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Neratinib is effective in breast tumors bearing both amplification and mutation of ERBB2 (HER2).

Cocco E, Javier Carmona F, Razavi P, Won HH, Cai Y, Rossi V, Chan C, Cownie J, Soong J, Toska E, Shifman SG, Sarotto I, Savas P, Wick MJ, Papadopoulos KP, Moriarty A, Cutler RE Jr, Avogadri-Connors F, Lalani AS, Bryce RP, Chandarlapaty S, Hyman DM, Solit DB, Boni V, Loi S, Baselga J, Berger MF, Montemurro F, Scaltriti M.

Sci Signal. 2018 Oct 9;11(551). pii: eaat9773. doi: 10.1126/scisignal.aat9773.


An Optimized Evans Blue Protocol to Assess Vascular Leak in the Mouse.

Wick MJ, Harral JW, Loomis ZL, Dempsey EC.

J Vis Exp. 2018 Sep 12;(139). doi: 10.3791/57037.


Zebrafish blastomere screen identifies retinoic acid suppression of MYB in adenoid cystic carcinoma.

Mandelbaum J, Shestopalov IA, Henderson RE, Chau NG, Knoechel B, Wick MJ, Zon LI.

J Exp Med. 2018 Oct 1;215(10):2673-2685. doi: 10.1084/jem.20180939. Epub 2018 Sep 12.


SLC46A3 as a potential predictive biomarker for antibody-drug conjugates bearing non-cleavable linked maytansinoid and pyrrolobenzodiazepine warheads.

Kinneer K, Meekin J, Tiberghien AC, Tai YT, Phipps S, Kiefer CM, Rebelatto MC, Dimasi N, Moriarty AD, Papadopoulos KP, Sridhar S, Gregson SJ, Wick MJ, Masterson LA, Anderson KC, Herbst R, Howard PW, Tice DA.

Clin Cancer Res. 2018 Aug 21. pii: clincanres.1300.2018. doi: 10.1158/1078-0432.CCR-18-1300. [Epub ahead of print]


Noninvasive Prenatal Genetic Screening Using Cell-free DNA.

Allyse MA, Wick MJ.

JAMA. 2018 Aug 14;320(6):591-592. doi: 10.1001/jama.2018.9418. No abstract available.


Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERαWT and ERαMUT Breast Cancer.

Puyang X, Furman C, Zheng GZ, Wu ZJ, Banka D, Aithal K, Agoulnik S, Bolduc DM, Buonamici S, Caleb B, Das S, Eckley S, Fekkes P, Hao MH, Hart A, Houtman R, Irwin S, Joshi JJ, Karr C, Kim A, Kumar N, Kumar P, Kuznetsov G, Lai WG, Larsen N, Mackenzie C, Martin LA, Melchers D, Moriarty A, Nguyen TV, Norris J, O'Shea M, Pancholi S, Prajapati S, Rajagopalan S, Reynolds DJ, Rimkunas V, Rioux N, Ribas R, Siu A, Sivakumar S, Subramanian V, Thomas M, Vaillancourt FH, Wang J, Wardell S, Wick MJ, Yao S, Yu L, Warmuth M, Smith PG, Zhu P, Korpal M.

Cancer Discov. 2018 Sep;8(9):1176-1193. doi: 10.1158/2159-8290.CD-17-1229. Epub 2018 Jul 10.


Increasing genetic counseling referral rates through bundled interventions after ovarian cancer diagnosis.

Swanson CL, Kumar A, Maharaj JM, Kemppainen JL, Thomas BC, Weinhold MR, Slaby KM, Mara KC, Wick MJ, Bakkum-Gamez JN.

Gynecol Oncol. 2018 Apr;149(1):121-126. doi: 10.1016/j.ygyno.2018.01.033. Epub 2018 Feb 3.


Long-lived plasma cells in human bone marrow can be either CD19+ or CD19.

Brynjolfsson SF, Mohaddes M, Kärrholm J, Wick MJ.

Blood Adv. 2017 May 19;1(13):835-838. doi: 10.1182/bloodadvances.2017004481. eCollection 2017 May 23.


Targeting the Oncogenic Transcriptional Regulator MYB in Adenoid Cystic Carcinoma by Inhibition of IGF1R/AKT Signaling.

Andersson MK, Afshari MK, Andrén Y, Wick MJ, Stenman G.

J Natl Cancer Inst. 2017 Sep 1;109(9). doi: 10.1093/jnci/djx017.


Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (Ulixertinib).

Germann UA, Furey BF, Markland W, Hoover RR, Aronov AM, Roix JJ, Hale M, Boucher DM, Sorrell DA, Martinez-Botella G, Fitzgibbon M, Shapiro P, Wick MJ, Samadani R, Meshaw K, Groover A, DeCrescenzo G, Namchuk M, Emery CM, Saha S, Welsch DJ.

Mol Cancer Ther. 2017 Nov;16(11):2351-2363. doi: 10.1158/1535-7163.MCT-17-0456. Epub 2017 Sep 22.


A multiplex preclinical model for adenoid cystic carcinoma of the salivary gland identifies regorafenib as a potential therapeutic drug.

Chen C, Choudhury S, Wangsa D, Lescott CJ, Wilkins DJ, Sripadhan P, Liu X, Wangsa D, Ried T, Moskaluk C, Wick MJ, Glasgow E, Schlegel R, Agarwal S.

Sci Rep. 2017 Sep 12;7(1):11410. doi: 10.1038/s41598-017-11764-2.


What do the new American College of Medical Genetics and Genomics (ACMG) guidelines mean for the provision of non-invasive prenatal genetic screening?

Allyse M, Wick MJ.

J Obstet Gynaecol. 2017 Aug;37(6):795-798. doi: 10.1080/01443615.2017.1291597. Epub 2017 Apr 1.


In-vitro and in-vivo combined effect of ARQ 092, an AKT inhibitor, with ARQ 087, a FGFR inhibitor.

Yu Y, Hall T, Eathiraj S, Wick MJ, Schwartz B, Abbadessa G.

Anticancer Drugs. 2017 Jun;28(5):503-513. doi: 10.1097/CAD.0000000000000486.


NCCN Guidelines Insights: Genetic/Familial High-Risk Assessment: Breast and Ovarian, Version 2.2017.

Daly MB, Pilarski R, Berry M, Buys SS, Farmer M, Friedman S, Garber JE, Kauff ND, Khan S, Klein C, Kohlmann W, Kurian A, Litton JK, Madlensky L, Merajver SD, Offit K, Pal T, Reiser G, Shannon KM, Swisher E, Vinayak S, Voian NC, Weitzel JN, Wick MJ, Wiesner GL, Dwyer M, Darlow S.

J Natl Compr Canc Netw. 2017 Jan;15(1):9-20.


Activating NOTCH1 Mutations Define a Distinct Subgroup of Patients With Adenoid Cystic Carcinoma Who Have Poor Prognosis, Propensity to Bone and Liver Metastasis, and Potential Responsiveness to Notch1 Inhibitors.

Ferrarotto R, Mitani Y, Diao L, Guijarro I, Wang J, Zweidler-McKay P, Bell D, William WN Jr, Glisson BS, Wick MJ, Kapoun AM, Patnaik A, Eckhardt G, Munster P, Faoro L, Dupont J, Lee JJ, Futreal A, El-Naggar AK, Heymach JV.

J Clin Oncol. 2017 Jan 20;35(3):352-360. doi: 10.1200/JCO.2016.67.5264. Epub 2016 Nov 21.


A Phase I Clinical Trial and Independent Patient-Derived Xenograft Study of Combined Targeted Treatment with Dacomitinib and Figitumumab in Advanced Solid Tumors.

Calvo E, Soria JC, Ma WW, Wang T, Bahleda R, Tolcher AW, Gernhardt D, O'Connell J, Millham R, Giri N, Wick MJ, Adjei AA, Hidalgo M.

Clin Cancer Res. 2017 Mar 1;23(5):1177-1185. doi: 10.1158/1078-0432.CCR-15-2301. Epub 2016 Oct 12.


Functional characterization of a GFAP variant of uncertain significance in an Alexander disease case within the setting of an individualized medicine clinic.

Boczek NJ, Sigafoos AN, Zimmermann MT, Maus RL, Cousin MA, Blackburn PR, Urrutia R, Clark KJ, Patterson MC, Wick MJ, Klee EW.

Clin Case Rep. 2016 Aug 15;4(9):885-95. doi: 10.1002/ccr3.655. eCollection 2016 Sep.


Protection against vascular leak in neprilysin transgenic mice with complex overexpression pattern.

Wick MJ, Loomis ZL, Harral JW, Le M, Wehling CA, Miller YE, Dempsey EC.

Transgenic Res. 2016 Dec;25(6):773-784. Epub 2016 Jul 1.


A reduced population of CD103(+)CD11b(+) dendritic cells has a limited impact on oral Salmonella infection.

Fernández-Santoscoy M, Wenzel UA, Persson E, Yrlid U, Agace W, Wick MJ.

Immunol Lett. 2016 Aug;176:72-80. doi: 10.1016/j.imlet.2016.05.012. Epub 2016 Jun 2.


Identification of methylated genes in salivary gland adenoid cystic carcinoma xenografts using global demethylation and methylation microarray screening.

Ling S, Rettig EM, Tan M, Chang X, Wang Z, Brait M, Bishop JA, Fertig EJ, Considine M, Wick MJ, Ha PK.

Int J Oncol. 2016 Jul;49(1):225-34. doi: 10.3892/ijo.2016.3532. Epub 2016 May 18.


False Negative Cell-Free DNA Screening Result in a Newborn with Trisomy 13.

Cao Y, Hoppman NL, Kerr SE, Sattler CA, Borowski KS, Wick MJ, Highsmith WE, Aypar U.

Case Rep Genet. 2016;2016:7397405. doi: 10.1155/2016/7397405. Epub 2016 Feb 22.


Outcome of Whole Exome Sequencing for Diagnostic Odyssey Cases of an Individualized Medicine Clinic: The Mayo Clinic Experience.

Lazaridis KN, Schahl KA, Cousin MA, Babovic-Vuksanovic D, Riegert-Johnson DL, Gavrilova RH, McAllister TM, Lindor NM, Abraham RS, Ackerman MJ, Pichurin PN, Deyle DR, Gavrilov DK, Hand JL, Klee EW, Stephens MC, Wick MJ, Atkinson EJ, Linden DR, Ferber MJ, Wieben ED, Farrugia G; Individualized Medicine Clinic Members.

Mayo Clin Proc. 2016 Mar;91(3):297-307. doi: 10.1016/j.mayocp.2015.12.018.


Targeting MDM2 for Treatment of Adenoid Cystic Carcinoma.

Warner KA, Nör F, Acasigua GA, Martins MD, Zhang Z, McLean SA, Spector ME, Chepeha DB, Helman J, Wick MJ, Moskaluk CA, Castilho RM, Pearson AT, Wang S, Nör JE.

Clin Cancer Res. 2016 Jul 15;22(14):3550-9. doi: 10.1158/1078-0432.CCR-15-1698. Epub 2016 Mar 2.


Genetic/Familial High-Risk Assessment: Breast and Ovarian, Version 2.2015.

Daly MB, Pilarski R, Axilbund JE, Berry M, Buys SS, Crawford B, Farmer M, Friedman S, Garber JE, Khan S, Klein C, Kohlmann W, Kurian A, Litton JK, Madlensky L, Marcom PK, Merajver SD, Offit K, Pal T, Rana H, Reiser G, Robson ME, Shannon KM, Swisher E, Voian NC, Weitzel JN, Whelan A, Wick MJ, Wiesner GL, Dwyer M, Kumar R, Darlow S.

J Natl Compr Canc Netw. 2016 Feb;14(2):153-62.


An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma.

Drier Y, Cotton MJ, Williamson KE, Gillespie SM, Ryan RJ, Kluk MJ, Carey CD, Rodig SJ, Sholl LM, Afrogheh AH, Faquin WC, Queimado L, Qi J, Wick MJ, El-Naggar AK, Bradner JE, Moskaluk CA, Aster JC, Knoechel B, Bernstein BE.

Nat Genet. 2016 Mar;48(3):265-72. doi: 10.1038/ng.3502. Epub 2016 Feb 1.


Reduced numbers of mucosal DR(int) macrophages and increased numbers of CD103(+) dendritic cells during anti-TNF-α treatment in patients with Crohn's disease.

Dige A, Magnusson MK, Öhman L, Hvas CL, Kelsen J, Wick MJ, Agnholt J.

Scand J Gastroenterol. 2016;51(6):692-9. doi: 10.3109/00365521.2015.1134649. Epub 2016 Jan 19.


The Gut Microbiota Reduces Colonization of the Mesenteric Lymph Nodes and IL-12-Independent IFN-γ Production During Salmonella Infection.

Fernández-Santoscoy M, Wenzel UA, Yrlid U, Cardell S, Bäckhed F, Wick MJ.

Front Cell Infect Microbiol. 2015 Dec 22;5:93. doi: 10.3389/fcimb.2015.00093. eCollection 2015.


Targeting AKT1-E17K and the PI3K/AKT Pathway with an Allosteric AKT Inhibitor, ARQ 092.

Yu Y, Savage RE, Eathiraj S, Meade J, Wick MJ, Hall T, Abbadessa G, Schwartz B.

PLoS One. 2015 Oct 15;10(10):e0140479. doi: 10.1371/journal.pone.0140479. eCollection 2015.


Synergy between CD40 and MyD88 Does Not Influence Host Survival to Salmonella Infection.

Wenzel UA, Fernandez-Santoscoy M, Tam MA, Tegtmeyer P, Wick MJ.

Front Immunol. 2015 Sep 14;6:460. doi: 10.3389/fimmu.2015.00460. eCollection 2015.


CD103+ CD11b+ Dendritic Cells Induce Th17 T Cells in Muc2-Deficient Mice with Extensively Spread Colitis.

Wenzel UA, Jonstrand C, Hansson GC, Wick MJ.

PLoS One. 2015 Jun 29;10(6):e0130750. doi: 10.1371/journal.pone.0130750. eCollection 2015.


Macrophage and dendritic cell subsets in IBD: ALDH+ cells are reduced in colon tissue of patients with ulcerative colitis regardless of inflammation.

Magnusson MK, Brynjólfsson SF, Dige A, Uronen-Hansson H, Börjesson LG, Bengtsson JL, Gudjonsson S, Öhman L, Agnholt J, Sjövall H, Agace WW, Wick MJ.

Mucosal Immunol. 2016 Jan;9(1):171-82. doi: 10.1038/mi.2015.48. Epub 2015 Jun 17.


Peloruside A Inhibits Growth of Human Lung and Breast Tumor Xenografts in an Athymic nu/nu Mouse Model.

Meyer CJ, Krauth M, Wick MJ, Shay JW, Gellert G, De Brabander JK, Northcote PT, Miller JH.

Mol Cancer Ther. 2015 Aug;14(8):1816-23. doi: 10.1158/1535-7163.MCT-15-0167. Epub 2015 Jun 8.


Spontaneous colitis in Muc2-deficient mice reflects clinical and cellular features of active ulcerative colitis.

Wenzel UA, Magnusson MK, Rydström A, Jonstrand C, Hengst J, Johansson ME, Velcich A, Öhman L, Strid H, Sjövall H, Hansson GC, Wick MJ.

PLoS One. 2014 Jun 19;9(6):e100217. doi: 10.1371/journal.pone.0100217. eCollection 2014.


Predicting vaginal birth after cesarean section: a cohort study.

Tessmer-Tuck JA, El-Nashar SA, Racek AR, Lohse CM, Famuyide AO, Wick MJ.

Gynecol Obstet Invest. 2014;77(2):121-6. doi: 10.1159/000357757. Epub 2014 Feb 11.


Challenging and complex decisions in the management of the BRCA mutation carrier.

Stan DL, Shuster LT, Wick MJ, Swanson CL, Pruthi S, Bakkum-Gamez JN.

J Womens Health (Larchmt). 2013 Oct;22(10):825-34. doi: 10.1089/jwh.2013.4407. Epub 2013 Aug 29. Review.


Serum IL-17A in newly diagnosed treatment-naive patients with ulcerative colitis reflects clinical disease severity and predicts the course of disease.

Ohman L, Dahlén R, Isaksson S, Sjöling A, Wick MJ, Sjövall H, Van Oudenhove L, Simrén M, Strid H.

Inflamm Bowel Dis. 2013 Oct;19(11):2433-9. doi: 10.1097/MIB.0b013e3182a563cb.


Second-trimester diagnosis of triploidy: a series of four cases.

Wick JB, Johnson KJ, O'Brien J, Wick MJ.

AJP Rep. 2013 May;3(1):37-40. doi: 10.1055/s-0032-1331378. Epub 2012 Dec 31.


Pregnancy in an individual with mild Smith-Lemli-Opitz syndrome.

Ellingson MS, Wick MJ, White WM, Raymond KM, Saenger AK, Pichurin PN, Wassif CA, Porter FD, Babovic-Vuksanovic D.

Clin Genet. 2014 May;85(5):495-7. doi: 10.1111/cge.12209. Epub 2013 Jun 24. No abstract available.


Long QT syndrome-associated mutations in intrauterine fetal death.

Crotti L, Tester DJ, White WM, Bartos DC, Insolia R, Besana A, Kunic JD, Will ML, Velasco EJ, Bair JJ, Ghidoni A, Cetin I, Van Dyke DL, Wick MJ, Brost B, Delisle BP, Facchinetti F, George AL, Schwartz PJ, Ackerman MJ.

JAMA. 2013 Apr 10;309(14):1473-82. doi: 10.1001/jama.2013.3219.


TrkC signaling is activated in adenoid cystic carcinoma and requires NT-3 to stimulate invasive behavior.

Ivanov SV, Panaccione A, Brown B, Guo Y, Moskaluk CA, Wick MJ, Brown JL, Ivanova AV, Issaeva N, El-Naggar AK, Yarbrough WG.

Oncogene. 2013 Aug 8;32(32):3698-710. doi: 10.1038/onc.2012.377. Epub 2012 Oct 1.


The clinical effect of the dual-targeting strategy involving PI3K/AKT/mTOR and RAS/MEK/ERK pathways in patients with advanced cancer.

Shimizu T, Tolcher AW, Papadopoulos KP, Beeram M, Rasco DW, Smith LS, Gunn S, Smetzer L, Mays TA, Kaiser B, Wick MJ, Alvarez C, Cavazos A, Mangold GL, Patnaik A.

Clin Cancer Res. 2012 Apr 15;18(8):2316-25. doi: 10.1158/1078-0432.CCR-11-2381. Epub 2012 Jan 19.


Loss-of-function thrombospondin-1 mutations in familial pulmonary hypertension.

Maloney JP, Stearman RS, Bull TM, Calabrese DW, Tripp-Addison ML, Wick MJ, Broeckel U, Robbins IM, Wheeler LA, Cogan JD, Loyd JE.

Am J Physiol Lung Cell Mol Physiol. 2012 Mar 15;302(6):L541-54. doi: 10.1152/ajplung.00282.2011. Epub 2011 Dec 23.


Prioritizing phase I treatment options through preclinical testing on personalized tumorgraft.

Morelli MP, Calvo E, Ordoñez E, Wick MJ, Viqueira BR, Lopez-Casas PP, Bruckheimer E, Calles-Blanco A, Sidransky D, Hidalgo M.

J Clin Oncol. 2012 Feb 1;30(4):e45-8. doi: 10.1200/JCO.2011.36.9678. Epub 2011 Dec 19. No abstract available.


A pilot clinical study of treatment guided by personalized tumorgrafts in patients with advanced cancer.

Hidalgo M, Bruckheimer E, Rajeshkumar NV, Garrido-Laguna I, De Oliveira E, Rubio-Viqueira B, Strawn S, Wick MJ, Martell J, Sidransky D.

Mol Cancer Ther. 2011 Aug;10(8):1311-6. doi: 10.1158/1535-7163.MCT-11-0233. Epub 2011 Jun 14.


Primary appendiceal mucinous adenocarcinoma in two first-degree relatives: case report and review.

Racek AR, Rabe KG, Wick MJ, Psychogios A, Lindor NM.

Hered Cancer Clin Pract. 2011 May 4;9(1):1. doi: 10.1186/1897-4287-9-1.


Plasmacytoid dendritic cells mature independently of MyD88 and IFN-αβR in response to Listeria and stimulate CD8 T cells.

Tam MA, Wenzel UA, Wick MJ.

Immunol Lett. 2011 Aug 30;138(2):104-12. doi: 10.1016/j.imlet.2011.03.007. Epub 2011 Mar 29.


Intestinal dendritic cell and macrophage subsets: Tipping the balance to Crohn's disease?

Magnusson MK, Wick MJ.

Eur J Microbiol Immunol (Bp). 2011 Mar;1(1):19-24. doi: 10.1556/EuJMI.1.2011.1.5. Review.


Decreased neprilysin and pulmonary vascular remodeling in chronic obstructive pulmonary disease.

Wick MJ, Buesing EJ, Wehling CA, Loomis ZL, Cool CD, Zamora MR, Miller YE, Colgan SP, Hersh LB, Voelkel NF, Dempsey EC.

Am J Respir Crit Care Med. 2011 Feb 1;183(3):330-40. doi: 10.1164/rccm.201002-0154OC. Epub 2010 Sep 2.


Salmonella inhibits monocyte differentiation into CD11c hi MHC-II hi cells in a MyD88-dependent fashion.

Rydström A, Wick MJ.

J Leukoc Biol. 2010 May;87(5):823-32. doi: 10.1189/jlb.0909615.


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