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Items: 1 to 50 of 107

1.

Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics.

Brinson RG, Marino JP, Delaglio F, Arbogast LW, Evans RM, Kearsley A, Gingras G, Ghasriani H, Aubin Y, Pierens GK, Jia X, Mobli M, Grant HG, Keizer DW, Schweimer K, Ståhle J, Widmalm G, Zartler ER, Lawrence CW, Reardon PN, Cort JR, Xu P, Ni F, Yanaka S, Kato K, Parnham SR, Tsao D, Blomgren A, Rundlöf T, Trieloff N, Schmieder P, Ross A, Skidmore K, Chen K, Keire D, Freedberg DI, Suter-Stahel T, Wider G, Ilc G, Plavec J, Bradley SA, Baldisseri DM, Sforça ML, Zeri ACM, Wei JY, Szabo CM, Amezcua CA, Jordan JB, Wikström M.

MAbs. 2019 Jan;11(1):94-105. doi: 10.1080/19420862.2018.1544454. Epub 2018 Dec 22.

2.

Activity of Tumor Necrosis Factor α Is Modulated by Dynamic Conformational Rearrangements.

Hofmann D, Salmon L, Wider G.

J Am Chem Soc. 2018 Jan 10;140(1):167-175. doi: 10.1021/jacs.7b05050. Epub 2017 Dec 20.

PMID:
29192773
3.

Computer vision-based automated peak picking applied to protein NMR spectra.

Klukowski P, Walczak MJ, Gonczarek A, Boudet J, Wider G.

Bioinformatics. 2015 Sep 15;31(18):2981-8. doi: 10.1093/bioinformatics/btv318. Epub 2015 May 20.

PMID:
25995228
4.

Posttranslational modifications of intact proteins detected by NMR spectroscopy: application to glycosylation.

Schubert M, Walczak MJ, Aebi M, Wider G.

Angew Chem Int Ed Engl. 2015 Jun 8;54(24):7096-100. doi: 10.1002/anie.201502093. Epub 2015 Apr 29.

PMID:
25924827
5.

Interactions of the acyl chain with the Saccharomyces cerevisiae acyl carrier protein.

Perez DR, Leibundgut M, Wider G.

Biochemistry. 2015 Apr 7;54(13):2205-13. doi: 10.1021/bi5014563. Epub 2015 Mar 25.

PMID:
25774789
6.

Copsin, a novel peptide-based fungal antibiotic interfering with the peptidoglycan synthesis.

Essig A, Hofmann D, Münch D, Gayathri S, Künzler M, Kallio PT, Sahl HG, Wider G, Schneider T, Aebi M.

J Biol Chem. 2014 Dec 12;289(50):34953-64. doi: 10.1074/jbc.M114.599878. Epub 2014 Oct 23.

7.

Strategy for automated NMR resonance assignment of RNA: application to 48-nucleotide K10.

Krähenbühl B, Lukavsky P, Wider G.

J Biomol NMR. 2014 Aug;59(4):231-40. doi: 10.1007/s10858-014-9841-3. Epub 2014 Jun 5.

PMID:
24899400
8.

Automated NMR resonance assignment strategy for RNA via the phosphodiester backbone based on high-dimensional through-bond APSY experiments.

Krähenbühl B, El Bakkali I, Schmidt E, Güntert P, Wider G.

J Biomol NMR. 2014 Jun;59(2):87-93. doi: 10.1007/s10858-014-9829-z. Epub 2014 Apr 27.

PMID:
24771326
9.

The RING domain of the scaffold protein Ste5 adopts a molten globular character with high thermal and chemical stability.

Walczak MJ, Samatanga B, van Drogen F, Peter M, Jelesarov I, Wider G.

Angew Chem Int Ed Engl. 2014 Jan 27;53(5):1320-3. doi: 10.1002/anie.201306702. Epub 2013 Dec 16.

PMID:
24356903
10.

Intramolecular donor strand complementation in the E. coli type 1 pilus subunit FimA explains the existence of FimA monomers as off-pathway products of pilus assembly that inhibit host cell apoptosis.

Walczak MJ, Puorger C, Glockshuber R, Wider G.

J Mol Biol. 2014 Feb 6;426(3):542-9. doi: 10.1016/j.jmb.2013.10.029. Epub 2013 Oct 30.

PMID:
24184277
11.

4D experiments measured with APSY for automated backbone resonance assignments of large proteins.

Krähenbühl B, Boudet J, Wider G.

J Biomol NMR. 2013 Jun;56(2):149-54. doi: 10.1007/s10858-013-9731-0. Epub 2013 Apr 30.

PMID:
23625454
12.

Automated projection spectroscopy (APSY) for the assignment of NMR resonances of biological macromolecules.

Krähenbühl B, Wider G.

Chimia (Aarau). 2012;66(10):770-4. doi: 10.2533/chimia.2012.770.

PMID:
23146263
13.

Sugar-to-base correlation in nucleic acids with a 5D APSY-HCNCH or two 3D APSY-HCN experiments.

Krähenbühl B, Hofmann D, Maris C, Wider G.

J Biomol NMR. 2012 Feb;52(2):141-50. doi: 10.1007/s10858-011-9588-z. Epub 2011 Dec 4.

PMID:
22143941
14.

4D APSY-HBCB(CG)CDHD experiment for automated assignment of aromatic amino acid side chains in proteins.

Krähenbühl B, Hiller S, Wider G.

J Biomol NMR. 2011 Nov;51(3):313-8. doi: 10.1007/s10858-011-9572-7. Epub 2011 Sep 27.

PMID:
21947871
15.

Structure, folding and stability of FimA, the main structural subunit of type 1 pili from uropathogenic Escherichia coli strains.

Puorger C, Vetsch M, Wider G, Glockshuber R.

J Mol Biol. 2011 Sep 23;412(3):520-35. doi: 10.1016/j.jmb.2011.07.044. Epub 2011 Jul 27.

PMID:
21816158
16.

Automated projection spectroscopy and its applications.

Hiller S, Wider G.

Top Curr Chem. 2012;316:21-47. doi: 10.1007/128_2011_189. Review.

PMID:
21710379
17.

Structural analysis of the conserved ubiquitin-binding motifs (UBMs) of the translesion polymerase iota in complex with ubiquitin.

Burschowsky D, Rudolf F, Rabut G, Herrmann T, Peter M, Wider G.

J Biol Chem. 2011 Jan 14;286(2):1364-73. doi: 10.1074/jbc.M110.135038. Epub 2010 Oct 6. Erratum in: J Biol Chem. 2011 May 13;286(19):17398. Matthias, Peter [corrected to Peter, Matthias].

18.

1H, 15N, 13C resonance assignment of the acyl carrier protein subunit of the Saccharomyces cerevisiae fatty acid synthase.

Perez DR, Wider G.

Biomol NMR Assign. 2009 Jun;3(1):133-6. doi: 10.1007/s12104-009-9158-4. Epub 2009 Apr 7.

PMID:
19636964
19.

APSY-NMR with proteins: practical aspects and backbone assignment.

Hiller S, Wider G, Wüthrich K.

J Biomol NMR. 2008 Nov;42(3):179-95. doi: 10.1007/s10858-008-9266-y. Epub 2008 Oct 8.

PMID:
18841481
20.

Automated NMR assignment of protein side chain resonances using automated projection spectroscopy (APSY).

Hiller S, Joss R, Wider G.

J Am Chem Soc. 2008 Sep 10;130(36):12073-9. doi: 10.1021/ja803161d. Epub 2008 Aug 19.

PMID:
18710239
21.

Projected [(1)H, (15)N]-HMQC-[ (1)H, (1)H]-NOESY for large molecular systems: application to a 121 kDa protein-DNA complex.

Galius V, Leontiou C, Richmond T, Wider G.

J Biomol NMR. 2008 Mar;40(3):175-81. doi: 10.1007/s10858-008-9219-5. Epub 2008 Jan 30.

PMID:
18231863
22.

Interactions with hydrophobic clusters in the urea-unfolded membrane protein OmpX.

Hiller S, Wider G, Imbach LL, Wüthrich K.

Angew Chem Int Ed Engl. 2008;47(5):977-81. No abstract available.

PMID:
18161715
23.

Structure-function analysis of the endoplasmic reticulum oxidoreductase TMX3 reveals interdomain stabilization of the N-terminal redox-active domain.

Haugstetter J, Maurer MA, Blicher T, Pagac M, Wider G, Ellgaard L.

J Biol Chem. 2007 Nov 16;282(46):33859-67. Epub 2007 Sep 18.

24.

Sequence-specific resonance assignment of soluble nonglobular proteins by 7D APSY-NMR spectroscopy.

Hiller S, Wasmer C, Wider G, Wüthrich K.

J Am Chem Soc. 2007 Sep 5;129(35):10823-8. Epub 2007 Aug 11.

PMID:
17691781
25.

Real-time imaging of the spatial distribution of rf-heating in NMR samples during broadband decoupling.

Wimmer R, Wider G.

J Magn Reson. 2007 Aug;187(2):184-92. Epub 2007 May 3.

PMID:
17507272
26.

Proton-proton Overhauser NMR spectroscopy with polypeptide chains in large structures.

Horst R, Wider G, Fiaux J, Bertelsen EB, Horwich AL, Wüthrich K.

Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15445-50. Epub 2006 Oct 10.

27.

Concentration measurements by PULCON using X-filtered or 2D NMR spectra.

Dreier L, Wider G.

Magn Reson Chem. 2006 Jul;44 Spec No:S206-12.

PMID:
16823904
28.

Automated resonance assignment of proteins: 6D APSY-NMR.

Fiorito F, Hiller S, Wider G, Wüthrich K.

J Biomol NMR. 2006 May;35(1):27-37. Epub 2006 May 31.

29.

Measuring protein concentrations by NMR spectroscopy.

Wider G, Dreier L.

J Am Chem Soc. 2006 Mar 1;128(8):2571-6.

PMID:
16492040
30.

NMR-derived dynamic aspects of N-type inactivation of a Kv channel suggest a transient interaction with the T1 domain.

Baker KA, Hilty C, Peti W, Prince A, Pfaffinger PJ, Wider G, Wüthrich K, Choe S.

Biochemistry. 2006 Feb 14;45(6):1663-72.

31.

Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis.

Bienko M, Green CM, Crosetto N, Rudolf F, Zapart G, Coull B, Kannouche P, Wider G, Peter M, Lehmann AR, Hofmann K, Dikic I.

Science. 2005 Dec 16;310(5755):1821-4.

32.

Effective rotational correlation times of proteins from NMR relaxation interference.

Lee D, Hilty C, Wider G, Wüthrich K.

J Magn Reson. 2006 Jan;178(1):72-6. Epub 2005 Sep 26.

PMID:
16188473
33.

Direct NMR observation of a substrate protein bound to the chaperonin GroEL.

Horst R, Bertelsen EB, Fiaux J, Wider G, Horwich AL, Wüthrich K.

Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12748-53. Epub 2005 Aug 22.

34.

Automated projection spectroscopy (APSY).

Hiller S, Fiorito F, Wüthrich K, Wider G.

Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):10876-81. Epub 2005 Jul 25.

35.

Managing the solvent water polarization to obtain improved NMR spectra of large molecular structures.

Hiller S, Wider G, Etezady-Esfarjani T, Horst R, Wüthrich K.

J Biomol NMR. 2005 May;32(1):61-70.

PMID:
16041484
36.
37.

NMR structures of salt-refolded forms of the 434-repressor DNA-binding domain in 6 M urea.

Pervushin K, Wider G, Iwai H, Wüthrich K.

Biochemistry. 2004 Nov 9;43(44):13937-43.

PMID:
15518542
38.

NMR structure of a variant 434 repressor DNA-binding domain devoid of hydroxyl groups.

Iwai H, Wider G, Wüthrich K.

J Biomol NMR. 2004 Jul;29(3):395-8. No abstract available.

PMID:
15213439
39.

Membrane protein-lipid interactions in mixed micelles studied by NMR spectroscopy with the use of paramagnetic reagents.

Hilty C, Wider G, Fernández C, Wüthrich K.

Chembiochem. 2004 Apr 2;5(4):467-73.

PMID:
15185370
40.

NMR structure of the integral membrane protein OmpX.

Fernández C, Hilty C, Wider G, Güntert P, Wüthrich K.

J Mol Biol. 2004 Mar 5;336(5):1211-21.

PMID:
15037080
41.

TROSY in NMR studies of the structure and function of large biological macromolecules.

Fernández C, Wider G.

Curr Opin Struct Biol. 2003 Oct;13(5):570-80. Review.

PMID:
14568611
42.

Dissection of heteronuclear NMR experiments for studies of magnetization transfer efficiencies.

Braun D, Wüthrich K, Wider G.

J Magn Reson. 2003 Nov;165(1):89-94.

PMID:
14568519
43.

NMR structure of the apoptosis- and inflammation-related NALP1 pyrin domain.

Hiller S, Kohl A, Fiorito F, Herrmann T, Wider G, Tschopp J, Grütter MG, Wüthrich K.

Structure. 2003 Oct;11(10):1199-205.

44.

Stereospecific assignments of the isopropyl methyl groups of the membrane protein OmpX in DHPC micelles.

Hilty C, Wider G, Fernández C, Wüthrich K.

J Biomol NMR. 2003 Dec;27(4):377-82.

PMID:
14512734
45.

Side chain NMR assignments in the membrane protein OmpX reconstituted in DHPC micelles.

Hilty C, Fernández C, Wider G, Wüthrich K.

J Biomol NMR. 2002 Aug;23(4):289-301.

PMID:
12398349
46.

Lipid-protein interactions in DHPC micelles containing the integral membrane protein OmpX investigated by NMR spectroscopy.

Fernández C, Hilty C, Wider G, Wüthrich K.

Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13533-7. Epub 2002 Oct 7.

47.
48.

NMR experiments for resonance assignments of 13C, 15N doubly-labeled flexible polypeptides: application to the human prion protein hPrP(23-230).

Liu A, Riek R, Wider G, von Schroetter C, Zahn R, Wüthrich K.

J Biomol NMR. 2000 Feb;16(2):127-38.

PMID:
10723992
49.

Sensitivity gain by simultaneous acquisition of two coherence pathways: the HNCA(+) experiment.

Salzmann M, Ross A, Czisch M, Wider G.

J Magn Reson. 2000 Mar;143(1):223-8.

PMID:
10698664
50.

NMR solution structure of the human prion protein.

Zahn R, Liu A, Lührs T, Riek R, von Schroetter C, López García F, Billeter M, Calzolai L, Wider G, Wüthrich K.

Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):145-50.

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