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Items: 20

1.

Pharmacological Inhibition of PARP6 Triggers Multipolar Spindle Formation and Elicits Therapeutic Effects in Breast Cancer.

Wang Z, Grosskurth SE, Cheung T, Petteruti P, Zhang J, Wang X, Wang W, Gharahdaghi F, Wu J, Su N, Howard RT, Mayo M, Widzowski D, Scott DA, Johannes JW, Lamb ML, Lawson D, Dry JR, Lyne PD, Tate EW, Zinda M, Mikule K, Fawell SE, Reimer C, Chen H.

Cancer Res. 2018 Dec 1;78(23):6691-6702. doi: 10.1158/0008-5472.CAN-18-1362. Epub 2018 Oct 8.

PMID:
30297535
2.

Broad analgesic activity of a novel, selective M1 agonist.

Wood MW, Martino G, Coupal M, Lindberg M, Schroeder P, Santhakumar V, Valiquette M, Sandin J, Widzowski D, Laird J.

Neuropharmacology. 2017 Sep 1;123:233-241. doi: 10.1016/j.neuropharm.2017.06.010. Epub 2017 Jun 13.

3.

Quetiapine and its metabolite norquetiapine: translation from in vitro pharmacology to in vivo efficacy in rodent models.

Cross AJ, Widzowski D, Maciag C, Zacco A, Hudzik T, Liu J, Nyberg S, Wood MW.

Br J Pharmacol. 2016 Jan;173(1):155-66. doi: 10.1111/bph.13346. Epub 2015 Dec 1.

4.
5.

Synthesis and SAR of aminothiazole fused benzazepines as selective dopamine D2 partial agonists.

Urbanek RA, Xiong H, Wu Y, Blackwell W, Steelman G, Rosamond J, Wesolowski SS, Campbell JB, Zhang M, Brockel B, Widzowski DV.

Bioorg Med Chem Lett. 2013 Jan 15;23(2):543-7. doi: 10.1016/j.bmcl.2012.11.023. Epub 2012 Nov 28.

PMID:
23237836
6.

Preclinical pharmacology and pharmacokinetics of AZD3783, a selective 5-hydroxytryptamine 1B receptor antagonist.

Zhang M, Zhou D, Wang Y, Maier DL, Widzowski DV, Sobotka-Briner CD, Brockel BJ, Potts WM, Shenvi AB, Bernstein PR, Pierson ME.

J Pharmacol Exp Ther. 2011 Nov;339(2):567-78. doi: 10.1124/jpet.110.174433. Epub 2011 Aug 8.

7.

Absence of direct effects on the dopamine D2 receptor by mGluR2/3-selective receptor agonists LY 354,740 and LY 379,268.

Zysk JR, Widzowski D, Sygowski LA, Knappenberger KS, Spear N, Elmore CS, Dorff P, Liu H, Doherty J, Chhajlani V.

Synapse. 2011 Jan;65(1):64-8. doi: 10.1002/syn.20817.

PMID:
20506301
8.

D2 receptor occupancy in conscious rat brain is not significantly distinguished with [3H]-MNPA, [3H]-(+)-PHNO, and [3H]-raclopride.

Peng T, Zysk J, Dorff P, Elmore CS, Ström P, Malmquist J, Ding M, Tuke D, Werkheiser J, Widzowski D, Mrzljak L, Maier D.

Synapse. 2010 Aug;64(8):624-33. doi: 10.1002/syn.20771.

PMID:
20340171
9.

Selective alpha7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes.

Sydserff S, Sutton EJ, Song D, Quirk MC, Maciag C, Li C, Jonak G, Gurley D, Gordon JC, Christian EP, Doherty JJ, Hudzik T, Johnson E, Mrzljak L, Piser T, Smagin GN, Wang Y, Widzowski D, Smith JS.

Biochem Pharmacol. 2009 Oct 1;78(7):880-8. doi: 10.1016/j.bcp.2009.07.005. Epub 2009 Jul 16.

PMID:
19615981
10.

Low affinity use-dependent NMDA receptor antagonists show promise for clinical development.

Palmer GC, Widzowski D.

Amino Acids. 2000;19(1):151-5. Review.

PMID:
11026483
11.

Long-term functional end points following middle cerebral artery occlusion in the rat.

Hudzik TJ, Borrelli A, Bialobok P, Widzowski D, Sydserff S, Howell A, Gendron P, Corbett D, Miller J, Palmer GC.

Pharmacol Biochem Behav. 2000 Mar;65(3):553-62.

PMID:
10683498
12.

Homogeneity of regional brain lead concentrations.

Widzowski DV, Cory-Slechta DA.

Neurotoxicology. 1994 Summer;15(2):295-307.

PMID:
7991218
13.

Time course of postnatal lead-induced changes in dopamine receptors and their relationship to changes in dopamine sensitivity.

Widzowski DV, Finkelstein JN, Pokora MJ, Cory-Slechta DA.

Neurotoxicology. 1994 Winter;15(4):853-65.

PMID:
7715856
14.

Apparent mediation of the stimulus properties of a low dose of quinpirole by dopaminergic autoreceptors.

Widzowski DV, Cory-Slechta DA.

J Pharmacol Exp Ther. 1993 Aug;266(2):526-34.

PMID:
8355188
15.

Functional alterations in dopamine systems assessed using drug discrimination procedures.

Cory-Slechta DA, Widzowski DV, Pokora MJ.

Neurotoxicology. 1993 Summer-Fall;14(2-3):105-14. Review.

PMID:
8247385
16.

Postnatal lead exposure induces supersensitivity to the stimulus properties of a D2-D3 agonist.

Cory-Slechta DA, Pokora MJ, Widzowski DV.

Brain Res. 1992 Dec 11;598(1-2):162-72.

PMID:
1362517
17.

Lead retards development of Drosophila melanogaster.

Cohn J, Widzowski DV, Cory-Slechta DA.

Comp Biochem Physiol C. 1992 May;102(1):45-9.

PMID:
1358527
18.

Low level lead exposure increases sensitivity to the stimulus properties of dopamine D1 and D2 agonists.

Cory-Slechta DA, Widzowski DV.

Brain Res. 1991 Jul 5;553(1):65-74.

PMID:
1681979
19.
20.

Behavioral differentiation of the stimulus properties of a dopaminergic D1 agonist from a D2 agonist.

Cory-Slechta DA, Widzowski DV, Newland MC.

J Pharmacol Exp Ther. 1989 Sep;250(3):800-8.

PMID:
2789282

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