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Items: 1 to 50 of 97


The Making of a Flight Feather: Bio-architectural Principles and Adaptation.

Chang WL, Wu H, Chiu YK, Wang S, Jiang TX, Luo ZL, Lin YC, Li A, Hsu JT, Huang HL, Gu HJ, Lin TY, Yang SM, Lee TT, Lai YC, Lei M, Shie MY, Yao CT, Chen YW, Tsai JC, Shieh SJ, Hwu YK, Cheng HC, Tang PC, Hung SC, Chen CF, Habib M, Widelitz RB, Wu P, Juan WT, Chuong CM.

Cell. 2019 Nov 27;179(6):1409-1423.e17. doi: 10.1016/j.cell.2019.11.008.


Self-assembly of biological networks via adaptive patterning revealed by avian intradermal muscle network formation.

Wu XS, Yeh CY, Harn HI, Jiang TX, Wu P, Widelitz RB, Baker RE, Chuong CM.

Proc Natl Acad Sci U S A. 2019 May 28;116(22):10858-10867. doi: 10.1073/pnas.1818506116. Epub 2019 May 9.


STAT3 signalling pathway is implicated in keloid pathogenesis by preliminary transcriptome and open chromatin analyses.

Lee YS, Liang YC, Wu P, Kulber DA, Tanabe K, Chuong CM, Widelitz R, Tuan TL.

Exp Dermatol. 2019 Apr;28(4):480-484. doi: 10.1111/exd.13923.


Instructive role of melanocytes during pigment pattern formation of the avian skin.

Inaba M, Jiang TX, Liang YC, Tsai S, Lai YC, Widelitz RB, Chuong CM.

Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6884-6890. doi: 10.1073/pnas.1816107116. Epub 2019 Mar 18.


Morpho-regulation in diverse chicken feather formation: Integrating branching modules and sex hormone-dependent morpho-regulatory modules.

Widelitz RB, Lin GW, Lai YC, Mayer JA, Tang PC, Cheng HC, Jiang TX, Chen CF, Chuong CM.

Dev Growth Differ. 2019 Jan;61(1):124-138. doi: 10.1111/dgd.12584. Epub 2018 Dec 19.


Calcium oscillations coordinate feather mesenchymal cell movement by SHH dependent modulation of gap junction networks.

Li A, Cho JH, Reid B, Tseng CC, He L, Tan P, Yeh CY, Wu P, Li Y, Widelitz RB, Zhou Y, Zhao M, Chow RH, Chuong CM.

Nat Commun. 2018 Dec 18;9(1):5377. doi: 10.1038/s41467-018-07661-5.


Transcriptome analyses of reprogrammed feather / scale chimeric explants revealed co-expressed epithelial gene networks during organ specification.

Lai YC, Liang YC, Jiang TX, Widelitz RB, Wu P, Chuong CM.

BMC Genomics. 2018 Oct 29;19(1):780. doi: 10.1186/s12864-018-5184-x.


Comparative genomics and transcriptomics of Chrysolophus provide insights into the evolution of complex plumage coloration.

Gao G, Xu M, Bai C, Yang Y, Li G, Xu J, Wei Z, Min J, Su G, Zhou X, Guo J, Hao Y, Zhang G, Yang X, Xu X, Widelitz RB, Chuong CM, Zhang C, Yin J, Zuo Y.

Gigascience. 2018 Oct 1;7(10). doi: 10.1093/gigascience/giy113.


Contraction of basal filopodia controls periodic feather branching via Notch and FGF signaling.

Cheng D, Yan X, Qiu G, Zhang J, Wang H, Feng T, Tian Y, Xu H, Wang M, He W, Wu P, Widelitz RB, Chuong CM, Yue Z.

Nat Commun. 2018 Apr 9;9(1):1345. doi: 10.1038/s41467-018-03801-z.


Msx2 Supports Epidermal Competency during Wound-Induced Hair Follicle Neogenesis.

Hughes MW, Jiang TX, Plikus MV, Guerrero-Juarez CF, Lin CH, Schafer C, Maxson R, Widelitz RB, Chuong CM.

J Invest Dermatol. 2018 Sep;138(9):2041-2050. doi: 10.1016/j.jid.2018.02.043. Epub 2018 Mar 23.


Multiple Regulatory Modules Are Required for Scale-to-Feather Conversion.

Wu P, Yan J, Lai YC, Ng CS, Li A, Jiang X, Elsey RM, Widelitz R, Bajpai R, Li WH, Chuong CM.

Mol Biol Evol. 2018 Feb 1;35(2):417-430. doi: 10.1093/molbev/msx295.


MicroCT Imaging on Living Alligator Teeth Reveals Natural Tooth Cycling.

Widelitz RB, Abdelhamid A, Khalil Khan M, Elkarargy A, Chuong CM, Wu P.

Methods Mol Biol. 2017;1650:355-362. doi: 10.1007/978-1-4939-7216-6_24.


Systems Biology Analyses in Chicken: Workflow for Transcriptome and ChIP-Seq Analyses Using the Chicken Skin Paradigm.

Lai YC, Widelitz RB, Chuong CM.

Methods Mol Biol. 2017;1650:87-100. doi: 10.1007/978-1-4939-7216-6_5.


Self-organization process in newborn skin organoid formation inspires strategy to restore hair regeneration of adult cells.

Lei M, Schumacher LJ, Lai YC, Juan WT, Yeh CY, Wu P, Jiang TX, Baker RE, Widelitz RB, Yang L, Chuong CM.

Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):E7101-E7110. doi: 10.1073/pnas.1700475114. Epub 2017 Aug 10.


Diverse feather shape evolution enabled by coupling anisotropic signalling modules with self-organizing branching programme.

Li A, Figueroa S, Jiang TX, Wu P, Widelitz R, Nie Q, Chuong CM.

Nat Commun. 2017 Jan 20;8:ncomms14139. doi: 10.1038/ncomms14139.


The Molecular Circuit Regulating Tooth Development in Crocodilians.

Tsai S, Abdelhamid A, Khan MK, Elkarargy A, Widelitz RB, Chuong CM, Wu P.

J Dent Res. 2016 Dec;95(13):1501-1510. Epub 2016 Oct 7.


Quorum sensing and other collective regenerative behavior in organ populations.

Widelitz R, Chuong CM.

Curr Opin Genet Dev. 2016 Oct;40:138-143. doi: 10.1016/j.gde.2016.07.001. Epub 2016 Aug 5. Review.


Topographical mapping of α- and β-keratins on developing chicken skin integuments: Functional interaction and evolutionary perspectives.

Wu P, Ng CS, Yan J, Lai YC, Chen CK, Lai YT, Wu SM, Chen JJ, Luo W, Widelitz RB, Li WH, Chuong CM.

Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):E6770-9. doi: 10.1073/pnas.1520566112. Epub 2015 Nov 23.


The Modulatable Stem Cell Niche: Tissue Interactions during Hair and Feather Follicle Regeneration.

Chen CC, Plikus MV, Tang PC, Widelitz RB, Chuong CM.

J Mol Biol. 2016 Apr 10;428(7):1423-40. doi: 10.1016/j.jmb.2015.07.009. Epub 2015 Jul 18. Review.


Proper BMP Signaling Levels Are Essential for 3D Assembly of Hepatic Cords from Hepatoblasts and Mesenchymal Cells.

Tsai MS, Suksaweang S, Jiang TX, Wu P, Kao YH, Lee PH, Widelitz R, Chuong CM.

Dig Dis Sci. 2015 Dec;60(12):3669-80. doi: 10.1007/s10620-015-3798-2. Epub 2015 Jul 15.


Organ-level quorum sensing directs regeneration in hair stem cell populations.

Chen CC, Wang L, Plikus MV, Jiang TX, Murray PJ, Ramos R, Guerrero-Juarez CF, Hughes MW, Lee OK, Shi S, Widelitz RB, Lander AD, Chuong CM.

Cell. 2015 Apr 9;161(2):277-90. doi: 10.1016/j.cell.2015.02.016.


Roles of GasderminA3 in Catagen-Telogen Transition During Hair Cycling.

Bai X, Lei M, Shi J, Yu Y, Qiu W, Lai X, Liu Y, Yang T, Yang L, Widelitz RB, Chuong CM, Lian X.

J Invest Dermatol. 2015 Sep;135(9):2162-2172. doi: 10.1038/jid.2015.147. Epub 2015 Apr 10.


Deciphering principles of morphogenesis from temporal and spatial patterns on the integument.

Li A, Lai YC, Figueroa S, Yang T, Widelitz RB, Kobielak K, Nie Q, Chuong CM.

Dev Dyn. 2015 Aug;244(8):905-20. doi: 10.1002/dvdy.24281. Epub 2015 Jul 6.


Development, regeneration, and evolution of feathers.

Chen CF, Foley J, Tang PC, Li A, Jiang TX, Wu P, Widelitz RB, Chuong CM.

Annu Rev Anim Biosci. 2015;3:169-95. doi: 10.1146/annurev-animal-022513-114127. Epub 2014 Nov 3. Review.


SnapShot: Branching Morphogenesis.

Chuong CM, Bhat R, Widelitz RB, Bissell MJ.

Cell. 2014 Aug 28;158(5):1212-1212.e1. doi: 10.1016/j.cell.2014.08.019.


Genomic organization, transcriptomic analysis, and functional characterization of avian α- and β-keratins in diverse feather forms.

Ng CS, Wu P, Fan WL, Yan J, Chen CK, Lai YT, Wu SM, Mao CT, Chen JJ, Lu MY, Ho MR, Widelitz RB, Chen CF, Chuong CM, Li WH.

Genome Biol Evol. 2014 Aug 24;6(9):2258-73. doi: 10.1093/gbe/evu181.


Modulating hair follicle size with Wnt10b/DKK1 during hair regeneration.

Lei M, Guo H, Qiu W, Lai X, Yang T, Widelitz RB, Chuong CM, Lian X, Yang L.

Exp Dermatol. 2014 Jun;23(6):407-13. doi: 10.1111/exd.12416.


Regenerative hair waves in aging mice and extra-follicular modulators follistatin, dkk1, and sfrp4.

Chen CC, Murray PJ, Jiang TX, Plikus MV, Chang YT, Lee OK, Widelitz RB, Chuong CM.

J Invest Dermatol. 2014 Aug;134(8):2086-2096. doi: 10.1038/jid.2014.139. Epub 2014 Mar 11.


Dkk2/Frzb in the dermal papillae regulates feather regeneration.

Chu Q, Cai L, Fu Y, Chen X, Yan Z, Lin X, Zhou G, Han H, Widelitz RB, Chuong CM, Wu W, Yue Z.

Dev Biol. 2014 Mar 15;387(2):167-78. doi: 10.1016/j.ydbio.2014.01.010. Epub 2014 Jan 21.


Disrupted ectodermal organ morphogenesis in mice with a conditional histone deacetylase 1, 2 deletion in the epidermis.

Hughes MW, Jiang TX, Lin SJ, Leung Y, Kobielak K, Widelitz RB, Chuong CM.

J Invest Dermatol. 2014 Jan;134(1):24-32. doi: 10.1038/jid.2013.283. Epub 2013 Jun 21.


Specialized stem cell niche enables repetitive renewal of alligator teeth.

Wu P, Wu X, Jiang TX, Elsey RM, Temple BL, Divers SJ, Glenn TC, Yuan K, Chen MH, Widelitz RB, Chuong CM.

Proc Natl Acad Sci U S A. 2013 May 28;110(22):E2009-18. doi: 10.1073/pnas.1213202110. Epub 2013 May 13.


Topology of feather melanocyte progenitor niche allows complex pigment patterns to emerge.

Lin SJ, Foley J, Jiang TX, Yeh CY, Wu P, Foley A, Yen CM, Huang YC, Cheng HC, Chen CF, Reeder B, Jee SH, Widelitz RB, Chuong CM.

Science. 2013 Jun 21;340(6139):1442-5. doi: 10.1126/science.1230374. Epub 2013 Apr 25.


Shaping organs by a wingless-int/Notch/nonmuscle myosin module which orients feather bud elongation.

Li A, Chen M, Jiang TX, Wu P, Nie Q, Widelitz R, Chuong CM.

Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):E1452-61. doi: 10.1073/pnas.1219813110. Epub 2013 Apr 1.


Module-based complexity formation: periodic patterning in feathers and hairs.

Chuong CM, Yeh CY, Jiang TX, Widelitz R.

Wiley Interdiscip Rev Dev Biol. 2013 Jan-Feb;2(1):97-112. Review.


Roles of EphB3/ephrin-B1 in feather morphogenesis.

Suksaweang S, Jiang TX, Roybal P, Chuong CM, Widelitz R.

Int J Dev Biol. 2012;56(9):719-28. doi: 10.1387/ijdb.120021rw.


Tuning Wnt signals for more or fewer hairs.

Lei MX, Chuong CM, Widelitz RB.

J Invest Dermatol. 2013 Jan;133(1):7-9. doi: 10.1038/jid.2012.446.


Competitive balance of intrabulge BMP/Wnt signaling reveals a robust gene network ruling stem cell homeostasis and cyclic activation.

Kandyba E, Leung Y, Chen YB, Widelitz R, Chuong CM, Kobielak K.

Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1351-6. doi: 10.1073/pnas.1121312110. Epub 2013 Jan 4.


Therapeutic strategy for hair regeneration: hair cycle activation, niche environment modulation, wound-induced follicle neogenesis, and stem cell engineering.

Chueh SC, Lin SJ, Chen CC, Lei M, Wang LM, Widelitz R, Hughes MW, Jiang TX, Chuong CM.

Expert Opin Biol Ther. 2013 Mar;13(3):377-91. doi: 10.1517/14712598.2013.739601. Epub 2013 Jan 5. Review.


Sprouty/FGF signaling regulates the proximal-distal feather morphology and the size of dermal papillae.

Yue Z, Jiang TX, Wu P, Widelitz RB, Chuong CM.

Dev Biol. 2012 Dec 1;372(1):45-54. doi: 10.1016/j.ydbio.2012.09.004. Epub 2012 Sep 18.


The chicken frizzle feather is due to an α-keratin (KRT75) mutation that causes a defective rachis.

Ng CS, Wu P, Foley J, Foley A, McDonald ML, Juan WT, Huang CJ, Lai YT, Lo WS, Chen CF, Leal SM, Zhang H, Widelitz RB, Patel PI, Li WH, Chuong CM.

PLoS Genet. 2012;8(7):e1002748. doi: 10.1371/journal.pgen.1002748. Epub 2012 Jul 19.


Progressive alopecia reveals decreasing stem cell activation probability during aging of mice with epidermal deletion of DNA methyltransferase 1.

Li J, Jiang TX, Hughes MW, Wu P, Yu J, Widelitz RB, Fan G, Chuong CM.

J Invest Dermatol. 2012 Dec;132(12):2681-90. doi: 10.1038/jid.2012.206. Epub 2012 Jul 5. Erratum in: J Invest Dermatol. 2013 Mar;133(3):859. Yu, Juehua [added].


Physiological regeneration of skin appendages and implications for regenerative medicine.

Chuong CM, Randall VA, Widelitz RB, Wu P, Jiang TX.

Physiology (Bethesda). 2012 Apr;27(2):61-72. doi: 10.1152/physiol.00028.2011. Review.


Self-organizing and stochastic behaviors during the regeneration of hair stem cells.

Plikus MV, Baker RE, Chen CC, Fare C, de la Cruz D, Andl T, Maini PK, Millar SE, Widelitz R, Chuong CM.

Science. 2011 Apr 29;332(6029):586-9. doi: 10.1126/science.1201647.


From buds to follicles: matrix metalloproteinases in developmental tissue remodeling during feather morphogenesis.

Jiang TX, Tuan TL, Wu P, Widelitz RB, Chuong CM.

Differentiation. 2011 Jun;81(5):307-14. doi: 10.1016/j.diff.2011.03.004. Epub 2011 Apr 17.


In search of the Golden Fleece: unraveling principles of morphogenesis by studying the integrative biology of skin appendages.

Hughes MW, Wu P, Jiang TX, Lin SJ, Dong CY, Li A, Hsieh FJ, Widelitz RB, Chuong CM.

Integr Biol (Camb). 2011 Apr;3(4):388-407. doi: 10.1039/c0ib00108b. Epub 2011 Mar 24.


Spots and stripes: pleomorphic patterning of stem cells via p-ERK-dependent cell chemotaxis shown by feather morphogenesis and mathematical simulation.

Lin CM, Jiang TX, Baker RE, Maini PK, Widelitz RB, Chuong CM.

Dev Biol. 2009 Oct 15;334(2):369-82. doi: 10.1016/j.ydbio.2009.07.036. Epub 2009 Aug 6.


Analyses of regenerative wave patterns in adult hair follicle populations reveal macro-environmental regulation of stem cell activity.

Plikus MV, Widelitz RB, Maxson R, Chuong CM.

Int J Dev Biol. 2009;53(5-6):857-68. doi: 10.1387/ijdb.072564mp. Review.


Wnt signaling in skin organogenesis.

Widelitz RB.

Organogenesis. 2008 Apr;4(2):123-33.


The river of stem cells.

Chuong CM, Widelitz RB.

Cell Stem Cell. 2009 Feb 6;4(2):100-2. doi: 10.1016/j.stem.2009.01.003.

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