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Items: 1 to 50 of 62

1.

Temporary faecal diversion in ileocolic resection for Crohn's disease: is there an impact on long-term surgical recurrence?

Bolckmans R, Singh S, Ratnatunga K, Wickramasinghe D, Sahnan K, Adegbola S, Kalman D, Jones H, Travis S, Warusavitarne J, Myrelid P, George B.

Colorectal Dis. 2019 Nov 12. doi: 10.1111/codi.14895. [Epub ahead of print]

PMID:
31715062
2.

Lamarck and Panspermia - On the Efficient Spread of Living Systems Throughout the Cosmos.

Steele EJ, Gorczynski RM, Lindley RA, Liu Y, Temple R, Tokoro G, Wickramasinghe DT, Wickramasinghe NC.

Prog Biophys Mol Biol. 2019 Aug 22. pii: S0079-6107(19)30112-9. doi: 10.1016/j.pbiomolbio.2019.08.010. [Epub ahead of print] Review.

3.

The role of the mesentery in reducing recurrence after surgery in Crohn's disease.

Wickramasinghe D, Warusavitarne J.

Updates Surg. 2019 Mar;71(1):11-12. doi: 10.1007/s13304-019-00623-6. Epub 2019 Feb 2. No abstract available.

PMID:
30712254
4.

Value of three-dimensional endoanal ultrasound scan (3D-EAUS) in preoperative assessment of fistula-in-ano.

Almeida IS, Jayarajah U, Wickramasinghe DP, Samarasekera DN.

BMC Res Notes. 2019 Jan 29;12(1):66. doi: 10.1186/s13104-019-4098-2.

5.

Reply to commentary by R Duggleby (2019).

Steele EJ, Al-Mufti S, Augustyn KA, Chandrajith R, Coghlan JP, Coulson SG, Ghosh S, Gillman M, Gorczynski RM, Klyce B, Louis G, Mahanama K, Oliver KR, Padron J, Qu J, Schuster JA, Smith WE, Snyder DP, Steele JA, Stewart BJ, Temple R, Tokoro G, Tout CA, Unzicker A, Wainwright M, Wallis J, Wallis DH, Wallis MK, Wetherall J, Wickramasinghe DT, Wickramasinghe JT, Wickramasinghe NC, Liu Y.

Prog Biophys Mol Biol. 2019 Jan;141:74-78. doi: 10.1016/j.pbiomolbio.2018.11.002. Epub 2018 Nov 9. No abstract available.

6.

Treatment of fistula in-ano with fistula plug: experience of a tertiary care centre in South Asia and comparison of results with the West.

Almeida IS, Wickramasinghe D, Weerakkody P, Samarasekera DN.

BMC Res Notes. 2018 Jul 28;11(1):513. doi: 10.1186/s13104-018-3641-x.

7.

Duration taken for the anal sphincter pressures to stabilize prior to anorectal manometry.

Wickramasinghe DP, Jayarajah U, Samarasekera DN.

BMC Res Notes. 2018 Jun 5;11(1):354. doi: 10.1186/s13104-018-3451-1.

8.

Three-Dimensional Endoanal Ultrasound Features of the Anal Sphincter in Asian Primigravidae.

Wickramasinghe DP, Senaratne S, Senanayake H, Samarasekera DN.

J Ultrasound Med. 2018 Dec;37(12):2821-2827. doi: 10.1002/jum.14640. Epub 2018 Apr 17.

PMID:
29665089
9.

Reply to editorial and commentaries on Steele, Al-Mufti, Augustyn, Chandrajith, Coghlan, Coulson et al. (2018) "Cause of Cambrian explosion - Terrestrial or Cosmic?"

Steele EJ, Al-Mufti S, Augustyn KA, Chandrajith R, Coghlan JP, Coulson SG, Ghosh S, Gillman M, Gorczynski RM, Klyce B, Louis G, Mahanama K, Oliver KR, Padron J, Qu J, Schuster JA, Smith WE, Snyder DP, Steele JA, Stewart BJ, Temple R, Tokoro G, Tout CA, Unzicker A, Wainwright M, Wallis J, Wallis DH, Wallis MK, Wetherall J, Wickramasinghe DT, Wickramasinghe JT, Wickramasinghe NC, Liu Y.

Prog Biophys Mol Biol. 2018 Aug;136:27-28. doi: 10.1016/j.pbiomolbio.2018.03.007. Epub 2018 Mar 13. No abstract available.

PMID:
29549026
10.

Cause of Cambrian Explosion - Terrestrial or Cosmic?

Steele EJ, Al-Mufti S, Augustyn KA, Chandrajith R, Coghlan JP, Coulson SG, Ghosh S, Gillman M, Gorczynski RM, Klyce B, Louis G, Mahanama K, Oliver KR, Padron J, Qu J, Schuster JA, Smith WE, Snyder DP, Steele JA, Stewart BJ, Temple R, Tokoro G, Tout CA, Unzicker A, Wainwright M, Wallis J, Wallis DH, Wallis MK, Wetherall J, Wickramasinghe DT, Wickramasinghe JT, Wickramasinghe NC, Liu Y.

Prog Biophys Mol Biol. 2018 Aug;136:3-23. doi: 10.1016/j.pbiomolbio.2018.03.004. Epub 2018 Mar 13. Review.

11.

Anal incontinence and quality of life following operative treatment of simple cryptoglandular fistula-in-ano: a prospective study.

Jayarajah U, Wickramasinghe DP, Samarasekera DN.

BMC Res Notes. 2017 Nov 7;10(1):572. doi: 10.1186/s13104-017-2895-z.

12.

Heavy metal-induced toxicity in the Indian green frog: Biochemical and histopathological alterations.

Jayawardena UA, Angunawela P, Wickramasinghe DD, Ratnasooriya WD, Udagama PV.

Environ Toxicol Chem. 2017 Oct;36(10):2855-2867. doi: 10.1002/etc.3848. Epub 2017 Jun 19.

PMID:
28474750
13.

Heavy metal mediated innate immune responses of the Indian green frog, Euphlyctis hexadactylus (Anura: Ranidae): Cellular profiles and associated Th1 skewed cytokine response.

Jayawardena UA, Ratnasooriya WD, Wickramasinghe DD, Udagama PV.

Sci Total Environ. 2016 Oct 1;566-567:1194-1204. doi: 10.1016/j.scitotenv.2016.05.171. Epub 2016 Jun 19.

PMID:
27335164
14.

Incidence of esophageal cancer in Sri Lanka: Analysis of cancer registry data and comparison with other South Asian populations.

Wickramasinghe DP, Samarasekera DN.

Asia Pac J Clin Oncol. 2017 Oct;13(5):e271-e277. doi: 10.1111/ajco.12481. Epub 2016 Mar 31.

PMID:
27030258
15.

Effect of vaginal delivery on anal sphincter function in Asian primigravida: a prospective study.

Wickramasinghe DP, Senaratne S, Senanayake H, Samarasekera DN.

Int Urogynecol J. 2016 Sep;27(9):1375-81. doi: 10.1007/s00192-016-2986-8. Epub 2016 Mar 7.

PMID:
26951430
16.

Population Structure Among and Within Iowa, Missouri, Ohio, and South Dakota Populations of Phytophthora sojae.

Stewart S, Robertson AE, Wickramasinghe D, Draper MA, Michel A, Dorrance AE.

Plant Dis. 2016 Feb;100(2):367-379. doi: 10.1094/PDIS-04-15-0437-RE. Epub 2015 Dec 19.

PMID:
30694137
17.

Families with both Hodgkin lymphoma and multiple myeloma in their pedigrees.

Wiernik PH, Wickramasinghe D, Dutcher JP.

Clin Adv Hematol Oncol. 2015 Apr;13(4):257-60.

PMID:
26352584
18.

Correlation of three dimensional anorectal manometry and three dimensional endoanal ultrasound findings in primi gravida: a cross sectional study.

Wickramasinghe DP, Perera CS, Senanayake H, Samarasekera DN.

BMC Res Notes. 2015 Aug 29;8:387. doi: 10.1186/s13104-015-1346-y.

19.

Outcomes in consecutive hospitalized UK patients with bacteraemia or fungaemia caused by medical devices and procedures.

Melzer M, Wickramasinghe D, Welch C.

J Hosp Infect. 2015 Oct;91(2):146-52. doi: 10.1016/j.jhin.2015.06.015. Epub 2015 Jul 8.

PMID:
26275709
20.

Three-Dimensional Anorectal Manometry Findings in Primigravida.

Wickramasinghe DP, Perera CS, Senanayake H, Samarasekera DN.

Dig Dis Sci. 2015 Dec;60(12):3764-70. doi: 10.1007/s10620-015-3784-8. Epub 2015 Jul 24.

PMID:
26204973
21.

Heavy metal mediated immunomodulation of the Indian green frog, Euphlyctis hexadactylus (Anura:Ranidae) in urban wetlands.

Priyadarshani S, Madhushani WA, Jayawardena UA, Wickramasinghe DD, Udagama PV.

Ecotoxicol Environ Saf. 2015 Jun;116:40-9. doi: 10.1016/j.ecoenv.2015.02.037. Epub 2015 Mar 10.

PMID:
25754457
22.

AMG 925 is a dual FLT3/CDK4 inhibitor with the potential to overcome FLT3 inhibitor resistance in acute myeloid leukemia.

Li C, Liu L, Liang L, Xia Z, Li Z, Wang X, McGee LR, Newhall K, Sinclair A, Kamb A, Wickramasinghe D, Dai K.

Mol Cancer Ther. 2015 Feb;14(2):375-83. doi: 10.1158/1535-7163.MCT-14-0388. Epub 2014 Dec 8.

23.

Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3.

Li Z, Wang X, Eksterowicz J, Gribble MW Jr, Alba GQ, Ayres M, Carlson TJ, Chen A, Chen X, Cho R, Connors RV, DeGraffenreid M, Deignan JT, Duquette J, Fan P, Fisher B, Fu J, Huard JN, Kaizerman J, Keegan KS, Li C, Li K, Li Y, Liang L, Liu W, Lively SE, Lo MC, Ma J, McMinn DL, Mihalic JT, Modi K, Ngo R, Pattabiraman K, Piper DE, Queva C, Ragains ML, Suchomel J, Thibault S, Walker N, Wang X, Wang Z, Wanska M, Wehn PM, Weidner MF, Zhang AJ, Zhao X, Kamb A, Wickramasinghe D, Dai K, McGee LR, Medina JC.

J Med Chem. 2014 Apr 24;57(8):3430-49. doi: 10.1021/jm500118j. Epub 2014 Apr 2.

PMID:
24641103
24.

Predictors in breast cancer screening behaviors of South Asian women.

Perera JC, Peiris V, Wickramasinghe DP, De Zoysa I.

Asia Pac J Clin Oncol. 2016 Jun;12(2):e229-33. doi: 10.1111/ajco.12168. Epub 2014 Feb 27.

PMID:
24575733
25.

Preclinical evaluation of AMG 925, a FLT3/CDK4 dual kinase inhibitor for treating acute myeloid leukemia.

Keegan K, Li C, Li Z, Ma J, Ragains M, Coberly S, Hollenback D, Eksterowicz J, Liang L, Weidner M, Huard J, Wang X, Alba G, Orf J, Lo MC, Zhao S, Ngo R, Chen A, Liu L, Carlson T, Quéva C, McGee LR, Medina J, Kamb A, Wickramasinghe D, Dai K.

Mol Cancer Ther. 2014 Apr;13(4):880-9. doi: 10.1158/1535-7163.MCT-13-0858. Epub 2014 Feb 13.

26.

Patterns and trends of medical student research.

Wickramasinghe DP, Perera CS, Senarathna S, Samarasekera DN.

BMC Med Educ. 2013 Dec 28;13:175. doi: 10.1186/1472-6920-13-175.

27.

Types and patterns of colonic polyps encountered at a tertiary care center in a developing country in South Asia.

Wickramasinghe DP, Samaranayaka SF, Lakmal C, Mathotaarachchi S, Kanishka Lal C, Keppetiyagama C, Samarasekera DN.

Anal Cell Pathol (Amst). 2014;2014:248142. doi: 10.1155/2014/248142. Epub 2014 Dec 7.

28.

Tumor and T cell engagement by BiTE.

Wickramasinghe D.

Discov Med. 2013 Oct;16(88):149-52. Review.

29.

Sphingosine kinase activity is not required for tumor cell viability.

Rex K, Jeffries S, Brown ML, Carlson T, Coxon A, Fajardo F, Frank B, Gustin D, Kamb A, Kassner PD, Li S, Li Y, Morgenstern K, Plant M, Quon K, Ruefli-Brasse A, Schmidt J, Swearingen E, Walker N, Wang Z, Watson JE, Wickramasinghe D, Wong M, Xu G, Wesche H.

PLoS One. 2013 Jul 5;8(7):e68328. doi: 10.1371/journal.pone.0068328. Print 2013.

30.

Endoglin requirement for BMP9 signaling in endothelial cells reveals new mechanism of action for selective anti-endoglin antibodies.

Nolan-Stevaux O, Zhong W, Culp S, Shaffer K, Hoover J, Wickramasinghe D, Ruefli-Brasse A.

PLoS One. 2012;7(12):e50920. doi: 10.1371/journal.pone.0050920. Epub 2012 Dec 27.

31.

Splenic infarction and spontaneous rupture in a patient with paratyphoid.

Wickramasinghe DP, Samarasekara DN.

Ceylon Med J. 2012 Sep;57(3):130-1. doi: 10.4038/cmj.v57i3.4709. No abstract available.

32.

Intestinal helminths detected in capsule endoscopy.

Wickramasinghe DP, Samarasekera DN.

Dig Endosc. 2012 Sep;24(5):388. doi: 10.1111/j.1443-1661.2012.01297.x. No abstract available.

PMID:
22925304
33.

A comparison of endoanal ultrasound and computed tomography in staging rectal cancer and in clinical decision making - a preliminary study.

Wickramasinghe DP, Samarasekera DN.

Ceylon Med J. 2012 Mar;57(1):33-5. doi: 10.4038/cmj.v57i1.4198.

34.

Discovery of amide replacements that improve activity and metabolic stability of a bis-amide smoothened antagonist hit.

Brown ML, Aaron W, Austin RJ, Chong A, Huang T, Jiang B, Kaizerman JA, Lee G, Lucas BS, McMinn DL, Orf J, Rong M, Toteva MM, Xu G, Ye Q, Zhong W, Degraffenreid MR, Wickramasinghe D, Powers JP, Hungate R, Johnson MG.

Bioorg Med Chem Lett. 2011 Sep 15;21(18):5206-9. doi: 10.1016/j.bmcl.2011.07.052. Epub 2011 Jul 23.

PMID:
21840217
35.

Comparison of three microsatellite analysis methods for detecting genetic diversity in Phytophthora sojae (Stramenopila: Oomycete).

Stewart S, Wickramasinghe D, Dorrance AE, Robertson AE.

Biotechnol Lett. 2011 Nov;33(11):2217-23. doi: 10.1007/s10529-011-0682-9. Epub 2011 Jul 9.

36.

Factors influencing the approaches to studying of preclinical and clinical students and postgraduate trainees.

Wickramasinghe DP, Samarasekera DN.

BMC Med Educ. 2011 May 20;11:22. doi: 10.1186/1472-6920-11-22.

37.

Patterns of approaches to studying of pre-clinical, clinical and post graduate students from a setting in a developing country in Asia.

Wickramasinghe DP, Samarasekera DN.

Med Teach. 2011;33(4):340. No abstract available.

PMID:
21591293
38.

Phenotypic detection of metallo-beta-lactamase producing Klebsiella pneumoniae by an inhibitor based method.

Fernando R, Wickramasinghe D, Munasinghe D, Priyankara R.

Ceylon Med J. 2010 Dec;55(4):137. No abstract available.

39.

Lumbosacral plexopathy due to a rupture of a common Iliac artery aneurysm.

Bushby N, Wickramasinghe SY, Wickramasinghe DN.

Emerg Med Australas. 2010 Aug;22(4):351-3. doi: 10.1111/j.1742-6723.2010.01310.x.

PMID:
20796013
40.

Addressing PXR liabilities of phthalazine-based hedgehog/smoothened antagonists using novel pyridopyridazines.

Kaizerman JA, Aaron W, An S, Austin R, Brown M, Chong A, Huang T, Hungate R, Jiang B, Johnson MG, Lee G, Lucas BS, Orf J, Rong M, Toteva MM, Wickramasinghe D, Xu G, Ye Q, Zhong W, McMinn DL.

Bioorg Med Chem Lett. 2010 Aug 1;20(15):4607-10. doi: 10.1016/j.bmcl.2010.06.006. Epub 2010 Jun 8.

PMID:
20594845
41.

Design of 1-piperazinyl-4-arylphthalazines as potent Smoothened antagonists.

Lucas BS, Aaron W, An S, Austin RJ, Brown M, Chan H, Chong A, Hungate R, Huang T, Jiang B, Johnson MG, Kaizerman JA, Lee G, McMinn DL, Orf J, Powers JP, Rong M, Toteva MM, Uyeda C, Wickramasinghe D, Xu G, Ye Q, Zhong W.

Bioorg Med Chem Lett. 2010 Jun 15;20(12):3618-22. doi: 10.1016/j.bmcl.2010.04.110. Epub 2010 Apr 28.

PMID:
20493695
42.

Discovery of potent LPA2 (EDG4) antagonists as potential anticancer agents.

Beck HP, Kohn T, Rubenstein S, Hedberg C, Schwandner R, Hasslinger K, Dai K, Li C, Liang L, Wesche H, Frank B, An S, Wickramasinghe D, Jaen J, Medina J, Hungate R, Shen W.

Bioorg Med Chem Lett. 2008 Feb 1;18(3):1037-41. doi: 10.1016/j.bmcl.2007.12.024. Epub 2008 Jan 4.

PMID:
18178086
43.

Social mobilisation, drug coverage and compliance and adverse reactions in a Mass Drug Administration (MDA) Programme for the Elimination of Lymphatic Filariasis in Sri Lanka.

Weerasooriya MV, Yahathugoda CT, Wickramasinghe D, Gunawardena KN, Dharmadasa RA, Vidanapathirana KK, Weerasekara SH, Samarawickrema WA.

Filaria J. 2007 Nov 15;6:11.

44.

Somatic mutations lead to an oncogenic deletion of met in lung cancer.

Kong-Beltran M, Seshagiri S, Zha J, Zhu W, Bhawe K, Mendoza N, Holcomb T, Pujara K, Stinson J, Fu L, Severin C, Rangell L, Schwall R, Amler L, Wickramasinghe D, Yauch R.

Cancer Res. 2006 Jan 1;66(1):283-9.

45.

CDK2/cyclinA inhibitors: targeting the cyclinA recruitment site with small molecules derived from peptide leads.

Castanedo G, Clark K, Wang S, Tsui V, Wong M, Nicholas J, Wickramasinghe D, Marsters JC Jr, Sutherlin D.

Bioorg Med Chem Lett. 2006 Mar 15;16(6):1716-20. Epub 2005 Dec 27.

PMID:
16384702
46.
47.

Met activation and receptor dimerization in cancer: a role for the Sema domain.

Wickramasinghe D, Kong-Beltran M.

Cell Cycle. 2005 May;4(5):683-5. Epub 2005 May 25. Review.

PMID:
15846105
48.

The Sema domain of Met is necessary for receptor dimerization and activation.

Kong-Beltran M, Stamos J, Wickramasinghe D.

Cancer Cell. 2004 Jul;6(1):75-84.

49.

Prenatal testing and pregnancy termination in Sri Lanka: views of medical students and doctors.

Simpson B, Dissanayake VH, Wickramasinghe D, Jayasekara RW.

Ceylon Med J. 2003 Dec;48(4):129-32.

50.

Knowledge on lymphatic filariasis and the response to July 2002 mass treatment campaign in two communities in the Galle district.

Yahathugoda TC, Wickramasinghe D, Liyanage TS, Weerasooriya MV, Mudalige MP, Waidyaratna EI, Samarawickrema WA.

Ceylon Med J. 2003 Sep;48(3):74-7.

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