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Items: 44


Cell biology and mechanopathology of laminopathic cardiomyopathies.

Miroshnikova YA, Hammesfahr T, Wickström SA.

J Cell Biol. 2019 Feb 4;218(2):393-394. doi: 10.1083/jcb.201805079. Epub 2019 Jan 10. No abstract available.


Signaling in the stem cell niche: regulating cell fate, function and plasticity.

Chacón-Martínez CA, Koester J, Wickström SA.

Development. 2018 Aug 1;145(15). pii: dev165399. doi: 10.1242/dev.165399. Review.


Cell adhesion and mechanics as drivers of tissue organization and differentiation: local cues for large scale organization.

Wickström SA, Niessen CM.

Curr Opin Cell Biol. 2018 Oct;54:89-97. doi: 10.1016/ Epub 2018 Jun 1. Review.


TGFB1 is secreted through an unconventional pathway dependent on the autophagic machinery and cytoskeletal regulators.

Nüchel J, Ghatak S, Zuk AV, Illerhaus A, Mörgelin M, Schönborn K, Blumbach K, Wickström SA, Krieg T, Sengle G, Plomann M, Eckes B.

Autophagy. 2018;14(3):465-486. doi: 10.1080/15548627.2017.1422850. Epub 2018 Mar 11.


Adhesion forces and cortical tension couple cell proliferation and differentiation to drive epidermal stratification.

Miroshnikova YA, Le HQ, Schneider D, Thalheim T, Rübsam M, Bremicker N, Polleux J, Kamprad N, Tarantola M, Wang I, Balland M, Niessen CM, Galle J, Wickström SA.

Nat Cell Biol. 2018 Jan;20(1):69-80. doi: 10.1038/s41556-017-0005-z. Epub 2017 Dec 11.


E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning.

Rübsam M, Mertz AF, Kubo A, Marg S, Jüngst C, Goranci-Buzhala G, Schauss AC, Horsley V, Dufresne ER, Moser M, Ziegler W, Amagai M, Wickström SA, Niessen CM.

Nat Commun. 2017 Nov 1;8(1):1250. doi: 10.1038/s41467-017-01170-7.


Adherens Junctions and Desmosomes Coordinate Mechanics and Signaling to Orchestrate Tissue Morphogenesis and Function: An Evolutionary Perspective.

Rübsam M, Broussard JA, Wickström SA, Nekrasova O, Green KJ, Niessen CM.

Cold Spring Harb Perspect Biol. 2018 Nov 1;10(11). pii: a029207. doi: 10.1101/cshperspect.a029207. Review.


Lipodystrophic laminopathy: Lamin A mutation relaxes chromatin architecture to impair adipogenesis.

Elzeneini E, Wickström SA.

J Cell Biol. 2017 Sep 4;216(9):2607-2610. doi: 10.1083/jcb.201707090. Epub 2017 Aug 15.


Emerging roles of mechanical forces in chromatin regulation.

Miroshnikova YA, Nava MM, Wickström SA.

J Cell Sci. 2017 Jul 15;130(14):2243-2250. doi: 10.1242/jcs.202192. Epub 2017 Jun 23. Review.


YAP-mediated mechanotransduction determines the podocyte's response to damage.

Rinschen MM, Grahammer F, Hoppe AK, Kohli P, Hagmann H, Kretz O, Bertsch S, Höhne M, Göbel H, Bartram MP, Gandhirajan RK, Krüger M, Brinkkoetter PT, Huber TB, Kann M, Wickström SA, Benzing T, Schermer B.

Sci Signal. 2017 Apr 11;10(474). pii: eaaf8165. doi: 10.1126/scisignal.aaf8165.


Hair follicle stem cell cultures reveal self-organizing plasticity of stem cells and their progeny.

Chacón-Martínez CA, Klose M, Niemann C, Glauche I, Wickström SA.

EMBO J. 2017 Jan 17;36(2):151-164. doi: 10.15252/embj.201694902. Epub 2016 Dec 9.


Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage commitment.

Le HQ, Ghatak S, Yeung CY, Tellkamp F, Günschmann C, Dieterich C, Yeroslaviz A, Habermann B, Pombo A, Niessen CM, Wickström SA.

Nat Cell Biol. 2016 Aug;18(8):864-75. doi: 10.1038/ncb3387. Epub 2016 Jul 11.


ILK Induction in Lymphoid Organs by a TNFα-NF-κB-Regulated Pathway Promotes the Development of Chronic Lymphocytic Leukemia.

Krenn PW, Hofbauer SW, Pucher S, Hutterer E, Hinterseer E, Denk U, Asslaber D, Ganghammer S, Sternberg C, Neureiter D, Aberger F, Wickström SA, Egle A, Greil R, Hartmann TN.

Cancer Res. 2016 Apr 15;76(8):2186-96. doi: 10.1158/0008-5472.CAN-15-3379. Epub 2016 Feb 2.


Integrin-linked kinase regulates the niche of quiescent epidermal stem cells.

Morgner J, Ghatak S, Jakobi T, Dieterich C, Aumailley M, Wickström SA.

Nat Commun. 2015 Sep 8;6:8198. doi: 10.1038/ncomms9198.


Invasion of Herpes Simplex Virus Type 1 into Murine Epidermis: An Ex Vivo Infection Study.

Rahn E, Petermann P, Thier K, Bloch W, Morgner J, Wickström SA, Knebel-Mörsdorf D.

J Invest Dermatol. 2015 Dec;135(12):3009-3016. doi: 10.1038/jid.2015.290. Epub 2015 Jul 23.


Force generation and transmission in keloid fibroblasts: dissecting the role of mechanosensitive molecules in cell function.

Schneider D, Wickström SA.

Exp Dermatol. 2015 Aug;24(8):574-5. doi: 10.1111/exd.12753. No abstract available.


The late endosomal p14-MP1 (LAMTOR2/3) complex regulates focal adhesion dynamics during cell migration.

Schiefermeier N, Scheffler JM, de Araujo ME, Stasyk T, Yordanov T, Ebner HL, Offterdinger M, Munck S, Hess MW, Wickström SA, Lange A, Wunderlich W, Fässler R, Teis D, Huber LA.

J Cell Biol. 2014 May 26;205(4):525-40. doi: 10.1083/jcb.201310043. Epub 2014 May 19.


Role of integrin signalling through integrin-linked kinase in skin physiology and pathology.

Eckes B, Krieg T, Wickström SA.

Exp Dermatol. 2014 Jul;23(7):453-6. doi: 10.1111/exd.12429.


The weakest link: a new paradigm for stabilizing the integrin-actin connection.

Morgner J, Wickström SA.

Cell Cycle. 2013 Sep 15;12(18):2929-30. doi: 10.4161/cc.26213. Epub 2013 Aug 23. No abstract available.


ILK: a pseudokinase with a unique function in the integrin-actin linkage.

Ghatak S, Morgner J, Wickström SA.

Biochem Soc Trans. 2013 Aug;41(4):995-1001. doi: 10.1042/BST20130062. Review.


The promotion of endothelial cell attachment and spreading using FNIII10 fused to VEGF-A165.

Traub S, Morgner J, Martino MM, Höning S, Swartz MA, Wickström SA, Hubbell JA, Eming SA.

Biomaterials. 2013 Aug;34(24):5958-68. doi: 10.1016/j.biomaterials.2013.04.050. Epub 2013 May 14.


Stabilization of integrin-linked kinase by the Hsp90-CHIP axis impacts cellular force generation, migration and the fibrotic response.

Radovanac K, Morgner J, Schulz JN, Blumbach K, Patterson C, Geiger T, Mann M, Krieg T, Eckes B, Fässler R, Wickström SA.

EMBO J. 2013 May 15;32(10):1409-24. doi: 10.1038/emboj.2013.90. Epub 2013 Apr 23.


Deletion of integrin linked kinase in endothelial cells results in defective RTK signaling caused by caveolin 1 mislocalization.

Malan D, Elischer A, Hesse M, Wickström SA, Fleischmann BK, Bloch W.

Development. 2013 Mar;140(5):987-95. doi: 10.1242/dev.091298.


In vivo SILAC-based proteomics reveals phosphoproteome changes during mouse skin carcinogenesis.

Zanivan S, Meves A, Behrendt K, Schoof EM, Neilson LJ, Cox J, Tang HR, Kalna G, van Ree JH, van Deursen JM, Trempus CS, Machesky LM, Linding R, Wickström SA, Fässler R, Mann M.

Cell Rep. 2013 Feb 21;3(2):552-66. doi: 10.1016/j.celrep.2013.01.003. Epub 2013 Jan 31.


Regulation of membrane traffic by integrin signaling.

Wickström SA, Fässler R.

Trends Cell Biol. 2011 May;21(5):266-73. doi: 10.1016/j.tcb.2011.02.003. Epub 2011 Mar 26. Review.


Genetic analyses of integrin signaling.

Wickström SA, Radovanac K, Fässler R.

Cold Spring Harb Perspect Biol. 2011 Feb 1;3(2). pii: a005116. doi: 10.1101/cshperspect.a005116. Review.


Integrin-linked kinase controls microtubule dynamics required for plasma membrane targeting of caveolae.

Wickström SA, Lange A, Hess MW, Polleux J, Spatz JP, Krüger M, Pfaller K, Lambacher A, Bloch W, Mann M, Huber LA, Fässler R.

Dev Cell. 2010 Oct 19;19(4):574-88. doi: 10.1016/j.devcel.2010.09.007.


The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase!

Wickström SA, Lange A, Montanez E, Fässler R.

EMBO J. 2010 Jan 20;29(2):281-91. doi: 10.1038/emboj.2009.376. Epub 2009 Dec 24. Review.


CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin.

Wickström SA, Masoumi KC, Khochbin S, Fässler R, Massoumi R.

EMBO J. 2010 Jan 6;29(1):131-44. doi: 10.1038/emboj.2009.317. Epub 2009 Nov 5.


Integrin-linked kinase is an adaptor with essential functions during mouse development.

Lange A, Wickström SA, Jakobson M, Zent R, Sainio K, Fässler R.

Nature. 2009 Oct 15;461(7266):1002-6. doi: 10.1038/nature08468.


Alpha-parvin controls vascular mural cell recruitment to vessel wall by regulating RhoA/ROCK signalling.

Montanez E, Wickström SA, Altstätter J, Chu H, Fässler R.

EMBO J. 2009 Oct 21;28(20):3132-44. doi: 10.1038/emboj.2009.295. Epub 2009 Oct 1.


Integrins anchor the invasive machinery.

Wickström SA, Fässler R.

Dev Cell. 2009 Aug;17(2):158-60. doi: 10.1016/j.devcel.2009.07.023.


Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry.

Zanivan S, Gnad F, Wickström SA, Geiger T, Macek B, Cox J, Fässler R, Mann M.

J Proteome Res. 2008 Dec;7(12):5314-26.


Genetic and cell biological analysis of integrin outside-in signaling.

Legate KR, Wickström SA, Fässler R.

Genes Dev. 2009 Feb 15;23(4):397-418. doi: 10.1101/gad.1758709. Review.


Integrin-linked kinase stabilizes myotendinous junctions and protects muscle from stress-induced damage.

Wang HV, Chang LW, Brixius K, Wickström SA, Montanez E, Thievessen I, Schwander M, Müller U, Bloch W, Mayer U, Fässler R.

J Cell Biol. 2008 Mar 10;180(5):1037-49. doi: 10.1083/jcb.200707175.


[Degradation products of endothelial basement membranes: their role as tumor suppressor].

Wickström SA, Keski-Oja J.

Duodecim. 2005;121(17):1829-37. Review. Finnish. No abstract available.


Endostatin signaling and regulation of endothelial cell-matrix interactions.

Wickström SA, Alitalo K, Keski-Oja J.

Adv Cancer Res. 2005;94:197-229. Review.


Binding of endostatin to phosphatidylserine-containing membranes and formation of amyloid-like fibers.

Zhao H, Jutila A, Nurminen T, Wickström SA, Keski-Oja J, Kinnunen PK.

Biochemistry. 2005 Mar 1;44(8):2857-63.


An endostatin-derived peptide interacts with integrins and regulates actin cytoskeleton and migration of endothelial cells.

Wickström SA, Alitalo K, Keski-Oja J.

J Biol Chem. 2004 May 7;279(19):20178-85. Epub 2004 Feb 18.


Endostatin associates with lipid rafts and induces reorganization of the actin cytoskeleton via down-regulation of RhoA activity.

Wickström SA, Alitalo K, Keski-Oja J.

J Biol Chem. 2003 Sep 26;278(39):37895-901. Epub 2003 Jul 8.


Matrix reloaded to circulation hits the tumor target.

Wickström SA, Keski-Oja J, Alitalo K.

Cancer Cell. 2003 Jun;3(6):513-4.


Endostatin-induced modulation of plasminogen activation with concomitant loss of focal adhesions and actin stress fibers in cultured human endothelial cells.

Wickström SA, Veikkola T, Rehn M, Pihlajaniemi T, Alitalo K, Keski-Oja J.

Cancer Res. 2001 Sep 1;61(17):6511-6.


Regulation of membrane-type-1 matrix metalloproteinase activity by its cytoplasmic domain.

Lehti K, Valtanen H, Wickström SA, Lohi J, Keski-Oja J.

J Biol Chem. 2000 May 19;275(20):15006-13. Erratum in: J Biol Chem. 2004 Sep 17;279(38):40246.

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