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Items: 1 to 50 of 250

1.

Genetics is the logic of life (at least of mine).

Wickner RB.

FEMS Yeast Res. 2019 Jan 1;19(1). doi: 10.1093/femsyr/foy115.

PMID:
30329039
2.

Study of Amyloids Using Yeast.

Wickner RB, Kryndushkin D, Shewmaker F, McGlinchey R, Edskes HK.

Methods Mol Biol. 2018;1779:313-339. doi: 10.1007/978-1-4939-7816-8_19.

PMID:
29886541
3.
4.

Yeast Prions Compared to Functional Prions and Amyloids.

Wickner RB, Edskes HK, Son M, Bezsonov EE, DeWilde M, Ducatez M.

J Mol Biol. 2018 Oct 12;430(20):3707-3719. doi: 10.1016/j.jmb.2018.04.022. Epub 2018 Apr 24. Review.

PMID:
29698650
5.

Anti-Prion Systems in Yeast and Inositol Polyphosphates.

Wickner RB, Bezsonov EE, Son M, Ducatez M, DeWilde M, Edskes HK.

Biochemistry. 2018 Feb 27;57(8):1285-1292. doi: 10.1021/acs.biochem.7b01285. Epub 2018 Feb 9.

PMID:
29377675
6.

Nonsense-mediated mRNA decay factors cure most [PSI+] prion variants.

Son M, Wickner RB.

Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):E1184-E1193. doi: 10.1073/pnas.1717495115. Epub 2018 Jan 22.

7.

Prion propagation and inositol polyphosphates.

Wickner RB, Edskes HK, Bezsonov EE, Son M, Ducatez M.

Curr Genet. 2018 Jun;64(3):571-574. doi: 10.1007/s00294-017-0788-2. Epub 2017 Dec 14. Review.

PMID:
29243174
8.

[PSI+] prion propagation is controlled by inositol polyphosphates.

Wickner RB, Kelly AC, Bezsonov EE, Edskes HK.

Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8402-E8410. doi: 10.1073/pnas.1714361114. Epub 2017 Sep 18.

9.

Hsp104 disaggregase at normal levels cures many [PSI+] prion variants in a process promoted by Sti1p, Hsp90, and Sis1p.

Gorkovskiy A, Reidy M, Masison DC, Wickner RB.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4193-E4202. doi: 10.1073/pnas.1704016114. Epub 2017 May 8.

10.

Prions.

Kryndushkin D, Edskes HK, Shewmaker FP, Wickner RB.

Cold Spring Harb Protoc. 2017 Feb 1;2017(2). doi: 10.1101/pdb.top077586.

PMID:
28148884
11.

Prion Transfection of Yeast.

Edskes HK, Kryndushkin D, Shewmaker F, Wickner RB.

Cold Spring Harb Protoc. 2017 Feb 1;2017(2). doi: 10.1101/pdb.prot089037.

PMID:
28148849
12.

Genetic Methods for Studying Yeast Prions.

Wickner RB, Edskes HK, Kryndushkin D, Shewmaker FP.

Cold Spring Harb Protoc. 2017 Feb 1;2017(2). doi: 10.1101/pdb.prot089029.

PMID:
28148848
13.

Yeast and Fungal Prions.

Wickner RB.

Cold Spring Harb Perspect Biol. 2016 Sep 1;8(9). pii: a023531. doi: 10.1101/cshperspect.a023531. Review.

14.

Yeast and Fungal Prions: Amyloid-Handling Systems, Amyloid Structure, and Prion Biology.

Wickner RB, Edskes HK, Gorkovskiy A, Bezsonov EE, Stroobant EE.

Adv Genet. 2016;93:191-236. doi: 10.1016/bs.adgen.2015.12.003. Epub 2016 Jan 22.

PMID:
26915272
15.

Prions are affected by evolution at two levels.

Wickner RB, Kelly AC.

Cell Mol Life Sci. 2016 Mar;73(6):1131-44. doi: 10.1007/s00018-015-2109-6. Epub 2015 Dec 28. Review.

16.

Yeast killer elements hold their hosts hostage.

Wickner RB, Edskes HK.

PLoS Genet. 2015 May 14;11(5):e1005139. doi: 10.1371/journal.pgen.1005139. eCollection 2015 May. No abstract available.

17.

Yeast prions: proteins templating conformation and an anti-prion system.

Wickner RB, Edskes HK, Bateman DA, Gorkovskiy A, Dayani Y, Bezsonov EE, Mukhamedova M.

PLoS Pathog. 2015 Feb 5;11(2):e1004584. doi: 10.1371/journal.ppat.1004584. eCollection 2015 Feb. Review. No abstract available.

18.

Yeast prions: structure, biology, and prion-handling systems.

Wickner RB, Shewmaker FP, Bateman DA, Edskes HK, Gorkovskiy A, Dayani Y, Bezsonov EE.

Microbiol Mol Biol Rev. 2015 Mar;79(1):1-17. doi: 10.1128/MMBR.00041-14. Review.

19.

Locating folds of the in-register parallel β-sheet of the Sup35p prion domain infectious amyloid.

Gorkovskiy A, Thurber KR, Tycko R, Wickner RB.

Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):E4615-22. doi: 10.1073/pnas.1417974111. Epub 2014 Oct 13.

20.

Amyloid diseases of yeast: prions are proteins acting as genes.

Wickner RB, Edskes HK, Bateman DA, Kelly AC, Gorkovskiy A, Dayani Y, Zhou A.

Essays Biochem. 2014;56:193-205. doi: 10.1042/bse0560193.

PMID:
25131596
21.

Sporadic distribution of prion-forming ability of Sup35p from yeasts and fungi.

Edskes HK, Khamar HJ, Winchester CL, Greenler AJ, Zhou A, McGlinchey RP, Gorkovskiy A, Wickner RB.

Genetics. 2014 Oct;198(2):605-16. doi: 10.1534/genetics.114.166538. Epub 2014 Jul 31.

22.

Parallel in-register intermolecular β-sheet architectures for prion-seeded prion protein (PrP) amyloids.

Groveman BR, Dolan MA, Taubner LM, Kraus A, Wickner RB, Caughey B.

J Biol Chem. 2014 Aug 29;289(35):24129-42. doi: 10.1074/jbc.M114.578344. Epub 2014 Jul 15.

23.

Normal levels of the antiprion proteins Btn2 and Cur1 cure most newly formed [URE3] prion variants.

Wickner RB, Bezsonov E, Bateman DA.

Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):E2711-20. doi: 10.1073/pnas.1409582111. Epub 2014 Jun 17.

24.

Effect of domestication on the spread of the [PIN+] prion in Saccharomyces cerevisiae.

Kelly AC, Busby B, Wickner RB.

Genetics. 2014 Jul;197(3):1007-24. doi: 10.1534/genetics.114.165670. Epub 2014 May 8.

25.

Saccharomyces cerevisiae: a sexy yeast with a prion problem.

Kelly AC, Wickner RB.

Prion. 2013 May-Jun;7(3):215-20. doi: 10.4161/pri.24845.

26.

Viruses and prions of Saccharomyces cerevisiae.

Wickner RB, Fujimura T, Esteban R.

Adv Virus Res. 2013;86:1-36. doi: 10.1016/B978-0-12-394315-6.00001-5. Review.

27.

The [URE3] prion in Candida.

Edskes HK, Wickner RB.

Eukaryot Cell. 2013 Apr;12(4):551-8. doi: 10.1128/EC.00015-13. Epub 2013 Feb 8.

28.

The [PSI+] prion exists as a dynamic cloud of variants.

Bateman DA, Wickner RB.

PLoS Genet. 2013;9(1):e1003257. doi: 10.1371/journal.pgen.1003257. Epub 2013 Jan 31. Erratum in: PLoS Genet. 2017 Feb 3;13(2):e1006591.

29.

Amyloids and yeast prion biology.

Wickner RB, Edskes HK, Bateman DA, Kelly AC, Gorkovskiy A, Dayani Y, Zhou A.

Biochemistry. 2013 Mar 5;52(9):1514-27. doi: 10.1021/bi301686a. Epub 2013 Feb 12.

PMID:
23379365
30.

Molecular structures of amyloid and prion fibrils: consensus versus controversy.

Tycko R, Wickner RB.

Acc Chem Res. 2013 Jul 16;46(7):1487-96. doi: 10.1021/ar300282r. Epub 2013 Jan 7. Review.

31.

Sex, prions, and plasmids in yeast.

Kelly AC, Shewmaker FP, Kryndushkin D, Wickner RB.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):E2683-90. doi: 10.1073/pnas.1213449109. Epub 2012 Sep 4.

32.

Study of amyloids using yeast.

Wickner RB, Kryndushkin D, Shewmaker F, McGlinchey R, Edskes HK.

Methods Mol Biol. 2012;849:321-46. doi: 10.1007/978-1-61779-551-0_22.

33.

Discovering protein-based inheritance through yeast genetics.

Wickner RB.

J Biol Chem. 2012 Apr 27;287(18):14432-42. doi: 10.1074/jbc.X112.355636. Epub 2012 Mar 6. Review. No abstract available.

34.

Experimentally derived structural constraints for amyloid fibrils of wild-type transthyretin.

Bateman DA, Tycko R, Wickner RB.

Biophys J. 2011 Nov 16;101(10):2485-92. doi: 10.1016/j.bpj.2011.10.009. Epub 2011 Nov 15.

35.

[PSI+] Prion transmission barriers protect Saccharomyces cerevisiae from infection: intraspecies 'species barriers'.

Bateman DA, Wickner RB.

Genetics. 2012 Feb;190(2):569-79. doi: 10.1534/genetics.111.136655. Epub 2011 Nov 17.

36.

Segmental polymorphism in a functional amyloid.

Hu KN, McGlinchey RP, Wickner RB, Tycko R.

Biophys J. 2011 Nov 2;101(9):2242-50. doi: 10.1016/j.bpj.2011.09.051. Epub 2011 Nov 1.

37.

The yeast prions [PSI+] and [URE3] are molecular degenerative diseases.

Wickner RB, Edskes HK, Bateman D, Kelly AC, Gorkovskiy A.

Prion. 2011 Oct-Dec;5(4):258-62. doi: 10.4161/pri.17748. Epub 2011 Oct 1. Review.

38.

Amyloid of the Candida albicans Ure2p prion domain is infectious and has an in-register parallel β-sheet structure.

Engel A, Shewmaker F, Edskes HK, Dyda F, Wickner RB.

Biochemistry. 2011 Jul 12;50(27):5971-8. doi: 10.1021/bi200142x. Epub 2011 Jun 15.

39.

Retraction for Nemecek et al.: A prion of yeast metacaspase homolog (Mca1p) detected by a genetic screen.

Nemecek J, Nakayashiki T, Wickner RB.

Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):10022. doi: 10.1073/pnas.1107490108. Epub 2011 May 31. No abstract available.

40.

The core of Ure2p prion fibrils is formed by the N-terminal segment in a parallel cross-β structure: evidence from solid-state NMR.

Kryndushkin DS, Wickner RB, Tycko R.

J Mol Biol. 2011 Jun 3;409(2):263-77. doi: 10.1016/j.jmb.2011.03.067. Epub 2011 Apr 8.

41.

Molecular chaperone Hsp104 can promote yeast prion generation.

Kryndushkin DS, Engel A, Edskes H, Wickner RB.

Genetics. 2011 Jun;188(2):339-48. doi: 10.1534/genetics.111.127779. Epub 2011 Apr 5.

42.

Structural insights into functional and pathological amyloid.

Shewmaker F, McGlinchey RP, Wickner RB.

J Biol Chem. 2011 May 13;286(19):16533-40. doi: 10.1074/jbc.R111.227108. Epub 2011 Mar 25. Review.

43.

FUS/TLS forms cytoplasmic aggregates, inhibits cell growth and interacts with TDP-43 in a yeast model of amyotrophic lateral sclerosis.

Kryndushkin D, Wickner RB, Shewmaker F.

Protein Cell. 2011 Mar;2(3):223-36. doi: 10.1007/s13238-011-1525-0. Epub 2011 Mar 30.

44.

Suicidal [PSI+] is a lethal yeast prion.

McGlinchey RP, Kryndushkin D, Wickner RB.

Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5337-41. doi: 10.1073/pnas.1102762108. Epub 2011 Mar 14.

45.

Prion-forming ability of Ure2 of yeasts is not evolutionarily conserved.

Edskes HK, Engel A, McCann LM, Brachmann A, Tsai HF, Wickner RB.

Genetics. 2011 May;188(1):81-90. doi: 10.1534/genetics.111.127217. Epub 2011 Mar 2.

46.

Prion diseases: Infectivity versus toxicity.

Wickner RB.

Nature. 2011 Feb 24;470(7335):470-1. doi: 10.1038/470470a. No abstract available.

PMID:
21350474
47.

Prion diseases of yeast: amyloid structure and biology.

Wickner RB, Edskes HK, Kryndushkin D, McGlinchey R, Bateman D, Kelly A.

Semin Cell Dev Biol. 2011 Jul;22(5):469-75. doi: 10.1016/j.semcdb.2011.02.021. Epub 2011 Feb 21. Review.

48.

The relationship of prions and translation.

Wickner RB, Edskes HK, Shewmaker FP, Kryndushkin D, Nemecek J, McGlinchey R, Bateman D.

Wiley Interdiscip Rev RNA. 2010 Jul-Aug;1(1):81-9. doi: 10.1002/wrna.8. Review.

49.

Repeat domains of melanosome matrix protein Pmel17 orthologs form amyloid fibrils at the acidic melanosomal pH.

McGlinchey RP, Shewmaker F, Hu KN, McPhie P, Tycko R, Wickner RB.

J Biol Chem. 2011 Mar 11;286(10):8385-93. doi: 10.1074/jbc.M110.197152. Epub 2010 Dec 10.

50.

Prion amyloid structure explains templating: how proteins can be genes.

Wickner RB, Shewmaker F, Edskes H, Kryndushkin D, Nemecek J, McGlinchey R, Bateman D, Winchester CL.

FEMS Yeast Res. 2010 Dec;10(8):980-91. doi: 10.1111/j.1567-1364.2010.00666.x. Review.

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