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Squalene: friend or foe for cancers.

Paolicelli RC, Widmann C.

Curr Opin Lipidol. 2019 Aug;30(4):353-354. doi: 10.1097/MOL.0000000000000619. No abstract available.


The PI3K/Akt pathway is not a main driver in HDL-mediated cell protection.

Zheng A, Dubuis G, Ferreira CSM, Pétremand J, Vanli G, Widmann C.

Cell Signal. 2019 Jun 20;62:109347. doi: 10.1016/j.cellsig.2019.109347. [Epub ahead of print]


Identification of Clotrimazole Derivatives as Specific Inhibitors of Arenavirus Fusion.

Torriani G, Trofimenko E, Mayor J, Fedeli C, Moreno H, Michel S, Heulot M, Chevalier N, Zimmer G, Shrestha N, Plattet P, Engler O, Rothenberger S, Widmann C, Kunz S.

J Virol. 2019 Mar 5;93(6). pii: e01744-18. doi: 10.1128/JVI.01744-18. Print 2019 Mar 15.


The Traditional Chinese Medicine MLC901 inhibits inflammation processes after focal cerebral ischemia.

Widmann C, Gandin C, Petit-Paitel A, Lazdunski M, Heurteaux C.

Sci Rep. 2018 Dec 24;8(1):18062. doi: 10.1038/s41598-018-36138-0.


Burning fat to keep your stem cells? The role of fatty acid oxidation in various tissue stem cells.

Knobloch M, Widmann C.

Curr Opin Lipidol. 2018 Oct;29(5):426-427. doi: 10.1097/MOL.0000000000000546. No abstract available.


Harnessing Oxidative Stress as an Innovative Target for Cancer Therapy.

Postovit L, Widmann C, Huang P, Gibson SB.

Oxid Med Cell Longev. 2018 May 24;2018:6135739. doi: 10.1155/2018/6135739. eCollection 2018. No abstract available.


A flavin-dependent halogenase from metagenomic analysis prefers bromination over chlorination.

Neubauer PR, Widmann C, Wibberg D, Schröder L, Frese M, Kottke T, Kalinowski J, Niemann HH, Sewald N.

PLoS One. 2018 May 10;13(5):e0196797. doi: 10.1371/journal.pone.0196797. eCollection 2018.


Beyond the limits - ECPR in putative fatal circumstances.

Graeff I, Schacher S, Lenkeit S, Widmann CN, Schewe JC.

CJEM. 2018 Oct;20(S2):S70-S73. doi: 10.1017/cem.2018.32. Epub 2018 Mar 25.


The ERICA Score: An MR Imaging-based Visual Scoring System for the Assessment of Entorhinal Cortex Atrophy in Alzheimer Disease.

Enkirch SJ, Traschütz A, Müller A, Widmann CN, Gielen GH, Heneka MT, Jurcoane A, Schild HH, Hattingen E.

Radiology. 2018 Jul;288(1):226-333. doi: 10.1148/radiol.2018171888. Epub 2018 Mar 7.


Characterization and clinical use of inflammatory cerebrospinal fluid protein markers in Alzheimer's disease.

Brosseron F, Traschütz A, Widmann CN, Kummer MP, Tacik P, Santarelli F, Jessen F, Heneka MT.

Alzheimers Res Ther. 2018 Feb 26;10(1):25. doi: 10.1186/s13195-018-0353-3.


Evaluation and validation of commercial antibodies for the detection of Shb.

Vanli G, Cuesta-Marban A, Widmann C.

PLoS One. 2017 Dec 1;12(12):e0188311. doi: 10.1371/journal.pone.0188311. eCollection 2017.


The Anticancer Peptide TAT-RasGAP317-326 Exerts Broad Antimicrobial Activity.

Heulot M, Jacquier N, Aeby S, Le Roy D, Roger T, Trofimenko E, Barras D, Greub G, Widmann C.

Front Microbiol. 2017 Jun 7;8:994. doi: 10.3389/fmicb.2017.00994. eCollection 2017.


Fatty acid metabolism regulates cell survival in specific niches.

Regazzi R, Widmann C.

Curr Opin Lipidol. 2017 Jun;28(3):284-285. doi: 10.1097/MOL.0000000000000418. Review. No abstract available.


TAT-RasGAP317-326 Enhances Radiosensitivity of Human Carcinoma Cell Lines In Vitro and In Vivo through Promotion of Delayed Mitotic Cell Death.

Tsoutsou P, Annibaldi A, Viertl D, Ollivier J, Buchegger F, Vozenin MC, Bourhis J, Widmann C, Matzinger O.

Radiat Res. 2017 May;187(5):562-569. doi: 10.1667/RR14509.1. Epub 2017 Mar 21.


The caspase-3/p120 RasGAP stress-sensing module reduces liver cancer incidence but does not affect overall survival in gamma-irradiated and carcinogen-treated mice.

Vanli G, Sempoux C, Widmann C.

Mol Carcinog. 2017 Jun;56(6):1680-1684. doi: 10.1002/mc.22624. Epub 2017 Feb 16.


Unravelling the dissociation pathways of acetic acid upon electron transfer in potassium collisions: experimental and theoretical studies.

Meneses G, Widmann C, Cunha T, Gil A, Ferreira da Silva F, Calhorda MJ, Limão-Vieira P.

Phys Chem Chem Phys. 2017 Jan 4;19(2):1083-1088. doi: 10.1039/c6cp06375f.


Acetate is the master of its fate, genetics, and molecular biology bimonthly update.

Amati F, Widmann C.

Curr Opin Lipidol. 2016 Dec;27(6):636-637. No abstract available.


Aldehyde dehydrogenase activity plays a Key role in the aggressive phenotype of neuroblastoma.

Flahaut M, Jauquier N, Chevalier N, Nardou K, Balmas Bourloud K, Joseph JM, Barras D, Widmann C, Gross N, Renella R, Mühlethaler-Mottet A.

BMC Cancer. 2016 Oct 10;16(1):781.


Endoplasmic Reticulum Stress Links Oxidative Stress to Impaired Pancreatic Beta-Cell Function Caused by Human Oxidized LDL.

Plaisance V, Brajkovic S, Tenenbaum M, Favre D, Ezanno H, Bonnefond A, Bonner C, Gmyr V, Kerr-Conte J, Gauthier BR, Widmann C, Waeber G, Pattou F, Froguel P, Abderrahmani A.

PLoS One. 2016 Sep 16;11(9):e0163046. doi: 10.1371/journal.pone.0163046. eCollection 2016.


The TAT-RasGAP317-326 anti-cancer peptide can kill in a caspase-, apoptosis-, and necroptosis-independent manner.

Heulot M, Chevalier N, Puyal J, Margue C, Michel S, Kreis S, Kulms D, Barras D, Nahimana A, Widmann C.

Oncotarget. 2016 Sep 27;7(39):64342-64359. doi: 10.18632/oncotarget.11841.


Are HDL receptors really located where we think they are in the liver?

Rütti S, Widmann C.

Curr Opin Lipidol. 2016 Aug;27(4):424-5. doi: 10.1097/MOL.0000000000000322. No abstract available.


MLC901 Favors Angiogenesis and Associated Recovery after Ischemic Stroke in Mice.

Gandin C, Widmann C, Lazdunski M, Heurteaux C.

Cerebrovasc Dis. 2016;42(1-2):139-54. doi: 10.1159/000444810. Epub 2016 Apr 22.


Genetics and molecular biology: HDL plasticity and diversity of functions.

Rütti S, Widmann C.

Curr Opin Lipidol. 2015 Dec;26(6):596-7. doi: 10.1097/MOL.0000000000000242. No abstract available.


The caspase-3-p120-RasGAP module generates a NF-κB repressor in response to cellular stress.

Khalil H, Loukili N, Regamey A, Cuesta-Marban A, Santori E, Huber M, Widmann C.

J Cell Sci. 2015 Sep 15;128(18):3502-13. doi: 10.1242/jcs.174409. Epub 2015 Jul 29.


Combinative effects of β-Lapachone and APO866 on pancreatic cancer cell death through reactive oxygen species production and PARP-1 activation.

Breton CS, Aubry D, Ginet V, Puyal J, Heulot M, Widmann C, Duchosal MA, Nahimana A.

Biochimie. 2015 Sep;116:141-53. doi: 10.1016/j.biochi.2015.07.012. Epub 2015 Jul 15.


RasGAP Shields Akt from Deactivating Phosphatases in Fibroblast Growth Factor Signaling but Loses This Ability Once Cleaved by Caspase-3.

Cailliau K, Lescuyer A, Burnol AF, Cuesta-Marbán Á, Widmann C, Browaeys-Poly E.

J Biol Chem. 2015 Aug 7;290(32):19653-65. doi: 10.1074/jbc.M115.644633. Epub 2015 Jun 24.


Assessment of the chemosensitizing activity of TAT-RasGAP317-326 in childhood cancers.

Chevalier N, Gross N, Widmann C.

PLoS One. 2015 Mar 31;10(3):e0120487. doi: 10.1371/journal.pone.0120487. eCollection 2015.


HDLs, diabetes, and metabolic syndrome.

Vollenweider P, von Eckardstein A, Widmann C.

Handb Exp Pharmacol. 2015;224:405-21. doi: 10.1007/978-3-319-09665-0_12. Review.


The activity of the anti-apoptotic fragment generated by the caspase-3/p120 RasGAP stress-sensing module displays strict Akt isoform specificity.

Vanli G, Peltzer N, Dubuis G, Widmann C.

Cell Signal. 2014 Dec;26(12):2992-7. doi: 10.1016/j.cellsig.2014.09.009. Epub 2014 Sep 22.


Sepsis-associated encephalopathy versus sepsis-induced encephalopathy--authors' reply.

Widmann CN, Schewe JC, Heneka MT.

Lancet Neurol. 2014 Oct;13(10):968-9. doi: 10.1016/S1474-4422(14)70204-2. No abstract available.


Triglyceride and HDL: the entangled pair.

Amati F, Widmann C.

Curr Opin Lipidol. 2014 Oct;25(5):404-5. doi: 10.1097/MOL.0000000000000118. No abstract available.


The δ-opioid receptor affects epidermal homeostasis via ERK-dependent inhibition of transcription factor POU2F3.

Neumann C, Bigliardi-Qi M, Widmann C, Bigliardi PL.

J Invest Dermatol. 2015 Feb;135(2):471-480. doi: 10.1038/jid.2014.370. Epub 2014 Sep 1.


A WXW motif is required for the anticancer activity of the TAT-RasGAP317-326 peptide.

Barras D, Chevalier N, Zoete V, Dempsey R, Lapouge K, Olayioye MA, Michielin O, Widmann C.

J Biol Chem. 2014 Aug 22;289(34):23701-11. doi: 10.1074/jbc.M114.576272. Epub 2014 Jul 9.


High-density lipoprotein, beta cells, and diabetes .

von Eckardstein A, Widmann C.

Cardiovasc Res. 2014 Aug 1;103(3):384-94. doi: 10.1093/cvr/cvu143. Epub 2014 Jun 4. Review.


Long-term cerebral consequences of sepsis.

Widmann CN, Heneka MT.

Lancet Neurol. 2014 Jun;13(6):630-6. doi: 10.1016/S1474-4422(14)70017-1.


Predictors of hippocampal atrophy in critically ill patients.

Lindlau A, Widmann CN, Putensen C, Jessen F, Semmler A, Heneka MT.

Eur J Neurol. 2015 Feb;22(2):410-5. doi: 10.1111/ene.12443. Epub 2014 Apr 12.


TAT-RasGAP317-326-mediated tumor cell death sensitization can occur independently of Bax and Bak.

Annibaldi A, Heulot M, Martinou JC, Widmann C.

Apoptosis. 2014 Apr;19(4):719-33. doi: 10.1007/s10495-013-0958-8.


Fragment N2, a caspase-3-generated RasGAP fragment, inhibits breast cancer metastatic progression.

Barras D, Lorusso G, Lhermitte B, Viertl D, Rüegg C, Widmann C.

Int J Cancer. 2014 Jul 1;135(1):242-7. doi: 10.1002/ijc.28674. Epub 2014 Mar 4.


GAP-independent functions of DLC1 in metastasis.

Barras D, Widmann C.

Cancer Metastasis Rev. 2014 Mar;33(1):87-100. doi: 10.1007/s10555-013-9458-0. Review.


The control of lipid-induced inflammation by macrophages.

Jaccard E, Widmann C.

Curr Opin Lipidol. 2013 Dec;24(6):528-9. doi: 10.1097/MOL.0000000000000030. No abstract available.


Inhibition of cell migration and invasion mediated by the TAT-RasGAP317-326 peptide requires the DLC1 tumor suppressor.

Barras D, Lorusso G, Rüegg C, Widmann C.

Oncogene. 2014 Oct 30;33(44):5163-72. doi: 10.1038/onc.2013.465. Epub 2013 Nov 11.


Caspase-3 and RasGAP: a stress-sensing survival/demise switch.

Khalil H, Bertrand MJ, Vandenabeele P, Widmann C.

Trends Cell Biol. 2014 Feb;24(2):83-9. doi: 10.1016/j.tcb.2013.08.002. Epub 2013 Sep 2.


HDLs protect the MIN6 insulinoma cell line against tunicamycin-induced apoptosis without inhibiting ER stress and without restoring ER functionality.

Puyal J, Pétremand J, Dubuis G, Rummel C, Widmann C.

Mol Cell Endocrinol. 2013 Dec 5;381(1-2):291-301. doi: 10.1016/j.mce.2013.08.016. Epub 2013 Aug 28.


Mapacalcine protects mouse neurons against hypoxia by blocking cell calcium overload.

Moha Ou Maati H, Widmann C, Sedjelmaci D, Gallois B, Heurteaux C, Borsotto M, Hugues M.

PLoS One. 2013 Jul 2;8(7):e66194. doi: 10.1371/journal.pone.0066194. Print 2013. Erratum in: PLoS One. 2013;8(9). doi:10.1371/annotation/d84d3131-a400-4ca6-9c5c-9ab0be4a6dd5. Gallois, Djamila Sedjelmaci Bernard [corrected to Sedjelmaci, Djamila]; Gallois, Djamila Sedjelmaci Bernard [corrected to Gallois, Bernard].


Role of mTOR, Bad, and Survivin in RasGAP Fragment N-Mediated Cell Protection.

Peltzer N, Vanli G, Yang JY, Widmann C.

PLoS One. 2013 Jun 27;8(6):e68123. doi: 10.1371/journal.pone.0068123. Print 2013.


NeuroAiD: properties for neuroprotection and neurorepair.

Heurteaux C, Widmann C, Moha ou Maati H, Quintard H, Gandin C, Borsotto M, Veyssiere J, Onteniente B, Lazdunski M.

Cerebrovasc Dis. 2013;35 Suppl 1:1-7. doi: 10.1159/000346228. Epub 2013 Mar 14. Review.


Clinical symptoms and risk factors in cerebral microangiopathy patients.

Okroglic S, Widmann CN, Urbach H, Scheltens P, Heneka MT.

PLoS One. 2013;8(2):e53455. doi: 10.1371/journal.pone.0053455. Epub 2013 Feb 5.


Genetics and molecular biology: HDL-endoplasmic reticulum connection and cholesterol sensor.

Widmann C.

Curr Opin Lipidol. 2013 Feb;24(1):103-4. doi: 10.1097/MOL.0b013e32835c7b49. No abstract available.


Persistent cognitive impairment, hippocampal atrophy and EEG changes in sepsis survivors.

Semmler A, Widmann CN, Okulla T, Urbach H, Kaiser M, Widman G, Mormann F, Weide J, Fliessbach K, Hoeft A, Jessen F, Putensen C, Heneka MT.

J Neurol Neurosurg Psychiatry. 2013 Jan;84(1):62-9. doi: 10.1136/jnnp-2012-302883. Epub 2012 Nov 7.


Caspase-3 protects stressed organs against cell death.

Khalil H, Peltzer N, Walicki J, Yang JY, Dubuis G, Gardiol N, Held W, Bigliardi P, Marsland B, Liaudet L, Widmann C.

Mol Cell Biol. 2012 Nov;32(22):4523-33. doi: 10.1128/MCB.00774-12. Epub 2012 Sep 4.

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