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Items: 1 to 50 of 136

1.

AT1R-AT2R-RXFP1 Functional Crosstalk in Myofibroblasts: Impact on the Therapeutic Targeting of Renal and Cardiac Fibrosis.

Chow BSM, Kocan M, Shen M, Wang Y, Han L, Chew JY, Wang C, Bosnyak S, Mirabito-Colafella KM, Barsha G, Wigg B, Johnstone EKM, Hossain MA, Pfleger KDG, Denton KM, Widdop RE, Summers RJ, Bathgate RAD, Hewitson TD, Samuel CS.

J Am Soc Nephrol. 2019 Sep 11. pii: ASN.2019060597. doi: 10.1681/ASN.2019060597. [Epub ahead of print]

PMID:
31511361
2.

Morphology and Function of the Lamb Ileum following Preterm Birth.

Flores TJ, Nguyen VB, Widdop RE, Sutherland MR, Polglase GR, Abud HE, Black MJ.

Front Pediatr. 2018 Jan 29;6:8. doi: 10.3389/fped.2018.00008. eCollection 2018.

3.

Dapagliflozin attenuates human vascular endothelial cell activation and induces vasorelaxation: A potential mechanism for inhibition of atherogenesis.

Gaspari T, Spizzo I, Liu H, Hu Y, Simpson RW, Widdop RE, Dear AE.

Diab Vasc Dis Res. 2018 Jan;15(1):64-73. doi: 10.1177/1479164117733626. Epub 2017 Oct 4. Erratum in: Diab Vasc Dis Res. 2018 Jul;15(4):364.

PMID:
28976221
4.

Anti-fibrotic Potential of AT2 Receptor Agonists.

Wang Y, Del Borgo M, Lee HW, Baraldi D, Hirmiz B, Gaspari TA, Denton KM, Aguilar MI, Samuel CS, Widdop RE.

Front Pharmacol. 2017 Aug 31;8:564. doi: 10.3389/fphar.2017.00564. eCollection 2017. Review.

5.

Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a.

Chassagnon IR, McCarthy CA, Chin YK, Pineda SS, Keramidas A, Mobli M, Pham V, De Silva TM, Lynch JW, Widdop RE, Rash LD, King GF.

Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):3750-3755. doi: 10.1073/pnas.1614728114. Epub 2017 Mar 20.

6.

Novel approaches for treating hypertension.

Freeman AJ, Vinh A, Widdop RE.

F1000Res. 2017 Jan 27;6:80. doi: 10.12688/f1000research.10117.1. eCollection 2017. Review.

7.

Angiotensin AT2-receptor stimulation improves survival and neurological outcome after experimental stroke in mice.

Schwengel K, Namsolleck P, Lucht K, Clausen BH, Lambertsen KL, Valero-Esquitino V, Thöne-Reineke C, Müller S, Widdop RE, Denton KM, Horiuchi M, Iwai M, Boato F, Dahlöf B, Hallberg A, Unger T, Steckelings UM.

J Mol Med (Berl). 2016 Aug;94(8):957-66. doi: 10.1007/s00109-016-1406-3. Epub 2016 Mar 16.

PMID:
26983606
8.

Decorated self-assembling β(3)-tripeptide foldamers form cell adhesive scaffolds.

Luder K, Kulkarni K, Lee HW, Widdop RE, Del Borgo MP, Aguilar MI.

Chem Commun (Camb). 2016 Mar 25;52(24):4549-52. doi: 10.1039/c6cc00247a.

PMID:
26940541
9.

Effect of a Selective Mas Receptor Agonist in Cerebral Ischemia In Vitro and In Vivo.

Lee S, Evans MA, Chu HX, Kim HA, Widdop RE, Drummond GR, Sobey CG.

PLoS One. 2015 Nov 5;10(11):e0142087. doi: 10.1371/journal.pone.0142087. eCollection 2015.

10.

Molecular and cellular mechanisms of glucagon-like peptide-1 receptor agonist-mediated attenuation of cardiac fibrosis.

Gaspari T, Brdar M, Lee HW, Spizzo I, Hu Y, Widdop RE, Simpson RW, Dear AE.

Diab Vasc Dis Res. 2016 Jan;13(1):56-68. doi: 10.1177/1479164115605000. Epub 2015 Sep 25.

PMID:
26408644
11.

PcTx1 affords neuroprotection in a conscious model of stroke in hypertensive rats via selective inhibition of ASIC1a.

McCarthy CA, Rash LD, Chassagnon IR, King GF, Widdop RE.

Neuropharmacology. 2015 Dec;99:650-7. doi: 10.1016/j.neuropharm.2015.08.040. Epub 2015 Aug 29.

PMID:
26320544
12.

β-Pro7Ang III is a novel highly selective angiotensin II type 2 receptor (AT2R) agonist, which acts as a vasodepressor agent via the AT2R in conscious spontaneously hypertensive rats.

Del Borgo M, Wang Y, Bosnyak S, Khan M, Walters P, Spizzo I, Perlmutter P, Hilliard L, Denton K, Aguilar MI, Widdop RE, Jones ES.

Clin Sci (Lond). 2015 Sep;129(6):505-13. doi: 10.1042/CS20150077. Epub 2015 May 8.

PMID:
26186568
13.

Structural determinants for binding to angiotensin converting enzyme 2 (ACE2) and angiotensin receptors 1 and 2.

Clayton D, Hanchapola I, Thomas WG, Widdop RE, Smith AI, Perlmutter P, Aguilar MI.

Front Pharmacol. 2015 Jan 30;6:5. doi: 10.3389/fphar.2015.00005. eCollection 2015.

14.

Compound 21, a selective agonist of angiotensin AT2 receptors, prevents endothelial inflammation and leukocyte adhesion in vitro and in vivo.

Sampson AK, Irvine JC, Shihata WA, Dragoljevic D, Lumsden N, Huet O, Barnes T, Unger T, Steckelings UM, Jennings GL, Widdop RE, Chin-Dusting JP.

Br J Pharmacol. 2016 Feb;173(4):729-40. doi: 10.1111/bph.13063. Epub 2015 Jun 29.

15.

Differential phenotypes of tissue-infiltrating T cells during angiotensin II-induced hypertension in mice.

Wei Z, Spizzo I, Diep H, Drummond GR, Widdop RE, Vinh A.

PLoS One. 2014 Dec 11;9(12):e114895. doi: 10.1371/journal.pone.0114895. eCollection 2014.

16.

Sex- and age-related differences in the chronic pressure-natriuresis relationship: role of the angiotensin type 2 receptor.

Mirabito KM, Hilliard LM, Kett MM, Brown RD, Booth SC, Widdop RE, Moritz KM, Evans RG, Denton KM.

Am J Physiol Renal Physiol. 2014 Oct 15;307(8):F901-7. doi: 10.1152/ajprenal.00288.2014. Epub 2014 Aug 27.

17.

A novel agent with histone deacetylase inhibitory activity attenuates neointimal hyperplasia.

Rahmatzadeh M, Liu HB, Krishna SM, Gaspari TA, Welungoda I, Widdop RE, Dear AE.

Cardiovasc Drugs Ther. 2014 Oct;28(5):395-406. doi: 10.1007/s10557-014-6540-y.

PMID:
25005755
18.

Role of inflammation and the angiotensin type 2 receptor in the regulation of arterial pressure during pregnancy in mice.

Mirabito KM, Hilliard LM, Wei Z, Tikellis C, Widdop RE, Vinh A, Denton KM.

Hypertension. 2014 Sep;64(3):626-31. doi: 10.1161/HYPERTENSIONAHA.114.03189. Epub 2014 Jun 16.

PMID:
24935937
19.

Serelaxin is a more efficacious antifibrotic than enalapril in an experimental model of heart disease.

Samuel CS, Bodaragama H, Chew JY, Widdop RE, Royce SG, Hewitson TD.

Hypertension. 2014 Aug;64(2):315-22. doi: 10.1161/HYPERTENSIONAHA.114.03594.

PMID:
24866131
20.

Angiotensin type 2 receptor stimulation increases renal function in female, but not male, spontaneously hypertensive rats.

Hilliard LM, Chow CL, Mirabito KM, Steckelings UM, Unger T, Widdop RE, Denton KM.

Hypertension. 2014 Aug;64(2):378-83. doi: 10.1161/HYPERTENSIONAHA.113.02809. Epub 2014 May 19.

PMID:
24842923
21.

The protective arms of the renin-angiontensin system in stroke.

McCarthy CA, Facey LJ, Widdop RE.

Curr Hypertens Rep. 2014 Jul;16(7):440. doi: 10.1007/s11906-014-0440-1. Review.

PMID:
24816974
22.

Electronic sculpting of ligand-GPCR subtype selectivity: the case of angiotensin II.

Magnani F, Pappas CG, Crook T, Magafa V, Cordopatis P, Ishiguro S, Ohta N, Selent J, Bosnyak S, Jones ES, Gerothanassis IP, Tamura M, Widdop RE, Tzakos AG.

ACS Chem Biol. 2014 Jul 18;9(7):1420-5. doi: 10.1021/cb500063y. Epub 2014 May 14.

23.

Direct angiotensin AT2 receptor stimulation using a novel AT2 receptor agonist, compound 21, evokes neuroprotection in conscious hypertensive rats.

McCarthy CA, Vinh A, Miller AA, Hallberg A, Alterman M, Callaway JK, Widdop RE.

PLoS One. 2014 Apr 21;9(4):e95762. doi: 10.1371/journal.pone.0095762. eCollection 2014.

24.

Vasoactive role for angiotensin II type 2 receptors in human radial artery.

Zulli A, Hare DL, Buxton BF, Widdop RE.

Int J Immunopathol Pharmacol. 2014 Jan-Mar;27(1):79-85.

PMID:
24674681
25.

Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis.

Chow BS, Kocan M, Bosnyak S, Sarwar M, Wigg B, Jones ES, Widdop RE, Summers RJ, Bathgate RA, Hewitson TD, Samuel CS.

Kidney Int. 2014 Jul;86(1):75-85. doi: 10.1038/ki.2013.518. Epub 2014 Jan 15.

26.

Pressor responsiveness to angiotensin II in female mice is enhanced with age: role of the angiotensin type 2 receptor.

Mirabito KM, Hilliard LM, Head GA, Widdop RE, Denton KM.

Biol Sex Differ. 2014 Sep 16;5:13. doi: 10.1186/s13293-014-0013-7. eCollection 2014.

27.

Direct AT₂ receptor stimulation is athero-protective and stabilizes plaque in apolipoprotein E-deficient mice.

Kljajic ST, Widdop RE, Vinh A, Welungoda I, Bosnyak S, Jones ES, Gaspari TA.

Int J Cardiol. 2013 Nov 15;169(4):281-7. doi: 10.1016/j.ijcard.2013.09.015. Epub 2013 Oct 6.

PMID:
24161533
28.

Comment on "protective arms of the renin-angiotensin system in neurological disease": Reply.

Sumners C, Horiuchi M, Widdop RE, McCarthy C, Unger T, Steckelings UM.

Clin Exp Pharmacol Physiol. 2013 Nov;40(11):838-9. doi: 10.1111/1440-1681.12168. No abstract available.

PMID:
24033585
29.

Nitroxyl donors retain their depressor effects in hypertension.

Irvine JC, Ravi RM, Kemp-Harper BK, Widdop RE.

Am J Physiol Heart Circ Physiol. 2013 Sep 15;305(6):H939-45. doi: 10.1152/ajpheart.00630.2012. Epub 2013 Jul 12.

30.

Protective arms of the renin-angiotensin-system in neurological disease.

Sumners C, Horiuchi M, Widdop RE, McCarthy C, Unger T, Steckelings UM.

Clin Exp Pharmacol Physiol. 2013 Aug;40(8):580-8. doi: 10.1111/1440-1681.12137. Review.

PMID:
23735163
31.

The GLP-1 receptor agonist liraglutide inhibits progression of vascular disease via effects on atherogenesis, plaque stability and endothelial function in an ApoE(-/-) mouse model.

Gaspari T, Welungoda I, Widdop RE, Simpson RW, Dear AE.

Diab Vasc Dis Res. 2013 Jul;10(4):353-60. doi: 10.1177/1479164113481817. Epub 2013 May 14.

PMID:
23673376
32.

Brain and retinal microglia in health and disease: an unrecognized target of the renin-angiotensin system.

McCarthy CA, Widdop RE, Deliyanti D, Wilkinson-Berka JL.

Clin Exp Pharmacol Physiol. 2013 Aug;40(8):571-9. doi: 10.1111/1440-1681.12099. Review.

PMID:
23601050
33.

Update on the angiotensin AT(2) receptor.

McCarthy CA, Widdop RE, Denton KM, Jones ES.

Curr Hypertens Rep. 2013 Feb;15(1):25-30. doi: 10.1007/s11906-012-0321-4. Review.

PMID:
23224511
34.

Angiotensin II type 2 receptor stimulation initiated after stroke causes neuroprotection in conscious rats.

McCarthy CA, Vinh A, Broughton BR, Sobey CG, Callaway JK, Widdop RE.

Hypertension. 2012 Dec;60(6):1531-7. doi: 10.1161/HYPERTENSIONAHA.112.199646. Epub 2012 Oct 22.

PMID:
23090772
35.

Reversal of vascular macrophage accumulation and hypertension by a CCR2 antagonist in deoxycorticosterone/salt-treated mice.

Chan CT, Moore JP, Budzyn K, Guida E, Diep H, Vinh A, Jones ES, Widdop RE, Armitage JA, Sakkal S, Ricardo SD, Sobey CG, Drummond GR.

Hypertension. 2012 Nov;60(5):1207-12. doi: 10.1161/HYPERTENSIONAHA.112.201251. Epub 2012 Oct 1.

PMID:
23033370
36.

Neuroprotective effect of an angiotensin receptor type 2 agonist following cerebral ischemia in vitro and in vivo.

Lee S, Brait VH, Arumugam TV, Evans MA, Kim HA, Widdop RE, Drummond GR, Sobey CG, Jones ES.

Exp Transl Stroke Med. 2012 Aug 24;4(1):16. doi: 10.1186/2040-7378-4-16.

37.

Ganging up on angiotensin II type 1 receptors in vascular remodeling.

Gaspari TA, Vinh A, Jones ES, Widdop RE.

Hypertension. 2012 Jul;60(1):17-9. doi: 10.1161/HYPERTENSIONAHA.112.193375. Epub 2012 Jun 4. No abstract available.

PMID:
22665119
39.

Differential mechanisms of ang (1-7)-mediated vasodepressor effect in adult and aged candesartan-treated rats.

Bosnyak S, Widdop RE, Denton KM, Jones ES.

Int J Hypertens. 2012;2012:192567. doi: 10.1155/2012/192567. Epub 2011 Nov 30.

40.

Sex-specific influence of angiotensin type 2 receptor stimulation on renal function: a novel therapeutic target for hypertension.

Hilliard LM, Jones ES, Steckelings UM, Unger T, Widdop RE, Denton KM.

Hypertension. 2012 Feb;59(2):409-14. doi: 10.1161/HYPERTENSIONAHA.111.184986. Epub 2011 Dec 12.

PMID:
22158645
41.

Sex differences in the pressor and tubuloglomerular feedback response to angiotensin II.

Brown RD, Hilliard LM, Head GA, Jones ES, Widdop RE, Denton KM.

Hypertension. 2012 Jan;59(1):129-35. doi: 10.1161/HYPERTENSIONAHA.111.178715. Epub 2011 Nov 28.

PMID:
22124434
42.

The arterial depressor response to chronic low-dose angiotensin II infusion in female rats is estrogen dependent.

Sampson AK, Hilliard LM, Moritz KM, Thomas MC, Tikellis C, Widdop RE, Denton KM.

Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R159-65. doi: 10.1152/ajpregu.00256.2011. Epub 2011 Oct 26.

43.

A GLP-1 receptor agonist liraglutide inhibits endothelial cell dysfunction and vascular adhesion molecule expression in an ApoE-/- mouse model.

Gaspari T, Liu H, Welungoda I, Hu Y, Widdop RE, Knudsen LB, Simpson RW, Dear AE.

Diab Vasc Dis Res. 2011 Apr;8(2):117-24. doi: 10.1177/1479164111404257. Erratum in: Diab Vasc Dis Res. 2012 Jan;9(1):79.

PMID:
21562063
44.

Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors.

Bosnyak S, Jones ES, Christopoulos A, Aguilar MI, Thomas WG, Widdop RE.

Clin Sci (Lond). 2011 Oct;121(7):297-303. doi: 10.1042/CS20110036.

PMID:
21542804
45.

A single beta-amino acid substitution to angiotensin II confers AT2 receptor selectivity and vascular function.

Jones ES, Del Borgo MP, Kirsch JF, Clayton D, Bosnyak S, Welungoda I, Hausler N, Unabia S, Perlmutter P, Thomas WG, Aguilar MI, Widdop RE.

Hypertension. 2011 Mar;57(3):570-6. doi: 10.1161/HYPERTENSIONAHA.110.164301. Epub 2011 Feb 7.

PMID:
21300665
46.

Gender differences in pressure-natriuresis and renal autoregulation: role of the Angiotensin type 2 receptor.

Hilliard LM, Nematbakhsh M, Kett MM, Teichman E, Sampson AK, Widdop RE, Evans RG, Denton KM.

Hypertension. 2011 Feb;57(2):275-82. doi: 10.1161/HYPERTENSIONAHA.110.166827. Epub 2010 Dec 28.

PMID:
21189402
47.

Non-peptide AT2-receptor agonists.

Steckelings UM, Larhed M, Hallberg A, Widdop RE, Jones ES, Wallinder C, Namsolleck P, Dahlöf B, Unger T.

Curr Opin Pharmacol. 2011 Apr;11(2):187-92. doi: 10.1016/j.coph.2010.11.002. Epub 2010 Dec 15. Review.

PMID:
21167778
48.

Chronic administration of the HNO donor Angeli's salt does not lead to tolerance, cross-tolerance, or endothelial dysfunction: comparison with GTN and DEA/NO.

Irvine JC, Kemp-Harper BK, Widdop RE.

Antioxid Redox Signal. 2011 May 1;14(9):1615-24. doi: 10.1089/ars.2010.3269. Epub 2011 Mar 3.

PMID:
20849324
49.

The angiotensin AT2 receptor in left ventricular hypertrophy.

Steckelings UM, Widdop RE, Paulis L, Unger T.

J Hypertens. 2010 Sep;28 Suppl 1:S50-5. doi: 10.1097/01.hjh.0000388495.66330.63. Review.

PMID:
20823717
50.

β-Amino acid substitution to investigate the recognition of angiotensin II (AngII) by angiotensin converting enzyme 2 (ACE2).

Clayton D, Hanchapola I, Hausler N, Unabia S, Lew RA, Widdop RE, Smith AI, Perlmutter P, Aguilar MI.

J Mol Recognit. 2011 Mar-Apr;24(2):235-44. doi: 10.1002/jmr.1041.

PMID:
20549604

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