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Items: 1 to 50 of 63

1.

Development of MAP4 Kinase Inhibitors as Motor Neuron-Protecting Agents.

Bos PH, Lowry ER, Costa J, Thams S, Garcia-Diaz A, Zask A, Wichterle H, Stockwell BR.

Cell Chem Biol. 2019 Oct 29. pii: S2451-9456(19)30350-2. doi: 10.1016/j.chembiol.2019.10.005. [Epub ahead of print]

PMID:
31676236
2.

FGF family members differentially regulate maturation and proliferation of stem cell-derived astrocytes.

Savchenko E, Teku GN, Boza-Serrano A, Russ K, Berns M, Deierborg T, Lamas NJ, Wichterle H, Rothstein J, Henderson CE, Vihinen M, Roybon L.

Sci Rep. 2019 Jul 3;9(1):9610. doi: 10.1038/s41598-019-46110-1.

3.

Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neurons.

An D, Fujiki R, Iannitelli DE, Smerdon JW, Maity S, Rose MF, Gelber A, Wanaselja EK, Yagudayeva I, Lee JY, Vogel C, Wichterle H, Engle EC, Mazzoni EO.

Elife. 2019 Jun 3;8. pii: e44423. doi: 10.7554/eLife.44423.

4.

High resolution discovery of chromatin interactions.

Guo Y, Krismer K, Closser M, Wichterle H, Gifford DK.

Nucleic Acids Res. 2019 Apr 8;47(6):e35. doi: 10.1093/nar/gkz051.

5.

A Stem Cell-Based Screening Platform Identifies Compounds that Desensitize Motor Neurons to Endoplasmic Reticulum Stress.

Thams S, Lowry ER, Larraufie MH, Spiller KJ, Li H, Williams DJ, Hoang P, Jiang E, Williams LA, Sandoe J, Eggan K, Lieberam I, Kanning KC, Stockwell BR, Henderson CE, Wichterle H.

Mol Ther. 2019 Jan 2;27(1):87-101. doi: 10.1016/j.ymthe.2018.10.010. Epub 2018 Oct 19.

PMID:
30446391
6.

Subtype Diversification and Synaptic Specificity of Stem Cell-Derived Spinal Interneurons.

Hoang PT, Chalif JI, Bikoff JB, Jessell TM, Mentis GZ, Wichterle H.

Neuron. 2018 Oct 10;100(1):135-149.e7. doi: 10.1016/j.neuron.2018.09.016.

7.

Rbfox Splicing Factors Promote Neuronal Maturation and Axon Initial Segment Assembly.

Jacko M, Weyn-Vanhentenryck SM, Smerdon JW, Yan R, Feng H, Williams DJ, Pai J, Xu K, Wichterle H, Zhang C.

Neuron. 2018 Feb 21;97(4):853-868.e6. doi: 10.1016/j.neuron.2018.01.020. Epub 2018 Feb 1.

8.

Expression of Terminal Effector Genes in Mammalian Neurons Is Maintained by a Dynamic Relay of Transient Enhancers.

Rhee HS, Closser M, Guo Y, Bashkirova EV, Tan GC, Gifford DK, Wichterle H.

Neuron. 2016 Dec 21;92(6):1252-1265. doi: 10.1016/j.neuron.2016.11.037. Epub 2016 Dec 8.

9.

ALS disrupts spinal motor neuron maturation and aging pathways within gene co-expression networks.

Ho R, Sances S, Gowing G, Amoroso MW, O'Rourke JG, Sahabian A, Wichterle H, Baloh RH, Sareen D, Svendsen CN.

Nat Neurosci. 2016 Sep;19(9):1256-67. doi: 10.1038/nn.4345. Epub 2016 Jul 18.

10.

Iterative Role of Notch Signaling in Spinal Motor Neuron Diversification.

Tan GC, Mazzoni EO, Wichterle H.

Cell Rep. 2016 Jul 26;16(4):907-916. doi: 10.1016/j.celrep.2016.06.067. Epub 2016 Jul 14.

11.

Protein Prenylation Constitutes an Endogenous Brake on Axonal Growth.

Li H, Kuwajima T, Oakley D, Nikulina E, Hou J, Yang WS, Lowry ER, Lamas NJ, Amoroso MW, Croft GF, Hosur R, Wichterle H, Sebti S, Filbin MT, Stockwell B, Henderson CE.

Cell Rep. 2016 Jul 12;16(2):545-558. doi: 10.1016/j.celrep.2016.06.013. Epub 2016 Jun 30.

12.

Modeling ALS with motor neurons derived from human induced pluripotent stem cells.

Sances S, Bruijn LI, Chandran S, Eggan K, Ho R, Klim JR, Livesey MR, Lowry E, Macklis JD, Rushton D, Sadegh C, Sareen D, Wichterle H, Zhang SC, Svendsen CN.

Nat Neurosci. 2016 Apr;19(4):542-53. doi: 10.1038/nn.4273. Review.

13.

Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.

Johnson-Kerner BL, Garcia Diaz A, Ekins S, Wichterle H.

PLoS One. 2015 Oct 13;10(10):e0140157. doi: 10.1371/journal.pone.0140157. eCollection 2015.

14.

High resolution mapping of enhancer-promoter interactions.

Reeder C, Closser M, Poh HM, Sandhu K, Wichterle H, Gifford D.

PLoS One. 2015 May 13;10(5):e0122420. doi: 10.1371/journal.pone.0122420. eCollection 2015.

15.

Intermediate filament protein accumulation in motor neurons derived from giant axonal neuropathy iPSCs rescued by restoration of gigaxonin.

Johnson-Kerner BL, Ahmad FS, Diaz AG, Greene JP, Gray SJ, Samulski RJ, Chung WK, Van Coster R, Maertens P, Noggle SA, Henderson CE, Wichterle H.

Hum Mol Genet. 2015 Mar 1;24(5):1420-31. doi: 10.1093/hmg/ddu556. Epub 2014 Nov 4.

16.

Neurotrophic requirements of human motor neurons defined using amplified and purified stem cell-derived cultures.

Lamas NJ, Johnson-Kerner B, Roybon L, Kim YA, Garcia-Diaz A, Wichterle H, Henderson CE.

PLoS One. 2014 Oct 22;9(10):e110324. doi: 10.1371/journal.pone.0110324. eCollection 2014. Erratum in: PLoS One. 2015;10(3):e0119195.

17.

Giant axonal neuropathy: An updated perspective on its pathology and pathogenesis.

Johnson-Kerner BL, Roth L, Greene JP, Wichterle H, Sproule DM.

Muscle Nerve. 2014 Oct;50(4):467-76. doi: 10.1002/mus.24321. Review.

PMID:
24947478
18.

Stem cells in the nervous system.

Maldonado-Soto AR, Oakley DH, Wichterle H, Stein J, Doetsch FK, Henderson CE.

Am J Phys Med Rehabil. 2014 Nov;93(11 Suppl 3):S132-44. doi: 10.1097/PHM.0000000000000111. Review.

19.

An integrated model of multiple-condition ChIP-Seq data reveals predeterminants of Cdx2 binding.

Mahony S, Edwards MD, Mazzoni EO, Sherwood RI, Kakumanu A, Morrison CA, Wichterle H, Gifford DK.

PLoS Comput Biol. 2014 Mar 27;10(3):e1003501. doi: 10.1371/journal.pcbi.1003501. eCollection 2014 Mar.

20.

Necroptosis drives motor neuron death in models of both sporadic and familial ALS.

Re DB, Le Verche V, Yu C, Amoroso MW, Politi KA, Phani S, Ikiz B, Hoffmann L, Koolen M, Nagata T, Papadimitriou D, Nagy P, Mitsumoto H, Kariya S, Wichterle H, Henderson CE, Przedborski S.

Neuron. 2014 Mar 5;81(5):1001-1008. doi: 10.1016/j.neuron.2014.01.011. Epub 2014 Feb 6.

21.

Human stem cell-derived spinal cord astrocytes with defined mature or reactive phenotypes.

Roybon L, Lamas NJ, Garcia AD, Yang EJ, Sattler R, Lewis VJ, Kim YA, Kachel CA, Rothstein JD, Przedborski S, Wichterle H, Henderson CE.

Cell Rep. 2013 Sep 12;4(5):1035-1048. doi: 10.1016/j.celrep.2013.06.021. Epub 2013 Aug 29.

22.

Saltatory remodeling of Hox chromatin in response to rostrocaudal patterning signals.

Mazzoni EO, Mahony S, Peljto M, Patel T, Thornton SR, McCuine S, Reeder C, Boyer LA, Young RA, Gifford DK, Wichterle H.

Nat Neurosci. 2013 Sep;16(9):1191-1198. doi: 10.1038/nn.3490. Epub 2013 Aug 18.

23.

Neuroscience. Mapping neuronal diversity one cell at a time.

Wichterle H, Gifford D, Mazzoni E.

Science. 2013 Aug 16;341(6147):726-7. doi: 10.1126/science.1235884. No abstract available.

PMID:
23950522
24.

Synergistic binding of transcription factors to cell-specific enhancers programs motor neuron identity.

Mazzoni EO, Mahony S, Closser M, Morrison CA, Nedelec S, Williams DJ, An D, Gifford DK, Wichterle H.

Nat Neurosci. 2013 Sep;16(9):1219-27. doi: 10.1038/nn.3467. Epub 2013 Jul 21.

25.

Accelerated high-yield generation of limb-innervating motor neurons from human stem cells.

Amoroso MW, Croft GF, Williams DJ, O'Keeffe S, Carrasco MA, Davis AR, Roybon L, Oakley DH, Maniatis T, Henderson CE, Wichterle H.

J Neurosci. 2013 Jan 9;33(2):574-86. doi: 10.1523/JNEUROSCI.0906-12.2013.

26.

Maturation of spinal motor neurons derived from human embryonic stem cells.

Takazawa T, Croft GF, Amoroso MW, Studer L, Wichterle H, Macdermott AB.

PLoS One. 2012;7(7):e40154. doi: 10.1371/journal.pone.0040154. Epub 2012 Jul 3.

27.

Lineage-based identification of cellular states and expression programs.

Hashimoto T, Jaakkola T, Sherwood R, Mazzoni EO, Wichterle H, Gifford D.

Bioinformatics. 2012 Jun 15;28(12):i250-7. doi: 10.1093/bioinformatics/bts204.

28.

Apoptosis of limb innervating motor neurons and erosion of motor pool identity upon lineage specific dicer inactivation.

Chen JA, Wichterle H.

Front Neurosci. 2012 May 17;6:69. doi: 10.3389/fnins.2012.00069. eCollection 2012.

29.

Concentration-dependent requirement for local protein synthesis in motor neuron subtype-specific response to axon guidance cues.

N├ędelec S, Peljto M, Shi P, Amoroso MW, Kam LC, Wichterle H.

J Neurosci. 2012 Jan 25;32(4):1496-506. doi: 10.1523/JNEUROSCI.4176-11.2012.

30.

Embryonic stem cell-based mapping of developmental transcriptional programs.

Mazzoni EO, Mahony S, Iacovino M, Morrison CA, Mountoufaris G, Closser M, Whyte WA, Young RA, Kyba M, Gifford DK, Wichterle H.

Nat Methods. 2011 Nov 13;8(12):1056-8. doi: 10.1038/nmeth.1775.

31.

An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming.

Gabut M, Samavarchi-Tehrani P, Wang X, Slobodeniuc V, O'Hanlon D, Sung HK, Alvarez M, Talukder S, Pan Q, Mazzoni EO, Nedelec S, Wichterle H, Woltjen K, Hughes TR, Zandstra PW, Nagy A, Wrana JL, Blencowe BJ.

Cell. 2011 Sep 30;147(1):132-46. doi: 10.1016/j.cell.2011.08.023. Epub 2011 Sep 15.

32.

Mir-17-3p controls spinal neural progenitor patterning by regulating Olig2/Irx3 cross-repressive loop.

Chen JA, Huang YP, Mazzoni EO, Tan GC, Zavadil J, Wichterle H.

Neuron. 2011 Feb 24;69(4):721-35. doi: 10.1016/j.neuron.2011.01.014.

33.

A functionally characterized test set of human induced pluripotent stem cells.

Boulting GL, Kiskinis E, Croft GF, Amoroso MW, Oakley DH, Wainger BJ, Williams DJ, Kahler DJ, Yamaki M, Davidow L, Rodolfa CT, Dimos JT, Mikkilineni S, MacDermott AB, Woolf CJ, Henderson CE, Wichterle H, Eggan K.

Nat Biotechnol. 2011 Mar;29(3):279-86. doi: 10.1038/nbt.1783. Epub 2011 Feb 3.

34.

Ligand-dependent dynamics of retinoic acid receptor binding during early neurogenesis.

Mahony S, Mazzoni EO, McCuine S, Young RA, Wichterle H, Gifford DK.

Genome Biol. 2011;12(1):R2. doi: 10.1186/gb-2011-12-1-r2. Epub 2011 Jan 13.

35.

MicroRNA regulation of neural stem cells and neurogenesis.

Shi Y, Zhao X, Hsieh J, Wichterle H, Impey S, Banerjee S, Neveu P, Kosik KS.

J Neurosci. 2010 Nov 10;30(45):14931-6. doi: 10.1523/JNEUROSCI.4280-10.2010. Review.

36.

Programming embryonic stem cells to neuronal subtypes.

Peljto M, Wichterle H.

Curr Opin Neurobiol. 2011 Feb;21(1):43-51. doi: 10.1016/j.conb.2010.09.012. Epub 2010 Oct 20. Review.

37.

Global control of motor neuron topography mediated by the repressive actions of a single hox gene.

Jung H, Lacombe J, Mazzoni EO, Liem KF Jr, Grinstein J, Mahony S, Mukhopadhyay D, Gifford DK, Young RA, Anderson KV, Wichterle H, Dasen JS.

Neuron. 2010 Sep 9;67(5):781-96. doi: 10.1016/j.neuron.2010.08.008.

38.

Functional diversity of ESC-derived motor neuron subtypes revealed through intraspinal transplantation.

Peljto M, Dasen JS, Mazzoni EO, Jessell TM, Wichterle H.

Cell Stem Cell. 2010 Sep 3;7(3):355-66. doi: 10.1016/j.stem.2010.07.013.

39.

What can pluripotent stem cells teach us about neurodegenerative diseases?

Wichterle H, Przedborski S.

Nat Neurosci. 2010 Jul;13(7):800-4. doi: 10.1038/nn.2577.

40.

The subventricular zone en-face: wholemount staining and ependymal flow.

Mirzadeh Z, Doetsch F, Sawamoto K, Wichterle H, Alvarez-Buylla A.

J Vis Exp. 2010 May 6;(39). pii: 1938. doi: 10.3791/1938.

41.

Combined microfluidics/protein patterning platform for pharmacological interrogation of axon pathfinding.

Shi P, Nedelec S, Wichterle H, Kam LC.

Lab Chip. 2010 Apr 21;10(8):1005-10. doi: 10.1039/b922143c. Epub 2010 Jan 25.

42.

Xenotransplantation of embryonic stem cell-derived motor neurons into the developing chick spinal cord.

Wichterle H, Peljto M, Nedelec S.

Methods Mol Biol. 2009;482:171-83. doi: 10.1007/978-1-59745-060-7_11.

PMID:
19089356
43.

Differentiation of mouse embryonic stem cells to spinal motor neurons.

Wichterle H, Peljto M.

Curr Protoc Stem Cell Biol. 2008 May;Chapter 1:Unit 1H.1.1-1H.1.9. doi: 10.1002/9780470151808.sc01h01s5.

PMID:
18770634
44.

Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons.

Dimos JT, Rodolfa KT, Niakan KK, Weisenthal LM, Mitsumoto H, Chung W, Croft GF, Saphier G, Leibel R, Goland R, Wichterle H, Henderson CE, Eggan K.

Science. 2008 Aug 29;321(5893):1218-21. doi: 10.1126/science.1158799. Epub 2008 Jul 31.

45.

Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons.

Nagai M, Re DB, Nagata T, Chalazonitis A, Jessell TM, Wichterle H, Przedborski S.

Nat Neurosci. 2007 May;10(5):615-22. Epub 2007 Apr 15.

46.

Multiprotein complexes of the survival of motor neuron protein SMN with Gemins traffic to neuronal processes and growth cones of motor neurons.

Zhang H, Xing L, Rossoll W, Wichterle H, Singer RH, Bassell GJ.

J Neurosci. 2006 Aug 16;26(33):8622-32.

47.

Olig2+ neuroepithelial motoneuron progenitors are not multipotent stem cells in vivo.

Mukouyama YS, Deneen B, Lukaszewicz A, Novitch BG, Wichterle H, Jessell TM, Anderson DJ.

Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1551-6. Epub 2006 Jan 23.

48.

New neurons follow the flow of cerebrospinal fluid in the adult brain.

Sawamoto K, Wichterle H, Gonzalez-Perez O, Cholfin JA, Yamada M, Spassky N, Murcia NS, Garcia-Verdugo JM, Marin O, Rubenstein JL, Tessier-Lavigne M, Okano H, Alvarez-Buylla A.

Science. 2006 Feb 3;311(5761):629-32. Epub 2006 Jan 12.

49.

Functional properties of motoneurons derived from mouse embryonic stem cells.

Miles GB, Yohn DC, Wichterle H, Jessell TM, Rafuse VF, Brownstone RM.

J Neurosci. 2004 Sep 8;24(36):7848-58.

50.

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