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Items: 18

1.

Co-existence of BRAF and NRAS driver mutations in the same melanoma cells results in heterogeneity of targeted therapy resistance.

Raaijmakers MI, Widmer DS, Narechania A, Eichhoff O, Freiberger SN, Wenzina J, Cheng PF, Mihic-Probst D, Desalle R, Dummer R, Levesque MP.

Oncotarget. 2016 Nov 22;7(47):77163-77174. doi: 10.18632/oncotarget.12848.

2.

Romidepsin and Azacitidine Synergize in their Epigenetic Modulatory Effects to Induce Apoptosis in CTCL.

Rozati S, Cheng PF, Widmer DS, Fujii K, Levesque MP, Dummer R.

Clin Cancer Res. 2016 Apr 15;22(8):2020-31. doi: 10.1158/1078-0432.CCR-15-1435. Epub 2015 Dec 9.

3.

Naevus spilus-type congenital melanocytic naevus associated with a novel NRAS codon 61 mutation.

Krengel S, Widmer DS, Kerl K, Levesque MP, Schiestl C, Weibel L.

Br J Dermatol. 2016 Mar;174(3):642-4. doi: 10.1111/bjd.14105. Epub 2015 Nov 21. No abstract available.

PMID:
26302237
4.

Melanoma's next top model, it is in the air.

Widmer DS, Eichhoff OM, Dummer R, Levesque MP.

Exp Dermatol. 2015 Sep;24(9):659-60. doi: 10.1111/exd.12757. Epub 2015 Jun 4. No abstract available.

PMID:
25977109
5.

Methylation-dependent SOX9 expression mediates invasion in human melanoma cells and is a negative prognostic factor in advanced melanoma.

Cheng PF, Shakhova O, Widmer DS, Eichhoff OM, Zingg D, Frommel SC, Belloni B, Raaijmakers MI, Goldinger SM, Santoro R, Hemmi S, Sommer L, Dummer R, Levesque MP.

Genome Biol. 2015 Feb 22;16:42. doi: 10.1186/s13059-015-0594-4.

6.

A new live-cell biobank workflow efficiently recovers heterogeneous melanoma cells from native biopsies.

Raaijmakers MI, Widmer DS, Maudrich M, Koch T, Langer A, Flace A, Schnyder C, Dummer R, Levesque MP.

Exp Dermatol. 2015 May;24(5):377-80. doi: 10.1111/exd.12683.

PMID:
25739758
7.

PI3K signalling is required for a TGFβ-induced epithelial-mesenchymal-like transition (EMT-like) in human melanoma cells.

Schlegel NC, von Planta A, Widmer DS, Dummer R, Christofori G.

Exp Dermatol. 2015 Jan;24(1):22-8. doi: 10.1111/exd.12580. Epub 2014 Nov 18.

PMID:
25363503
8.

Characterization of pigmented dermo-epidermal skin substitutes in a long-term in vivo assay.

Böttcher-Haberzeth S, Biedermann T, Klar AS, Widmer DS, Neuhaus K, Schiestl C, Meuli M, Reichmann E.

Exp Dermatol. 2015 Jan;24(1):16-21. doi: 10.1111/exd.12570.

PMID:
25346346
9.

The influence of stromal cells on the pigmentation of tissue-engineered dermo-epidermal skin grafts.

Biedermann T, Böttcher-Haberzeth S, Klar AS, Widmer DS, Pontiggia L, Weber AD, Weber DM, Schiestl C, Meuli M, Reichmann E.

Tissue Eng Part A. 2015 Mar;21(5-6):960-9. doi: 10.1089/ten.TEA.2014.0327. Epub 2015 Jan 7.

10.

An Aggressive Hypoxia Related Subpopulation of Melanoma Cells is TRP-2 Negative.

Lenggenhager D, Curioni-Fontecedro A, Storz M, Shakhova O, Sommer L, Widmer DS, Seifert B, Moch H, Dummer R, Mihic-Probst D.

Transl Oncol. 2014 Apr;7(2):206-12. doi: 10.1016/j.tranon.2014.02.018. Epub 2014 Apr 17.

11.

Hypoxia contributes to melanoma heterogeneity by triggering HIF1α-dependent phenotype switching.

Widmer DS, Hoek KS, Cheng PF, Eichhoff OM, Biedermann T, Raaijmakers MIG, Hemmi S, Dummer R, Levesque MP.

J Invest Dermatol. 2013 Oct;133(10):2436-2443. doi: 10.1038/jid.2013.115. Epub 2013 Mar 8.

12.

Melanoma immunotherapy: historical precedents, recent successes and future prospects.

Raaijmakers MI, Rozati S, Goldinger SM, Widmer DS, Dummer R, Levesque MP.

Immunotherapy. 2013 Feb;5(2):169-82. doi: 10.2217/imt.12.162. Review.

PMID:
23413908
13.

Human eccrine sweat gland cells turn into melanin-uptaking keratinocytes in dermo-epidermal skin substitutes.

Böttcher-Haberzeth S, Biedermann T, Pontiggia L, Braziulis E, Schiestl C, Hendriks B, Eichhoff OM, Widmer DS, Meuli-Simmen C, Meuli M, Reichmann E.

J Invest Dermatol. 2013 Feb;133(2):316-24. doi: 10.1038/jid.2012.290. Epub 2012 Sep 13.

14.

Systematic classification of melanoma cells by phenotype-specific gene expression mapping.

Widmer DS, Cheng PF, Eichhoff OM, Belloni BC, Zipser MC, Schlegel NC, Javelaud D, Mauviel A, Dummer R, Hoek KS.

Pigment Cell Melanoma Res. 2012 May;25(3):343-53. doi: 10.1111/j.1755-148X.2012.00986.x. Epub 2012 Mar 2.

PMID:
22336146
15.

Engineering melanoma progression in a humanized environment in vivo.

Kiowski G, Biedermann T, Widmer DS, Civenni G, Burger C, Dummer R, Sommer L, Reichmann E.

J Invest Dermatol. 2012 Jan;132(1):144-53. doi: 10.1038/jid.2011.275. Epub 2011 Sep 1.

16.

Differential LEF1 and TCF4 expression is involved in melanoma cell phenotype switching.

Eichhoff OM, Weeraratna A, Zipser MC, Denat L, Widmer DS, Xu M, Kriegl L, Kirchner T, Larue L, Dummer R, Hoek KS.

Pigment Cell Melanoma Res. 2011 Aug;24(4):631-42. doi: 10.1111/j.1755-148X.2011.00871.x. Epub 2011 Jun 9.

PMID:
21599871
17.

A proliferative melanoma cell phenotype is responsive to RAF/MEK inhibition independent of BRAF mutation status.

Zipser MC, Eichhoff OM, Widmer DS, Schlegel NC, Schoenewolf NL, Stuart D, Liu W, Gardner H, Smith PD, Nuciforo P, Dummer R, Hoek KS.

Pigment Cell Melanoma Res. 2011 Apr;24(2):326-33. doi: 10.1111/j.1755-148X.2010.00823.x. Epub 2011 Jan 12.

PMID:
21176117
18.

Novel MITF targets identified using a two-step DNA microarray strategy.

Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E.

Pigment Cell Melanoma Res. 2008 Dec;21(6):665-76. doi: 10.1111/j.1755-148X.2008.00505.x.

PMID:
19067971

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