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Unequal interactions between alcohol and nicotine co-consumption: suppression and enhancement of concurrent drug intake.

DeBaker MC, Moen JK, Robinson JM, Wickman K, Lee AM.

Psychopharmacology (Berl). 2019 Dec 20. doi: 10.1007/s00213-019-05426-6. [Epub ahead of print]


Differential patterns of alcohol and nicotine intake: Combined alcohol and nicotine binge consumption behaviors in mice.

DeBaker MC, Robinson JM, Moen JK, Wickman K, Lee AM.

Alcohol. 2019 Sep 23. pii: S0741-8329(19)30113-2. doi: 10.1016/j.alcohol.2019.09.006. [Epub ahead of print]


VU0810464, a non-urea G protein-gated inwardly rectifying K+ (Kir 3/GIRK) channel activator, exhibits enhanced selectivity for neuronal Kir 3 channels and reduces stress-induced hyperthermia in mice.

Vo BN, Abney KK, Anderson A, Marron Fernandez de Velasco E, Benneyworth MA, Daniels JS, Morrison RD, Hopkins CR, Weaver CD, Wickman K.

Br J Pharmacol. 2019 Jul;176(13):2238-2249. doi: 10.1111/bph.14671. Epub 2019 May 30.


Correction to Analgesic Effects of the GIRK Activator, VU0466551, Alone and in Combination with Morphine in Acute and Persistent Pain Models.

Abney KK, Bubser M, Du Y, Kozek KA, Bridges TM, Lindsley CW, Daniels JS, Morrison RD, Wickman K, Hopkins CR, Jones CK, Weaver CD.

ACS Chem Neurosci. 2019 May 15;10(5):2621. doi: 10.1021/acschemneuro.9b00165. Epub 2019 Mar 26. No abstract available.


GIRK Channel Activity in Dopamine Neurons of the Ventral Tegmental Area Bidirectionally Regulates Behavioral Sensitivity to Cocaine.

McCall NM, Marron Fernandez de Velasco E, Wickman K.

J Neurosci. 2019 May 8;39(19):3600-3610. doi: 10.1523/JNEUROSCI.3101-18.2019. Epub 2019 Mar 5.


Analgesic Effects of the GIRK Activator, VU0466551, Alone and in Combination with Morphine in Acute and Persistent Pain Models.

Abney KK, Bubser M, Du Y, Kozek KA, Bridges TM, Linsdley CW, Daniels JS, Morrison RD, Wickman K, Hopkins CR, Jones CK, Weaver CD.

ACS Chem Neurosci. 2019 Mar 20;10(3):1294-1299. doi: 10.1021/acschemneuro.8b00370. Epub 2018 Dec 11. Erratum in: ACS Chem Neurosci. 2019 May 15;10(5):2621.


Inhibition of Pyramidal Neurons in the Basal Amygdala Promotes Fear Learning.

Tipps M, Marron Fernandez de Velasco E, Schaeffer A, Wickman K.

eNeuro. 2018 Oct 31;5(5). pii: ENEURO.0272-18.2018. doi: 10.1523/ENEURO.0272-18.2018. eCollection 2018 Sep-Oct.


Atrial GIRK Channels Mediate the Effects of Vagus Nerve Stimulation on Heart Rate Dynamics and Arrhythmogenesis.

Lee SW, Anderson A, Guzman PA, Nakano A, Tolkacheva EG, Wickman K.

Front Physiol. 2018 Jul 19;9:943. doi: 10.3389/fphys.2018.00943. eCollection 2018.


Correction: The influences of the M2R-GIRK4-RGS6 dependent parasympathetic pathway on electrophysiological properties of the mouse heart.

Kulkarni K, Xie X, Marron Fernandez de Velasco E, Anderson A, Martemyanov KA, Wickman K, Tolkacheva EG.

PLoS One. 2018 Jul 6;13(7):e0200553. doi: 10.1371/journal.pone.0200553. eCollection 2018.


The influences of the M2R-GIRK4-RGS6 dependent parasympathetic pathway on electrophysiological properties of the mouse heart.

Kulkarni K, Xie X, Marron Fernandez de Velasco E, Anderson A, Martemyanov KA, Wickman K, Tolkacheva EG.

PLoS One. 2018 Apr 18;13(4):e0193798. doi: 10.1371/journal.pone.0193798. eCollection 2018. Erratum in: PLoS One. 2018 Jul 6;13(7):e0200553.


Expression and relevance of the G protein-gated K+ channel in the mouse ventricle.

Anderson A, Kulkarni K, Marron Fernandez de Velasco E, Carlblom N, Xia Z, Nakano A, Martemyanov KA, Tolkacheva EG, Wickman K.

Sci Rep. 2018 Jan 19;8(1):1192. doi: 10.1038/s41598-018-19719-x.


Differential association of GABAB receptors with their effector ion channels in Purkinje cells.

Luján R, Aguado C, Ciruela F, Cózar J, Kleindienst D, de la Ossa L, Bettler B, Wickman K, Watanabe M, Shigemoto R, Fukazawa Y.

Brain Struct Funct. 2018 Apr;223(3):1565-1587. doi: 10.1007/s00429-017-1568-y. Epub 2017 Nov 25.


Discovery and Characterization of 1H-Pyrazol-5-yl-2-phenylacetamides as Novel, Non-Urea-Containing GIRK1/2 Potassium Channel Activators.

Wieting JM, Vadukoot AK, Sharma S, Abney KK, Bridges TM, Daniels JS, Morrison RD, Wickman K, Weaver CD, Hopkins CR.

ACS Chem Neurosci. 2017 Sep 20;8(9):1873-1879. doi: 10.1021/acschemneuro.7b00217. Epub 2017 Jul 19.


GIRK2 splice variants and neuronal G protein-gated K+ channels: implications for channel function and behavior.

Marron Fernandez de Velasco E, Zhang L, N Vo B, Tipps M, Farris S, Xia Z, Anderson A, Carlblom N, Weaver CD, Dudek SM, Wickman K.

Sci Rep. 2017 May 9;7(1):1639. doi: 10.1038/s41598-017-01820-2.


Suppression of inhibitory G protein signaling in forebrain pyramidal neurons triggers plasticity of glutamatergic neurotransmission in the nucleus accumbens core.

Marron Fernandez de Velasco E, Carlblom N, Xia Z, Wickman K.

Neuropharmacology. 2017 May 1;117:33-40. doi: 10.1016/j.neuropharm.2017.01.021. Epub 2017 Jan 25.


G Protein-Gated K+ Channel Ablation in Forebrain Pyramidal Neurons Selectively Impairs Fear Learning.

Victoria NC, Marron Fernandez de Velasco E, Ostrovskaya O, Metzger S, Xia Z, Kotecki L, Benneyworth MA, Zink AN, Martemyanov KA, Wickman K.

Biol Psychiatry. 2016 Nov 15;80(10):796-806. doi: 10.1016/j.biopsych.2015.10.004. Epub 2015 Nov 10.


Selective Ablation of GIRK Channels in Dopamine Neurons Alters Behavioral Effects of Cocaine in Mice.

McCall NM, Kotecki L, Dominguez-Lopez S, Marron Fernandez de Velasco E, Carlblom N, Sharpe AL, Beckstead MJ, Wickman K.

Neuropsychopharmacology. 2017 Feb;42(3):707-715. doi: 10.1038/npp.2016.138. Epub 2016 Jul 29.


A Role for the GIRK3 Subunit in Methamphetamine-Induced Attenuation of GABAB Receptor-Activated GIRK Currents in VTA Dopamine Neurons.

Munoz MB, Padgett CL, Rifkin R, Terunuma M, Wickman K, Contet C, Moss SJ, Slesinger PA.

J Neurosci. 2016 Mar 16;36(11):3106-14. doi: 10.1523/JNEUROSCI.1327-15.2016.


G protein-gated IKACh channels as therapeutic targets for treatment of sick sinus syndrome and heart block.

Mesirca P, Bidaud I, Briec F, Evain S, Torrente AG, Le Quang K, Leoni AL, Baudot M, Marger L, Chung You Chong A, Nargeot J, Striessnig J, Wickman K, Charpentier F, Mangoni ME.

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E932-41. doi: 10.1073/pnas.1517181113. Epub 2016 Feb 1.


G-protein-gated Inwardly Rectifying Potassium Channels Modulate Respiratory Depression by Opioids.

Montandon G, Ren J, Victoria NC, Liu H, Wickman K, Greer JJ, Horner RL.

Anesthesiology. 2016 Mar;124(3):641-50. doi: 10.1097/ALN.0000000000000984.



Slesinger PA, Wickman K.

Int Rev Neurobiol. 2015;123:xi-xii. doi: 10.1016/S0074-7742(15)00092-6. No abstract available.


GIRK Channel Plasticity and Implications for Drug Addiction.

Marron Fernandez de Velasco E, McCall N, Wickman K.

Int Rev Neurobiol. 2015;123:201-38. doi: 10.1016/bs.irn.2015.05.011. Epub 2015 Jun 22.


GIRK3 gates activation of the mesolimbic dopaminergic pathway by ethanol.

Herman MA, Sidhu H, Stouffer DG, Kreifeldt M, Le D, Cates-Gatto C, Munoz MB, Roberts AJ, Parsons LH, Roberto M, Wickman K, Slesinger PA, Contet C.

Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):7091-6. doi: 10.1073/pnas.1416146112. Epub 2015 May 11.


GIRK Channels Modulate Opioid-Induced Motor Activity in a Cell Type- and Subunit-Dependent Manner.

Kotecki L, Hearing M, McCall NM, Marron Fernandez de Velasco E, Pravetoni M, Arora D, Victoria NC, Munoz MB, Xia Z, Slesinger PA, Weaver CD, Wickman K.

J Neurosci. 2015 May 6;35(18):7131-42. doi: 10.1523/JNEUROSCI.5051-14.2015.


Sex differences in GABA(B)R-GIRK signaling in layer 5/6 pyramidal neurons of the mouse prelimbic cortex.

Marron Fernandez de Velasco E, Hearing M, Xia Z, Victoria NC, Luján R, Wickman K.

Neuropharmacology. 2015 Aug;95:353-60. doi: 10.1016/j.neuropharm.2015.03.029. Epub 2015 Apr 2.


Cardiac arrhythmia induced by genetic silencing of 'funny' (f) channels is rescued by GIRK4 inactivation.

Mesirca P, Alig J, Torrente AG, Müller JC, Marger L, Rollin A, Marquilly C, Vincent A, Dubel S, Bidaud I, Fernandez A, Seniuk A, Engeland B, Singh J, Miquerol L, Ehmke H, Eschenhagen T, Nargeot J, Wickman K, Isbrandt D, Mangoni ME.

Nat Commun. 2014 Aug 21;5:4664. doi: 10.1038/ncomms5664.


Mechanisms underlying the activation of G-protein-gated inwardly rectifying K+ (GIRK) channels by the novel anxiolytic drug, ML297.

Wydeven N, Marron Fernandez de Velasco E, Du Y, Benneyworth MA, Hearing MC, Fischer RA, Thomas MJ, Weaver CD, Wickman K.

Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10755-60. doi: 10.1073/pnas.1405190111. Epub 2014 Jul 7.


RGS7/Gβ5/R7BP complex regulates synaptic plasticity and memory by modulating hippocampal GABABR-GIRK signaling.

Ostrovskaya O, Xie K, Masuho I, Fajardo-Serrano A, Lujan R, Wickman K, Martemyanov KA.

Elife. 2014 Apr 22;3:e02053. doi: 10.7554/eLife.02053.


HIV-1 protein Tat produces biphasic changes in NMDA-evoked increases in intracellular Ca2+ concentration via activation of Src kinase and nitric oxide signaling pathways.

Krogh KA, Wydeven N, Wickman K, Thayer SA.

J Neurochem. 2014 Sep;130(5):642-56. doi: 10.1111/jnc.12724. Epub 2014 Apr 19.


RGS6, but not RGS4, is the dominant regulator of G protein signaling (RGS) modulator of the parasympathetic regulation of mouse heart rate.

Wydeven N, Posokhova E, Xia Z, Martemyanov KA, Wickman K.

J Biol Chem. 2014 Jan 24;289(4):2440-9. doi: 10.1074/jbc.M113.520742. Epub 2013 Dec 6.


New insights into the therapeutic potential of Girk channels.

Luján R, Marron Fernandez de Velasco E, Aguado C, Wickman K.

Trends Neurosci. 2014 Jan;37(1):20-9. doi: 10.1016/j.tins.2013.10.006. Epub 2013 Nov 21. Review.


Essential role of the m2R-RGS6-IKACh pathway in controlling intrinsic heart rate variability.

Posokhova E, Ng D, Opel A, Masuho I, Tinker A, Biesecker LG, Wickman K, Martemyanov KA.

PLoS One. 2013 Oct 29;8(10):e76973. doi: 10.1371/journal.pone.0076973. eCollection 2013.


G-protein-coupled inward rectifier potassium current contributes to ventricular repolarization.

Liang B, Nissen JD, Laursen M, Wang X, Skibsbye L, Hearing MC, Andersen MN, Rasmussen HB, Wickman K, Grunnet M, Olesen SP, Jespersen T.

Cardiovasc Res. 2014 Jan 1;101(1):175-84. doi: 10.1093/cvr/cvt240. Epub 2013 Oct 22.


Repeated cocaine weakens GABA(B)-Girk signaling in layer 5/6 pyramidal neurons in the prelimbic cortex.

Hearing M, Kotecki L, Marron Fernandez de Velasco E, Fajardo-Serrano A, Chung HJ, Luján R, Wickman K.

Neuron. 2013 Oct 2;80(1):159-70. doi: 10.1016/j.neuron.2013.07.019. Epub 2013 Oct 2.


The G-protein-gated K+ channel, IKACh, is required for regulation of pacemaker activity and recovery of resting heart rate after sympathetic stimulation.

Mesirca P, Marger L, Toyoda F, Rizzetto R, Audoubert M, Dubel S, Torrente AG, Difrancesco ML, Muller JC, Leoni AL, Couette B, Nargeot J, Clapham DE, Wickman K, Mangoni ME.

J Gen Physiol. 2013 Aug;142(2):113-26. doi: 10.1085/jgp.201310996. Epub 2013 Jul 15.


Association of Rgs7/Gβ5 complexes with Girk channels and GABAB receptors in hippocampal CA1 pyramidal neurons.

Fajardo-Serrano A, Wydeven N, Young D, Watanabe M, Shigemoto R, Martemyanov KA, Wickman K, Luján R.

Hippocampus. 2013 Dec;23(12):1231-45. doi: 10.1002/hipo.22161. Epub 2013 Jul 24.


Differential GABAB-receptor-mediated effects in perisomatic- and dendrite-targeting parvalbumin interneurons.

Booker SA, Gross A, Althof D, Shigemoto R, Bettler B, Frotscher M, Hearing M, Wickman K, Watanabe M, Kulik Á, Vida I.

J Neurosci. 2013 May 1;33(18):7961-74. doi: 10.1523/JNEUROSCI.1186-12.2013.


Structural elements in the Girk1 subunit that potentiate G protein-gated potassium channel activity.

Wydeven N, Young D, Mirkovic K, Wickman K.

Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21492-7. doi: 10.1073/pnas.1212019110. Epub 2012 Dec 10.


Behavioral characterization of mice lacking Trek channels.

Mirkovic K, Palmersheim J, Lesage F, Wickman K.

Front Behav Neurosci. 2012 Sep 7;6:60. doi: 10.3389/fnbeh.2012.00060. eCollection 2012.


Cocaine-induced adaptations in metabotropic inhibitory signaling in the mesocorticolimbic system.

Hearing MC, Zink AN, Wickman K.

Rev Neurosci. 2012;23(4):325-51. doi: 10.1515/revneuro-2012-0045. Review.


Developmental regulation of G protein-gated inwardly-rectifying K+ (GIRK/Kir3) channel subunits in the brain.

Fernández-Alacid L, Watanabe M, Molnár E, Wickman K, Luján R.

Eur J Neurosci. 2011 Dec;34(11):1724-36. doi: 10.1111/j.1460-9568.2011.07886.x. Epub 2011 Nov 18.


Acute cocaine exposure weakens GABA(B) receptor-dependent G-protein-gated inwardly rectifying K+ signaling in dopamine neurons of the ventral tegmental area.

Arora D, Hearing M, Haluk DM, Mirkovic K, Fajardo-Serrano A, Wessendorf MW, Watanabe M, Luján R, Wickman K.

J Neurosci. 2011 Aug 24;31(34):12251-7. doi: 10.1523/JNEUROSCI.0494-11.2011.


Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels.

Sohn JW, Xu Y, Jones JE, Wickman K, Williams KW, Elmquist JK.

Neuron. 2011 Aug 11;71(3):488-97. doi: 10.1016/j.neuron.2011.06.012.


Identification and characterization of alternative splice variants of the mouse Trek2/Kcnk10 gene.

Mirkovic K, Wickman K.

Neuroscience. 2011 Oct 27;194:11-8. doi: 10.1016/j.neuroscience.2011.07.064. Epub 2011 Jul 31.


RGS6/Gβ5 complex accelerates IKACh gating kinetics in atrial myocytes and modulates parasympathetic regulation of heart rate.

Posokhova E, Wydeven N, Allen KL, Wickman K, Martemyanov KA.

Circ Res. 2010 Nov 26;107(11):1350-4. doi: 10.1161/CIRCRESAHA.110.224212. Epub 2010 Sep 30. Erratum in: Circ Res. 2011 Feb 4;108(3):e3.


Altered neurotransmission in the mesolimbic reward system of Girk mice.

Arora D, Haluk DM, Kourrich S, Pravetoni M, Fernández-Alacid L, Nicolau JC, Luján R, Wickman K.

J Neurochem. 2010 Sep 1;114(5):1487-97. doi: 10.1111/j.1471-4159.2010.06864.x. Epub 2010 Jun 16.


Gbeta5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling.

Xie K, Allen KL, Kourrich S, Colón-Saez J, Thomas MJ, Wickman K, Martemyanov KA.

Nat Neurosci. 2010 Jun;13(6):661-3. doi: 10.1038/nn.2549. Epub 2010 May 9.


Changing the culture of hand hygiene compliance using a bundle that includes a violation letter.

Chou T, Kerridge J, Kulkarni M, Wickman K, Malow J.

Am J Infect Control. 2010 Sep;38(7):575-8. doi: 10.1016/j.ajic.2010.01.016. Epub 2010 Apr 24.


R7BP complexes with RGS9-2 and RGS7 in the striatum differentially control motor learning and locomotor responses to cocaine.

Anderson GR, Cao Y, Davidson S, Truong HV, Pravetoni M, Thomas MJ, Wickman K, Giesler GJ Jr, Martemyanov KA.

Neuropsychopharmacology. 2010 Mar;35(4):1040-50. doi: 10.1038/npp.2009.212. Epub 2009 Dec 30.


Evaluation of study design variables and their impact on food-maintained operant responding in mice.

Haluk DM, Wickman K.

Behav Brain Res. 2010 Mar 5;207(2):394-401. doi: 10.1016/j.bbr.2009.10.025. Epub 2009 Oct 29.

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