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Target-mediated disposition population pharmacokinetics model of erythropoietin in premature neonates following multiple intravenous and subcutaneous dosing regimens.

D'Cunha R, Schmidt R, Widness JA, Mock DM, Yan X, Cress GA, Kuruvilla D, Veng-Pedersen P, An G.

Eur J Pharm Sci. 2019 Oct 1;138:105013. doi: 10.1016/j.ejps.2019.105013. Epub 2019 Jul 21.


Anemia induces gut inflammation and injury in an animal model of preterm infants.

Arthur CM, Nalbant D, Feldman HA, Saeedi BJ, Matthews J, Robinson BS, Kamili NA, Bennett A, Cress GA, Sola-Visner M, Jones RM, Zimmerman MB, Neish AS, Patel RM, Nopoulos P, Georgieff MK, Roback JD, Widness JA, Josephson CD, Stowell SR.

Transfusion. 2019 Apr;59(4):1233-1245. doi: 10.1111/trf.15254. Epub 2019 Mar 21.


A Mechanism-Based Population Pharmacokinetics Model of Erythropoietin in Premature Infants and Healthy Adults Following Multiple Intravenous Doses.

D'Cunha R, Widness JA, Yan X, Schmidt RL, Veng-Pedersen P, An G.

J Clin Pharmacol. 2019 Jun;59(6):835-846. doi: 10.1002/jcph.1368. Epub 2019 Jan 7.


Overlooked Issues on Pharmacokinetics Data Interpretation of Protein Drugs-a Case Example of Erythropoietin.

An G, Schmidt RL, Mock DM, Veng-Pedersen P, Widness JA.

AAPS J. 2018 Nov 26;21(1):6. doi: 10.1208/s12248-018-0269-7. No abstract available.


A Brief History of Milk Hygiene and Its Impact on Infant Mortality from 1875 to 1925 and Implications for Today: A Review.

Currier RW, Widness JA.

J Food Prot. 2018 Oct;81(10):1713-1722. doi: 10.4315/0362-028X.JFP-18-186. Review.


Robust increases in erythropoietin production by the hypoxic fetus is a response to protect the brain and other vital organs.

Teramo KA, Klemetti MM, Widness JA.

Pediatr Res. 2018 Dec;84(6):807-812. doi: 10.1038/s41390-018-0054-4. Epub 2018 Jun 12. Review.


Development, validation, and potential applications of biotinylated red blood cells for posttransfusion kinetics and other physiological studies: evidenced-based analysis and recommendations.

Mock DM, Nalbant D, Kyosseva SV, Schmidt RL, An G, Matthews NI, Vlaar APJ, van Bruggen R, de Korte D, Strauss RG, Cancelas JA, Franco RS, Veng-Pedersen P, Widness JA.

Transfusion. 2018 Aug;58(8):2068-2081. doi: 10.1111/trf.14647. Epub 2018 May 16. Review.


In premature infants there is no decrease in 24-hour posttransfusion allogeneic red blood cell recovery after 42 days of storage.

Nalbant D, Cancelas JA, Mock DM, Kyosseva SV, Schmidt RL, Cress GA, Zimmerman MB, Strauss RG, Widness JA.

Transfusion. 2018 Feb;58(2):352-358. doi: 10.1111/trf.14396. Epub 2017 Nov 29.


Antibodies to biotinylated red blood cells in adults and infants: improved detection, partial characterization, and dependence on red blood cell-biotin dose.

Schmidt RL, Mock DM, Franco RS, Cohen RM, North AK, Cancelas JA, Geisen C, Strauss RG, Vlaar AP, Nalbant D, Widness JA.

Transfusion. 2017 Jun;57(6):1488-1496. doi: 10.1111/trf.14075. Epub 2017 Mar 5.


Population Pharmacokinetics of Darbepoetin in Infants Following Single Intravenous and Subcutaneous Dosing.

An G, Ohls RK, Christensen RD, Widness JA, Mock DM, Veng-Pedersen P.

J Pharm Sci. 2017 Jun;106(6):1644-1649. doi: 10.1016/j.xphs.2017.02.001. Epub 2017 Feb 9.


Estimation of adult and neonatal RBC lifespans in anemic neonates using RBCs labeled at several discrete biotin densities.

Kuruvilla DJ, Widness JA, Nalbant D, Schmidt RL, Mock DM, An G, Veng-Pedersen P.

Pediatr Res. 2017 Jun;81(6):905-910. doi: 10.1038/pr.2017.14. Epub 2017 Jan 18.


Research Opportunities to Improve Neonatal Red Blood Cell Transfusion.

Patel RM, Meyer EK, Widness JA.

Transfus Med Rev. 2016 Oct;30(4):165-73. doi: 10.1016/j.tmrv.2016.06.005. Epub 2016 Jul 4. Review.


A Novel Physiology-Based Mathematical Model to Estimate Red Blood Cell Lifespan in Different Human Age Groups.

An G, Widness JA, Mock DM, Veng-Pedersen P.

AAPS J. 2016 Sep;18(5):1182-1191. doi: 10.1208/s12248-016-9923-0. Epub 2016 May 23.


Platelet Transfusion Practices Among Very-Low-Birth-Weight Infants.

Sparger KA, Assmann SF, Granger S, Winston A, Christensen RD, Widness JA, Josephson C, Stowell SR, Saxonhouse M, Sola-Visner M.

JAMA Pediatr. 2016 Jul 1;170(7):687-94. doi: 10.1001/jamapediatrics.2016.0507.


Clearance of stored red blood cells is not increased compared with fresh red blood cells in a human endotoxemia model.

Peters AL, Beuger B, Mock DM, Widness JA, de Korte D, Juffermans NP, Vlaar AP, van Bruggen R.

Transfusion. 2016 Jun;56(6):1362-9. doi: 10.1111/trf.13595. Epub 2016 Apr 4.


Models for the red blood cell lifespan.

Shrestha RP, Horowitz J, Hollot CV, Germain MJ, Widness JA, Mock DM, Veng-Pedersen P, Chait Y.

J Pharmacokinet Pharmacodyn. 2016 Jun;43(3):259-74. doi: 10.1007/s10928-016-9470-4. Epub 2016 Apr 2.


Iron is prioritized to red blood cells over the brain in phlebotomized anemic newborn lambs.

Zamora TG, Guiang SF 3rd, Widness JA, Georgieff MK.

Pediatr Res. 2016 Jun;79(6):922-8. doi: 10.1038/pr.2016.20. Epub 2016 Feb 11.


Predictive factors and practice trends in red blood cell transfusions for very-low-birth-weight infants.

Ekhaguere OA, Morriss FH Jr, Bell EF, Prakash N, Widness JA.

Pediatr Res. 2016 May;79(5):736-41. doi: 10.1038/pr.2016.4. Epub 2016 Jan 12.


A Mass Balance-Based Semiparametric Approach to Evaluate Neonatal Erythropoiesis.

Kuruvilla DJ, Widness JA, Nalbant D, Schmidt RL, Mock DM, Veng-Pedersen P.

AAPS J. 2016 Jan;18(1):187-95. doi: 10.1208/s12248-015-9831-8. Epub 2015 Oct 26.


Autologous Infant and Allogeneic Adult Red Cells Demonstrate Similar Concurrent Post-Transfusion Survival in Very Low Birth Weight Neonates.

Widness JA, Kuruvilla DJ, Mock DM, Matthews NI, Nalbant D, Cress GA, Schmidt RL, Strauss RG, Zimmerman MB, Veng-Pedersen P.

J Pediatr. 2015 Nov;167(5):1001-6. doi: 10.1016/j.jpeds.2015.08.028. Epub 2015 Sep 9.


A Method to Evaluate Fetal Erythropoiesis from Postnatal Survival of Fetal RBCs.

Kuruvilla DJ, Widness JA, Nalbant D, Schmidt RL, Mock DM, Veng-Pedersen P.

AAPS J. 2015 Sep;17(5):1246-54. doi: 10.1208/s12248-015-9784-y. Epub 2015 May 28.


Reticulocyte Hemoglobin Content During the First Month of Life in Critically Ill Very Low Birth Weight Neonates Differs From Term Infants, Children, and Adults.

Al-Ghananim RT, Nalbant D, Schmidt RL, Cress GA, Zimmerman MB, Widness JA.

J Clin Lab Anal. 2016 Jul;30(4):326-34. doi: 10.1002/jcla.21859. Epub 2015 May 13.


Erythropoiesis Stimulating Agents Demonstrate Safety and Show Promise as Neuroprotective Agents in Neonates.

Ohls RK, Christensen RD, Widness JA, Juul SE.

J Pediatr. 2015 Jul;167(1):10-2. doi: 10.1016/j.jpeds.2015.03.054. Epub 2015 Apr 25. No abstract available.


Mathematical model of platelet turnover in thrombocytopenic and nonthrombocytopenic preterm neonates.

Kulshrestha M, Sola-Visner M, Widness JA, Veng-Pedersen P, Mager DE.

Am J Physiol Heart Circ Physiol. 2015 Jan 1;308(1):H68-73. doi: 10.1152/ajpheart.00528.2013. Epub 2014 Oct 31.


High plasma erythropoietin levels are associated with prolonged coma duration and increased mortality in children with cerebral malaria.

Shabani E, Opoka RO, Idro R, Schmidt R, Park GS, Bangirana P, Vercellotti GM, Hodges JS, Widness JA, John CC.

Clin Infect Dis. 2015 Jan 1;60(1):27-35. doi: 10.1093/cid/ciu735. Epub 2014 Sep 16.


One size will never fit all: the future of research in pediatric transfusion medicine.

Josephson CD, Mondoro TH, Ambruso DR, Sanchez R, Sloan SR, Luban NL, Widness JA.

Pediatr Res. 2014 Nov;76(5):425-31. doi: 10.1038/pr.2014.120. Epub 2014 Aug 13. Review.


Measurement of posttransfusion red cell survival with the biotin label.

Mock DM, Widness JA, Veng-Pedersen P, Strauss RG, Cancelas JA, Cohen RM, Lindsell CJ, Franco RS.

Transfus Med Rev. 2014 Jul;28(3):114-25. doi: 10.1016/j.tmrv.2014.03.003. Epub 2014 Apr 5. Review.


Mean remaining life span: a new clinically relevant parameter to assess the quality of transfused red blood cells.

Kuruvilla DJ, Nalbant D, Widness JA, Veng-Pedersen P.

Transfusion. 2014 Oct;54(10 Pt 2):2724-9. doi: 10.1111/trf.12562. Epub 2014 Feb 24.


Pharmacodynamically optimized erythropoietin treatment combined with phlebotomy reduction predicted to eliminate blood transfusions in selected preterm infants.

Rosebraugh MR, Widness JA, Nalbant D, Cress G, Veng-Pedersen P.

Pediatr Res. 2014 Feb;75(2):336-42. doi: 10.1038/pr.2013.213. Epub 2013 Nov 11.


Tracking donor RBC survival in premature infants: agreement of multiple populations of biotin-labeled RBCs with Kidd antigen-mismatched RBCs.

Widness JA, Nalbant D, Matthews NI, Strauss RG, Schmidt RL, Cress GA, Zimmerman MB, Mock DM.

Pediatr Res. 2013 Dec;74(6):689-97. doi: 10.1038/pr.2013.163. Epub 2013 Sep 4.


Comparison of multiple red cell volume methods performed concurrently in premature infants following allogeneic transfusion.

Nalbant D, Bhandary P, Matthews NI, Schmidt RL, Bogusiewicz A, Cress GA, Zimmerman MB, Strauss RG, Mock DM, Widness JA.

Pediatr Res. 2013 Nov;74(5):592-600. doi: 10.1038/pr.2013.143. Epub 2013 Sep 3.


Population pharmacodynamic analysis of erythropoiesis in preterm infants for determining the anemia treatment potential of erythropoietin.

Saleh MI, Nalbant D, Widness JA, Veng-Pedersen P.

Am J Physiol Regul Integr Comp Physiol. 2013 May 1;304(9):R772-81. doi: 10.1152/ajpregu.00173.2012. Epub 2013 Mar 13.


A mathematical modeling approach to quantify the role of phlebotomy losses and need for transfusions in neonatal anemia.

Rosebraugh MR, Widness JA, Nalbant D, Veng-Pedersen P.

Transfusion. 2013 Jun;53(6):1353-60. doi: 10.1111/j.1537-2995.2012.03908.x. Epub 2012 Oct 4.


International survey of transfusion practices for extremely premature infants.

Guillén U, Cummings JJ, Bell EF, Hosono S, Frantz AR, Maier RF, Whyte RK, Boyle E, Vento M, Widness JA, Kirpalani H.

Semin Perinatol. 2012 Aug;36(4):244-7. doi: 10.1053/j.semperi.2012.04.004. Review.


Nonpharmacological, blood conservation techniques for preventing neonatal anemia--effective and promising strategies for reducing transfusion.

Carroll PD, Widness JA.

Semin Perinatol. 2012 Aug;36(4):232-43. doi: 10.1053/j.semperi.2012.04.003. Review.


Posttransfusion red blood cell (RBC) survival determined using biotin-labeled RBCs has distinct advantages over labeling with (51) Cr.

Mock DM, Widness JA, Strauss RG, Franco RS.

Transfusion. 2012 Jul;52(7):1596-8. doi: 10.1111/j.1537-2995.2012.03588.x. No abstract available.


Multidose optimization simulation of erythropoietin treatment in preterm infants.

Rosebraugh MR, Widness JA, Veng-Pedersen P.

Pediatr Res. 2012 Apr;71(4 Pt 1):332-7. doi: 10.1038/pr.2011.75. Epub 2012 Feb 15.


Comparison of red blood cell survival in sheep determined using red blood cells labeled with either biotin at multiple densities or [14C]cyanate: validation of a model to study human physiology and disease.

Mock DM, Matthews NI, Zhu S, Strauss RG, Schmidt RL, Zimmerman MB, Nalbant D, Freise KJ, Saleh M, Veng-Pedersen P, Widness JA.

Transfusion. 2012 May;52(5):963-73. doi: 10.1111/j.1537-2995.2011.03512.x. Epub 2012 Jan 9.


Accelerated removal of antibody-coated red blood cells from the circulation is accurately tracked by a biotin label.

Mock DM, Lankford GL, Matthews NI, Burmeister LF, Kahn D, Widness JA, Strauss RG.

Transfusion. 2012 May;52(5):1097-105. doi: 10.1111/j.1537-2995.2011.03397.x. Epub 2011 Oct 24.


Differential pharmacokinetic analysis of in vivo erythropoietin receptor interaction with erythropoietin and continuous erythropoietin receptor activator in sheep.

El-Komy MH, Schmidt RL, Widness JA, Veng-Pedersen P.

Biopharm Drug Dispos. 2011 Jul;32(5):276-88. doi: 10.1002/bdd.757. Epub 2011 Jun 15.


Receptor-based dosing optimization of erythropoietin in juvenile sheep after phlebotomy.

Rosebraugh M, Widness JA, Veng-Pedersen P.

Drug Metab Dispos. 2011 Jul;39(7):1214-20. doi: 10.1124/dmd.110.036855. Epub 2011 Apr 1.


Pharmacodynamic analysis of stress erythropoiesis: change in erythropoietin receptor pool size following double phlebotomies in sheep.

Saleh MI, Widness JA, Veng-Pedersen P.

Biopharm Drug Dispos. 2011 Apr;32(3):131-9. doi: 10.1002/bdd.743. Epub 2011 Jan 10.


Pharmacokinetic analysis of continuous erythropoietin receptor activator disposition in adult sheep using a target-mediated, physiologic recirculation model and a tracer interaction methodology.

El-Komy MH, Widness JA, Veng-Pedersen P.

Drug Metab Dispos. 2011 Apr;39(4):603-9. doi: 10.1124/dmd.110.036236. Epub 2011 Jan 5. Erratum in: Drug Metab Dispos. 2012 Jul;40(7):1450.


Long-term outcome of brain structure in premature infants: effects of liberal vs restricted red blood cell transfusions.

Nopoulos PC, Conrad AL, Bell EF, Strauss RG, Widness JA, Magnotta VA, Zimmerman MB, Georgieff MK, Lindgren SD, Richman LC.

Arch Pediatr Adolesc Med. 2011 May;165(5):443-50. doi: 10.1001/archpediatrics.2010.269. Epub 2011 Jan 3.


Acute physiological effects of packed red blood cell transfusion in preterm infants with different degrees of anaemia.

Fredrickson LK, Bell EF, Cress GA, Johnson KJ, Zimmerman MB, Mahoney LT, Widness JA, Strauss RG.

Arch Dis Child Fetal Neonatal Ed. 2011 Jul;96(4):F249-53. doi: 10.1136/adc.2010.191023. Epub 2010 Nov 20.


Red blood cell (RBC) survival determined in humans using RBCs labeled at multiple biotin densities.

Mock DM, Matthews NI, Zhu S, Strauss RG, Schmidt RL, Nalbant D, Cress GA, Widness JA.

Transfusion. 2011 May;51(5):1047-57. doi: 10.1111/j.1537-2995.2010.02926.x. Epub 2010 Nov 9.


Red blood cell (RBC) volume can be independently determined in vivo in humans using RBCs labeled at different densities of biotin.

Mock DM, Matthews NI, Zhu S, Burmeister LF, Zimmerman MB, Strauss RG, Schmidt RL, Nalbant D, Cress GA, Widness JA.

Transfusion. 2011 Jan;51(1):148-57. doi: 10.1111/j.1537-2995.2010.02770.x.


Red blood cell (RBC) volume can be independently determined in vivo in the sheep using ovine RBCs labeled at different densities of biotin.

Mock DM, Matthews NI, Zhu S, Burmeister LF, Zimmerman MB, Strauss RG, Schmidt RL, Nalbant D, Freise KJ, Veng-Pedersen P, Widness JA.

Transfusion. 2010 Dec;50(12):2553-64. doi: 10.1111/j.1537-2995.2010.02744.x.


Is there a role for autologous/placental red blood cell transfusions in the anemia of prematurity?

Strauss RG, Widness JA.

Transfus Med Rev. 2010 Apr;24(2):125-9. doi: 10.1016/j.tmrv.2009.11.003. Review.


Evidence of receptor-mediated elimination of erythropoietin by analysis of erythropoietin receptor mRNA expression in bone marrow and erythropoietin clearance during anemia.

Nalbant D, Saleh M, Goldman FD, Widness JA, Veng-Pedersen P.

J Pharmacol Exp Ther. 2010 May;333(2):528-32. doi: 10.1124/jpet.109.163568. Epub 2010 Jan 26.

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