.

PMID:
29384656
10.

Design, Synthesis, and Biological Evaluation of 1-Benzylamino-2-hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer's Agents.

Panek D, Więckowska A, Jończyk J, Godyń J, Bajda M, Wichur T, Pasieka A, Knez D, Pišlar A, Korabecny J, Soukup O, Sepsova V, Sabaté R, Kos J, Gobec S, Malawska B.

ACS Chem Neurosci. 2018 May 16;9(5):1074-1094. doi: 10.1021/acschemneuro.7b00461. Epub 2018 Feb 1.

PMID:
29345897
11.

Aryl- and heteroaryl-substituted phenylalanines as AMPA receptor ligands.

Szymańska E, Chałupnik P, Johansen TN, Nielsen B, Cuñado Moral AM, Pickering DS, Więckowska A, Kieć-Kononowicz K.

Chem Biol Drug Des. 2017 Dec;90(6):1271-1281. doi: 10.1111/cbdd.13048. Epub 2017 Jul 18.

PMID:
28636281
12.

Reticulated vitreous carbon as a scaffold for enzymatic fuel cell designing.

Kizling M, Dzwonek M, Olszewski B, Bącal P, Tymecki Ł, Więckowska A, Stolarczyk K, Bilewicz R.

Biosens Bioelectron. 2017 Sep 15;95:1-7. doi: 10.1016/j.bios.2017.03.070. Epub 2017 Apr 4.

PMID:
28399444
13.

Lipophilic properties of anti-Alzheimer's agents determined by micellar electrokinetic chromatography and reversed-phase thin-layer chromatography.

Godyń J, Hebda M, Więckowska A, Więckowski K, Malawska B, Bajda M.

Electrophoresis. 2017 May;38(9-10):1268-1275. doi: 10.1002/elps.201600473. Epub 2017 Mar 15.

PMID:
28169440
14.

Development of an in-vivo active reversible butyrylcholinesterase inhibitor.

Košak U, Brus B, Knez D, Šink R, Žakelj S, Trontelj J, Pišlar A, Šlenc J, Gobec M, Živin M, Tratnjek L, Perše M, Sałat K, Podkowa A, Filipek B, Nachon F, Brazzolotto X, Więckowska A, Malawska B, Stojan J, Raščan IM, Kos J, Coquelle N, Colletier JP, Gobec S.

Sci Rep. 2016 Dec 21;6:39495. doi: 10.1038/srep39495.

15.

Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation.

Panek D, Więckowska A, Wichur T, Bajda M, Godyń J, Jończyk J, Mika K, Janockova J, Soukup O, Knez D, Korabecny J, Gobec S, Malawska B.

Eur J Med Chem. 2017 Jan 5;125:676-695. doi: 10.1016/j.ejmech.2016.09.078. Epub 2016 Sep 26.

PMID:
27721153
16.

Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HT6 receptor antagonists. Design, synthesis and biological evaluation.

Więckowska A, Kołaczkowski M, Bucki A, Godyń J, Marcinkowska M, Więckowski K, Zaręba P, Siwek A, Kazek G, Głuch-Lutwin M, Mierzejewski P, Bienkowski P, Sienkiewicz-Jarosz H, Knez D, Wichur T, Gobec S, Malawska B.

Eur J Med Chem. 2016 Nov 29;124:63-81. doi: 10.1016/j.ejmech.2016.08.016. Epub 2016 Aug 11.

PMID:
27560283
17.

RNA-sequencing of a mouse-model of spinal muscular atrophy reveals tissue-wide changes in splicing of U12-dependent introns.

Doktor TK, Hua Y, Andersen HS, Brøner S, Liu YH, Wieckowska A, Dembic M, Bruun GH, Krainer AR, Andresen BS.

Nucleic Acids Res. 2017 Jan 9;45(1):395-416. doi: 10.1093/nar/gkw731. Epub 2016 Aug 23.

18.

Cholinesterase inhibitory activity of chlorophenoxy derivatives-Histamine H3 receptor ligands.

Łażewska D, Jończyk J, Bajda M, Szałaj N, Więckowska A, Panek D, Moore C, Kuder K, Malawska B, Kieć-Kononowicz K.

Bioorg Med Chem Lett. 2016 Aug 15;26(16):4140-5. doi: 10.1016/j.bmcl.2016.04.054. Epub 2016 Apr 20.

PMID:
27445168
19.

Synthesis, Molecular Modelling and Biological Evaluation of Novel Heterodimeric, Multiple Ligands Targeting Cholinesterases and Amyloid Beta.

Hebda M, Bajda M, Więckowska A, Szałaj N, Pasieka A, Panek D, Godyń J, Wichur T, Knez D, Gobec S, Malawska B.

Molecules. 2016 Mar 26;21(4):410. doi: 10.3390/molecules21040410.

20.

SEARCH FOR POTENTIAL CHOLINESTERASE INHIBITORS FROM THE ZINC DATABASE BY VIRTUAL SCREENING METHOD.

Bajda M, Panek D, Hebda M, Więckowska A, Guzior N, Malawska B.

Acta Pol Pharm. 2015 Jul-Aug;72(4):737-45.

21.

Cholestasis and Hepatic Failure in a Neonate: A Case Report of Severe Pyruvate Kinase Deficiency.

Olivier F, Wieckowska A, Piedboeuf B, Alvarez F.

Pediatrics. 2015 Nov;136(5):e1366-8. doi: 10.1542/peds.2015-0834. Epub 2015 Oct 12.

22.

Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with β-amyloid anti-aggregation properties and beneficial effects on memory in vivo.

Więckowska A, Więckowski K, Bajda M, Brus B, Sałat K, Czerwińska P, Gobec S, Filipek B, Malawska B.

Bioorg Med Chem. 2015 May 15;23(10):2445-57. doi: 10.1016/j.bmc.2015.03.051. Epub 2015 Mar 27.

PMID:
25868744
23.

Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer's disease.

Guzior N, Wieckowska A, Panek D, Malawska B.

Curr Med Chem. 2015;22(3):373-404. Review.

24.

N-Aryl Isoleucine Derivatives as Angiotensin II AT2 Receptor Ligands.

Behrends M, Wallinder C, Wieckowska A, Guimond MO, Hallberg A, Gallo-Payet N, Larhed M.

ChemistryOpen. 2014 Apr;3(2):65-75. doi: 10.1002/open.201300040. Epub 2014 Mar 13.

25.

DXR inhibition by potent mono- and disubstituted fosmidomycin analogues.

Jansson AM, Więckowska A, Björkelid C, Yahiaoui S, Sooriyaarachchi S, Lindh M, Bergfors T, Dharavath S, Desroses M, Suresh S, Andaloussi M, Nikhil R, Sreevalli S, Srinivasa BR, Larhed M, Jones TA, Karlén A, Mowbray SL.

J Med Chem. 2013 Aug 8;56(15):6190-9. doi: 10.1021/jm4006498. Epub 2013 Jul 17.

PMID:
23819803
26.

Structure-based search for new inhibitors of cholinesterases.

Bajda M, Więckowska A, Hebda M, Guzior N, Sotriffer CA, Malawska B.

Int J Mol Sci. 2013 Mar 11;14(3):5608-32. doi: 10.3390/ijms14035608.

27.

Synthesis and pharmacological properties of new GABA uptake inhibitors.

Sałat K, Więckowska A, Więckowski K, Höfner GC, Kamiński J, Wanner KT, Malawska B, Filipek B, Kulig K.

Pharmacol Rep. 2012;64(4):817-33.

28.

Dual-acting diether derivatives of piperidine and homopiperidine with histamine H(3) receptor antagonistic and anticholinesterase activity.

Bajda M, Kuder KJ, Lażewska D, Kieć-Kononowicz K, Więckowska A, Ignasik M, Guzior N, Jończyk J, Malawska B.

Arch Pharm (Weinheim). 2012 Aug;345(8):591-7. doi: 10.1002/ardp.201200018. Epub 2012 May 2.

PMID:
22549828
29.

Macrocyclic multicenter complexes of nickel and copper of increasing complexity.

Małecka J, Lewandowska U, Kamiński R, Mames I, Więckowska A, Bilewicz R, Korybut-Daszkiewicz B, Woźniak K.

Chemistry. 2011 Oct 24;17(44):12385-95. doi: 10.1002/chem.201100342. Epub 2011 Sep 23.

PMID:
21953984
30.

Substitution of the phosphonic acid and hydroxamic acid functionalities of the DXR inhibitor FR900098: an attempt to improve the activity against Mycobacterium tuberculosis.

Andaloussi M, Lindh M, Björkelid C, Suresh S, Wieckowska A, Iyer H, Karlén A, Larhed M.

Bioorg Med Chem Lett. 2011 Sep 15;21(18):5403-7. doi: 10.1016/j.bmcl.2011.07.005. Epub 2011 Jul 20.

PMID:
21824775
31.

Design, synthesis, and X-ray crystallographic studies of α-aryl substituted fosmidomycin analogues as inhibitors of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase.

Andaloussi M, Henriksson LM, Więckowska A, Lindh M, Björkelid C, Larsson AM, Suresh S, Iyer H, Srinivasa BR, Bergfors T, Unge T, Mowbray SL, Larhed M, Jones TA, Karlén A.

J Med Chem. 2011 Jul 28;54(14):4964-76. doi: 10.1021/jm2000085. Epub 2011 Jul 1.

PMID:
21678907
32.

Structuring of supported hybrid phospholipid bilayers on electrodes with phospholipase A2.

Więckowska A, Jabłonowska E, Rogalska E, Bilewicz R.

Phys Chem Chem Phys. 2011 May 28;13(20):9716-24. doi: 10.1039/c0cp02229b. Epub 2011 Apr 18.

PMID:
21503329
33.

Microwave-assisted synthesis of Weinreb and MAP aryl amides via Pd-catalyzed Heck aminocarbonylation using Mo(CO)6 or W(CO)6.

Wieckowska A, Fransson R, Odell LR, Larhed M.

J Org Chem. 2011 Feb 4;76(3):978-81. doi: 10.1021/jo102151u. Epub 2011 Jan 13.

PMID:
21229975
34.

Synthesis and biological evaluation of new derivatives of 2-substituted 4-hydroxybutanamides as GABA uptake inhibitors.

Kulig K, Więckowski K, Więckowska A, Gajda J, Pochwat B, Höfner GC, Wanner KT, Malawska B.

Eur J Med Chem. 2011 Jan;46(1):183-90. doi: 10.1016/j.ejmech.2010.11.001. Epub 2010 Nov 4.

PMID:
21111516
35.

Novel alkyl- and arylcarbamate derivatives with N-benzylpiperidine and N-benzylpiperazine moieties as cholinesterases inhibitors.

Więckowska A, Bajda M, Guzior N, Malawska B.

Eur J Med Chem. 2010 Dec;45(12):5602-11. doi: 10.1016/j.ejmech.2010.09.010. Epub 2010 Sep 17.

PMID:
20926161
36.
37.

Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: a multicenter validation study.

Feldstein AE, Wieckowska A, Lopez AR, Liu YC, Zein NN, McCullough AJ.

Hepatology. 2009 Oct;50(4):1072-8. doi: 10.1002/hep.23050.

38.

Electrochemical and conformational consequences of copper (Cu(I) and Cu(II)) binding to beta-amyloid(1-40).

Brzyska M, Trzesniewska K, Wieckowska A, Szczepankiewicz A, Elbaum D.

Chembiochem. 2009 Apr 17;10(6):1045-55. doi: 10.1002/cbic.200800732.

PMID:
19263448
39.

Role of interleukin-6 in human nonalcoholic steatohepatitis. Response to Dogru et al.

Wieckowska A, Papouchado BG, Li Z, Lopez R, Zein NN, Feldstein AE.

Am J Gastroenterol. 2009 Mar;104(3):author reply 788. doi: 10.1038/ajg.2008.107. Epub 2009 Jan 27. No abstract available.

PMID:
19174778
40.

Diagnosis of nonalcoholic fatty liver disease: invasive versus noninvasive.

Wieckowska A, Feldstein AE.

Semin Liver Dis. 2008 Nov;28(4):386-95. doi: 10.1055/s-0028-1091983. Epub 2008 Oct 27. Review.

PMID:
18956295
41.

Probing kinase activities by electrochemistry, contact-angle measurements, and molecular-force interactions.

Wilner OI, Guidotti C, Wieckowska A, Gill R, Willner I.

Chemistry. 2008;14(26):7774-81. doi: 10.1002/chem.200800765.

PMID:
18698570
42.

Increased hepatic and circulating interleukin-6 levels in human nonalcoholic steatohepatitis.

Wieckowska A, Papouchado BG, Li Z, Lopez R, Zein NN, Feldstein AE.

Am J Gastroenterol. 2008 Jun;103(6):1372-9. doi: 10.1111/j.1572-0241.2007.01774.x. Epub 2008 May 28.

PMID:
18510618
43.

Following protein kinase acivity by electrochemical means and contact angle measurements.

Wieckowska A, Li D, Gill R, Willner I.

Chem Commun (Camb). 2008 May 28;(20):2376-8. doi: 10.1039/b800247a. Epub 2008 Apr 8.

PMID:
18473075
44.

Optical analysis of Hg2+ ions by oligonucleotide-gold-nanoparticle hybrids and DNA-based machines.

Li D, Wieckowska A, Willner I.

Angew Chem Int Ed Engl. 2008;47(21):3927-31. doi: 10.1002/anie.200705991. No abstract available.

PMID:
18404745
45.

The study of the lipophilicity of alpha-(4-phenylpiperazin-1-yl)-gamma-phthalimidobutyramides using chromatographic and computational methods.

Malawska B, Kulig K, Bucki A, Zbek P, Wieckowska A.

Biomed Chromatogr. 2008 Jul;22(7):688-94. doi: 10.1002/bmc.982.

PMID:
18254141
47.

Electrochemical control of surface properties using a quinone-functionalized monolayer: effects of donor-acceptor complexes.

Wieckowska A, Braunschweig AB, Willner I.

Chem Commun (Camb). 2007 Oct 14;(38):3918-20. Epub 2007 Aug 20.

PMID:
17896032
48.

Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: present and future.

Wieckowska A, McCullough AJ, Feldstein AE.

Hepatology. 2007 Aug;46(2):582-9. Review.

PMID:
17661414
49.

Influence of inorganic ions on MTBE degradation by Fenton's reagent.

Siedlecka EM, Wieckowska A, Stepnowski P.

J Hazard Mater. 2007 Aug 17;147(1-2):497-502. Epub 2007 Jan 18.

PMID:
17383092

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