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An immunocompetent rat model of infection with Cryptosporidium hominis and Cryptosporidium parvum.

Dayao DA, Sheoran A, Carvalho A, Xu H, Beamer G, Widmer G, Tzipori S.

Int J Parasitol. 2019 Nov 22. pii: S0020-7519(19)30268-1. doi: 10.1016/j.ijpara.2019.10.002. [Epub ahead of print]


Modelling Macular Edema: The Effect of IL-6 and IL-6R Blockade on Human Blood-Retinal Barrier Integrity In Vitro.

Mesquida M, Drawnel F, Lait PJ, Copland DA, Stimpson ML, Llorenç V, Sainz de la Maza M, Adan A, Widmer G, Strassburger P, Fauser S, Dick AD, Lee RWJ, Molins B.

Transl Vis Sci Technol. 2019 Oct 28;8(5):32. doi: 10.1167/tvst.8.5.32. eCollection 2019 Sep.


Deprivation of dietary fiber enhances susceptibility of mice to cryptosporidiosis.

Oliveira BCM, Bresciani KDS, Widmer G.

PLoS Negl Trop Dis. 2019 Sep 27;13(9):e0007411. doi: 10.1371/journal.pntd.0007411. eCollection 2019 Sep.


Early local activation of complement in aqueous humour of patients with age-related macular degeneration.

Altay L, Sitnilska V, Schick T, Widmer G, Duchateau-Nguyen G, Piraino P, Jayagopal A, Drawnel FM, Fauser S.

Eye (Lond). 2019 Dec;33(12):1859-1864. doi: 10.1038/s41433-019-0501-4. Epub 2019 Jul 2.


The transcriptome of Cryptosporidium oocysts and intracellular stages.

Matos LVS, McEvoy J, Tzipori S, Bresciani KDS, Widmer G.

Sci Rep. 2019 May 27;9(1):7856. doi: 10.1038/s41598-019-44289-x.


Targeting key angiogenic pathways with a bispecific CrossMAb optimized for neovascular eye diseases.

Regula JT, Lundh von Leithner P, Foxton R, Barathi VA, Chui Ming GC, Tun SBB, Wey YS, Iwata D, Dostalek M, Moelleken J, Stubenrauch KG, Nogoceke E, Widmer G, Strassburger P, Koss MJ, Klein C, Shima DT, Hartmann G.

EMBO Mol Med. 2019 May;11(5). pii: e10666. doi: 10.15252/emmm.201910666. No abstract available.


DeepSNP: An End-to-End Deep Neural Network with Attention-Based Localization for Breakpoint Detection in Single-Nucleotide Polymorphism Array Genomic Data.

Eghbal-Zadeh H, Fischer L, Popitsch N, Kromp F, Taschner-Mandl S, Gerber T, Bozsaky E, Ambros PF, Ambros IM, Widmer G, Moser BA.

J Comput Biol. 2019 Jun;26(6):572-596. doi: 10.1089/cmb.2018.0172. Epub 2018 Dec 26.


Genotypic Characterization of Cryptosporidium Species in Humans and Peri-Domestic Animals in Ekiti and Oyo States, Nigeria.

Ayinmode AB, Oliveira BCM, Obebe OO, Dada-Adgebola HO, Ayede AI, Widmer G.

J Parasitol. 2018 Dec;104(6):639-644. doi: 10.1645/17-74. Epub 2018 Sep 12.


Probiotic Product Enhances Susceptibility of Mice to Cryptosporidiosis.

Oliveira BCM, Widmer G.

Appl Environ Microbiol. 2018 Oct 17;84(21). pii: e01408-18. doi: 10.1128/AEM.01408-18. Print 2018 Nov 1.


Cryopreservation of infectious Cryptosporidium parvum oocysts.

Jaskiewicz JJ, Sandlin RD, Swei AA, Widmer G, Toner M, Tzipori S.

Nat Commun. 2018 Jul 23;9(1):2883. doi: 10.1038/s41467-018-05240-2.


Transcriptome analysis of pig intestinal cell monolayers infected with Cryptosporidium parvum asexual stages.

Mirhashemi ME, Noubary F, Chapman-Bonofiglio S, Tzipori S, Huggins GS, Widmer G.

Parasit Vectors. 2018 Mar 12;11(1):176. doi: 10.1186/s13071-018-2754-3.


Glucocorticosteroids and ciclosporin do not significantly impact canine cutaneous microbiota.

Widmer G, Ferrer L, Favrot C, Paps J, Huynh K, Olivry T.

BMC Vet Res. 2018 Feb 23;14(1):51. doi: 10.1186/s12917-018-1370-y.


Diverse single-amino-acid repeat profiles in the genus Cryptosporidium.

Widmer G.

Parasitology. 2018 Aug;145(9):1151-1160. doi: 10.1017/S0031182018000112. Epub 2018 Feb 12.


Maternal high fat diet and its consequence on the gut microbiome: A rat model.

Mann PE, Huynh K, Widmer G.

Gut Microbes. 2018 Mar 4;9(2):143-154. doi: 10.1080/19490976.2017.1395122. Epub 2017 Nov 28.


Cryptosporidium infecting wild cricetid rodents from the subfamilies Arvicolinae and Neotominae.

Stenger BLS, Horčičková M, Clark ME, Kváč M, Čondlová Š, Khan E, Widmer G, Xiao L, Giddings CW, Pennil C, Stanko M, Sak B, McEvoy JM.

Parasitology. 2018 Mar;145(3):326-334. doi: 10.1017/S0031182017001524. Epub 2017 Sep 5.


First description of Cryptosporidium parvum in carrier pigeons (Columba livia).

Oliveira BCM, Ferrari ED, da Cruz Panegossi MF, Nakamura AA, Corbucci FS, Nagata WB, Dos Santos BM, Gomes JF, Meireles MV, Widmer G, Bresciani KDS.

Vet Parasitol. 2017 Aug 30;243:148-150. doi: 10.1016/j.vetpar.2017.06.023. Epub 2017 Jun 27.


Detection and molecular identification of Cryptosporidium species in laboratory rats (Rattus norvegicus) in Ibadan, Nigeria

Ayinmode AB, Ogbonna NF, Widmer G.

Ann Parasitol. 2017;63(2):105-109. doi: 10.17420/ap6302.92.


Targeting key angiogenic pathways with a bispecific CrossMAb optimized for neovascular eye diseases.

Regula JT, Lundh von Leithner P, Foxton R, Barathi VA, Gemmy Cheung CM, Bo Tun SB, Wey YS, Iwata D, Dostalek M, Moelleken J, Stubenrauch KG, Nogoceke E, Widmer G, Strassburger P, Koss MJ, Klein C, Shima DT, Hartmann G.

EMBO Mol Med. 2017 Jul;9(7):985. doi: 10.15252/emmm.201707895. No abstract available.


Cryptosporidium hominis gene catalog: a resource for the selection of novel Cryptosporidium vaccine candidates.

Ifeonu OO, Simon R, Tennant SM, Sheoran AS, Daly MC, Felix V, Kissinger JC, Widmer G, Levine MM, Tzipori S, Silva JC.

Database (Oxford). 2016 Oct 19;2016. pii: baw137. doi: 10.1093/database/baw137. Print 2016.


First description of Cryptosporidium hominis GP60 genotype IkA20G1 and Cryptosporidium parvum GP60 genotypes IIaA18G3R1 and IIaA15G2R1 in foals in Brazil.

Inácio SV, Widmer G, de Brito RL, Zucatto AS, de Aquino MC, Oliveira BC, Nakamura AA, Neto LD, Carvalho JG, Gomes JF, Meireles MV, Bresciani KD.

Vet Parasitol. 2017 Jan 15;233:48-51. doi: 10.1016/j.vetpar.2016.11.021. Epub 2016 Dec 2.


Targeting key angiogenic pathways with a bispecific CrossMAb optimized for neovascular eye diseases.

Regula JT, Lundh von Leithner P, Foxton R, Barathi VA, Cheung CM, Bo Tun SB, Wey YS, Iwata D, Dostalek M, Moelleken J, Stubenrauch KG, Nogoceke E, Widmer G, Strassburger P, Koss MJ, Klein C, Shima DT, Hartmann G.

EMBO Mol Med. 2016 Nov 2;8(11):1265-1288. doi: 10.15252/emmm.201505889. Print 2016 Nov. Erratum in: EMBO Mol Med. 2019 May;11(5):.


Annotated draft genome sequences of three species of Cryptosporidium: Cryptosporidium meleagridis isolate UKMEL1, C. baileyi isolate TAMU-09Q1 and C. hominis isolates TU502_2012 and UKH1.

Ifeonu OO, Chibucos MC, Orvis J, Su Q, Elwin K, Guo F, Zhang H, Xiao L, Sun M, Chalmers RM, Fraser CM, Zhu G, Kissinger JC, Widmer G, Silva JC.

Pathog Dis. 2016 Oct;74(7). pii: ftw080. Epub 2016 Aug 12.


Development of SYN-004, an oral beta-lactamase treatment to protect the gut microbiome from antibiotic-mediated damage and prevent Clostridium difficile infection.

Kaleko M, Bristol JA, Hubert S, Parsley T, Widmer G, Tzipori S, Subramanian P, Hasan N, Koski P, Kokai-Kun J, Sliman J, Jones A, Connelly S.

Anaerobe. 2016 Oct;41:58-67. doi: 10.1016/j.anaerobe.2016.05.015. Epub 2016 Jun 2.


Pneumo-thorax/mediastinum/(retro)peritoneum/ scrotum - a full house of complications following JET ventilation.

Pézier TF, Widmer GM, Huber GF.

Acta Otorhinolaryngol Ital. 2017 Feb;37(1):72-75. doi: 10.14639/0392-100X-726.


Cryptosporidium within-host genetic diversity: systematic bibliographical search and narrative overview.

Grinberg A, Widmer G.

Int J Parasitol. 2016 Jul;46(8):465-71. doi: 10.1016/j.ijpara.2016.03.002. Epub 2016 Mar 25. Review.


Glycoproteins and Gal-GalNAc cause Cryptosporidium to switch from an invasive sporozoite to a replicative trophozoite.

Edwinson A, Widmer G, McEvoy J.

Int J Parasitol. 2016 Jan;46(1):67-74. doi: 10.1016/j.ijpara.2015.09.001. Epub 2015 Sep 30.


Continuous culture of Cryptosporidium parvum using hollow fiber technology.

Morada M, Lee S, Gunther-Cummins L, Weiss LM, Widmer G, Tzipori S, Yarlett N.

Int J Parasitol. 2016 Jan;46(1):21-9. doi: 10.1016/j.ijpara.2015.07.006. Epub 2015 Sep 2.


Impact of Bioreactor Environment and Recovery Method on the Profile of Bacterial Populations from Water Distribution Systems.

Luo X, Jellison KL, Huynh K, Widmer G.

PLoS One. 2015 Jul 21;10(7):e0133427. doi: 10.1371/journal.pone.0133427. eCollection 2015.


First Molecular Characterization of Cryptosporidium spp. Infecting Buffalo Calves in Brazil.

Aquino MC, Widmer G, Zucatto AS, Viol MA, Inácio SV, Nakamura AA, Coelho WM, Perri SH, Meireles MV, Bresciani KD.

J Eukaryot Microbiol. 2015 Sep-Oct;62(5):657-61. doi: 10.1111/jeu.12223. Epub 2015 May 28.


Perturbation of the intestinal microbiota of mice infected with Cryptosporidium parvum.

Ras R, Huynh K, Desoky E, Badawy A, Widmer G.

Int J Parasitol. 2015 Jul;45(8):567-73. doi: 10.1016/j.ijpara.2015.03.005. Epub 2015 Apr 23.


A comparison of sequence and length polymorphism for genotyping Cryptosporidium isolates.

Widmer G, Cacciò SM.

Parasitology. 2015 Jul;142(8):1080-5. doi: 10.1017/S0031182015000396. Epub 2015 Apr 20.


Geographical segregation of Cryptosporidium parvum multilocus genotypes in Europe.

Cacciò SM, de Waele V, Widmer G.

Infect Genet Evol. 2015 Apr;31:245-9. doi: 10.1016/j.meegid.2015.02.008. Epub 2015 Feb 14.


Cryptosporidium muris: infectivity and illness in healthy adult volunteers.

Chappell CL, Okhuysen PC, Langer-Curry RC, Lupo PJ, Widmer G, Tzipori S.

Am J Trop Med Hyg. 2015 Jan;92(1):50-5. doi: 10.4269/ajtmh.14-0525. Epub 2014 Oct 13.


A highly divergent 33 kDa Cryptosporidium parvum antigen.

Jenkins MC, Widmer G, O'Brien C, Bauchan G, Murphy C, Santin M, Fayer R.

J Parasitol. 2014 Aug;100(4):527-31. doi: 10.1645/13-433.1. Epub 2014 Mar 6.


Fatally invasive actinomycosis masquerading as a tonsillar carcinoma.

Pézier TF, Kastrinidis N, Widmer GM, Huber GF, Probst R.

Head Neck. 2014 Dec;36(12):E129-30. doi: 10.1002/hed.23659. Epub 2014 Apr 30.


Population structure of natural and propagated isolates of Cryptosporidium parvum, C. hominis and C. meleagridis.

Widmer G, Ras R, Chalmers RM, Elwin K, Desoky E, Badawy A.

Environ Microbiol. 2015 Apr;17(4):984-93. doi: 10.1111/1462-2920.12447. Epub 2014 Apr 2.


Epithelial cyst in the posterior triangle of the neck: atypical branchial cyst or cystic lymph node metastasis?

Vital D, Huber GF, Pézier TF, Rössle M, Probst R, Widmer GM.

Case Rep Otolaryngol. 2014;2014:912347. doi: 10.1155/2014/912347. Epub 2014 Jan 12.


Frequent occurrence of mixed Enterocytozoon bieneusi infections in humans.

Widmer G, Dilo J, Tumwine JK, Tzipori S, Akiyoshi DE.

Appl Environ Microbiol. 2013 Sep;79(17):5357-62. doi: 10.1128/AEM.01260-13. Epub 2013 Jun 28.


A pig model of the human gastrointestinal tract.

Zhang Q, Widmer G, Tzipori S.

Gut Microbes. 2013 May-Jun;4(3):193-200. doi: 10.4161/gmic.23867. Epub 2013 Apr 2.


Evidence that Cryptosporidium parvum populations are panmictic and unstructured in the Upper Midwest of the United States.

Herges GR, Widmer G, Clark ME, Khan E, Giddings CW, Brewer M, McEvoy JM.

Appl Environ Microbiol. 2012 Nov;78(22):8096-101. doi: 10.1128/AEM.02105-12. Epub 2012 Sep 14.


Survey and genetic characterization of wastewater in Tunisia for Cryptosporidium spp., Giardia duodenalis, Enterocytozoon bieneusi, Cyclospora cayetanensis and Eimeria spp.

Ben Ayed L, Yang W, Widmer G, Cama V, Ortega Y, Xiao L.

J Water Health. 2012 Sep;10(3):431-44. doi: 10.2166/wh.2012.204.


Comparative genome analysis of two Cryptosporidium parvum isolates with different host range.

Widmer G, Lee Y, Hunt P, Martinelli A, Tolkoff M, Bodi K.

Infect Genet Evol. 2012 Aug;12(6):1213-21. doi: 10.1016/j.meegid.2012.03.027. Epub 2012 Apr 12.


Evidence of host-associated populations of Cryptosporidium parvum in Italy.

Drumo R, Widmer G, Morrison LJ, Tait A, Grelloni V, D'Avino N, Pozio E, Cacciò SM.

Appl Environ Microbiol. 2012 May;78(10):3523-9. doi: 10.1128/AEM.07686-11. Epub 2012 Mar 2. Erratum in: Appl Environ Microbiol. 2012 Jul;78(14):5033.


Infection with Cryptosporidium hominis provides incomplete protection of the host against Cryptosporidium parvum.

Sheoran A, Wiffin A, Widmer G, Singh P, Tzipori S.

J Infect Dis. 2012 Mar 15;205(6):1019-23. doi: 10.1093/infdis/jir874. Epub 2012 Jan 25.


Cryptosporidium meleagridis: infectivity in healthy adult volunteers.

Chappell CL, Okhuysen PC, Langer-Curry RC, Akiyoshi DE, Widmer G, Tzipori S.

Am J Trop Med Hyg. 2011 Aug;85(2):238-42. doi: 10.4269/ajtmh.2011.10-0664.


Genomics and population biology of Cryptosporidium species.

Widmer G, Sullivan S.

Parasite Immunol. 2012 Feb-Mar;34(2-3):61-71. doi: 10.1111/j.1365-3024.2011.01301.x. Review.


A comparison of the Giardia lamblia trophozoite and cyst transcriptome using microarrays.

Faghiri Z, Widmer G.

BMC Microbiol. 2011 May 4;11:91. doi: 10.1186/1471-2180-11-91.


Comparison of single- and multilocus genetic diversity in the protozoan parasites Cryptosporidium parvum and C. hominis.

Widmer G, Lee Y.

Appl Environ Microbiol. 2010 Oct;76(19):6639-44. doi: 10.1128/AEM.01268-10. Epub 2010 Aug 13.


High-throughput screening in suboptimal growth conditions identifies agonists of Giardia lamblia proliferation.

Faghiri Z, Santiago RB, Wu Z, Widmer G.

Parasitology. 2011 Feb;138(2):194-200. doi: 10.1017/S0031182010001101. Epub 2010 Aug 10.


Cell sorting-assisted microarray profiling of host cell response to Cryptosporidium parvum infection.

Yang YL, Buck GA, Widmer G.

Infect Immun. 2010 Mar;78(3):1040-8. doi: 10.1128/IAI.01009-09. Epub 2009 Dec 28.

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