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Secretome of adipose-derived mesenchymal stem cells promotes skeletal muscle regeneration through synergistic action of extracellular vesicle cargo and soluble proteins.

Mitchell R, Mellows B, Sheard J, Antonioli M, Kretz O, Chambers D, Zeuner MT, Tomkins JE, Denecke B, Musante L, Joch B, Debacq-Chainiaux F, Holthofer H, Ray S, Huber TB, Dengjel J, De Coppi P, Widera D, Patel K.

Stem Cell Res Ther. 2019 Apr 5;10(1):116. doi: 10.1186/s13287-019-1213-1.


Toll-like receptor 4 and protease-activated receptor 2 in physiology and pathophysiology of the nervous system: more than just receptor cooperation?

Widera D, Martínez Aguilar R, Cottrell GS.

Neural Regen Res. 2019 Jul;14(7):1196-1201. doi: 10.4103/1673-5374.251290.


Stem Cells from Human Extracted Deciduous Teeth Expanded in Foetal Bovine and Human Sera Express Different Paracrine Factors After Exposure to Freshly Prepared Human Serum.

Haque N, Widera D, Abu Kasim NH.

Adv Exp Med Biol. 2019 Feb 16. doi: 10.1007/5584_2018_299. [Epub ahead of print]


Editorial: Tissue Repair and Regenerative Mechanisms by Stem/Progenitor Cells and Their Secretome.

Gramignoli R, Sallustio F, Widera D, Raschzok N.

Front Med (Lausanne). 2019 Jan 31;6:11. doi: 10.3389/fmed.2019.00011. eCollection 2019. No abstract available.


Inhibition of NF-κB Signaling Reduces the Stemness Characteristics of Lung Cancer Stem Cells.

Zakaria N, Mohd Yusoff N, Zakaria Z, Widera D, Yahaya BH.

Front Oncol. 2018 May 17;8:166. doi: 10.3389/fonc.2018.00166. eCollection 2018.


Isolation and Characterization of Neural Crest-Derived Stem Cells From Adult Ovine Palatal Tissue.

Zeuner MT, Didenko NN, Humphries D, Stergiadis S, Morash TM, Patel K, Grimm WD, Widera D.

Front Cell Dev Biol. 2018 Apr 11;6:39. doi: 10.3389/fcell.2018.00039. eCollection 2018.


Toll-Like Receptor 4 Signalling and Its Impact on Platelet Function, Thrombosis, and Haemostasis.

Vallance TM, Zeuner MT, Williams HF, Widera D, Vaiyapuri S.

Mediators Inflamm. 2017;2017:9605894. doi: 10.1155/2017/9605894. Epub 2017 Oct 17. Review.


Quantitative single-molecule imaging of TLR4 reveals ligand-specific receptor dimerization.

Krüger CL, Zeuner MT, Cottrell GS, Widera D, Heilemann M.

Sci Signal. 2017 Oct 31;10(503). pii: eaan1308. doi: 10.1126/scisignal.aan1308.


Development and Characterisation of a Novel NF-κB Reporter Cell Line for Investigation of Neuroinflammation.

Zeuner MT, Vallance T, Vaiyapuri S, Cottrell GS, Widera D.

Mediators Inflamm. 2017;2017:6209865. doi: 10.1155/2017/6209865. Epub 2017 Jul 16.


Protein and Molecular Characterization of a Clinically Compliant Amniotic Fluid Stem Cell-Derived Extracellular Vesicle Fraction Capable of Accelerating Muscle Regeneration Through Enhancement of Angiogenesis.

Mellows B, Mitchell R, Antonioli M, Kretz O, Chambers D, Zeuner MT, Denecke B, Musante L, Ramachandra DL, Debacq-Chainiaux F, Holthofer H, Joch B, Ray S, Widera D, David AL, Huber TB, Dengjel J, De Coppi P, Patel K.

Stem Cells Dev. 2017 Sep 15;26(18):1316-1333. doi: 10.1089/scd.2017.0089. Epub 2017 Aug 22.


The use of mesenchymal stromal cells in treatment of lung disorders.

Kardia E, Zakaria N, Sarmiza Abdul Halim NS, Widera D, Yahaya BH.

Regen Med. 2017 Mar;12(2):203-216. doi: 10.2217/rme-2016-0112. Epub 2017 Feb 17. Review.


Biased signalling is an essential feature of TLR4 in glioma cells.

Zeuner MT, Krüger CL, Volk K, Bieback K, Cottrell GS, Heilemann M, Widera D.

Biochim Biophys Acta. 2016 Dec;1863(12):3084-3095. doi: 10.1016/j.bbamcr.2016.09.016. Epub 2016 Sep 23.


Single-particle tracking uncovers dynamics of glutamate-induced retrograde transport of NF-κB p65 in living neurons.

Widera D, Klenke C, Nair D, Heidbreder M, Malkusch S, Sibarita JB, Choquet D, Kaltschmidt B, Heilemann M, Kaltschmidt C.

Neurophotonics. 2016 Oct;3(4):041804. doi: 10.1117/1.NPh.3.4.041804. Epub 2016 May 18.


1,8-Cineole potentiates IRF3-mediated antiviral response in human stem cells and in an ex vivo model of rhinosinusitis.

Müller J, Greiner JF, Zeuner M, Brotzmann V, Schäfermann J, Wieters F, Widera D, Sudhoff H, Kaltschmidt B, Kaltschmidt C.

Clin Sci (Lond). 2016 Aug 1;130(15):1339-52. doi: 10.1042/CS20160218. Epub 2016 Apr 25.


Paracrine effects of TLR4-polarised mesenchymal stromal cells are mediated by extracellular vesicles.

Zeuner MT, Patel K, Denecke B, Giebel B, Widera D.

J Transl Med. 2016 Feb 2;14:34. doi: 10.1186/s12967-016-0794-z.


Helium Ion Microscopy Visualizes Lipid Nanodomains in Mammalian Cells.

Schürmann M, Frese N, Beyer A, Heimann P, Widera D, Mönkemöller V, Huser T, Kaltschmidt B, Kaltschmidt C, Gölzhäuser A.

Small. 2015 Nov 18;11(43):5781-9. doi: 10.1002/smll.201501540. Epub 2015 Oct 5.


Controversial Role of Toll-like Receptor 4 in Adult Stem Cells.

Zeuner M, Bieback K, Widera D.

Stem Cell Rev. 2015 Aug;11(4):621-34. doi: 10.1007/s12015-015-9589-5. Review.


Intrastriatal transplantation of adult human neural crest-derived stem cells improves functional outcome in parkinsonian rats.

Müller J, Ossig C, Greiner JF, Hauser S, Fauser M, Widera D, Kaltschmidt C, Storch A, Kaltschmidt B.

Stem Cells Transl Med. 2015 Jan;4(1):31-43. doi: 10.5966/sctm.2014-0078. Epub 2014 Dec 5.


Alternative generation of CNS neural stem cells and PNS derivatives from neural crest-derived peripheral stem cells.

Weber M, Apostolova G, Widera D, Mittelbronn M, Dechant G, Kaltschmidt B, Rohrer H.

Stem Cells. 2015 Feb;33(2):574-88. doi: 10.1002/stem.1880.


Interaction of adult human neural crest-derived stem cells with a nanoporous titanium surface is sufficient to induce their osteogenic differentiation.

Schürmann M, Wolff A, Widera D, Hauser S, Heimann P, Hütten A, Kaltschmidt C, Kaltschmidt B.

Stem Cell Res. 2014 Jul;13(1):98-110. doi: 10.1016/j.scr.2014.04.017. Epub 2014 May 9.


Culture bag systems for clinical applications of adult human neural crest-derived stem cells.

Greiner JF, Grunwald LM, Müller J, Sudhoff H, Widera D, Kaltschmidt C, Kaltschmidt B.

Stem Cell Res Ther. 2014 Mar 14;5(2):34. doi: 10.1186/scrt422.


Methods for the modulation and analysis of NF-κB-dependent adult neurogenesis.

Widera D, Müller J, Imielski Y, Heimann P, Kaltschmidt C, Kaltschmidt B.

J Vis Exp. 2014 Feb 13;(84):e50870. doi: 10.3791/50870.


Quantitative single-molecule localization microscopy combined with rule-based modeling reveals ligand-induced TNF-R1 reorganization toward higher-order oligomers.

Fricke F, Malkusch S, Wangorsch G, Greiner JF, Kaltschmidt B, Kaltschmidt C, Widera D, Dandekar T, Heilemann M.

Histochem Cell Biol. 2014 Jul;142(1):91-101. doi: 10.1007/s00418-014-1195-0. Epub 2014 Feb 12.


An investigation of the specificity of research antibodies against NF-κB-subunit p65.

Slotta C, Müller J, Tran L, Hauser S, Widera D, Kaltschmidt B, Kaltschmidt C.

J Histochem Cytochem. 2014 Feb;62(2):157-61. doi: 10.1369/0022155413515484. Epub 2013 Nov 19. No abstract available.


Prolonged cultivation of hippocampal neural precursor cells shifts their differentiation potential and selects for aneuploid cells.

Nguyen TD, Widera D, Greiner J, Müller J, Martin I, Slotta C, Hauser S, Kaltschmidt C, Kaltschmidt B.

Biol Chem. 2013 Dec;394(12):1623-36. doi: 10.1515/hsz-2013-0191.


1,8-Cineol inhibits nuclear translocation of NF-κB p65 and NF-κB-dependent transcriptional activity.

Greiner JF, Müller J, Zeuner MT, Hauser S, Seidel T, Klenke C, Grunwald LM, Schomann T, Widera D, Sudhoff H, Kaltschmidt B, Kaltschmidt C.

Biochim Biophys Acta. 2013 Dec;1833(12):2866-2878. doi: 10.1016/j.bbamcr.2013.07.001. Epub 2013 Jul 18.


Hsc70 is a novel interactor of NF-kappaB p65 in living hippocampal neurons.

Klenke C, Widera D, Engelen T, Müller J, Noll T, Niehaus K, Schmitz ML, Kaltschmidt B, Kaltschmidt C.

PLoS One. 2013 Jun 7;8(6):e65280. doi: 10.1371/journal.pone.0065280. Print 2013.


Simple method for sub-diffraction resolution imaging of cellular structures on standard confocal microscopes by three-photon absorption of quantum dots.

Sporbert A, Cseresnyes Z, Heidbreder M, Domaing P, Hauser S, Kaltschmidt B, Kaltschmidt C, Heilemann M, Widera D.

PLoS One. 2013 May 21;8(5):e64023. doi: 10.1371/journal.pone.0064023. Print 2013.


Improved method for ex ovo-cultivation of developing chicken embryos for human stem cell xenografts.

Schomann T, Qunneis F, Widera D, Kaltschmidt C, Kaltschmidt B.

Stem Cells Int. 2013;2013:960958. doi: 10.1155/2013/960958. Epub 2013 Mar 11.


Identification of novel cholesteatoma-related gene expression signatures using full-genome microarrays.

Klenke C, Janowski S, Borck D, Widera D, Ebmeyer J, Kalinowski J, Leichtle A, Hofestädt R, Upile T, Kaltschmidt C, Kaltschmidt B, Sudhoff H.

PLoS One. 2012;7(12):e52718. doi: 10.1371/journal.pone.0052718. Epub 2012 Dec 20.


An intronic G run within HIV-1 intron 2 is critical for splicing regulation of vif mRNA.

Widera M, Erkelenz S, Hillebrand F, Krikoni A, Widera D, Kaisers W, Deenen R, Gombert M, Dellen R, Pfeiffer T, Kaltschmidt B, Münk C, Bosch V, Köhrer K, Schaal H.

J Virol. 2013 Mar;87(5):2707-20. doi: 10.1128/JVI.02755-12. Epub 2012 Dec 19.


Origin and regenerative potential of vertebrate mechanoreceptor-associated stem cells.

Widera D, Hauser S, Kaltschmidt C, Kaltschmidt B.

Anat Res Int. 2012;2012:837626. doi: 10.1155/2012/837626. Epub 2012 Oct 2.


Label-free enrichment of avian Leucocytozoon using flow cytometric sorting.

Chakarov N, Greiner JF, Hauser S, Schuetzmann D, Krüger O, Boerner M, Wıdera D.

Parasitology. 2012 Oct;139(12):1547-52. doi: 10.1017/S0031182012000972. Epub 2012 Jul 19.


TNF-α influences the lateral dynamics of TNF receptor I in living cells.

Heidbreder M, Zander C, Malkusch S, Widera D, Kaltschmidt B, Kaltschmidt C, Nair D, Choquet D, Sibarita JB, Heilemann M.

Biochim Biophys Acta. 2012 Oct;1823(10):1984-9. doi: 10.1016/j.bbamcr.2012.06.026. Epub 2012 Jun 27.


Generation of Schwann cell-derived multipotent neurospheres isolated from intact sciatic nerve.

Martin I, Nguyen TD, Krell V, Greiner JF, Müller J, Hauser S, Heimann P, Widera D.

Stem Cell Rev. 2012 Dec;8(4):1178-87. doi: 10.1007/s12015-012-9387-2.


Efficient animal-serum free 3D cultivation method for adult human neural crest-derived stem cell therapeutics.

Greiner JF, Hauser S, Widera D, Müller J, Qunneis F, Zander C, Martin I, Mallah J, Schuetzmann D, Prante C, Schwarze H, Prohaska W, Beyer A, Rott K, Hütten A, Gölzhäuser A, Sudhoff H, Kaltschmidt C, Kaltschmidt B.

Eur Cell Mater. 2011 Dec 17;22:403-19.


Adult craniofacial stem cells: sources and relation to the neural crest.

Kaltschmidt B, Kaltschmidt C, Widera D.

Stem Cell Rev. 2012 Sep;8(3):658-71. doi: 10.1007/s12015-011-9340-9. Review.


Isolation of novel multipotent neural crest-derived stem cells from adult human inferior turbinate.

Hauser S, Widera D, Qunneis F, Müller J, Zander C, Greiner J, Strauss C, Lüningschrör P, Heimann P, Schwarze H, Ebmeyer J, Sudhoff H, Araúzo-Bravo MJ, Greber B, Zaehres H, Schöler H, Kaltschmidt C, Kaltschmidt B.

Stem Cells Dev. 2012 Mar 20;21(5):742-56. doi: 10.1089/scd.2011.0419. Epub 2012 Jan 26.


Schwann cells can be reprogrammed to multipotency by culture.

Widera D, Heimann P, Zander C, Imielski Y, Heidbreder M, Heilemann M, Kaltschmidt C, Kaltschmidt B.

Stem Cells Dev. 2011 Dec;20(12):2053-64. doi: 10.1089/scd.2010.0525. Epub 2011 Jun 1.


Subdiffraction fluorescence imaging of biomolecular structure and distributions with quantum dots.

Heidbreder M, Endesfelder U, van de Linde S, Hennig S, Widera D, Kaltschmidt B, Kaltschmidt C, Heilemann M.

Biochim Biophys Acta. 2010 Oct;1803(10):1224-9. doi: 10.1016/j.bbamcr.2010.06.004. Epub 2010 Jun 23.


Morphological characterization of periodontium-derived human stem cells.

Arnold WH, Becher S, Dannan A, Widera D, Dittmar T, Jacob M, Mannherz HG, Dittmar T, Kaltschmidt B, Kaltschmidt C, Grimm WD.

Ann Anat. 2010 Aug 20;192(4):215-9. doi: 10.1016/j.aanat.2010.05.004. Epub 2010 Jun 11.


Neural stem cells adopt tumorigenic properties by constitutively activated NF-kappaB and subsequent VEGF up-regulation.

Kaus A, Widera D, Kassmer S, Peter J, Zaenker K, Kaltschmidt C, Kaltschmidt B.

Stem Cells Dev. 2010 Jul;19(7):999-1015. doi: 10.1089/scd.2009.0416.


Adult palatum as a novel source of neural crest-related stem cells.

Widera D, Zander C, Heidbreder M, Kasperek Y, Noll T, Seitz O, Saldamli B, Sudhoff H, Sader R, Kaltschmidt C, Kaltschmidt B.

Stem Cells. 2009 Aug;27(8):1899-910. doi: 10.1002/stem.104.


Neural stem cells, inflammation and NF-kappaB: basic principle of maintenance and repair or origin of brain tumours?

Widera D, Kaus A, Kaltschmidt C, Kaltschmidt B.

J Cell Mol Med. 2008 Apr;12(2):459-70. doi: 10.1111/j.1582-4934.2007.00208.x. Epub 2007 Dec 20. Review.


Impact of polysialylated CD56 on natural killer cell cytotoxicity.

Moebius JM, Widera D, Schmitz J, Kaltschmidt C, Piechaczek C.

BMC Immunol. 2007 Aug 6;8:13.


Transcription factor NF-kappaB is transported to the nucleus via cytoplasmic dynein/dynactin motor complex in hippocampal neurons.

Mikenberg I, Widera D, Kaus A, Kaltschmidt B, Kaltschmidt C.

PLoS One. 2007 Jul 11;2(7):e589.


Highly efficient neural differentiation of human somatic stem cells, isolated by minimally invasive periodontal surgery.

Widera D, Grimm WD, Moebius JM, Mikenberg I, Piechaczek C, Gassmann G, Wolff NA, Thévenod F, Kaltschmidt C, Kaltschmidt B.

Stem Cells Dev. 2007 Jun;16(3):447-60.


Mathematical model for NF-kappaB-driven proliferation of adult neural stem cells.

Piotrowska MJ, Widera D, Kaltschmidt B, an der Heiden U, Kaltschmidt C.

Cell Prolif. 2006 Dec;39(6):441-55.


Tumor necrosis factor alpha triggers proliferation of adult neural stem cells via IKK/NF-kappaB signaling.

Widera D, Mikenberg I, Elvers M, Kaltschmidt C, Kaltschmidt B.

BMC Neurosci. 2006 Sep 20;7:64.


Long-term depression activates transcription of immediate early transcription factor genes: involvement of serum response factor/Elk-1.

Lindecke A, Korte M, Zagrebelsky M, Horejschi V, Elvers M, Widera D, Prüllage M, Pfeiffer J, Kaltschmidt B, Kaltschmidt C.

Eur J Neurosci. 2006 Jul;24(2):555-63.


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